-
1
-
-
9144247189
-
Therapeutic Silencing of an Endogenous Gene by Systemic Administration of Modified siRNAs
-
Soutschek, J.; Akinc, A.; Bramlage, B.; Charisse, K.; Constien, R.; Donoghue, M.; Elbashir, S.; Geick, A.; Hadwiger, P.; Harborth, J.; John, M.; Kesavan, V.; Lavine, G.; Pandey, R. K.; Racie, T.; Rajeev, K. G.; Rohl, I.; Toudjarska, I.; Wang, G.; Wuschko, S.; Bumcrot, D.; Koteliansky, V.; Limmer, S.; Manoharan, M.; Vornlocher, H. P. Therapeutic Silencing of an Endogenous Gene by Systemic Administration of Modified siRNAs Nature 2004, 432, 173-178 10.1038/nature03121
-
(2004)
Nature
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
Akinc, A.2
Bramlage, B.3
Charisse, K.4
Constien, R.5
Donoghue, M.6
Elbashir, S.7
Geick, A.8
Hadwiger, P.9
Harborth, J.10
John, M.11
Kesavan, V.12
Lavine, G.13
Pandey, R.K.14
Racie, T.15
Rajeev, K.G.16
Rohl, I.17
Toudjarska, I.18
Wang, G.19
Wuschko, S.20
Bumcrot, D.21
Koteliansky, V.22
Limmer, S.23
Manoharan, M.24
Vornlocher, H.P.25
more..
-
2
-
-
34447559636
-
Interfering with Disease: A Progress Report on siRNA-Based Therapeutics
-
de Fougerolles, A.; Vornlocher, H. P.; Maraganore, J.; Lieberman, J. Interfering with Disease: A Progress Report on siRNA-Based Therapeutics Nat. Rev. Drug Discovery 2007, 6, 443-453 10.1038/nrd2310
-
(2007)
Nat. Rev. Drug Discovery
, vol.6
, pp. 443-453
-
-
De Fougerolles, A.1
Vornlocher, H.P.2
Maraganore, J.3
Lieberman, J.4
-
3
-
-
0030032042
-
Antisense Oligonucleotide Therapeutics: Drug Delivery and Targeting
-
Rojanasakul, Y. Antisense Oligonucleotide Therapeutics: Drug Delivery and Targeting Adv. Drug Delivery Rev. 1996, 18, 115-131 10.1016/0169-409X(95)00020-8
-
(1996)
Adv. Drug Delivery Rev.
, vol.18
, pp. 115-131
-
-
Rojanasakul, Y.1
-
4
-
-
0026002671
-
Stability of Antisense DNA Oligodeoxynucleotide Analogs in Cellular Extracts and Sera
-
Akhtar, S.; Kole, R.; Juliano, R. L. Stability of Antisense DNA Oligodeoxynucleotide Analogs in Cellular Extracts and Sera Life Sci. 1991, 49, 1793-1801 10.1016/0024-3205(91)90480-Y
-
(1991)
Life Sci.
, vol.49
, pp. 1793-1801
-
-
Akhtar, S.1
Kole, R.2
Juliano, R.L.3
-
5
-
-
0031300863
-
Pharmacokinetics of Oligonucleotides
-
discussion 75-68
-
Agrawal, S.; Zhang, R. Pharmacokinetics of Oligonucleotides Ciba Found. Symp. 1997, 209, 60-75 discussion 75-68.
-
(1997)
Ciba Found. Symp.
, vol.209
, pp. 60-75
-
-
Agrawal, S.1
Zhang, R.2
-
6
-
-
77957925036
-
A Status Report on RNAi Therapeutics
-
Vaishnaw, A. K.; Gollob, J.; Gamba-Vitalo, C.; Hutabarat, R.; Sah, D.; Meyers, R.; de Fougerolles, T.; Maraganore, J. A Status Report on RNAi Therapeutics Silence 2010, 1, 14 10.1186/1758-907X-1-14
-
(2010)
Silence
, vol.1
, pp. 14
-
-
Vaishnaw, A.K.1
Gollob, J.2
Gamba-Vitalo, C.3
Hutabarat, R.4
Sah, D.5
Meyers, R.6
De Fougerolles, T.7
Maraganore, J.8
-
7
-
-
33746438424
-
Toxicity of Cationic Lipids and Cationic Polymers in Gene Delivery
-
Lv, H.; Zhang, S.; Wang, B.; Cui, S.; Yan, J. Toxicity of Cationic Lipids and Cationic Polymers in Gene Delivery J. Controlled Release 2006, 114, 100-109 10.1016/j.jconrel.2006.04.014
-
(2006)
J. Controlled Release
, vol.114
, pp. 100-109
-
-
Lv, H.1
Zhang, S.2
Wang, B.3
Cui, S.4
Yan, J.5
-
8
-
-
46549090126
-
Progress in Developing Cationic Vectors for Non-Viral Systemic Gene Therapy against Cancer
-
Morille, M.; Passirani, C.; Vonarbourg, A.; Clavreul, A.; Benoit, J. P. Progress in Developing Cationic Vectors for Non-Viral Systemic Gene Therapy against Cancer Biomaterials 2008, 29, 3477-3496 10.1016/j.biomaterials.2008.04.036
-
(2008)
Biomaterials
, vol.29
, pp. 3477-3496
-
-
Morille, M.1
Passirani, C.2
Vonarbourg, A.3
Clavreul, A.4
Benoit, J.P.5
-
9
-
-
33750406161
-
Theory of Self-Assembly of Hydrocarbon Amphiphiles into Micelles and Bilayers
-
Israelachvili, J. N.; Mitchell, D. J.; Ninham, B. W. Theory of Self-Assembly of Hydrocarbon Amphiphiles into Micelles and Bilayers J. Chem. Soc., Faraday Trans. 2 1976, 72, 1525-1568 10.1039/f29767201525
-
(1976)
J. Chem. Soc., Faraday Trans. 2
, vol.72
, pp. 1525-1568
-
-
Israelachvili, J.N.1
Mitchell, D.J.2
Ninham, B.W.3
-
10
-
-
33750689490
-
Ordered 2-D and 3-D Nanostructured Amphiphile Self-Assembly Materials Stable in Excess Solvent
-
Kaasgaard, T.; Drummond, C. J. Ordered 2-D and 3-D Nanostructured Amphiphile Self-Assembly Materials Stable in Excess Solvent Phys. Chem. Chem. Phys. 2006, 8, 4957-4975 10.1039/b609510k
-
(2006)
Phys. Chem. Chem. Phys.
, vol.8
, pp. 4957-4975
-
-
Kaasgaard, T.1
Drummond, C.J.2
-
11
-
-
79960778918
-
Interaction of Cholesterol-Conjugated Ionizable Amino Lipids with Biomembranes: Lipid Polymorphism, Structure-Activity Relationship, and Implications for siRNA Delivery
-
Zhang, J.; Fan, H.; Levorse, D. A.; Crocker, L. S. Interaction of Cholesterol-Conjugated Ionizable Amino Lipids with Biomembranes: Lipid Polymorphism, Structure-Activity Relationship, and Implications for siRNA Delivery Langmuir 2011, 27, 9473-9483 10.1021/la201464k
-
(2011)
Langmuir
, vol.27
, pp. 9473-9483
-
-
Zhang, J.1
Fan, H.2
Levorse, D.A.3
Crocker, L.S.4
-
12
-
-
33845190449
-
Cationic Lipids, Lipoplexes and Intracellular Delivery of Genes
-
Wasungu, L.; Hoekstra, D. Cationic Lipids, Lipoplexes and Intracellular Delivery of Genes J. Controlled Release 2006, 116, 255-264 10.1016/j.jconrel.2006.06.024
-
(2006)
J. Controlled Release
, vol.116
, pp. 255-264
-
-
Wasungu, L.1
Hoekstra, D.2
-
13
-
-
0023447252
-
Lipofection: A Highly Efficient, Lipid-Mediated DNA-Transfection Procedure
-
Felgner, P. L.; Gadek, T. R.; Holm, M.; Roman, R.; Chan, H. W.; Wenz, M.; Northrop, J. P.; Ringold, G. M.; Danielsen, M. Lipofection: A Highly Efficient, Lipid-Mediated DNA-Transfection Procedure Proc. Natl. Acad. Sci. U. S. A. 1987, 84, 7413-7417 10.1073/pnas.84.21.7413
-
(1987)
Proc. Natl. Acad. Sci. U. S. A.
, vol.84
, pp. 7413-7417
-
-
Felgner, P.L.1
Gadek, T.R.2
Holm, M.3
Roman, R.4
Chan, H.W.5
Wenz, M.6
Northrop, J.P.7
Ringold, G.M.8
Danielsen, M.9
-
14
-
-
0034971315
-
Synthesis of a Novel Series of Cationic Lipids That Can Act as Efficient Gene Delivery Vehicles through Systematic Heterocyclic Substitution of Cholesterol Derivatives
-
Gao, H.; Hui, K. M. Synthesis of a Novel Series of Cationic Lipids That Can Act as Efficient Gene Delivery Vehicles through Systematic Heterocyclic Substitution of Cholesterol Derivatives Gene Ther. 2001, 8, 855-863 10.1038/sj.gt.3301471
-
(2001)
Gene Ther.
, vol.8
, pp. 855-863
-
-
Gao, H.1
Hui, K.M.2
-
15
-
-
0034736033
-
Cation Substitution in Cationic Phosphonolipids: A New Concept to Improve Transfection Activity and Decrease Cellular Toxicity
-
Floch, V.; Loisel, S.; Guenin, E.; Herve, A. C.; Clement, J. C.; Yaouanc, J. J. des Abbayes, H. and Ferec, C. Cation Substitution in Cationic Phosphonolipids: A New Concept to Improve Transfection Activity and Decrease Cellular Toxicity J. Med. Chem. 2000, 43, 4617-4628 10.1021/jm000006z
-
(2000)
J. Med. Chem.
, vol.43
, pp. 4617-4628
-
-
Floch, V.1
Loisel, S.2
Guenin, E.3
Herve, A.C.4
Clement, J.C.5
Yaouanc, J.J.6
Des Abbayes, H.7
Ferec, C.8
-
16
-
-
0028245537
-
Cationic Liposomes for Direct Gene Transfer in Therapy of Cancer and Other Diseases
-
discussion 34-25
-
Farhood, H.; Gao, X.; Son, K.; Yang, Y. Y.; Lazo, J. S.; Huang, L.; Barsoum, J.; Bottega, R.; Epand, R. M. Cationic Liposomes for Direct Gene Transfer in Therapy of Cancer and Other Diseases Ann. N. Y. Acad. Sci. 1994, 716, 23-34 discussion 34-25. 10.1111/j.1749-6632.1994.tb21701.x
-
(1994)
Ann. N. Y. Acad. Sci.
