메뉴 건너뛰기




Volumn 11, Issue 8, 2017, Pages 7572-7586

Next-Generation Lipids in RNA Interference Therapeutics

Author keywords

cationic lipids; delivery; gene silencing; ionizable amino lipids; lipid nanoparticles; lipidoids; RNA interference; RNAi therapeutics; siRNA; toxicity

Indexed keywords

DISEASES; GENE TRANSFER; GENES; NANOPARTICLES; NUCLEIC ACIDS; RNA; TOXICITY;

EID: 85028513904     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.7b04734     Document Type: Review
Times cited : (165)

References (110)
  • 3
    • 0030032042 scopus 로고    scopus 로고
    • Antisense Oligonucleotide Therapeutics: Drug Delivery and Targeting
    • Rojanasakul, Y. Antisense Oligonucleotide Therapeutics: Drug Delivery and Targeting Adv. Drug Delivery Rev. 1996, 18, 115-131 10.1016/0169-409X(95)00020-8
    • (1996) Adv. Drug Delivery Rev. , vol.18 , pp. 115-131
    • Rojanasakul, Y.1
  • 4
    • 0026002671 scopus 로고
    • Stability of Antisense DNA Oligodeoxynucleotide Analogs in Cellular Extracts and Sera
    • Akhtar, S.; Kole, R.; Juliano, R. L. Stability of Antisense DNA Oligodeoxynucleotide Analogs in Cellular Extracts and Sera Life Sci. 1991, 49, 1793-1801 10.1016/0024-3205(91)90480-Y
    • (1991) Life Sci. , vol.49 , pp. 1793-1801
    • Akhtar, S.1    Kole, R.2    Juliano, R.L.3
  • 5
    • 0031300863 scopus 로고    scopus 로고
    • Pharmacokinetics of Oligonucleotides
    • discussion 75-68
    • Agrawal, S.; Zhang, R. Pharmacokinetics of Oligonucleotides Ciba Found. Symp. 1997, 209, 60-75 discussion 75-68.
    • (1997) Ciba Found. Symp. , vol.209 , pp. 60-75
    • Agrawal, S.1    Zhang, R.2
  • 7
    • 33746438424 scopus 로고    scopus 로고
    • Toxicity of Cationic Lipids and Cationic Polymers in Gene Delivery
    • Lv, H.; Zhang, S.; Wang, B.; Cui, S.; Yan, J. Toxicity of Cationic Lipids and Cationic Polymers in Gene Delivery J. Controlled Release 2006, 114, 100-109 10.1016/j.jconrel.2006.04.014
    • (2006) J. Controlled Release , vol.114 , pp. 100-109
    • Lv, H.1    Zhang, S.2    Wang, B.3    Cui, S.4    Yan, J.5
  • 8
    • 46549090126 scopus 로고    scopus 로고
    • Progress in Developing Cationic Vectors for Non-Viral Systemic Gene Therapy against Cancer
    • Morille, M.; Passirani, C.; Vonarbourg, A.; Clavreul, A.; Benoit, J. P. Progress in Developing Cationic Vectors for Non-Viral Systemic Gene Therapy against Cancer Biomaterials 2008, 29, 3477-3496 10.1016/j.biomaterials.2008.04.036
    • (2008) Biomaterials , vol.29 , pp. 3477-3496
    • Morille, M.1    Passirani, C.2    Vonarbourg, A.3    Clavreul, A.4    Benoit, J.P.5
  • 9
    • 33750406161 scopus 로고
    • Theory of Self-Assembly of Hydrocarbon Amphiphiles into Micelles and Bilayers
    • Israelachvili, J. N.; Mitchell, D. J.; Ninham, B. W. Theory of Self-Assembly of Hydrocarbon Amphiphiles into Micelles and Bilayers J. Chem. Soc., Faraday Trans. 2 1976, 72, 1525-1568 10.1039/f29767201525
    • (1976) J. Chem. Soc., Faraday Trans. 2 , vol.72 , pp. 1525-1568
    • Israelachvili, J.N.1    Mitchell, D.J.2    Ninham, B.W.3
  • 10
    • 33750689490 scopus 로고    scopus 로고
    • Ordered 2-D and 3-D Nanostructured Amphiphile Self-Assembly Materials Stable in Excess Solvent
    • Kaasgaard, T.; Drummond, C. J. Ordered 2-D and 3-D Nanostructured Amphiphile Self-Assembly Materials Stable in Excess Solvent Phys. Chem. Chem. Phys. 2006, 8, 4957-4975 10.1039/b609510k
    • (2006) Phys. Chem. Chem. Phys. , vol.8 , pp. 4957-4975
    • Kaasgaard, T.1    Drummond, C.J.2
  • 11
    • 79960778918 scopus 로고    scopus 로고
    • Interaction of Cholesterol-Conjugated Ionizable Amino Lipids with Biomembranes: Lipid Polymorphism, Structure-Activity Relationship, and Implications for siRNA Delivery
    • Zhang, J.; Fan, H.; Levorse, D. A.; Crocker, L. S. Interaction of Cholesterol-Conjugated Ionizable Amino Lipids with Biomembranes: Lipid Polymorphism, Structure-Activity Relationship, and Implications for siRNA Delivery Langmuir 2011, 27, 9473-9483 10.1021/la201464k
    • (2011) Langmuir , vol.27 , pp. 9473-9483
    • Zhang, J.1    Fan, H.2    Levorse, D.A.3    Crocker, L.S.4
  • 12
    • 33845190449 scopus 로고    scopus 로고
    • Cationic Lipids, Lipoplexes and Intracellular Delivery of Genes
    • Wasungu, L.; Hoekstra, D. Cationic Lipids, Lipoplexes and Intracellular Delivery of Genes J. Controlled Release 2006, 116, 255-264 10.1016/j.jconrel.2006.06.024
    • (2006) J. Controlled Release , vol.116 , pp. 255-264
