Adenylation and S -methylation of cysteine by the bifunctional enzyme TioN in thiocoraline biosynthesis

Journal of the American Chemical Society

Volumn 136, Issue 49, 2014, Pages 17350-17354

  Al Mestarihi, Ahmad H ^a   Villamizar, Germán ^b   Fernández, Javier ^b   Zolova, Olga E ^c   Lombó, Felipe ^b   Garneau Tsodikova, Sylvie ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; METHYLATION;

ADENYLATION DOMAINS; ANTI-TUMOR AGENTS; BIFUNCTIONAL ENZYMES; COMBINATORIAL BIOSYNTHESIS; L-CYSTEINE RESIDUE; METHYLTRANSFERASES; NONRIBOSOMAL PEPTIDE; S ADENOSYL L METHIONINES;

LOADING;

BINDING PROTEIN; CYSTEINE; ESTERASE; METHYLTRANSFERASE; RECOMBINANT PROTEIN; RECOMBINANT TION PROTEIN; RECOMBINANT TIOT PROTEIN; S ADENOSYLMETHIONINE; THIOCORALINE; TION ENZYME; TIOS PROTEIN; TIOT PROTEIN; UNCLASSIFIED DRUG; DEPSIPEPTIDE;

ADENYLATION; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SYNTHESIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; THIOLATION; BIOSYNTHESIS; CHEMISTRY; CONFORMATION; METABOLISM; METHYLATION;

CYSTEINE; DEPSIPEPTIDES; METHYLATION; METHYLTRANSFERASES; MOLECULAR CONFORMATION;

EID: 84918499989     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja510489j     Document Type: Article

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