, vol.716
, pp. 23-34
-
-
Farhood, H.1
Gao, X.2
Son, K.3
Yang, Y.Y.4
Lazo, J.S.5
Huang, L.6
Barsoum, J.7
Bottega, R.8
Epand, R.M.9
-
17
-
-
0026497428
-
Effect of Cationic Cholesterol Derivatives on Gene Transfer and Protein Kinase C Activity
-
Farhood, H.; Bottega, R.; Epand, R. M.; Huang, L. Effect of Cationic Cholesterol Derivatives on Gene Transfer and Protein Kinase C Activity Biochim. Biophys. Acta, Biomembr. 1992, 1111, 239-246 10.1016/0005-2736(92)90316-E
-
(1992)
Biochim. Biophys. Acta, Biomembr.
, vol.1111
, pp. 239-246
-
-
Farhood, H.1
Bottega, R.2
Epand, R.M.3
Huang, L.4
-
18
-
-
0026667564
-
Inhibition of Protein Kinase C by Cationic Amphiphiles
-
Bottega, R.; Epand, R. M. Inhibition of Protein Kinase C by Cationic Amphiphiles Biochemistry 1992, 31, 9025-9030 10.1021/bi00152a045
-
(1992)
Biochemistry
, vol.31
, pp. 9025-9030
-
-
Bottega, R.1
Epand, R.M.2
-
19
-
-
0028801156
-
A Novel Series of Amphiphilic Imidazolinium Compounds for in Vitro and in Vivo Gene Delivery
-
Solodin, I.; Brown, C. S.; Bruno, M. S.; Chow, C.-Y.; Jang, E.-H.; Debs, R. J.; Heath, T. D. A Novel Series of Amphiphilic Imidazolinium Compounds for In Vitro and In Vivo Gene Delivery Biochemistry 1995, 34, 13537-13544 10.1021/bi00041a033
-
(1995)
Biochemistry
, vol.34
, pp. 13537-13544
-
-
Solodin, I.1
Brown, C.S.2
Bruno, M.S.3
Chow, C.-Y.4
Jang, E.-H.5
Debs, R.J.6
Heath, T.D.7
-
20
-
-
12844262409
-
Pyridinium Cationic Lipids in Gene Delivery: An in Vitro and in Vivo Comparison of Transfection Efficiency Versus a Tetraalkylammonium Congener
-
Ilies, M. A.; Johnson, B. H.; Makori, F.; Miller, A.; Seitz, W. A.; Thompson, E. B.; Balaban, A. T. Pyridinium Cationic Lipids in Gene Delivery: An In Vitro and In Vivo Comparison of Transfection Efficiency Versus a Tetraalkylammonium Congener Arch. Biochem. Biophys. 2005, 435, 217-226 10.1016/j.abb.2004.12.010
-
(2005)
Arch. Biochem. Biophys.
, vol.435
, pp. 217-226
-
-
Ilies, M.A.1
Johnson, B.H.2
Makori, F.3
Miller, A.4
Seitz, W.A.5
Thompson, E.B.6
Balaban, A.T.7
-
21
-
-
0031028138
-
Novel Pyridinium Surfactants for Efficient, Nontoxic in Vitro Gene Delivery
-
van der Woude, I.; Wagenaar, A.; Meekel, A. A.; ter Beest, M. B.; Ruiters, M. H.; Engberts, J. B.; Hoekstra, D. Novel Pyridinium Surfactants for Efficient, Nontoxic In Vitro Gene Delivery Proc. Natl. Acad. Sci. U. S. A. 1997, 94, 1160-1165 10.1073/pnas.94.4.1160
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 1160-1165
-
-
Van Der Woude, I.1
Wagenaar, A.2
Meekel, A.A.3
Ter Beest, M.B.4
Ruiters, M.H.5
Engberts, J.B.6
Hoekstra, D.7
-
22
-
-
0842284168
-
Solid-Phase Synthesis of 89 Polyamine-Based Cationic Lipids for DNA Delivery to Mammalian Cells
-
Yingyongnarongkul, B. E.; Howarth, M.; Elliott, T.; Bradley, M. Solid-Phase Synthesis of 89 Polyamine-Based Cationic Lipids for DNA Delivery to Mammalian Cells Chem.-Eur. J. 2004, 10, 463-473 10.1002/chem.200305232
-
(2004)
Chem. - Eur. J.
, vol.10
, pp. 463-473
-
-
Yingyongnarongkul, B.E.1
Howarth, M.2
Elliott, T.3
Bradley, M.4
-
23
-
-
0032557206
-
Transgene Expression Kinetics after Transfection with Cationic Phosphonolipids in Hematopoietic Non Adherent Cells
-
Floch, V.; Audrezet, M. P.; Guillaume, C.; Gobin, E.; Le Bolch, G.; Clement, J. C.; Yaouanc, J. J.; Des Abbayes, H.; Mercier, B.; Leroy, J. P.; Abgrall, J. F.; Ferec, C. Transgene Expression Kinetics after Transfection with Cationic Phosphonolipids in Hematopoietic Non Adherent Cells Biochim. Biophys. Acta, Biomembr. 1998, 1371, 53-70 10.1016/S0005-2736(98)00002-9
-
(1998)
Biochim. Biophys. Acta, Biomembr.
, vol.1371
, pp. 53-70
-
-
Floch, V.1
Audrezet, M.P.2
Guillaume, C.3
Gobin, E.4
Le Bolch, G.5
Clement, J.C.6
Yaouanc, J.J.7
Des Abbayes, H.8
Mercier, B.9
Leroy, J.P.10
Abgrall, J.F.11
Ferec, C.12
-
24
-
-
0028024919
-
Enhanced Gene Delivery and Mechanism Studies with a Novel Series of Cationic Lipid Formulations
-
Felgner, J. H.; Kumar, R.; Sridhar, C. N.; Wheeler, C. J.; Tsai, Y. J.; Border, R.; Ramsey, P.; Martin, M.; Felgner, P. L. Enhanced Gene Delivery and Mechanism Studies with a Novel Series of Cationic Lipid Formulations J. Biol. Chem. 1994, 269, 2550-2561
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2550-2561
-
-
Felgner, J.H.1
Kumar, R.2
Sridhar, C.N.3
Wheeler, C.J.4
Tsai, Y.J.5
Border, R.6
Ramsey, P.7
Martin, M.8
Felgner, P.L.9
-
25
-
-
0037011904
-
Synthesis of Novel Cationic Lipids: Effect of Structural Modification on the Efficiency of Gene Transfer
-
Heyes, J. A.; Niculescu-Duvaz, D.; Cooper, R. G.; Springer, C. J. Synthesis of Novel Cationic Lipids: Effect of Structural Modification on the Efficiency of Gene Transfer J. Med. Chem. 2002, 45, 99-114 10.1021/jm010918g
-
(2002)
J. Med. Chem.
, vol.45
, pp. 99-114
-
-
Heyes, J.A.1
Niculescu-Duvaz, D.2
Cooper, R.G.3
Springer, C.J.4
-
26
-
-
0032828009
-
Synthesis of a Single-Tailed Cationic Lipid and Investigation of Its Transfection
-
Tang, F.; Hughes, J. A. Synthesis of a Single-Tailed Cationic Lipid and Investigation of Its Transfection J. Controlled Release 1999, 62, 345-358 10.1016/S0168-3659(99)00158-3
-
(1999)
J. Controlled Release
, vol.62
, pp. 345-358
-
-
Tang, F.1
Hughes, J.A.2
-
27
-
-
84887324806
-
Overcoming Nonviral Gene Delivery Barriers: Perspective and Future
-
Jones, C. H.; Chen, C. K.; Ravikrishnan, A.; Rane, S.; Pfeifer, B. A. Overcoming Nonviral Gene Delivery Barriers: Perspective and Future Mol. Pharmaceutics 2013, 10, 4082-4098 10.1021/mp400467x
-
(2013)
Mol. Pharmaceutics
, vol.10
, pp. 4082-4098
-
-
Jones, C.H.1
Chen, C.K.2
Ravikrishnan, A.3
Rane, S.4
Pfeifer, B.A.5
-
28
-
-
84873413702
-
Influence of Cationic Lipid Composition on Uptake and Intracellular Processing of Lipid Nanoparticle Formulations of siRNA
-
Lin, P. J.; Tam, Y. Y.; Hafez, I.; Sandhu, A.; Chen, S.; Ciufolini, M. A.; Nabi, I. R.; Cullis, P. R. Influence of Cationic Lipid Composition on Uptake and Intracellular Processing of Lipid Nanoparticle Formulations of siRNA Nanomedicine 2013, 9, 233-246 10.1016/j.nano.2012.05.019
-
(2013)
Nanomedicine
, vol.9
, pp. 233-246
-
-
Lin, P.J.1
Tam, Y.Y.2
Hafez, I.3
Sandhu, A.4
Chen, S.5
Ciufolini, M.A.6
Nabi, I.R.7
Cullis, P.R.8
-
29
-
-
19944420826
-
Synthesis of Carbamate-Linked Lipids for Gene Delivery
-
Liu, D.; Hu, J.; Qiao, W.; Li, Z.; Zhang, S.; Cheng, L. Synthesis of Carbamate-Linked Lipids for Gene Delivery Bioorg. Med. Chem. Lett. 2005, 15, 3147-3150 10.1016/j.bmcl.2005.04.010
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 3147-3150
-
-
Liu, D.1
Hu, J.2
Qiao, W.3
Li, Z.4
Zhang, S.5
Cheng, L.6
-
30
-
-
25844493624
-
Synthesis and Characterization of a Series of Carbamate-Linked Cationic Lipids for Gene Delivery
-
Liu, D.; Hu, i.; Qiao, W.; Li, Z.; Zhan, S.; Cheng, L. Synthesis and Characterization of a Series of Carbamate-Linked Cationic Lipids for Gene Delivery Lipids 2005, 40, 839-848 10.1007/s11745-005-1446-5
-
(2005)
Lipids
, vol.40
, pp. 839-848
-
-
Liu, D.1
Hu, I.2
Qiao, W.3
Li, Z.4
Zhan, S.5
Cheng, L.6
-
31
-
-
0027246678
-
Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines
-
Wagner, R. W.; Matteucci, M. D.; Lewis, J. G.; Gutierrez, A. J.; Moulds, C.; Froehler, B. C. Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines Science 1993, 260, 1510-1513 10.1126/science.7684856
-
(1993)
Science
, vol.260
, pp. 1510-1513
-
-
Wagner, R.W.1
Matteucci, M.D.2
Lewis, J.G.3
Gutierrez, A.J.4
Moulds, C.5
Froehler, B.C.6
-
32
-
-
0027092897
-
Cationic Lipids Enhance Cellular Uptake and Activity of Phosphorothioate Antisense Oligonucleotides
-
Bennett, C. F.; Chiang, M. Y.; Chan, H.; Shoemaker, J. E.; Mirabelli, C. K. Cationic Lipids Enhance Cellular Uptake and Activity of Phosphorothioate Antisense Oligonucleotides Mol. Pharmacol. 1992, 41, 1023-1033
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 1023-1033
-
-
Bennett, C.F.1
Chiang, M.Y.2
Chan, H.3
Shoemaker, J.E.4
Mirabelli, C.K.5
-
33
-
-
0026878142
-
Gene Transfer in Vivo with DNA-Liposome Complexes: Safety and Acute Toxicity in Mice
-
Stewart, M. J.; Plautz, G. E.; Del Buono, L.; Yang, Z. Y.; Xu, L.; Gao, X.; Huang, L.; Nabel, E. G.; Nabel, G. J. Gene Transfer In Vivo with DNA-Liposome Complexes: Safety and Acute Toxicity in Mice Hum. Gene Ther. 1992, 3, 267-275 10.1089/hum.1992.3.3-267
-
(1992)
Hum. Gene Ther.
