Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes

Cell Stem Cell

Volumn 21, Issue 3, 2017, Pages 374-382.e4

  Coombs, Catherine C ^a   Zehir, Ahmet ^a   Devlin, Sean M ^a   Kishtagari, Ashwin ^a   Syed, Aijazuddin ^a   Jonsson, Philip ^a   Hyman, David M ^a,b   Solit, David B ^a,b   Robson, Mark E ^a,b   Baselga, José ^a,b   Arcila, Maria E ^a   Ladanyi, Marc ^a   Tallman, Martin S ^a,b   Levine, Ross L ^a,b   Berger, Michael F ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

biological sciences; cancer; cancer genomics; diseases; genetics; health sciences; hematological cancer; hematological diseases; mutation

Indexed keywords

PROTEIN P53;

ADULT; ADVANCED CANCER; ADVERSE OUTCOME; ARTICLE; BLOOD SAMPLING; CANCER CHEMOTHERAPY; CANCER INCIDENCE; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL OUTCOME; CLONAL HEMATOPOIESIS; FEMALE; GENE MUTATION; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; LEUKEMIA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEXT GENERATION SEQUENCING; PRIORITY JOURNAL; SOLID MALIGNANT NEOPLASM; TOBACCO USE; AGED; CELL CLONE; COHORT ANALYSIS; GENETIC ASSOCIATION STUDY; GENETICS; HEMATOLOGIC DISEASE; MUTATION; PATHOLOGY; RISK FACTOR; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

AGED; CLONE CELLS; COHORT STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; HEMATOLOGIC NEOPLASMS; HEMATOPOIESIS; HUMANS; MALE; MIDDLE AGED; MUTATION; RISK FACTORS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 85028324157     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2017.07.010     Document Type: Article

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