    • Wasungu, L.1    Hoekstra, D.2
  • 14
    • 0034971315 scopus 로고    scopus 로고
    • Synthesis of a Novel Series of Cationic Lipids That Can Act as Efficient Gene Delivery Vehicles through Systematic Heterocyclic Substitution of Cholesterol Derivatives
    • Gao, H.; Hui, K. M. Synthesis of a Novel Series of Cationic Lipids That Can Act as Efficient Gene Delivery Vehicles through Systematic Heterocyclic Substitution of Cholesterol Derivatives Gene Ther. 2001, 8, 855-863 10.1038/sj.gt.3301471
    • (2001) Gene Ther. , vol.8 , pp. 855-863
    • Gao, H.1    Hui, K.M.2
  • 15
    • 0034736033 scopus 로고    scopus 로고
    • Cation Substitution in Cationic Phosphonolipids: A New Concept to Improve Transfection Activity and Decrease Cellular Toxicity
    • Floch, V.; Loisel, S.; Guenin, E.; Herve, A. C.; Clement, J. C.; Yaouanc, J. J. des Abbayes, H. and Ferec, C. Cation Substitution in Cationic Phosphonolipids: A New Concept to Improve Transfection Activity and Decrease Cellular Toxicity J. Med. Chem. 2000, 43, 4617-4628 10.1021/jm000006z
    • (2000) J. Med. Chem. , vol.43 , pp. 4617-4628
    • Floch, V.1    Loisel, S.2    Guenin, E.3    Herve, A.C.4    Clement, J.C.5    Yaouanc, J.J.6    Des Abbayes, H.7    Ferec, C.8
  • 16
    • 0028245537 scopus 로고
    • Cationic Liposomes for Direct Gene Transfer in Therapy of Cancer and Other Diseases
    • discussion 34-25
    • Farhood, H.; Gao, X.; Son, K.; Yang, Y. Y.; Lazo, J. S.; Huang, L.; Barsoum, J.; Bottega, R.; Epand, R. M. Cationic Liposomes for Direct Gene Transfer in Therapy of Cancer and Other Diseases Ann. N. Y. Acad. Sci. 1994, 716, 23-34 discussion 34-25. 10.1111/j.1749-6632.1994.tb21701.x
    • (1994) Ann. N. Y. Acad. Sci. , vol.716 , pp. 23-34
    • Farhood, H.1    Gao, X.2    Son, K.3    Yang, Y.Y.4    Lazo, J.S.5    Huang, L.6    Barsoum, J.7    Bottega, R.8    Epand, R.M.9
  • 17
    • 0026497428 scopus 로고
    • Effect of Cationic Cholesterol Derivatives on Gene Transfer and Protein Kinase C Activity
    • Farhood, H.; Bottega, R.; Epand, R. M.; Huang, L. Effect of Cationic Cholesterol Derivatives on Gene Transfer and Protein Kinase C Activity Biochim. Biophys. Acta, Biomembr. 1992, 1111, 239-246 10.1016/0005-2736(92)90316-E
    • (1992) Biochim. Biophys. Acta, Biomembr. , vol.1111 , pp. 239-246
    • Farhood, H.1    Bottega, R.2    Epand, R.M.3    Huang, L.4
  • 18
    • 0026667564 scopus 로고
    • Inhibition of Protein Kinase C by Cationic Amphiphiles
    • Bottega, R.; Epand, R. M. Inhibition of Protein Kinase C by Cationic Amphiphiles Biochemistry 1992, 31, 9025-9030 10.1021/bi00152a045
    • (1992) Biochemistry , vol.31 , pp. 9025-9030
    • Bottega, R.1    Epand, R.M.2
  • 19
    • 0028801156 scopus 로고
    • A Novel Series of Amphiphilic Imidazolinium Compounds for in Vitro and in Vivo Gene Delivery
    • Solodin, I.; Brown, C. S.; Bruno, M. S.; Chow, C.-Y.; Jang, E.-H.; Debs, R. J.; Heath, T. D. A Novel Series of Amphiphilic Imidazolinium Compounds for In Vitro and In Vivo Gene Delivery Biochemistry 1995, 34, 13537-13544 10.1021/bi00041a033
    • (1995) Biochemistry , vol.34 , pp. 13537-13544
    • Solodin, I.1    Brown, C.S.2    Bruno, M.S.3    Chow, C.-Y.4    Jang, E.-H.5    Debs, R.J.6    Heath, T.D.7
  • 20
    • 12844262409 scopus 로고    scopus 로고
    • Pyridinium Cationic Lipids in Gene Delivery: An in Vitro and in Vivo Comparison of Transfection Efficiency Versus a Tetraalkylammonium Congener
    • Ilies, M. A.; Johnson, B. H.; Makori, F.; Miller, A.; Seitz, W. A.; Thompson, E. B.; Balaban, A. T. Pyridinium Cationic Lipids in Gene Delivery: An In Vitro and In Vivo Comparison of Transfection Efficiency Versus a Tetraalkylammonium Congener Arch. Biochem. Biophys. 2005, 435, 217-226 10.1016/j.abb.2004.12.010
    • (2005) Arch. Biochem. Biophys. , vol.435 , pp. 217-226
    • Ilies, M.A.1    Johnson, B.H.2    Makori, F.3    Miller, A.4    Seitz, W.A.5    Thompson, E.B.6    Balaban, A.T.7
  • 22
    • 0842284168 scopus 로고    scopus 로고
    • Solid-Phase Synthesis of 89 Polyamine-Based Cationic Lipids for DNA Delivery to Mammalian Cells
    • Yingyongnarongkul, B. E.; Howarth, M.; Elliott, T.; Bradley, M. Solid-Phase Synthesis of 89 Polyamine-Based Cationic Lipids for DNA Delivery to Mammalian Cells Chem.-Eur. J. 2004, 10, 463-473 10.1002/chem.200305232
    • (2004) Chem. - Eur. J. , vol.10 , pp. 463-473
    • Yingyongnarongkul, B.E.1    Howarth, M.2    Elliott, T.3    Bradley, M.4
  • 25