, vol.3
, pp. 267-275
-
-
Stewart, M.J.1
Plautz, G.E.2
Del Buono, L.3
Yang, Z.Y.4
Xu, L.5
Gao, X.6
Huang, L.7
Nabel, E.G.8
Nabel, G.J.9
-
34
-
-
0026562708
-
Oligonucleotides Encapsulated in pH Sensitive Liposomes Are Efficient toward Friend Retrovirus
-
Ropert, C.; Lavignon, M.; Dubernet, C.; Couvreur, P.; Malvy, C. Oligonucleotides Encapsulated in pH Sensitive Liposomes Are Efficient toward Friend Retrovirus Biochem. Biophys. Res. Commun. 1992, 183, 879-885 10.1016/0006-291X(92)90565-3
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.183
, pp. 879-885
-
-
Ropert, C.1
Lavignon, M.2
Dubernet, C.3
Couvreur, P.4
Malvy, C.5
-
35
-
-
84893531193
-
Toxicity Profiling of Several Common RNAi-Based Nanomedicines: A Comparative Study
-
Landesman-Milo, D.; Peer, D. Toxicity Profiling of Several Common RNAi-Based Nanomedicines: A Comparative Study Drug Delivery Transl. Res. 2014, 4, 96-103 10.1007/s13346-013-0158-7
-
(2014)
Drug Delivery Transl. Res.
, vol.4
, pp. 96-103
-
-
Landesman-Milo, D.1
Peer, D.2
-
36
-
-
84869200994
-
Immunotoxicity Derived from Manipulating Leukocytes with Lipid-Based Nanoparticles
-
Peer, D. Immunotoxicity Derived from Manipulating Leukocytes with Lipid-Based Nanoparticles Adv. Drug Delivery Rev. 2012, 64, 1738-1748 10.1016/j.addr.2012.06.013
-
(2012)
Adv. Drug Delivery Rev.
, vol.64
, pp. 1738-1748
-
-
Peer, D.1
-
37
-
-
0033084717
-
Polycation-Based DNA Complexes for Tumor-Targeted Gene Delivery in Vivo
-
Kircheis, R.; Schuller, S.; Brunner, S.; Ogris, M.; Heider, K. H.; Zauner, W.; Wagner, E. Polycation-Based DNA Complexes for Tumor-Targeted Gene Delivery In Vivo J. Gene Med. 1999, 1, 111-120 10.1002/(SICI)1521-2254(199903/04)1:2<111::AID-JGM22>3.3.CO;2-P
-
(1999)
J. Gene Med.
, vol.1
, pp. 111-120
-
-
Kircheis, R.1
Schuller, S.2
Brunner, S.3
Ogris, M.4
Heider, K.H.5
Zauner, W.6
Wagner, E.7
-
38
-
-
77954385672
-
The Systemic Toxicity of Positively Charged Lipid Nanoparticles and the Role of Toll-Like Receptor 4 in Immune Activation
-
Kedmi, R.; Ben-Arie, N.; Peer, D. The Systemic Toxicity of Positively Charged Lipid Nanoparticles and the Role of Toll-Like Receptor 4 in Immune Activation Biomaterials 2010, 31, 6867-6875 10.1016/j.biomaterials.2010.05.027
-
(2010)
Biomaterials
, vol.31
, pp. 6867-6875
-
-
Kedmi, R.1
Ben-Arie, N.2
Peer, D.3
-
39
-
-
0031048990
-
Limitations of Cationic Liposomes for Antisense Oligonucleotide Delivery
-
Litzinger, D. C. Limitations of Cationic Liposomes for Antisense Oligonucleotide Delivery J. Liposome Res. 1997, 7, 51-61 10.3109/08982109709035481
-
(1997)
J. Liposome Res.
, vol.7
, pp. 51-61
-
-
Litzinger, D.C.1
-
40
-
-
0028075403
-
Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic Liposomes
-
Lappalainen, K.; Jaaskelainen, I.; Syrjanen, K.; Urtti, A.; Syrjanen, S. Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic Liposomes Pharm. Res. 1994, 11, 1127-1131 10.1023/A:1018932714745
-
(1994)
Pharm. Res.
, vol.11
, pp. 1127-1131
-
-
Lappalainen, K.1
Jaaskelainen, I.2
Syrjanen, K.3
Urtti, A.4
Syrjanen, S.5
-
41
-
-
14744299236
-
Implications of Pharmacokinetic Behavior of Lipoplex for Its Inflammatory Toxicity
-
Zhang, J.-S.; Liu, F.; Huang, L. Implications of Pharmacokinetic Behavior of Lipoplex for Its Inflammatory Toxicity Adv. Drug Delivery Rev. 2005, 57, 689-698 10.1016/j.addr.2004.12.004
-
(2005)
Adv. Drug Delivery Rev.
, vol.57
, pp. 689-698
-
-
Zhang, J.-S.1
Liu, F.2
Huang, L.3
-
42
-
-
4244142621
-
Organ-Specific Endothelial Cell Uptake of Cationic Liposome-DNA Complexes in Mice
-
McLean, J. W.; Fox, E. A.; Baluk, P.; Bolton, P. B.; Haskell, A.; Pearlman, R.; Thurston, G.; Umemoto, E. Y.; McDonald, D. M. Organ-Specific Endothelial Cell Uptake of Cationic Liposome-DNA Complexes in Mice Am. J. Physiol. Heart Circ. Physiol. 1997, 273, H387-H404
-
(1997)
Am. J. Physiol. Heart Circ. Physiol.
, vol.273
, pp. H387-H404
-
-
McLean, J.W.1
Fox, E.A.2
Baluk, P.3
Bolton, P.B.4
Haskell, A.5
Pearlman, R.6
Thurston, G.7
Umemoto, E.Y.8
McDonald, D.M.9
-
43
-
-
0029061020
-
In Vivo Disposition Characteristics of Plasmid DNA Complexed with Cationic Liposomes
-
Mahato, R. I.; Kawabata, K.; Takakura, Y.; Hashida, M. In Vivo Disposition Characteristics of Plasmid DNA Complexed with Cationic Liposomes J. Drug Target 1995, 3, 149-157 10.3109/10611869509059214
-
(1995)
J. Drug Target
, vol.3
, pp. 149-157
-
-
Mahato, R.I.1
Kawabata, K.2
Takakura, Y.3
Hashida, M.4
-
44
-
-
0035830624
-
Efficient Encapsulation of Antisense Oligonucleotides in Lipid Vesicles Using Ionizable Aminolipids: Formation of Novel Small Multilamellar Vesicle Structures
-
Semple, S. C.; Klimuk, S. K.; Harasym, T. O.; Dos Santos, N.; Ansell, S. M.; Wong, K. F.; Maurer, N.; Stark, H.; Cullis, P. R.; Hope, M. J.; Scherrer, P. Efficient Encapsulation of Antisense Oligonucleotides in Lipid Vesicles Using Ionizable Aminolipids: Formation of Novel Small Multilamellar Vesicle Structures Biochim. Biophys. Acta, Biomembr. 2001, 1510, 152-166 10.1016/S0005-2736(00)00343-6
-
(2001)
Biochim. Biophys. Acta, Biomembr.
, vol.1510
, pp. 152-166
-
-
Semple, S.C.1
Klimuk, S.K.2
Harasym, T.O.3
Dos Santos, N.4
Ansell, S.M.5
Wong, K.F.6
Maurer, N.7
Stark, H.8
Cullis, P.R.9
Hope, M.J.10
Scherrer, P.11
-
45
-
-
84865079107
-
Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing in Vivo
-
Jayaraman, M.; Ansell, S. M.; Mui, B. L.; Tam, Y. K.; Chen, J.; Du, X.; Butler, D.; Eltepu, L.; Matsuda, S.; Narayanannair, J. K.; Rajeev, K. G.; Hafez, I. M.; Akinc, A.; Maier, M. A.; Tracy, M. A.; Cullis, P. R.; Madden, T. D.; Manoharan, M.; Hope, M. J. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo Angew. Chem., Int. Ed. 2012, 51, 8529-8533 10.1002/anie.201203263
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 8529-8533
-
-
Jayaraman, M.1
Ansell, S.M.2
Mui, B.L.3
Tam, Y.K.4
Chen, J.5
Du, X.6
Butler, D.7
Eltepu, L.8
Matsuda, S.9
Narayanannair, J.K.10
Rajeev, K.G.11
Hafez, I.M.12
Akinc, A.13
Maier, M.A.14
Tracy, M.A.15
Cullis, P.R.16
Madden, T.D.17
Manoharan, M.18
Hope, M.J.19
-
46
-
-
0032568628
-
Evidence of Interlipidic Ion-Pairing in Anion-Induced DNA Release from Cationic Amphiphile-DNA Complexes. Mechanistic Implications in Transfection
-
Bhattacharya, S.; Mandal, S. S. Evidence of Interlipidic Ion-Pairing in Anion-Induced DNA Release from Cationic Amphiphile-DNA Complexes. Mechanistic Implications in Transfection Biochemistry 1998, 37, 7764-7777 10.1021/bi971772j
-
(1998)
Biochemistry
, vol.37
, pp. 7764-7777
-
-
Bhattacharya, S.1
Mandal, S.S.2
-
47
-
-
84886261520
-
Delivery Materials for siRNA Therapeutics
-
Kanasty, R.; Dorkin, J. R.; Vegas, A.; Anderson, D. Delivery Materials for siRNA Therapeutics Nat. Mater. 2013, 12, 967-977 10.1038/nmat3765
-
(2013)
Nat. Mater.
