Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

Nature Communications

Volumn 8, Issue 1, 2017, Pages

  Ma, Junying ^a   Huang, Hongbo ^a   Xie, Yunchang ^a   Liu, Zhiyong ^b   Zhao, Jin ^c   Zhang, Chunyan ^a,d   Jia, Yanxi ^a,d   Zhang, Yun ^a   Zhang, Hua ^c   Zhang, Tianyu ^b   Ju, Jianhua ^a,d  

^a SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY   (China)

^b GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^c GUANGDONG MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 HEXENOIC ACID; 3 NITROTYROSINE; ANTIMYCOBACTERIAL AGENT; ILAMYCIN DERIVATIVE; SHORT CHAIN FATTY ACID; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; 3-NITROTYROSINE; CYCLOPEPTIDE; TYROSINE;

BACTERIUM; CONCENTRATION (COMPOSITION); DISEASE INCIDENCE; DRUG; DRUG RESISTANCE; EXPERIMENTAL STUDY; GENE; GENE EXPRESSION; GENETIC ENGINEERING; ORGANIC ACID; TUBERCULOSIS; VIRUS;

A-549 CELL LINE; ANTITUBERCULOSIS ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CNE-2 CELL LINE; CYTOTOXICITY ASSAY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; GENE CLUSTER; GENE INACTIVATION; GENETIC ENGINEERING; HELA CELL LINE; HEP-G2 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; ISOTOPE LABELING; MCF-7 CELL LINE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRECURSOR; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES; STREPTOMYCES ATRATUS; TUBERCULOSIS; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; GENETICS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MYCOBACTERIUM TUBERCULOSIS; PHYSIOLOGY; SYNTHESIS;

MYCOBACTERIUM TUBERCULOSIS; STREPTOMYCES ATRATUS;

ANTITUBERCULAR AGENTS; DRUG DESIGN; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PEPTIDES, CYCLIC; TUBERCULOSIS; TYROSINE;

EID: 85028561302     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-00419-5     Document Type: Article

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