    • 0037011904 scopus 로고    scopus 로고
    • Synthesis of Novel Cationic Lipids: Effect of Structural Modification on the Efficiency of Gene Transfer
    • Heyes, J. A.; Niculescu-Duvaz, D.; Cooper, R. G.; Springer, C. J. Synthesis of Novel Cationic Lipids: Effect of Structural Modification on the Efficiency of Gene Transfer J. Med. Chem. 2002, 45, 99-114 10.1021/jm010918g
    • (2002) J. Med. Chem. , vol.45 , pp. 99-114
    • Heyes, J.A.1    Niculescu-Duvaz, D.2    Cooper, R.G.3    Springer, C.J.4
  • 26
    • 0032828009 scopus 로고    scopus 로고
    • Synthesis of a Single-Tailed Cationic Lipid and Investigation of Its Transfection
    • Tang, F.; Hughes, J. A. Synthesis of a Single-Tailed Cationic Lipid and Investigation of Its Transfection J. Controlled Release 1999, 62, 345-358 10.1016/S0168-3659(99)00158-3
    • (1999) J. Controlled Release , vol.62 , pp. 345-358
    • Tang, F.1    Hughes, J.A.2
  • 27
    • 84887324806 scopus 로고    scopus 로고
    • Overcoming Nonviral Gene Delivery Barriers: Perspective and Future
    • Jones, C. H.; Chen, C. K.; Ravikrishnan, A.; Rane, S.; Pfeifer, B. A. Overcoming Nonviral Gene Delivery Barriers: Perspective and Future Mol. Pharmaceutics 2013, 10, 4082-4098 10.1021/mp400467x
    • (2013) Mol. Pharmaceutics , vol.10 , pp. 4082-4098
    • Jones, C.H.1    Chen, C.K.2    Ravikrishnan, A.3    Rane, S.4    Pfeifer, B.A.5
  • 28
    • 84873413702 scopus 로고    scopus 로고
    • Influence of Cationic Lipid Composition on Uptake and Intracellular Processing of Lipid Nanoparticle Formulations of siRNA
    • Lin, P. J.; Tam, Y. Y.; Hafez, I.; Sandhu, A.; Chen, S.; Ciufolini, M. A.; Nabi, I. R.; Cullis, P. R. Influence of Cationic Lipid Composition on Uptake and Intracellular Processing of Lipid Nanoparticle Formulations of siRNA Nanomedicine 2013, 9, 233-246 10.1016/j.nano.2012.05.019
    • (2013) Nanomedicine , vol.9 , pp. 233-246
    • Lin, P.J.1    Tam, Y.Y.2    Hafez, I.3    Sandhu, A.4    Chen, S.5    Ciufolini, M.A.6    Nabi, I.R.7    Cullis, P.R.8
  • 29
    • 19944420826 scopus 로고    scopus 로고
    • Synthesis of Carbamate-Linked Lipids for Gene Delivery
    • Liu, D.; Hu, J.; Qiao, W.; Li, Z.; Zhang, S.; Cheng, L. Synthesis of Carbamate-Linked Lipids for Gene Delivery Bioorg. Med. Chem. Lett. 2005, 15, 3147-3150 10.1016/j.bmcl.2005.04.010
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 3147-3150
    • Liu, D.1    Hu, J.2    Qiao, W.3    Li, Z.4    Zhang, S.5    Cheng, L.6
  • 30
    • 25844493624 scopus 로고    scopus 로고
    • Synthesis and Characterization of a Series of Carbamate-Linked Cationic Lipids for Gene Delivery
    • Liu, D.; Hu, i.; Qiao, W.; Li, Z.; Zhan, S.; Cheng, L. Synthesis and Characterization of a Series of Carbamate-Linked Cationic Lipids for Gene Delivery Lipids 2005, 40, 839-848 10.1007/s11745-005-1446-5
    • (2005) Lipids , vol.40 , pp. 839-848
    • Liu, D.1    Hu, I.2    Qiao, W.3    Li, Z.4    Zhan, S.5    Cheng, L.6
  • 31
    • 0027246678 scopus 로고
    • Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines
    • Wagner, R. W.; Matteucci, M. D.; Lewis, J. G.; Gutierrez, A. J.; Moulds, C.; Froehler, B. C. Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines Science 1993, 260, 1510-1513 10.1126/science.7684856
    • (1993) Science , vol.260 , pp. 1510-1513
    • Wagner, R.W.1    Matteucci, M.D.2    Lewis, J.G.3    Gutierrez, A.J.4    Moulds, C.5    Froehler, B.C.6
  • 32
    • 0027092897 scopus 로고
    • Cationic Lipids Enhance Cellular Uptake and Activity of Phosphorothioate Antisense Oligonucleotides
    • Bennett, C. F.; Chiang, M. Y.; Chan, H.; Shoemaker, J. E.; Mirabelli, C. K. Cationic Lipids Enhance Cellular Uptake and Activity of Phosphorothioate Antisense Oligonucleotides Mol. Pharmacol. 1992, 41, 1023-1033
    • (1992) Mol. Pharmacol. , vol.41 , pp. 1023-1033
    • Bennett, C.F.1    Chiang, M.Y.2    Chan, H.3    Shoemaker, J.E.4    Mirabelli, C.K.5
  • 34
    • 0026562708 scopus 로고
    • Oligonucleotides Encapsulated in pH Sensitive Liposomes Are Efficient toward Friend Retrovirus
    • Ropert, C.; Lavignon, M.; Dubernet, C.; Couvreur, P.; Malvy, C. Oligonucleotides Encapsulated in pH Sensitive Liposomes Are Efficient toward Friend Retrovirus Biochem. Biophys. Res. Commun. 1992, 183, 879-885 10.1016/0006-291X(92)90565-3
    • (1992) Biochem. Biophys. Res. Commun. , vol.183 , pp. 879-885
    • Ropert, C.1    Lavignon, M.2    Dubernet, C.3    Couvreur, P.4    Malvy, C.5
  • 35