, vol.12
, pp. 967-977
-
-
Kanasty, R.1
Dorkin, J.R.2
Vegas, A.3
Anderson, D.4
-
48
-
-
24944577514
-
Cationic Lipid Saturation Influences Intracellular Delivery of Encapsulated Nucleic Acids
-
Heyes, J.; Palmer, L.; Bremner, K.; MacLachlan, I. Cationic Lipid Saturation Influences Intracellular Delivery of Encapsulated Nucleic Acids J. Controlled Release 2005, 107, 276-287 10.1016/j.jconrel.2005.06.014
-
(2005)
J. Controlled Release
, vol.107
, pp. 276-287
-
-
Heyes, J.1
Palmer, L.2
Bremner, K.3
MacLachlan, I.4
-
49
-
-
76349111051
-
Rational Design of Cationic Lipids for siRNA Delivery
-
Semple, S. C.; Akinc, A.; Chen, J.; Sandhu, A. P.; Mui, B. L.; Cho, C. K.; Sah, D. W. Y.; Stebbing, D.; Crosley, E. J.; Yaworski, E.; Hafez, I. M.; Dorkin, J. R.; Qin, J.; Lam, K.; Rajeev, K. G.; Wong, K. F.; Jeffs, L. B.; Nechev, L.; Eisenhardt, M. L.; Jayaraman, M.; Kazem, M.; Maier, M. A.; Srinivasulu, M.; Weinstein, M. J.; Chen, Q.; Alvarez, R.; Barros, S. A.; De, S.; Klimuk, S. K.; Borland, T.; Kosovrasti, V.; Cantley, W. L.; Tam, Y. K.; Manoharan, M.; Ciufolini, M. A.; Tracy, M. A.; de Fougerolles, A.; MacLachlan, I.; Cullis, P. R.; Madden, T. D.; Hope, M. J. Rational Design of Cationic Lipids for siRNA Delivery Nat. Biotechnol. 2010, 28, 172-176 10.1038/nbt.1602
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 172-176
-
-
Semple, S.C.1
Akinc, A.2
Chen, J.3
Sandhu, A.P.4
Mui, B.L.5
Cho, C.K.6
Sah, D.W.Y.7
Stebbing, D.8
Crosley, E.J.9
Yaworski, E.10
Hafez, I.M.11
Dorkin, J.R.12
Qin, J.13
Lam, K.14
Rajeev, K.G.15
Wong, K.F.16
Jeffs, L.B.17
Nechev, L.18
Eisenhardt, M.L.19
Jayaraman, M.20
Kazem, M.21
Maier, M.A.22
Srinivasulu, M.23
Weinstein, M.J.24
Chen, Q.25
Alvarez, R.26
Barros, S.A.27
De, S.28
Klimuk, S.K.29
Borland, T.30
Kosovrasti, V.31
Cantley, W.L.32
Tam, Y.K.33
Manoharan, M.34
Ciufolini, M.A.35
Tracy, M.A.36
De Fougerolles, A.37
MacLachlan, I.38
Cullis, P.R.39
Madden, T.D.40
Hope, M.J.41
more..
-
50
-
-
84881408604
-
Multiparametric Approach for the Evaluation of Lipid Nanoparticles for siRNA Delivery
-
Alabi, C. A.; Love, K. T.; Sahay, G.; Yin, H.; Luly, K. M.; Langer, R.; Anderson, D. G. Multiparametric Approach for the Evaluation of Lipid Nanoparticles for siRNA Delivery Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 12881-12886 10.1073/pnas.1306529110
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 12881-12886
-
-
Alabi, C.A.1
Love, K.T.2
Sahay, G.3
Yin, H.4
Luly, K.M.5
Langer, R.6
Anderson, D.G.7
-
51
-
-
84881292568
-
Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics
-
Maier, M. A.; Jayaraman, M.; Matsuda, S.; Liu, J.; Barros, S.; Querbes, W.; Tam, Y. K.; Ansell, S. M.; Kumar, V.; Qin, J.; Zhang, X.; Wang, Q.; Panesar, S.; Hutabarat, R.; Carioto, M.; Hettinger, J.; Kandasamy, P.; Butler, D.; Rajeev, K. G.; Pang, B.; Charisse, K.; Fitzgerald, K.; Mui, B. L.; Du, X.; Cullis, P.; Madden, T. D.; Hope, M. J.; Manoharan, M.; Akinc, A. Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics Mol. Ther. 2013, 21, 1570-1578 10.1038/mt.2013.124
-
(2013)
Mol. Ther.
, vol.21
, pp. 1570-1578
-
-
Maier, M.A.1
Jayaraman, M.2
Matsuda, S.3
Liu, J.4
Barros, S.5
Querbes, W.6
Tam, Y.K.7
Ansell, S.M.8
Kumar, V.9
Qin, J.10
Zhang, X.11
Wang, Q.12
Panesar, S.13
Hutabarat, R.14
Carioto, M.15
Hettinger, J.16
Kandasamy, P.17
Butler, D.18
Rajeev, K.G.19
Pang, B.20
Charisse, K.21
Fitzgerald, K.22
Mui, B.L.23
Du, X.24
Cullis, P.25
Madden, T.D.26
Hope, M.J.27
Manoharan, M.28
Akinc, A.29
more..
-
52
-
-
85015182398
-
Lipid Nanoparticle-Mediated siRNA Transfer against PCTAIRE1/PCTK1/CDK16 Inhibits in Vivo Cancer Growth
-
Yanagi, T.; Tachikawa, K.; Wilkie-Grantham, R.; Hishiki, A.; Nagai, K.; Toyonaga, E.; Chivukula, P.; Matsuzawa, S. Lipid Nanoparticle-Mediated siRNA Transfer against PCTAIRE1/PCTK1/CDK16 Inhibits In Vivo Cancer Growth Mol. Ther. - Nucleic Acids 2016, 5, e327 10.1038/mtna.2016.40
-
(2016)
Mol. Ther. - Nucleic Acids
, vol.5
, pp. e327
-
-
Yanagi, T.1
Tachikawa, K.2
Wilkie-Grantham, R.3
Hishiki, A.4
Nagai, K.5
Toyonaga, E.6
Chivukula, P.7
Matsuzawa, S.8
-
53
-
-
85014634181
-
Systemic Delivery of Factor IX Messenger RNA for Protein Replacement Therapy
-
Ramaswamy, S.; Tonnu, N.; Tachikawa, K.; Limphong, P.; Vega, J. B.; Karmali, P. P.; Chivukula, P.; Verma, I. M. Systemic Delivery of Factor IX Messenger RNA for Protein Replacement Therapy Proc. Natl. Acad. Sci. U. S. A. 2017, 114, E1941-E1950 10.1073/pnas.1619653114
-
(2017)
Proc. Natl. Acad. Sci. U. S. A.
, vol.114
, pp. E1941-E1950
-
-
Ramaswamy, S.1
Tonnu, N.2
Tachikawa, K.3
Limphong, P.4
Vega, J.B.5
Karmali, P.P.6
Chivukula, P.7
Verma, I.M.8
-
54
-
-
85009228793
-
Biodegradable Lipid Nanoparticles Induce a Prolonged RNA Interference-Mediated Protein Knockdown and Show Rapid Hepatic Clearance in Mice and Nonhuman Primates
-
Suzuki, Y.; Hyodo, K.; Suzuki, T.; Tanaka, Y.; Kikuchi, H.; Ishihara, H. Biodegradable Lipid Nanoparticles Induce a Prolonged RNA Interference-Mediated Protein Knockdown and Show Rapid Hepatic Clearance in Mice and Nonhuman Primates Int. J. Pharm. 2017, 519, 34-43 10.1016/j.ijpharm.2017.01.016
-
(2017)
Int. J. Pharm.
, vol.519
, pp. 34-43
-
-
Suzuki, Y.1
Hyodo, K.2
Suzuki, T.3
Tanaka, Y.4
Kikuchi, H.5
Ishihara, H.6
-
55
-
-
0029964866
-
Mechanism of Oligonucleotide Release from Cationic Liposomes
-
Zelphati, O.; Szoka, F. C., Jr. Mechanism of Oligonucleotide Release from Cationic Liposomes Proc. Natl. Acad. Sci. U. S. A. 1996, 93, 11493-11498 10.1073/pnas.93.21.11493
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 11493-11498
-
-
Zelphati, O.1
Szoka, F.C.2
-
56
-
-
0029056088
-
Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid
-
Zabner, J.; Fasbender, A. J.; Moninger, T.; Poellinger, K. A.; Welsh, M. J. Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid J. Biol. Chem. 1995, 270, 18997-19007 10.1074/jbc.270.32.18997
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18997-19007
-
-
Zabner, J.1
Fasbender, A.J.2
Moninger, T.3
Poellinger, K.A.4
Welsh, M.J.5
-
57
-
-
0031551011
-
Gene Transfer Mediated by Cationic Lipids: Lack of a Correlation between Lipid Mixing and Transfection
-
Stegmann, T.; Legendre, J. Y. Gene Transfer Mediated by Cationic Lipids: Lack of a Correlation between Lipid Mixing and Transfection Biochim. Biophys. Acta, Biomembr. 1997, 1325, 71-79 10.1016/S0005-2736(96)00241-6
-
(1997)
Biochim. Biophys. Acta, Biomembr.
, vol.1325
, pp. 71-79
-
-
Stegmann, T.1
Legendre, J.Y.2
-
58
-
-
0034714228
-
Membrane Perturbation and the Mechanism of Lipid-Mediated Transfer of DNA into Cells
-
Mui, B.; Ahkong, Q. F.; Chow, L.; Hope, M. J. Membrane Perturbation and the Mechanism of Lipid-Mediated Transfer of DNA into Cells Biochim. Biophys. Acta, Biomembr. 2000, 1467, 281-292 10.1016/S0005-2736(00)00226-1
-
(2000)
Biochim. Biophys. Acta, Biomembr.
, vol.1467
, pp. 281-292
-
-
Mui, B.1
Ahkong, Q.F.2
Chow, L.3
Hope, M.J.4
-
59
-
-
0034882516
-
On the Mechanism Whereby Cationic Lipids Promote Intracellular Delivery of Polynucleic Acids
-
Hafez, I. M.; Maurer, N.; Cullis, P. R. On the Mechanism Whereby Cationic Lipids Promote Intracellular Delivery of Polynucleic Acids Gene Ther. 2001, 8, 1188-1196 10.1038/sj.gt.3301506
-
(2001)
Gene Ther.
, vol.8
, pp. 1188-1196
-
-
Hafez, I.M.1
Maurer, N.2
Cullis, P.R.3
-
60
-
-
85027927478
-
An Amino Acid-Based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA
-
Adami, R. C.; Seth, S.; Harvie, P.; Johns, R.; Fam, R.; Fosnaugh, K.; Zhu, T.; Farber, K.; McCutcheon, M.; Goodman, T. T.; Liu, Y.; Chen, Y.; Kwang, E.; Templin, M. V.; Severson, G.; Brown, T.; Vaish, N.; Chen, F.; Charmley, P.; Polisky, B.; Houston, M. E., Jr. An Amino Acid-Based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA Mol. Ther. 2011, 19, 1141-1151 10.1038/mt.2011.56
-
(2011)
Mol. Ther.
