UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?

Molecular Pharmaceutics

Volumn 14, Issue 9, 2017, Pages 2875-2883

  Troberg, Johanna ^a   Järvinen, Erkka ^a   Ge, Guang Bo ^b   Yang, Ling ^b   Finel, Moshe ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

AMC; bavachinin; estradiol; estrone; intestinal glucuronidation; intestine microsomes; morphine; NCHN; recombinant UGT1A10; SN 38; UDP glucuronosyltransferase

Indexed keywords

7 AMINO 4 METHYLCOUMARIN; BAVACHININ; COUMARIN DERIVATIVE; DICLOFENAC; ESTRADIOL; ESTRONE; FIRTECAN; GLUCURONOSYLTRANSFERASE 1A10; HERBACEOUS AGENT; HYMECROMONE; MORPHINE; N (3 CARBOXYPROPYL) 4 HYDROXY 1,8 NAPHTHALIMIDE; NILOTINIB; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; 7-AMINO-4-METHYLCOUMARIN; BILIRUBIN URIDINE-DIPHOSPHOGLUCURONOSYL TRANSFERASE 1A10; CAMPTOTHECIN; FLAVONOID; GLUCURONOSYLTRANSFERASE; IRINOTECAN;

ARTICLE; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG STRUCTURE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE FUNCTION; MICROSOME; PRIORITY JOURNAL; SMALL INTESTINE; ANALOGS AND DERIVATIVES; ANIMAL; HUMAN; INTESTINE; KINETICS; LIVER MICROSOME; METABOLISM; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CAMPTOTHECIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; DICLOFENAC; ESTRADIOL; ESTRONE; FLAVONOIDS; GLUCURONOSYLTRANSFERASE; HUMANS; HYMECROMONE; INTESTINES; KINETICS; MICROSOMES, LIVER;

EID: 85028882307     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.6b00852     Document Type: Article

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