    • 84893531193 scopus 로고    scopus 로고
    • Toxicity Profiling of Several Common RNAi-Based Nanomedicines: A Comparative Study
    • Landesman-Milo, D.; Peer, D. Toxicity Profiling of Several Common RNAi-Based Nanomedicines: A Comparative Study Drug Delivery Transl. Res. 2014, 4, 96-103 10.1007/s13346-013-0158-7
    • (2014) Drug Delivery Transl. Res. , vol.4 , pp. 96-103
    • Landesman-Milo, D.1    Peer, D.2
  • 36
    • 84869200994 scopus 로고    scopus 로고
    • Immunotoxicity Derived from Manipulating Leukocytes with Lipid-Based Nanoparticles
    • Peer, D. Immunotoxicity Derived from Manipulating Leukocytes with Lipid-Based Nanoparticles Adv. Drug Delivery Rev. 2012, 64, 1738-1748 10.1016/j.addr.2012.06.013
    • (2012) Adv. Drug Delivery Rev. , vol.64 , pp. 1738-1748
    • Peer, D.1
  • 37
    • 0033084717 scopus 로고    scopus 로고
    • Polycation-Based DNA Complexes for Tumor-Targeted Gene Delivery in Vivo
    • Kircheis, R.; Schuller, S.; Brunner, S.; Ogris, M.; Heider, K. H.; Zauner, W.; Wagner, E. Polycation-Based DNA Complexes for Tumor-Targeted Gene Delivery In Vivo J. Gene Med. 1999, 1, 111-120 10.1002/(SICI)1521-2254(199903/04)1:2<111::AID-JGM22>3.3.CO;2-P
    • (1999) J. Gene Med. , vol.1 , pp. 111-120
    • Kircheis, R.1    Schuller, S.2    Brunner, S.3    Ogris, M.4    Heider, K.H.5    Zauner, W.6    Wagner, E.7
  • 38
    • 77954385672 scopus 로고    scopus 로고
    • The Systemic Toxicity of Positively Charged Lipid Nanoparticles and the Role of Toll-Like Receptor 4 in Immune Activation
    • Kedmi, R.; Ben-Arie, N.; Peer, D. The Systemic Toxicity of Positively Charged Lipid Nanoparticles and the Role of Toll-Like Receptor 4 in Immune Activation Biomaterials 2010, 31, 6867-6875 10.1016/j.biomaterials.2010.05.027
    • (2010) Biomaterials , vol.31 , pp. 6867-6875
    • Kedmi, R.1    Ben-Arie, N.2    Peer, D.3
  • 39
    • 0031048990 scopus 로고    scopus 로고
    • Limitations of Cationic Liposomes for Antisense Oligonucleotide Delivery
    • Litzinger, D. C. Limitations of Cationic Liposomes for Antisense Oligonucleotide Delivery J. Liposome Res. 1997, 7, 51-61 10.3109/08982109709035481
    • (1997) J. Liposome Res. , vol.7 , pp. 51-61
    • Litzinger, D.C.1
  • 40
    • 0028075403 scopus 로고
    • Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic Liposomes
    • Lappalainen, K.; Jaaskelainen, I.; Syrjanen, K.; Urtti, A.; Syrjanen, S. Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic Liposomes Pharm. Res. 1994, 11, 1127-1131 10.1023/A:1018932714745
    • (1994) Pharm. Res. , vol.11 , pp. 1127-1131
    • Lappalainen, K.1    Jaaskelainen, I.2    Syrjanen, K.3    Urtti, A.4    Syrjanen, S.5
  • 41
    • 14744299236 scopus 로고    scopus 로고
    • Implications of Pharmacokinetic Behavior of Lipoplex for Its Inflammatory Toxicity
    • Zhang, J.-S.; Liu, F.; Huang, L. Implications of Pharmacokinetic Behavior of Lipoplex for Its Inflammatory Toxicity Adv. Drug Delivery Rev. 2005, 57, 689-698 10.1016/j.addr.2004.12.004
    • (2005) Adv. Drug Delivery Rev. , vol.57 , pp. 689-698
    • Zhang, J.-S.1    Liu, F.2    Huang, L.3
  • 43
    • 0029061020 scopus 로고
    • In Vivo Disposition Characteristics of Plasmid DNA Complexed with Cationic Liposomes
    • Mahato, R. I.; Kawabata, K.; Takakura, Y.; Hashida, M. In Vivo Disposition Characteristics of Plasmid DNA Complexed with Cationic Liposomes J. Drug Target 1995, 3, 149-157 10.3109/10611869509059214
    • (1995) J. Drug Target , vol.3 , pp. 149-157
    • Mahato, R.I.1    Kawabata, K.2    Takakura, Y.3    Hashida, M.4
  • 46
    • 0032568628 scopus 로고    scopus 로고
    • Evidence of Interlipidic Ion-Pairing in Anion-Induced DNA Release from Cationic Amphiphile-DNA Complexes. Mechanistic Implications in Transfection
    • Bhattacharya, S.; Mandal, S. S. Evidence of Interlipidic Ion-Pairing in Anion-Induced DNA Release from Cationic Amphiphile-DNA Complexes. Mechanistic Implications in Transfection Biochemistry 1998, 37, 7764-7777 10.1021/bi971772j
    • (1998) Biochemistry , vol.37 , pp. 7764-7777
    • Bhattacharya, S.1    Mandal, S.S.2
  • 47
    • 84886261520 scopus 로고    scopus 로고
    • Delivery Materials for siRNA Therapeutics
    • Kanasty, R.; Dorkin, J. R.; Vegas, A.; Anderson, D. Delivery Materials for siRNA Therapeutics Nat. Mater. 2013, 12, 967-977 10.1038/nmat3765
    • (2013) Nat. Mater. , vol.12 , pp. 967-977
    • Kanasty, R.1    Dorkin, J.R.2    Vegas, A.3    Anderson, D.4
  • 48
    • 24944577514 scopus 로고    scopus 로고