, vol.19
, pp. 1141-1151
-
-
Adami, R.C.1
Seth, S.2
Harvie, P.3
Johns, R.4
Fam, R.5
Fosnaugh, K.6
Zhu, T.7
Farber, K.8
McCutcheon, M.9
Goodman, T.T.10
Liu, Y.11
Chen, Y.12
Kwang, E.13
Templin, M.V.14
Severson, G.15
Brown, T.16
Vaish, N.17
Chen, F.18
Charmley, P.19
Polisky, B.20
Houston, M.E.21
more..
-
61
-
-
17644419268
-
Nonbilayer Phase of Lipoplex-Membrane Mixture Determines Endosomal Escape of Genetic Cargo and Transfection Efficiency
-
Zuhorn, I. S.; Bakowsky, U.; Polushkin, E.; Visser, W. H.; Stuart, M. C.; Engberts, J. B.; Hoekstra, D. Nonbilayer Phase of Lipoplex-Membrane Mixture Determines Endosomal Escape of Genetic Cargo and Transfection Efficiency Mol. Ther. 2005, 11, 801-810 10.1016/j.ymthe.2004.12.018
-
(2005)
Mol. Ther.
, vol.11
, pp. 801-810
-
-
Zuhorn, I.S.1
Bakowsky, U.2
Polushkin, E.3
Visser, W.H.4
Stuart, M.C.5
Engberts, J.B.6
Hoekstra, D.7
-
62
-
-
0037005729
-
Characterization of the Inhibitory Effect of PEG-Lipid Conjugates on the Intracellular Delivery of Plasmid and Antisense DNA Mediated by Cationic Lipid Liposomes
-
Song, L. Y.; Ahkong, Q. F.; Rong, Q.; Wang, Z.; Ansell, S.; Hope, M. J.; Mui, B. Characterization of the Inhibitory Effect of PEG-Lipid Conjugates on the Intracellular Delivery of Plasmid and Antisense DNA Mediated by Cationic Lipid Liposomes Biochim. Biophys. Acta, Biomembr. 2002, 1558, 1-13 10.1016/S0005-2736(01)00399-6
-
(2002)
Biochim. Biophys. Acta, Biomembr.
, vol.1558
, pp. 1-13
-
-
Song, L.Y.1
Ahkong, Q.F.2
Rong, Q.3
Wang, Z.4
Ansell, S.5
Hope, M.J.6
Mui, B.7
-
63
-
-
84872122976
-
How Cationic Lipids Transfer Nucleic Acids into Cells and across Cellular Membranes: Recent Advances
-
Rehman, Z.u.; Zuhorn, I. S.; Hoekstra, D. How Cationic Lipids Transfer Nucleic Acids into Cells and across Cellular Membranes: Recent Advances J. Controlled Release 2013, 166, 46-56 10.1016/j.jconrel.2012.12.014
-
(2013)
J. Controlled Release
, vol.166
, pp. 46-56
-
-
Rehman, Z.U.1
Zuhorn, I.S.2
Hoekstra, D.3
-
64
-
-
84872547866
-
Synthesis, Characterization, and Evaluation of Ionizable Lysine-Based Lipids for siRNA Delivery
-
Walsh, C. L.; Nguyen, J.; Tiffany, M. R.; Szoka, F. C. Synthesis, Characterization, and Evaluation of Ionizable Lysine-Based Lipids for siRNA Delivery Bioconjugate Chem. 2013, 24, 36-43 10.1021/bc300346h
-
(2013)
Bioconjugate Chem.
, vol.24
, pp. 36-43
-
-
Walsh, C.L.1
Nguyen, J.2
Tiffany, M.R.3
Szoka, F.C.4
-
65
-
-
84865714123
-
Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core
-
Leung, A. K. K.; Hafez, I. M.; Baoukina, S.; Belliveau, N. M.; Zhigaltsev, I. V.; Afshinmanesh, E.; Tieleman, D. P.; Hansen, C. L.; Hope, M. J.; Cullis, P. R. Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core J. Phys. Chem. C 2012, 116, 18440-18450 10.1021/jp303267y
-
(2012)
J. Phys. Chem. C
, vol.116
, pp. 18440-18450
-
-
Leung, A.K.K.1
Hafez, I.M.2
Baoukina, S.3
Belliveau, N.M.4
Zhigaltsev, I.V.5
Afshinmanesh, E.6
Tieleman, D.P.7
Hansen, C.L.8
Hope, M.J.9
Cullis, P.R.10
-
66
-
-
23444445660
-
Potent and Persistent in Vivo Anti-HBV Activity of Chemically Modified siRNAs
-
Morrissey, D. V.; Lockridge, J. A.; Shaw, L.; Blanchard, K.; Jensen, K.; Breen, W.; Hartsough, K.; Machemer, L.; Radka, S.; Jadhav, V.; Vaish, N.; Zinnen, S.; Vargeese, C.; Bowman, K.; Shaffer, C. S.; Jeffs, L. B.; Judge, A.; MacLachlan, I.; Polisky, B. Potent and Persistent In Vivo Anti-HBV Activity of Chemically Modified siRNAs Nat. Biotechnol. 2005, 23, 1002-1007 10.1038/nbt1122
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
Blanchard, K.4
Jensen, K.5
Breen, W.6
Hartsough, K.7
Machemer, L.8
Radka, S.9
Jadhav, V.10
Vaish, N.11
Zinnen, S.12
Vargeese, C.13
Bowman, K.14
Shaffer, C.S.15
Jeffs, L.B.16
Judge, A.17
MacLachlan, I.18
Polisky, B.19
-
67
-
-
33646185371
-
RNAi-Mediated Gene Silencing in Non-Human Primates
-
Zimmermann, T. S.; Lee, A. C. H.; Akinc, A.; Bramlage, B.; Bumcrot, D.; Fedoruk, M. N.; Harborth, J.; Heyes, J. A.; Jeffs, L. B.; John, M.; Judge, A. D.; Lam, K.; McClintock, K.; Nechev, L. V.; Palmer, L. R.; Racie, T.; Röhl, I.; Seiffert, S.; Shanmugam, S.; Sood, V.; Soutschek, J.; Toudjarska, I.; Wheat, A. J.; Yaworski, E.; Zedalis, W.; Koteliansky, V.; Manoharan, M.; Vornlocher, H.-P.; MacLachlan, I. RNAi-Mediated Gene Silencing in Non-Human Primates Nature 2006, 441, 111-114 10.1038/nature04688
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.H.2
Akinc, A.3
Bramlage, B.4
Bumcrot, D.5
Fedoruk, M.N.6
Harborth, J.7
Heyes, J.A.8
Jeffs, L.B.9
John, M.10
Judge, A.D.11
Lam, K.12
McClintock, K.13
Nechev, L.V.14
Palmer, L.R.15
Racie, T.16
Röhl, I.17
Seiffert, S.18
Shanmugam, S.19
Sood, V.20
Soutschek, J.21
Toudjarska, I.22
Wheat, A.J.23
Yaworski, E.24
Zedalis, W.25
Koteliansky, V.26
Manoharan, M.27
Vornlocher, H.-P.28
MacLachlan, I.29
more..
-
68
-
-
43049176170
-
A Combinatorial Library of Lipid-Like Materials for Delivery of RNAi Therapeutics
-
Akinc, A.; Zumbuehl, A.; Goldberg, M.; Leshchiner, E. S.; Busini, V.; Hossain, N.; Bacallado, S. A.; Nguyen, D. N.; Fuller, J.; Alvarez, R.; Borodovsky, A.; Borland, T.; Constien, R.; de Fougerolles, A.; Dorkin, J. R.; Narayanannair Jayaprakash, K.; Jayaraman, M.; John, M.; Koteliansky, V.; Manoharan, M.; Nechev, L.; Qin, J.; Racie, T.; Raitcheva, D.; Rajeev, K. G.; Sah, D. W. Y.; Soutschek, J.; Toudjarska, I.; Vornlocher, H.-P.; Zimmermann, T. S.; Langer, R.; Anderson, D. G. A Combinatorial Library of Lipid-Like Materials for Delivery of RNAi Therapeutics Nat. Biotechnol. 2008, 26, 561-569 10.1038/nbt1402
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 561-569
-
-
Akinc, A.1
Zumbuehl, A.2
Goldberg, M.3
Leshchiner, E.S.4
Busini, V.5
Hossain, N.6
Bacallado, S.A.7
Nguyen, D.N.8
Fuller, J.9
Alvarez, R.10
Borodovsky, A.11
Borland, T.12
Constien, R.13
De Fougerolles, A.14
Dorkin, J.R.15
Narayanannair Jayaprakash, K.16
Jayaraman, M.17
John, M.18
Koteliansky, V.19
Manoharan, M.20
Nechev, L.21
Qin, J.22
Racie, T.23
Raitcheva, D.24
Rajeev, K.G.25
Sah, D.W.Y.26
Soutschek, J.27
Toudjarska, I.28
Vornlocher, H.-P.29
Zimmermann, T.S.30
Langer, R.31
Anderson, D.G.32
more..
-
69
-
-
76649098887
-
Lipid-Like Materials for Low-Dose, in Vivo Gene Silencing
-
Love, K. T.; Mahon, K. P.; Levins, C. G.; Whitehead, K. A.; Querbes, W.; Dorkin, J. R.; Qin, J.; Cantley, W.; Qin, L. L.; Racie, T.; Frank-Kamenetsky, M.; Yip, K. N.; Alvarez, R.; Sah, D. W. Y.; de Fougerolles, A.; Fitzgerald, K.; Koteliansky, V.; Akinc, A.; Langer, R.; Anderson, D. G. Lipid-Like Materials for Low-Dose, In Vivo Gene Silencing Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 1864-1869 10.1073/pnas.0910603106
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 1864-1869
-
-
Love, K.T.1
Mahon, K.P.2
Levins, C.G.3
Whitehead, K.A.4
Querbes, W.5
Dorkin, J.R.6
Qin, J.7
Cantley, W.8
Qin, L.L.9
Racie, T.10
Frank-Kamenetsky, M.11
Yip, K.N.12
Alvarez, R.13
Sah, D.W.Y.14
De Fougerolles, A.15
Fitzgerald, K.16
Koteliansky, V.17
Akinc, A.18
Langer, R.19
Anderson, D.G.20
more..
-
70
-
-
84941287130
-
Lipidoid Nanoparticles for siRNA Delivery to the Intestinal Epithelium: In Vitro Investigations in a Caco-2 Model
-
Ball, R. L.; Knapp, C. M.; Whitehead, K. A. Lipidoid Nanoparticles for siRNA Delivery to the Intestinal Epithelium: In Vitro Investigations in a Caco-2 Model PLoS One 2015, 10, e0133154 10.1371/journal.pone.0133154
-
(2015)
PLoS One
, vol.10
, pp. e0133154
-
-
Ball, R.L.1
Knapp, C.M.2
Whitehead, K.A.3
-
71
-
-
84963682649
-
Lipidoid Tail Structure Strongly Influences siRNA Delivery Activity
-
Knapp, C. M.; Guo, P.; Whitehead, K. A. Lipidoid Tail Structure Strongly Influences siRNA Delivery Activity Cell. Mol. Bioeng. 2016, 9, 305-314 10.1007/s12195-016-0436-9
-
(2016)
Cell. Mol. Bioeng.
, vol.9
, pp. 305-314
-
-
Knapp, C.M.1
Guo, P.2
Whitehead, K.A.3
-
72
-
-
84903643579
-
Degradable Lipid Nanoparticles with Predictable in Vivo siRNA Delivery Activity
-
Whitehead, K. A.; Dorkin, J. R.; Vegas, A. J.; Chang, P. H.; Veiseh, O.; Matthews, J.; Fenton, O. S.; Zhang, Y.; Olejnik, K. T.; Yesilyurt, V.; Chen, D.; Barros, S.; Klebanov, B.; Novobrantseva, T.; Langer, R.; Anderson, D. G. Degradable Lipid Nanoparticles with Predictable In Vivo siRNA Delivery Activity Nat. Commun. 2014, 5, 4277 10.1038/ncomms5277
-
(2014)
Nat. Commun.
, vol.5
, pp. 4277
-
-
Whitehead, K.A.1
Dorkin, J.R.2
Vegas, A.J.3
Chang, P.H.4
Veiseh, O.5
Matthews, J.6
Fenton, O.S.7
Zhang, Y.8
Olejnik, K.T.9
Yesilyurt, V.10
Chen, D.11
Barros, S.12
Klebanov, B.13
Novobrantseva, T.14
Langer, R.15
Anderson, D.G.16
-
73
-
-
84971635810
-
Lipidoid Nanoparticle Mediated Silencing of Mcl-1 Induces Apoptosis in Mantle Cell Lymphoma
-
Knapp, C. M.; He, J.; Lister, J.; Whitehead, K. A. Lipidoid Nanoparticle Mediated Silencing of Mcl-1 Induces Apoptosis in Mantle Cell Lymphoma Exp. Biol. Med. (London, U. K.) 2016, 241, 1007-1013 10.1177/1535370216640944
-
(2016)
Exp. Biol. Med. (London, U. K.)
, vol.241
, pp. 1007-1013
-
-
Knapp, C.M.1
He, J.2
Lister, J.3
Whitehead, K.A.4
-
74
-
-
84880274434
-
Efficiency of siRNA Delivery by Lipid Nanoparticles Is Limited by Endocytic Recycling
-
Sahay, G.; Querbes, W.; Alabi, C.; Eltoukhy, A.; Sarkar, S.; Zurenko, C.; Karagiannis, E.; Love, K.; Chen, D.; Zoncu, R.; Buganim, Y.; Schroeder, A.; Langer, R.; Anderson, D. G. Efficiency of siRNA Delivery by Lipid Nanoparticles Is Limited by Endocytic Recycling Nat. Biotechnol. 2013, 31, 653-658 10.1038/nbt.2614
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 653-658
-
-
Sahay, G.1
Querbes, W.2
Alabi, C.3
Eltoukhy, A.4
Sarkar, S.5
Zurenko, C.6
Karagiannis, E.7
Love, K.8
Chen, D.9
Zoncu, R.10
Buganim, Y.11
Schroeder, A.12
Langer, R.13
Anderson, D.G.14
-
75
-
-
84880304273
-
Image-Based Analysis of Lipid Nanoparticle-Mediated siRNA Delivery, Intracellular Trafficking and Endosomal Escape
-
Gilleron, J.; Querbes, W.; Zeigerer, A.; Borodovsky, A.; Marsico, G.; Schubert, U.; Manygoats, K.; Seifert, S.; Andree, C.; Stoter, M.; Epstein-Barash, H.; Zhang, L.; Koteliansky, V.; Fitzgerald, K.; Fava, E.; Bickle, M.; Kalaidzidis, Y.; Akinc, A.; Maier, M.; Zerial, M. Image-Based Analysis of Lipid Nanoparticle-Mediated siRNA Delivery, Intracellular Trafficking and Endosomal Escape Nat. Biotechnol. 2013, 31, 638-646 10.1038/nbt.2612
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 638-646
-
-
Gilleron, J.1
Querbes, W.2
Zeigerer, A.3
Borodovsky, A.4
Marsico, G.5
Schubert, U.6
Manygoats, K.7
Seifert, S.8
Andree, C.9
Stoter, M.10
Epstein-Barash, H.11
Zhang, L.12
Koteliansky, V.13
Fitzgerald, K.14
Fava, E.15
Bickle, M.16
Kalaidzidis, Y.17
Akinc, A.18
Maier, M.19
Zerial, M.20
more..
-
76
-
-
84994164431
-
The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA
-
Wang, H.; Tam, Y. Y. C.; Chen, S.; Zaifman, J.; van der Meel, R.; Ciufolini, M. A.; Cullis, P. R. The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA Mol. Ther. 2016, 24, 2100-2108 10.1038/mt.2016.179
-
(2016)
Mol. Ther.
, vol.24
, pp. 2100-2108
-
-
Wang, H.1
Tam, Y.Y.C.2
Chen, S.3
Zaifman, J.4
Van Der Meel, R.5
Ciufolini, M.A.6
Cullis, P.R.7
-
77
-
-
84880289242
-
A Window onto siRNA Delivery
-
Wang, Y.; Huang, L. A Window onto siRNA Delivery Nat. Biotechnol. 2013, 31, 611-612 10.1038/nbt.2634
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 611-612
-
-
Wang, Y.1
Huang, L.2
-
78
-
-
80155200721
-
Therapeutic siRNA Silencing in Inflammatory Monocytes in Mice
-
Leuschner, F.; Dutta, P.; Gorbatov, R.; Novobrantseva, T. I.; Donahoe, J. S.; Courties, G.; Lee, K. M.; Kim, J. I.; Markmann, J. F.; Marinelli, B.; Panizzi, P.; Lee, W. W.; Iwamoto, Y.; Milstein, S.; Epstein-Barash, H.; Cantley, W.; Wong, J.; Cortez-Retamozo, V.; Newton, A.; Love, K.; Libby, P.; Pittet, M. J.; Swirski, F. K.; Koteliansky, V.; Langer, R.; Weissleder, R.; Anderson, D. G.; Nahrendorf, M. Therapeutic siRNA Silencing in Inflammatory Monocytes in Mice Nat. Biotechnol. 2011, 29, 1005-1010 10.1038/nbt.1989
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 1005-1010
-
-
Leuschner, F.1
Dutta, P.2
Gorbatov, R.3
Novobrantseva, T.I.4
Donahoe, J.S.5
Courties, G.6
Lee, K.M.7
Kim, J.I.8
Markmann, J.F.9
Marinelli, B.10
Panizzi, P.11
Lee, W.W.12
Iwamoto, Y.13
Milstein, S.14
Epstein-Barash, H.15
Cantley, W.16
Wong, J.17
Cortez-Retamozo, V.18
Newton, A.19
Love, K.20
Libby, P.21
Pittet, M.J.22
Swirski, F.K.23
Koteliansky, V.24
Langer, R.25
Weissleder, R.26
Anderson, D.G.27
Nahrendorf, M.28
more..
-
79
-
-
84878000143
-
Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice
-
Majmudar, M. D.; Keliher, E. J.; Heidt, T.; Leuschner, F.; Truelove, J.; Sena, B. F.; Gorbatov, R.; Iwamoto, Y.; Dutta, P.; Wojtkiewicz, G.; Courties, G.; Sebas, M.; Borodovsky, A.; Fitzgerald, K.; Nolte, M. W.; Dickneite, G.; Chen, J. W.; Anderson, D. G.; Swirski, F. K.; Weissleder, R.; Nahrendorf, M. Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice Circulation 2013, 127, 2038-2046 10.1161/CIRCULATIONAHA.112.000116
-
(2013)
Circulation
, vol.127
, pp. 2038-2046
-
-
Majmudar, M.D.1
Keliher, E.J.2
Heidt, T.3
Leuschner, F.4
Truelove, J.5
Sena, B.F.6
Gorbatov, R.7
Iwamoto, Y.8
Dutta, P.9
Wojtkiewicz, G.10
Courties, G.11
Sebas, M.12
Borodovsky, A.13
Fitzgerald, K.14
Nolte, M.W.15
Dickneite, G.16
Chen, J.W.17
Anderson, D.G.18
Swirski, F.K.19
Weissleder, R.20
Nahrendorf, M.21
more..
-
80
-
-
84973866282
-
RNAi Targeting Multiple Cell Adhesion Molecules Reduces Immune Cell Recruitment and Vascular Inflammation after Myocardial Infarction
-
Sager, H. B.; Dutta, P.; Dahlman, J. E.; Hulsmans, M.; Courties, G.; Sun, Y.; Heidt, T.; Vinegoni, C.; Borodovsky, A.; Fitzgerald, K.; Wojtkiewicz, G. R.; Iwamoto, Y.; Tricot, B.; Khan, O. F.; Kauffman, K. J.; Xing, Y.; Shaw, T. E.; Libby, P.; Langer, R.; Weissleder, R.; Swirski, F. K.; Anderson, D. G.; Nahrendorf, M. RNAi Targeting Multiple Cell Adhesion Molecules Reduces Immune Cell Recruitment and Vascular Inflammation after Myocardial Infarction Sci. Transl. Med. 2016, 8, 342ra80 10.1126/scitranslmed.aaf1435
-
(2016)
Sci. Transl. Med.
, vol.8
, pp. 342ra80
-
-
Sager, H.B.1
Dutta, P.2
Dahlman, J.E.3
Hulsmans, M.4
Courties, G.5
Sun, Y.6
Heidt, T.7
Vinegoni, C.8
Borodovsky, A.9
Fitzgerald, K.10
Wojtkiewicz, G.R.11
Iwamoto, Y.12
Tricot, B.13
Khan, O.F.14
Kauffman, K.J.15
Xing, Y.16
Shaw, T.E.17
Libby, P.18
Langer, R.19
Weissleder, R.20
Swirski, F.K.21
Anderson, D.G.22
Nahrendorf, M.23
more..