    • Cationic Lipid Saturation Influences Intracellular Delivery of Encapsulated Nucleic Acids
    • Heyes, J.; Palmer, L.; Bremner, K.; MacLachlan, I. Cationic Lipid Saturation Influences Intracellular Delivery of Encapsulated Nucleic Acids J. Controlled Release 2005, 107, 276-287 10.1016/j.jconrel.2005.06.014
    • (2005) J. Controlled Release , vol.107 , pp. 276-287
    • Heyes, J.1    Palmer, L.2    Bremner, K.3    MacLachlan, I.4
  • 54
    • 85009228793 scopus 로고    scopus 로고
    • Biodegradable Lipid Nanoparticles Induce a Prolonged RNA Interference-Mediated Protein Knockdown and Show Rapid Hepatic Clearance in Mice and Nonhuman Primates
    • Suzuki, Y.; Hyodo, K.; Suzuki, T.; Tanaka, Y.; Kikuchi, H.; Ishihara, H. Biodegradable Lipid Nanoparticles Induce a Prolonged RNA Interference-Mediated Protein Knockdown and Show Rapid Hepatic Clearance in Mice and Nonhuman Primates Int. J. Pharm. 2017, 519, 34-43 10.1016/j.ijpharm.2017.01.016
    • (2017) Int. J. Pharm. , vol.519 , pp. 34-43
    • Suzuki, Y.1    Hyodo, K.2    Suzuki, T.3    Tanaka, Y.4    Kikuchi, H.5    Ishihara, H.6
  • 55
    • 0029964866 scopus 로고    scopus 로고
    • Mechanism of Oligonucleotide Release from Cationic Liposomes
    • Zelphati, O.; Szoka, F. C., Jr. Mechanism of Oligonucleotide Release from Cationic Liposomes Proc. Natl. Acad. Sci. U. S. A. 1996, 93, 11493-11498 10.1073/pnas.93.21.11493
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 11493-11498
    • Zelphati, O.1    Szoka, F.C.2
  • 56
    • 0029056088 scopus 로고
    • Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid
    • Zabner, J.; Fasbender, A. J.; Moninger, T.; Poellinger, K. A.; Welsh, M. J. Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid J. Biol. Chem. 1995, 270, 18997-19007 10.1074/jbc.270.32.18997
    • (1995) J. Biol. Chem. , vol.270 , pp. 18997-19007
    • Zabner, J.1    Fasbender, A.J.2    Moninger, T.3    Poellinger, K.A.4    Welsh, M.J.5
  • 57
    • 0031551011 scopus 로고    scopus 로고
    • Gene Transfer Mediated by Cationic Lipids: Lack of a Correlation between Lipid Mixing and Transfection
    • Stegmann, T.; Legendre, J. Y. Gene Transfer Mediated by Cationic Lipids: Lack of a Correlation between Lipid Mixing and Transfection Biochim. Biophys. Acta, Biomembr. 1997, 1325, 71-79 10.1016/S0005-2736(96)00241-6
    • (1997) Biochim. Biophys. Acta, Biomembr. , vol.1325 , pp. 71-79
    • Stegmann, T.1    Legendre, J.Y.2
  • 58
    • 0034714228 scopus 로고    scopus 로고
    • Membrane Perturbation and the Mechanism of Lipid-Mediated Transfer of DNA into Cells
    • Mui, B.; Ahkong, Q. F.; Chow, L.; Hope, M. J. Membrane Perturbation and the Mechanism of Lipid-Mediated Transfer of DNA into Cells Biochim. Biophys. Acta, Biomembr. 2000, 1467, 281-292 10.1016/S0005-2736(00)00226-1
    • (2000) Biochim. Biophys. Acta, Biomembr. , vol.1467 , pp. 281-292
    • Mui, B.1    Ahkong, Q.F.2    Chow, L.3    Hope, M.J.4
  • 59
    • 0034882516 scopus 로고    scopus 로고
    • On the Mechanism Whereby Cationic Lipids Promote Intracellular Delivery of Polynucleic Acids
    • Hafez, I. M.; Maurer, N.; Cullis, P. R. On the Mechanism Whereby Cationic Lipids Promote Intracellular Delivery of Polynucleic Acids Gene Ther. 2001, 8, 1188-1196 10.1038/sj.gt.3301506
    • (2001) Gene Ther. , vol.8 , pp. 1188-1196
    • Hafez, I.M.1    Maurer, N.2    Cullis, P.R.3
  • 61
    • 17644419268 scopus 로고    scopus 로고
    • Nonbilayer Phase of Lipoplex-Membrane Mixture Determines Endosomal Escape of Genetic Cargo and Transfection Efficiency
    • Zuhorn, I. S.; Bakowsky, U.; Polushkin, E.; Visser, W. H.; Stuart, M. C.; Engberts, J. B.; Hoekstra, D. Nonbilayer Phase of Lipoplex-Membrane Mixture Determines Endosomal Escape of Genetic Cargo and Transfection Efficiency Mol. Ther. 2005, 11, 801-810 10.1016/j.ymthe.2004.12.018
    • (2005) Mol. Ther. , vol.11 , pp. 801-810
    • Zuhorn, I.S.1    Bakowsky, U.2    Polushkin, E.3    Visser, W.H.4    Stuart, M.C.5    Engberts, J.B.6    Hoekstra, D.7
  • 62
    • 0037005729 scopus 로고    scopus 로고
    • Characterization of the Inhibitory Effect of PEG-Lipid Conjugates on the Intracellular Delivery of Plasmid and Antisense DNA Mediated by Cationic Lipid Liposomes
    • Song, L. Y.; Ahkong, Q. F.; Rong, Q.; Wang, Z.; Ansell, S.; Hope, M. J.; Mui, B. Characterization of the Inhibitory Effect of PEG-Lipid Conjugates on the Intracellular Delivery of Plasmid and Antisense DNA Mediated by Cationic Lipid Liposomes Biochim. Biophys. Acta, Biomembr. 2002, 1558, 1-13 10.1016/S0005-2736(01)00399-6