-
81
-
-
84900844706
-
In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing
-
Courties, G.; Heidt, T.; Sebas, M.; Iwamoto, Y.; Jeon, D.; Truelove, J.; Tricot, B.; Wojtkiewicz, G.; Dutta, P.; Sager, H. B.; Borodovsky, A.; Novobrantseva, T.; Klebanov, B.; Fitzgerald, K.; Anderson, D. G.; Libby, P.; Swirski, F. K.; Weissleder, R.; Nahrendorf, M. In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing J. Am. Coll. Cardiol. 2014, 63, 1556-1566 10.1016/j.jacc.2013.11.023
-
(2014)
J. Am. Coll. Cardiol.
, vol.63
, pp. 1556-1566
-
-
Courties, G.1
Heidt, T.2
Sebas, M.3
Iwamoto, Y.4
Jeon, D.5
Truelove, J.6
Tricot, B.7
Wojtkiewicz, G.8
Dutta, P.9
Sager, H.B.10
Borodovsky, A.11
Novobrantseva, T.12
Klebanov, B.13
Fitzgerald, K.14
Anderson, D.G.15
Libby, P.16
Swirski, F.K.17
Weissleder, R.18
Nahrendorf, M.19
-
82
-
-
84864995694
-
Systemic RNAi-Mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells
-
Novobrantseva, T. I.; Borodovsky, A.; Wong, J.; Klebanov, B.; Zafari, M.; Yucius, K.; Querbes, W.; Ge, P.; Ruda, V. M.; Milstein, S.; Speciner, L.; Duncan, R.; Barros, S.; Basha, G.; Cullis, P.; Akinc, A.; Donahoe, J. S.; Narayanannair Jayaprakash, K.; Jayaraman, M.; Bogorad, R. L.; Love, K.; Whitehead, K.; Levins, C.; Manoharan, M.; Swirski, F. K.; Weissleder, R.; Langer, R.; Anderson, D. G.; de Fougerolles, A.; Nahrendorf, M.; Koteliansky, V. Systemic RNAi-Mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells Mol. Ther. - Nucleic Acids 2012, 1, e4 10.1038/mtna.2011.3
-
(2012)
Mol. Ther. - Nucleic Acids
, vol.1
, pp. e4
-
-
Novobrantseva, T.I.1
Borodovsky, A.2
Wong, J.3
Klebanov, B.4
Zafari, M.5
Yucius, K.6
Querbes, W.7
Ge, P.8
Ruda, V.M.9
Milstein, S.10
Speciner, L.11
Duncan, R.12
Barros, S.13
Basha, G.14
Cullis, P.15
Akinc, A.16
Donahoe, J.S.17
Narayanannair Jayaprakash, K.18
Jayaraman, M.19
Bogorad, R.L.20
Love, K.21
Whitehead, K.22
Levins, C.23
Manoharan, M.24
Swirski, F.K.25
Weissleder, R.26
Langer, R.27
Anderson, D.G.28
De Fougerolles, A.29
Nahrendorf, M.30
Koteliansky, V.31
more..
-
83
-
-
84987864167
-
Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin
-
Basha, G.; Ordobadi, M.; Scott, W. R.; Cottle, A.; Liu, Y.; Wang, H.; Cullis, P. R. Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin Mol. Ther. - Nucleic Acids 2016, 5, e363 10.1038/mtna.2016.68
-
(2016)
Mol. Ther. - Nucleic Acids
, vol.5
, pp. e363
-
-
Basha, G.1
Ordobadi, M.2
Scott, W.R.3
Cottle, A.4
Liu, Y.5
Wang, H.6
Cullis, P.R.7
-
84
-
-
84923013790
-
Delivery Systems for siRNA Drug Development in Cancer Therapy
-
Xu, C.-f.; Wang, J. Delivery Systems for siRNA Drug Development in Cancer Therapy Asian J. Pharm. Sci. 2015, 10, 1-12 10.1016/j.ajps.2014.08.011
-
(2015)
Asian J. Pharm. Sci.
, vol.10
, pp. 1-12
-
-
Xu, C.-F.1
Wang, J.2
-
85
-
-
36849067019
-
Nanocarriers as an Emerging Platform for Cancer Therapy
-
Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an Emerging Platform for Cancer Therapy Nat. Nanotechnol. 2007, 2, 751-760 10.1038/nnano.2007.387
-
(2007)
Nat. Nanotechnol.
, vol.2
, pp. 751-760
-
-
Peer, D.1
Karp, J.M.2
Hong, S.3
Farokhzad, O.C.4
Margalit, R.5
Langer, R.6
-
86
-
-
34848918210
-
Impact of Tumor-Specific Targeting on the Biodistribution and Efficacy of siRNA Nanoparticles Measured by Multimodality in Vivo Imaging
-
Bartlett, D. W.; Su, H.; Hildebrandt, I. J.; Weber, W. A.; Davis, M. E. Impact of Tumor-Specific Targeting on the Biodistribution and Efficacy of siRNA Nanoparticles Measured by Multimodality In Vivo Imaging Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 15549-15554 10.1073/pnas.0707461104
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 15549-15554
-
-
Bartlett, D.W.1
Su, H.2
Hildebrandt, I.J.3
Weber, W.A.4
Davis, M.E.5
-
87
-
-
51049104302
-
Pharmacokinetics and Biodistribution of Nanoparticles
-
Li, S. D.; Huang, L. Pharmacokinetics and Biodistribution of Nanoparticles Mol. Pharmaceutics 2008, 5, 496-504 10.1021/mp800049w
-
(2008)
Mol. Pharmaceutics
, vol.5
, pp. 496-504
-
-
Li, S.D.1
Huang, L.2
-
88
-
-
84887165714
-
Factors Controlling the Pharmacokinetics, Biodistribution and Intratumoral Penetration of Nanoparticles
-
Ernsting, M. J.; Murakami, M.; Roy, A.; Li, S.-D. Factors Controlling the Pharmacokinetics, Biodistribution and Intratumoral Penetration of Nanoparticles J. Controlled Release 2013, 172, 782-794 10.1016/j.jconrel.2013.09.013
-
(2013)
J. Controlled Release
, vol.172
, pp. 782-794
-
-
Ernsting, M.J.1
Murakami, M.2
Roy, A.3
Li, S.-D.4
-
89
-
-
33746172167
-
Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models
-
Kirpotin, D. B.; Drummond, D. C.; Shao, Y.; Shalaby, M. R.; Hong, K.; Nielsen, U. B.; Marks, J. D.; Benz, C. C.; Park, J. W. Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models Cancer Res. 2006, 66, 6732-6740 10.1158/0008-5472.CAN-05-4199
-
(2006)
Cancer Res.
, vol.66
, pp. 6732-6740
-
-
Kirpotin, D.B.1
Drummond, D.C.2
Shao, Y.3
Shalaby, M.R.4
Hong, K.5
Nielsen, U.B.6
Marks, J.D.7
Benz, C.C.8
Park, J.W.9
-
90
-
-
84944339790
-
Targeted Print Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation
-
Reuter, K. G.; Perry, J. L.; Kim, D.; Luft, J. C.; Liu, R.; DeSimone, J. M. Targeted Print Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation Nano Lett. 2015, 15, 6371-6378 10.1021/acs.nanolett.5b01362
-
(2015)
Nano Lett.
, vol.15
, pp. 6371-6378
-
-
Reuter, K.G.1
Perry, J.L.2
Kim, D.3
Luft, J.C.4
Liu, R.5
DeSimone, J.M.6
-
91
-
-
0025131849
-
Inhibition of Expression of Human Immunodeficiency Virus-1 in Vitro by Antibody-Targeted Liposomes Containing Antisense RNA to the Env Region
-
Renneisen, K.; Leserman, L.; Matthes, E.; Schroder, H. C.; Muller, W. E. Inhibition of Expression of Human Immunodeficiency Virus-1 In Vitro by Antibody-Targeted Liposomes Containing Antisense RNA to the Env Region J. Biol. Chem. 1990, 265, 16337-16342
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 16337-16342
-
-
Renneisen, K.1
Leserman, L.2
Matthes, E.3
Schroder, H.C.4
Muller, W.E.5
-
92
-
-
76349095131
-
RNAi-Mediated CCR5 Silencing by LFA-1-Targeted Nanoparticles Prevents HIV Infection in BLT Mice
-
Kim, S. S.; Peer, D.; Kumar, P.; Subramanya, S.; Wu, H.; Asthana, D.; Habiro, K.; Yang, Y. G.; Manjunath, N.; Shimaoka, M.; Shankar, P. RNAi-Mediated CCR5 Silencing by LFA-1-Targeted Nanoparticles Prevents HIV Infection in BLT Mice Mol. Ther. 2010, 18, 370-376 10.1038/mt.2009.271
-
(2010)
Mol. Ther.
, vol.18
, pp. 370-376
-
-
Kim, S.S.1
Peer, D.2
Kumar, P.3
Subramanya, S.4
Wu, H.5
Asthana, D.6
Habiro, K.7
Yang, Y.G.8
Manjunath, N.9
Shimaoka, M.10
Shankar, P.11
-
93
-
-
84938152114
-
Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles
-
Ramishetti, S.; Kedmi, R.; Goldsmith, M.; Leonard, F.; Sprague, A. G.; Godin, B.; Gozin, M.; Cullis, P. R.; Dykxhoorn, D. M.; Peer, D. Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles ACS Nano 2015, 9, 6706-6716 10.1021/acsnano.5b02796
-
(2015)
ACS Nano
, vol.9
, pp. 6706-6716
-
-
Ramishetti, S.1
Kedmi, R.2
Goldsmith, M.3
Leonard, F.4
Sprague, A.G.5
Godin, B.6
Gozin, M.7
Cullis, P.R.8
Dykxhoorn, D.M.9
Peer, D.10
-
94
-
-
84953242595
-
Harnessing RNAi-Based Nanomedicines for Therapeutic Gene Silencing in B-Cell Malignancies
-
Weinstein, S.; Toker, I. A.; Emmanuel, R.; Ramishetti, S.; Hazan-Halevy, I.; Rosenblum, D.; Goldsmith, M.; Abraham, A.; Benjamini, O.; Bairey, O.; Raanani, P.; Nagler, A.; Lieberman, J.; Peer, D. Harnessing RNAi-Based Nanomedicines for Therapeutic Gene Silencing in B-Cell Malignancies Proc. Natl. Acad. Sci. U. S. A. 2016, 113, E16-22 10.1073/pnas.1519273113
-
(2016)
Proc. Natl. Acad. Sci. U. S. A.