    • (2002) Biochim. Biophys. Acta, Biomembr. , vol.1558 , pp. 1-13
    • Song, L.Y.1    Ahkong, Q.F.2    Rong, Q.3    Wang, Z.4    Ansell, S.5    Hope, M.J.6    Mui, B.7
  • 63
    • 84872122976 scopus 로고    scopus 로고
    • How Cationic Lipids Transfer Nucleic Acids into Cells and across Cellular Membranes: Recent Advances
    • Rehman, Z.u.; Zuhorn, I. S.; Hoekstra, D. How Cationic Lipids Transfer Nucleic Acids into Cells and across Cellular Membranes: Recent Advances J. Controlled Release 2013, 166, 46-56 10.1016/j.jconrel.2012.12.014
    • (2013) J. Controlled Release , vol.166 , pp. 46-56
    • Rehman, Z.U.1    Zuhorn, I.S.2    Hoekstra, D.3
  • 64
    • 84872547866 scopus 로고    scopus 로고
    • Synthesis, Characterization, and Evaluation of Ionizable Lysine-Based Lipids for siRNA Delivery
    • Walsh, C. L.; Nguyen, J.; Tiffany, M. R.; Szoka, F. C. Synthesis, Characterization, and Evaluation of Ionizable Lysine-Based Lipids for siRNA Delivery Bioconjugate Chem. 2013, 24, 36-43 10.1021/bc300346h
    • (2013) Bioconjugate Chem. , vol.24 , pp. 36-43
    • Walsh, C.L.1    Nguyen, J.2    Tiffany, M.R.3    Szoka, F.C.4
  • 70
    • 84941287130 scopus 로고    scopus 로고
    • Lipidoid Nanoparticles for siRNA Delivery to the Intestinal Epithelium: In Vitro Investigations in a Caco-2 Model
    • Ball, R. L.; Knapp, C. M.; Whitehead, K. A. Lipidoid Nanoparticles for siRNA Delivery to the Intestinal Epithelium: In Vitro Investigations in a Caco-2 Model PLoS One 2015, 10, e0133154 10.1371/journal.pone.0133154
    • (2015) PLoS One , vol.10 , pp. e0133154
    • Ball, R.L.1    Knapp, C.M.2    Whitehead, K.A.3
  • 71
    • 84963682649 scopus 로고    scopus 로고
    • Lipidoid Tail Structure Strongly Influences siRNA Delivery Activity
    • Knapp, C. M.; Guo, P.; Whitehead, K. A. Lipidoid Tail Structure Strongly Influences siRNA Delivery Activity Cell. Mol. Bioeng. 2016, 9, 305-314 10.1007/s12195-016-0436-9
    • (2016) Cell. Mol. Bioeng. , vol.9 , pp. 305-314
    • Knapp, C.M.1    Guo, P.2    Whitehead, K.A.3
  • 73
    • 84971635810 scopus 로고    scopus 로고
    • Lipidoid Nanoparticle Mediated Silencing of Mcl-1 Induces Apoptosis in Mantle Cell Lymphoma
    • Knapp, C. M.; He, J.; Lister, J.; Whitehead, K. A. Lipidoid Nanoparticle Mediated Silencing of Mcl-1 Induces Apoptosis in Mantle Cell Lymphoma Exp. Biol. Med. (London, U. K.) 2016, 241, 1007-1013 10.1177/1535370216640944
    • (2016) Exp. Biol. Med. (London, U. K.) , vol.241 , pp. 1007-1013
    • Knapp, C.M.1    He, J.2    Lister, J.3    Whitehead, K.A.4
  • 76
    • 84994164431 scopus 로고    scopus 로고
    • The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA
    • Wang, H.; Tam, Y. Y. C.; Chen, S.; Zaifman, J.; van der Meel, R.; Ciufolini, M. A.; Cullis, P. R. The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA Mol. Ther. 2016, 24, 2100-2108 10.1038/mt.2016.179
    • (2016) Mol. Ther. , vol.24 , pp. 2100-2108
    • Wang, H.1    Tam, Y.Y.C.2    Chen, S.3    Zaifman, J.4    Van Der Meel, R.5    Ciufolini, M.A.6    Cullis, P.R.7
  • 77
    • 84880289242 scopus 로고    scopus 로고
    • A Window onto siRNA Delivery
    • Wang, Y.; Huang, L. A Window onto siRNA Delivery Nat. Biotechnol. 2013, 31, 611-612 10.1038/nbt.2634
    • (2013) Nat. Biotechnol. , vol.31 , pp. 611-612
    • Wang, Y.1    Huang, L.2
  • 83
    • 84987864167 scopus 로고    scopus 로고
    • Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin
    • Basha, G.; Ordobadi, M.; Scott, W. R.; Cottle, A.; Liu, Y.; Wang, H.; Cullis, P. R. Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin Mol. Ther. - Nucleic Acids 2016, 5, e363 10.1038/mtna.2016.68
    • (2016) Mol. Ther. - Nucleic Acids , vol.5 , pp. e363
    • Basha, G.1    Ordobadi, M.2    Scott, W.R.3    Cottle, A.4    Liu, Y.5    Wang, H.6    Cullis, P.R.7
  • 84
    • 84923013790 scopus 로고    scopus 로고
    • Delivery Systems for siRNA Drug Development in Cancer Therapy
    • Xu, C.-f.; Wang, J. Delivery Systems for siRNA Drug Development in Cancer Therapy Asian J. Pharm. Sci. 2015, 10, 1-12 10.1016/j.ajps.2014.08.011
    • (2015) Asian J. Pharm. Sci. , vol.10 , pp. 1-12
    • Xu, C.-F.1    Wang, J.2
  • 86
    • 34848918210 scopus 로고    scopus 로고
    • Impact of Tumor-Specific Targeting on the Biodistribution and Efficacy of siRNA Nanoparticles Measured by Multimodality in Vivo Imaging
    • Bartlett, D. W.; Su, H.; Hildebrandt, I. J.; Weber, W. A.; Davis, M. E. Impact of Tumor-Specific Targeting on the Biodistribution and Efficacy of siRNA Nanoparticles Measured by Multimodality In Vivo Imaging Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 15549-15554 10.1073/pnas.0707461104
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 15549-15554
    • Bartlett, D.W.1    Su, H.2    Hildebrandt, I.J.3    Weber, W.A.4    Davis, M.E.5
  • 87
    • 51049104302 scopus 로고    scopus 로고
    • Pharmacokinetics and Biodistribution of Nanoparticles
    • Li, S. D.; Huang, L. Pharmacokinetics and Biodistribution of Nanoparticles Mol. Pharmaceutics 2008, 5, 496-504 10.1021/mp800049w
    • (2008) Mol. Pharmaceutics , vol.5 , pp. 496-504
    • Li, S.D.1    Huang, L.2
  • 88
    • 84887165714 scopus 로고    scopus 로고
    • Factors Controlling the Pharmacokinetics, Biodistribution and Intratumoral Penetration of Nanoparticles
    • Ernsting, M. J.; Murakami, M.; Roy, A.; Li, S.-D. Factors Controlling the Pharmacokinetics, Biodistribution and Intratumoral Penetration of Nanoparticles J. Controlled Release 2013, 172, 782-794 10.1016/j.jconrel.2013.09.013
    • (2013) J. Controlled Release , vol.172 , pp. 782-794
    • Ernsting, M.J.1    Murakami, M.2    Roy, A.3    Li, S.-D.4
  • 89
    • 33746172167 scopus 로고    scopus 로고
    • Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models
    • Kirpotin, D. B.; Drummond, D. C.; Shao, Y.; Shalaby, M. R.; Hong, K.; Nielsen, U. B.; Marks, J. D.; Benz, C. C.; Park, J. W. Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models Cancer Res. 2006, 66, 6732-6740 10.1158/0008-5472.CAN-05-4199
    • (2006) Cancer Res. , vol.66 , pp. 6732-6740
    • Kirpotin, D.B.1    Drummond, D.C.2    Shao, Y.3    Shalaby, M.R.4    Hong, K.5    Nielsen, U.B.6    Marks, J.D.7    Benz, C.C.8    Park, J.W.9
  • 90
    • 84944339790 scopus 로고    scopus 로고
    • Targeted Print Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation
    • Reuter, K. G.; Perry, J. L.; Kim, D.; Luft, J. C.; Liu, R.; DeSimone, J. M. Targeted Print Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation Nano Lett. 2015, 15, 6371-6378 10.1021/acs.nanolett.5b01362
    • (2015) Nano Lett. , vol.15 , pp. 6371-6378
    • Reuter, K.G.1    Perry, J.L.2    Kim, D.3    Luft, J.C.4    Liu, R.5    DeSimone, J.M.6
  • 91
    • 0025131849 scopus 로고
    • Inhibition of Expression of Human Immunodeficiency Virus-1 in Vitro by Antibody-Targeted Liposomes Containing Antisense RNA to the Env Region
    • Renneisen, K.; Leserman, L.; Matthes, E.; Schroder, H. C.; Muller, W. E. Inhibition of Expression of Human Immunodeficiency Virus-1 In Vitro by Antibody-Targeted Liposomes Containing Antisense RNA to the Env Region J. Biol. Chem. 1990, 265, 16337-16342
    • (1990) J. Biol. Chem. , vol.265 , pp. 16337-16342
    • Renneisen, K.1    Leserman, L.2    Matthes, E.3    Schroder, H.C.4    Muller, W.E.5
  • 95
    • 84923459414 scopus 로고    scopus 로고
    • Localized RNAi Therapeutics of Chemoresistant Grade IV Glioma Using Hyaluronan-Grafted Lipid-Based Nanoparticles
    • Cohen, Z. R.; Ramishetti, S.; Peshes-Yaloz, N.; Goldsmith, M.; Wohl, A.; Zibly, Z.; Peer, D. Localized RNAi Therapeutics of Chemoresistant Grade IV Glioma Using Hyaluronan-Grafted Lipid-Based Nanoparticles ACS Nano 2015, 9, 1581-1591 10.1021/nn506248s
    • (2015) ACS Nano , vol.9 , pp. 1581-1591
    • Cohen, Z.R.1    Ramishetti, S.2    Peshes-Yaloz, N.3    Goldsmith, M.4    Wohl, A.5    Zibly, Z.6    Peer, D.7
  • 96
    • 38849166053 scopus 로고    scopus 로고
    • Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target
    • Peer, D.; Park, E. J.; Morishita, Y.; Carman, C. V.; Shimaoka, M. Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target Science 2008, 319, 627-630 10.1126/science.1149859
    • (2008) Science , vol.319 , pp. 627-630
    • Peer, D.1    Park, E.J.2    Morishita, Y.3    Carman, C.V.4    Shimaoka, M.5
  • 98
    • 54949125913 scopus 로고    scopus 로고
    • Folate-Linked Lipid-Based Nanoparticles for Synthetic siRNA Delivery in KB Tumor Xenografts
    • Yoshizawa, T.; Hattori, Y.; Hakoshima, M.; Koga, K.; Maitani, Y. Folate-Linked Lipid-Based Nanoparticles for Synthetic siRNA Delivery in KB Tumor Xenografts Eur. J. Pharm. Biopharm. 2008, 70, 718-725 10.1016/j.ejpb.2008.06.026
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , pp. 718-725
    • Yoshizawa, T.1    Hattori, Y.2    Hakoshima, M.3    Koga, K.4    Maitani, Y.5