, vol.113
, pp. E16-22
-
-
Weinstein, S.1
Toker, I.A.2
Emmanuel, R.3
Ramishetti, S.4
Hazan-Halevy, I.5
Rosenblum, D.6
Goldsmith, M.7
Abraham, A.8
Benjamini, O.9
Bairey, O.10
Raanani, P.11
Nagler, A.12
Lieberman, J.13
Peer, D.14
-
95
-
-
84923459414
-
Localized RNAi Therapeutics of Chemoresistant Grade IV Glioma Using Hyaluronan-Grafted Lipid-Based Nanoparticles
-
Cohen, Z. R.; Ramishetti, S.; Peshes-Yaloz, N.; Goldsmith, M.; Wohl, A.; Zibly, Z.; Peer, D. Localized RNAi Therapeutics of Chemoresistant Grade IV Glioma Using Hyaluronan-Grafted Lipid-Based Nanoparticles ACS Nano 2015, 9, 1581-1591 10.1021/nn506248s
-
(2015)
ACS Nano
, vol.9
, pp. 1581-1591
-
-
Cohen, Z.R.1
Ramishetti, S.2
Peshes-Yaloz, N.3
Goldsmith, M.4
Wohl, A.5
Zibly, Z.6
Peer, D.7
-
96
-
-
38849166053
-
Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target
-
Peer, D.; Park, E. J.; Morishita, Y.; Carman, C. V.; Shimaoka, M. Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target Science 2008, 319, 627-630 10.1126/science.1149859
-
(2008)
Science
, vol.319
, pp. 627-630
-
-
Peer, D.1
Park, E.J.2
Morishita, Y.3
Carman, C.V.4
Shimaoka, M.5
-
97
-
-
77954243341
-
Targeted Delivery of RNAi Therapeutics with Endogenous and Exogenous Ligand-Based Mechanisms
-
Akinc, A.; Querbes, W.; De, S.; Qin, J.; Frank-Kamenetsky, M.; Jayaprakash, K. N.; Jayaraman, M.; Rajeev, K. G.; Cantley, W. L.; Dorkin, J. R.; Butler, J. S.; Qin, L.; Racie, T.; Sprague, A.; Fava, E.; Zeigerer, A.; Hope, M. J.; Zerial, M.; Sah, D. W.; Fitzgerald, K.; Tracy, M. A.; Manoharan, M.; Koteliansky, V.; Fougerolles, A.; Maier, M. A. Targeted Delivery of RNAi Therapeutics with Endogenous and Exogenous Ligand-Based Mechanisms Mol. Ther. 2010, 18, 1357-1364 10.1038/mt.2010.85
-
(2010)
Mol. Ther.
, vol.18
, pp. 1357-1364
-
-
Akinc, A.1
Querbes, W.2
De, S.3
Qin, J.4
Frank-Kamenetsky, M.5
Jayaprakash, K.N.6
Jayaraman, M.7
Rajeev, K.G.8
Cantley, W.L.9
Dorkin, J.R.10
Butler, J.S.11
Qin, L.12
Racie, T.13
Sprague, A.14
Fava, E.15
Zeigerer, A.16
Hope, M.J.17
Zerial, M.18
Sah, D.W.19
Fitzgerald, K.20
Tracy, M.A.21
Manoharan, M.22
Koteliansky, V.23
Fougerolles, A.24
Maier, M.A.25
more..
-
98
-
-
54949125913
-
Folate-Linked Lipid-Based Nanoparticles for Synthetic siRNA Delivery in KB Tumor Xenografts
-
Yoshizawa, T.; Hattori, Y.; Hakoshima, M.; Koga, K.; Maitani, Y. Folate-Linked Lipid-Based Nanoparticles for Synthetic siRNA Delivery in KB Tumor Xenografts Eur. J. Pharm. Biopharm. 2008, 70, 718-725 10.1016/j.ejpb.2008.06.026
-
(2008)
Eur. J. Pharm. Biopharm.
, vol.70
, pp. 718-725
-
-
Yoshizawa, T.1
Hattori, Y.2
Hakoshima, M.3
Koga, K.4
Maitani, Y.5
-
99
-
-
0028430957
-
Folate Receptor Mediated DNA Delivery into Tumor Cells: Potosomal Disruption Results in Enhanced Gene Expression
-
Gottschalk, S.; Cristiano, R. J.; Smith, L. C.; Woo, S. L. Folate Receptor Mediated DNA Delivery into Tumor Cells: Potosomal Disruption Results in Enhanced Gene Expression Gene Ther. 1994, 1, 185-191
-
(1994)
Gene Ther.
, vol.1
, pp. 185-191
-
-
Gottschalk, S.1
Cristiano, R.J.2
Smith, L.C.3
Woo, S.L.4
-
100
-
-
84856098210
-
Challenges in the Pharmaceutical Development of Lipid-Based Short Interfering Ribonucleic Acid Therapeutics
-
Gindy, M. E.; Leone, A. M.; Cunningham, J. J. Challenges in the Pharmaceutical Development of Lipid-Based Short Interfering Ribonucleic Acid Therapeutics Expert Opin. Drug Delivery 2012, 9, 171-182 10.1517/17425247.2012.642363
-
(2012)
Expert Opin. Drug Delivery
, vol.9
, pp. 171-182
-
-
Gindy, M.E.1
Leone, A.M.2
Cunningham, J.J.3
-
101
-
-
84871033897
-
Microfluidic Technologies for Accelerating the Clinical Translation of Nanoparticles
-
Valencia, P. M.; Farokhzad, O. C.; Karnik, R.; Langer, R. Microfluidic Technologies for Accelerating the Clinical Translation of Nanoparticles Nat. Nanotechnol. 2012, 7, 623-629 10.1038/nnano.2012.168
-
(2012)
Nat. Nanotechnol.
, vol.7
, pp. 623-629
-
-
Valencia, P.M.1
Farokhzad, O.C.2
Karnik, R.3
Langer, R.4
-
102
-
-
74149092120
-
Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-Treatment
-
Abrams, M. T.; Koser, M. L.; Seitzer, J.; Williams, S. C.; DiPietro, M. A.; Wang, W.; Shaw, A. W.; Mao, X.; Jadhav, V.; Davide, J. P.; Burke, P. A.; Sachs, A. B.; Stirdivant, S. M.; Sepp-Lorenzino, L. Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-Treatment Mol. Ther. 2010, 18, 171-180 10.1038/mt.2009.208
-
(2010)
Mol. Ther.
, vol.18
, pp. 171-180
-
-
Abrams, M.T.1
Koser, M.L.2
Seitzer, J.3
Williams, S.C.4
DiPietro, M.A.5
Wang, W.6
Shaw, A.W.7
Mao, X.8
Jadhav, V.9
Davide, J.P.10
Burke, P.A.11
Sachs, A.B.12
Stirdivant, S.M.13
Sepp-Lorenzino, L.14
-
103
-
-
84868338479
-
Microfluidic Synthesis of Highly Potent Limit-Size Lipid Nanoparticles for in Vivo Delivery of siRNA
-
Belliveau, N. M.; Huft, J.; Lin, P. J.; Chen, S.; Leung, A. K.; Leaver, T. J.; Wild, A. W.; Lee, J. B.; Taylor, R. J.; Tam, Y. K.; Hansen, C. L.; Cullis, P. R. Microfluidic Synthesis of Highly Potent Limit-Size Lipid Nanoparticles for In Vivo Delivery of siRNA Mol. Ther. - Nucleic Acids 2012, 1, e37 10.1038/mtna.2012.28
-
(2012)
Mol. Ther. - Nucleic Acids
, vol.1
, pp. e37
-
-
Belliveau, N.M.1
Huft, J.2
Lin, P.J.3
Chen, S.4
Leung, A.K.5
Leaver, T.J.6
Wild, A.W.7
Lee, J.B.8
Taylor, R.J.9
Tam, Y.K.10
Hansen, C.L.11
Cullis, P.R.12
-
104
-
-
84860344186
-
Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation
-
Chen, D.; Love, K. T.; Chen, Y.; Eltoukhy, A. A.; Kastrup, C.; Sahay, G.; Jeon, A.; Dong, Y.; Whitehead, K. A.; Anderson, D. G. Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation J. Am. Chem. Soc. 2012, 134, 6948-6951 10.1021/ja301621z
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 6948-6951
-
-
Chen, D.1
Love, K.T.2
Chen, Y.3
Eltoukhy, A.A.4
Kastrup, C.5
Sahay, G.6
Jeon, A.7
Dong, Y.8
Whitehead, K.A.9
Anderson, D.G.10
-
105
-
-
84937135320
-
Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems
-
Leung, A. K. K.; Tam, Y. Y. C.; Chen, S.; Hafez, I. M.; Cullis, P. R. Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems J. Phys. Chem. B 2015, 119, 8698-8706 10.1021/acs.jpcb.5b02891
-
(2015)
J. Phys. Chem. B
, vol.119
, pp. 8698-8706
-
-
Leung, A.K.K.1
Tam, Y.Y.C.2
Chen, S.3
Hafez, I.M.4
Cullis, P.R.5
-
106
-
-
0028326452
-
Liposome-Complement Interactions in Rat Serum: Implications for Liposome Survival Studies
-
Devine, D. V.; Wong, K.; Serrano, K.; Chonn, A.; Cullis, P. R. Liposome-Complement Interactions in Rat Serum: Implications for Liposome Survival Studies Biochim. Biophys. Acta, Biomembr. 1994, 1191, 43-51 10.1016/0005-2736(94)90231-3
-
(1994)
Biochim. Biophys. Acta, Biomembr.
, vol.1191
, pp. 43-51
-
-
Devine, D.V.1
Wong, K.2
Serrano, K.3
Chonn, A.4
Cullis, P.R.5
-
107
-
-
0026052844
-
The Role of Surface Charge in the Activation of the Classical and Alternative Pathways of Complement by Liposomes
-
Chonn, A.; Cullis, P. R.; Devine, D. V. The Role of Surface Charge in the Activation of the Classical and Alternative Pathways of Complement by Liposomes J. Immunol. 1991, 146, 4234-4241
-
(1991)
J. Immunol.
, vol.146
, pp. 4234-4241
-
-
Chonn, A.1
Cullis, P.R.2
Devine, D.V.3
-
108
-
-
22344454846
-
Sequence-Dependent Stimulation of the Mammalian Innate Immune Response by Synthetic siRNA
-
Judge, A. D.; Sood, V.; Shaw, J. R.; Fang, D.; McClintock, K.; MacLachlan, I. Sequence-Dependent Stimulation of the Mammalian Innate Immune Response by Synthetic siRNA Nat. Biotechnol. 2005, 23, 457-462 10.1038/nbt1081
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
Sood, V.2
Shaw, J.R.3
Fang, D.4
McClintock, K.5
MacLachlan, I.6
-
109
-
-
0031023264
-
Stabilization of Cationic Liposome-Plasmid DNA Complexes by Polyamines and Poly(Ethylene Glycol)-Phospholipid Conjugates for Efficient in Vivo Gene Delivery
-
Hong, K.; Zheng, W.; Baker, A.; Papahadjopoulos, D. Stabilization of Cationic Liposome-Plasmid DNA Complexes by Polyamines and Poly(Ethylene Glycol)-Phospholipid Conjugates for Efficient In Vivo Gene Delivery FEBS Lett. 1997, 400, 233-237 10.1016/S0014-5793(96)01397-X
-
(1997)
FEBS Lett.
, vol.400
, pp. 233-237
-
-
Hong, K.1
Zheng, W.2
Baker, A.3
Papahadjopoulos, D.4
-
110
-
-
84948717926
-
Clinical Experiences with Systemically Administered siRNA-Based Therapeutics in Cancer
-
Zuckerman, J. E.; Davis, M. E. Clinical Experiences with Systemically Administered siRNA-Based Therapeutics in Cancer Nat. Rev. Drug Discovery 2015, 14, 843-856 10.1038/nrd4685
-
(2015)
Nat. Rev. Drug Discovery
, vol.14
, pp. 843-856
-
-
Zuckerman, J.E.1
Davis, M.E.2
|