  • 99
    • 0028430957 scopus 로고
    • Folate Receptor Mediated DNA Delivery into Tumor Cells: Potosomal Disruption Results in Enhanced Gene Expression
    • Gottschalk, S.; Cristiano, R. J.; Smith, L. C.; Woo, S. L. Folate Receptor Mediated DNA Delivery into Tumor Cells: Potosomal Disruption Results in Enhanced Gene Expression Gene Ther. 1994, 1, 185-191
    • (1994) Gene Ther. , vol.1 , pp. 185-191
    • Gottschalk, S.1    Cristiano, R.J.2    Smith, L.C.3    Woo, S.L.4
  • 100
    • 84856098210 scopus 로고    scopus 로고
    • Challenges in the Pharmaceutical Development of Lipid-Based Short Interfering Ribonucleic Acid Therapeutics
    • Gindy, M. E.; Leone, A. M.; Cunningham, J. J. Challenges in the Pharmaceutical Development of Lipid-Based Short Interfering Ribonucleic Acid Therapeutics Expert Opin. Drug Delivery 2012, 9, 171-182 10.1517/17425247.2012.642363
    • (2012) Expert Opin. Drug Delivery , vol.9 , pp. 171-182
    • Gindy, M.E.1    Leone, A.M.2    Cunningham, J.J.3
  • 101
    • 84871033897 scopus 로고    scopus 로고
    • Microfluidic Technologies for Accelerating the Clinical Translation of Nanoparticles
    • Valencia, P. M.; Farokhzad, O. C.; Karnik, R.; Langer, R. Microfluidic Technologies for Accelerating the Clinical Translation of Nanoparticles Nat. Nanotechnol. 2012, 7, 623-629 10.1038/nnano.2012.168
    • (2012) Nat. Nanotechnol. , vol.7 , pp. 623-629
    • Valencia, P.M.1    Farokhzad, O.C.2    Karnik, R.3    Langer, R.4
  • 105
    • 84937135320 scopus 로고    scopus 로고
    • Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems
    • Leung, A. K. K.; Tam, Y. Y. C.; Chen, S.; Hafez, I. M.; Cullis, P. R. Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems J. Phys. Chem. B 2015, 119, 8698-8706 10.1021/acs.jpcb.5b02891
    • (2015) J. Phys. Chem. B , vol.119 , pp. 8698-8706
    • Leung, A.K.K.1    Tam, Y.Y.C.2    Chen, S.3    Hafez, I.M.4    Cullis, P.R.5
  • 106
    • 0028326452 scopus 로고
    • Liposome-Complement Interactions in Rat Serum: Implications for Liposome Survival Studies
    • Devine, D. V.; Wong, K.; Serrano, K.; Chonn, A.; Cullis, P. R. Liposome-Complement Interactions in Rat Serum: Implications for Liposome Survival Studies Biochim. Biophys. Acta, Biomembr. 1994, 1191, 43-51 10.1016/0005-2736(94)90231-3
    • (1994) Biochim. Biophys. Acta, Biomembr. , vol.1191 , pp. 43-51
    • Devine, D.V.1    Wong, K.2    Serrano, K.3    Chonn, A.4    Cullis, P.R.5
  • 107
    • 0026052844 scopus 로고
    • The Role of Surface Charge in the Activation of the Classical and Alternative Pathways of Complement by Liposomes
    • Chonn, A.; Cullis, P. R.; Devine, D. V. The Role of Surface Charge in the Activation of the Classical and Alternative Pathways of Complement by Liposomes J. Immunol. 1991, 146, 4234-4241
    • (1991) J. Immunol. , vol.146 , pp. 4234-4241
    • Chonn, A.1    Cullis, P.R.2    Devine, D.V.3
  • 108
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-Dependent Stimulation of the Mammalian Innate Immune Response by Synthetic siRNA
    • Judge, A. D.; Sood, V.; Shaw, J. R.; Fang, D.; McClintock, K.; MacLachlan, I. Sequence-Dependent Stimulation of the Mammalian Innate Immune Response by Synthetic siRNA Nat. Biotechnol. 2005, 23, 457-462 10.1038/nbt1081
    • (2005) Nat. Biotechnol. , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 109
    • 0031023264 scopus 로고    scopus 로고
    • Stabilization of Cationic Liposome-Plasmid DNA Complexes by Polyamines and Poly(Ethylene Glycol)-Phospholipid Conjugates for Efficient in Vivo Gene Delivery
    • Hong, K.; Zheng, W.; Baker, A.; Papahadjopoulos, D. Stabilization of Cationic Liposome-Plasmid DNA Complexes by Polyamines and Poly(Ethylene Glycol)-Phospholipid Conjugates for Efficient In Vivo Gene Delivery FEBS Lett. 1997, 400, 233-237 10.1016/S0014-5793(96)01397-X
    • (1997) FEBS Lett. , vol.400 , pp. 233-237
    • Hong, K.1    Zheng, W.2    Baker, A.3    Papahadjopoulos, D.4
  • 110
    • 84948717926 scopus 로고    scopus 로고
    • Clinical Experiences with Systemically Administered siRNA-Based Therapeutics in Cancer
    • Zuckerman, J. E.; Davis, M. E. Clinical Experiences with Systemically Administered siRNA-Based Therapeutics in Cancer Nat. Rev. Drug Discovery 2015, 14, 843-856 10.1038/nrd4685
    • (2015) Nat. Rev. Drug Discovery , vol.14 , pp. 843-856
    • Zuckerman, J.E.1    Davis, M.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.