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Volumn 190, Issue , 2017, Pages 159-168

The potential and promise of IL-15 in immuno-oncogenic therapies

Author keywords

ALT 803; Clinical trials; Cytotoxic lymphocytes; IL 15; Immunotherapy; Soluble IL 15 complexes

Indexed keywords

ALEMTUZUMAB; ALT 803; BCG VACCINE; CYCLOPHOSPHAMIDE; ELOTUZUMAB; FLUDARABINE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; HYBRID PROTEIN; INTERLEUKIN 15; INTERLEUKIN 15 DERIVATIVE; INTERLEUKIN 15 RECEPTOR ALPHA; INTERLEUKIN 2; MELPHALAN; NIVOLUMAB; PACLITAXEL; RECOMBINANT INTERLEUKIN 15; RECOMBINANT INTERLEUKIN 2; RITUXIMAB; UNCLASSIFIED DRUG; INTERLEUKIN 15 RECEPTOR;

EID: 85028027225     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2017.08.010     Document Type: Review
Times cited : (144)

References (91)
  • 1
    • 0032471712 scopus 로고    scopus 로고
    • Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the antigens mediating response
    • Rosenberg, S.A., Yang, J.C., White, D.E., et al. Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the antigens mediating response. Ann. Surg. 228 (1998), 307–319.
    • (1998) Ann. Surg. , vol.228 , pp. 307-319
    • Rosenberg, S.A.1    Yang, J.C.2    White, D.E.3
  • 2
    • 0042914703 scopus 로고    scopus 로고
    • Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
    • Yang, J.C., Sherry, R.M., Steinberg, S.M., et al. Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J. Clin. Oncol. 21 (2003), 3127–3132.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3127-3132
    • Yang, J.C.1    Sherry, R.M.2    Steinberg, S.M.3
  • 3
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • Fyfe, G., Fisher, R.I., Rosenberg, S.A., et al. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J. Clin. Oncol. 13 (1995), 688–696.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 688-696
    • Fyfe, G.1    Fisher, R.I.2    Rosenberg, S.A.3
  • 4
    • 53049088033 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines
    • Smith, F.O., Downey, S.G., Klapper, J.A., et al. Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines. Clin. Cancer Res. 14 (2008), 5610–5618.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5610-5618
    • Smith, F.O.1    Downey, S.G.2    Klapper, J.A.3
  • 5
    • 20244366111 scopus 로고    scopus 로고
    • Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
    • Dudley, M.E., Wunderlich, J.R., Yang, J.C., et al. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J. Clin. Oncol. 23 (2005), 2346–2357.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2346-2357
    • Dudley, M.E.1    Wunderlich, J.R.2    Yang, J.C.3
  • 6
    • 55949125601 scopus 로고    scopus 로고
    • Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens
    • Dudley, M.E., Yang, J.C., Sherry, R., et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J. Clin. Oncol. 26 (2008), 5233–5239.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5233-5239
    • Dudley, M.E.1    Yang, J.C.2    Sherry, R.3
  • 7
    • 41149132993 scopus 로고    scopus 로고
    • Twelve immunotherapy drugs that could cure cancers
    • Cheever, M.A., Twelve immunotherapy drugs that could cure cancers. Immunol. Rev. 222 (2008), 357–368.
    • (2008) Immunol. Rev. , vol.222 , pp. 357-368
    • Cheever, M.A.1
  • 8
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi, F.S., O'Day, S.J., McDermott, D.F., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363 (2010), 711–723.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 9
    • 84862859820 scopus 로고    scopus 로고
    • Safety activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S.L., Hodi, F.S., Brahmer, J.R., et al. Safety activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366 (2012), 2443–2454.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 10
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
    • Sharma, P., Allison, J.P., Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161 (2015), 205–214.
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 11
    • 84935099494 scopus 로고    scopus 로고
    • IL-15-PI3K-AKT-mTOR: a critical pathway in the life journey of natural killer cells
    • Ali, A.K., Nandagopal, N., Lee, S.H., IL-15-PI3K-AKT-mTOR: a critical pathway in the life journey of natural killer cells. Front. Immunol., 6, 2015, 355-.
    • (2015) Front. Immunol. , vol.6 , pp. 355-
    • Ali, A.K.1    Nandagopal, N.2    Lee, S.H.3
  • 12
    • 0034610970 scopus 로고    scopus 로고
    • Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    • Kennedy, M.K., Glaccum, M., Brown, S.N., et al. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191 (2000), 771–780.
    • (2000) J. Exp. Med. , vol.191 , pp. 771-780
    • Kennedy, M.K.1    Glaccum, M.2    Brown, S.N.3
  • 13
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce, J.P., Boone, D.L., Chai, S., et al. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9 (1998), 669–676.
    • (1998) Immunity , vol.9 , pp. 669-676
    • Lodolce, J.P.1    Boone, D.L.2    Chai, S.3
  • 14
    • 58149390259 scopus 로고    scopus 로고
    • Dendritic cells drive memory CD8 T cell homeostasis via IL-15 trans-presentation
    • Stonier, S.W., Ma, L.J., Castillo, E.F., et al. Dendritic cells drive memory CD8 T cell homeostasis via IL-15 trans-presentation. Blood, 2008, 4546–4554.
    • (2008) Blood , pp. 4546-4554
    • Stonier, S.W.1    Ma, L.J.2    Castillo, E.F.3
  • 15
    • 70449533145 scopus 로고    scopus 로고
    • Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8(+) T cell subsets
    • Mortier, E., Advincula, R., Kim, L., et al. Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8(+) T cell subsets. Immunity 31 (2009), 811–822.
    • (2009) Immunity , vol.31 , pp. 811-822
    • Mortier, E.1    Advincula, R.2    Kim, L.3
  • 16
    • 84924368722 scopus 로고    scopus 로고
    • Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways
    • Anthony, S.M., Howard, M.E., Hailemichael, Y., et al. Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways. PLoS One, 10, 2015, e0120274-.
    • (2015) PLoS One , vol.10 , pp. e0120274-
    • Anthony, S.M.1    Howard, M.E.2    Hailemichael, Y.3
  • 17
    • 84975108664 scopus 로고    scopus 로고
    • Inflammatory signals regulate IL-15 in response to lymphodepletion
    • Anthony, S.M., Rivas, S.C., Colpitts, S.L., et al. Inflammatory signals regulate IL-15 in response to lymphodepletion. J. Immunol. 196 (2016), 4544–4552.
    • (2016) J. Immunol. , vol.196 , pp. 4544-4552
    • Anthony, S.M.1    Rivas, S.C.2    Colpitts, S.L.3
  • 18
    • 33745135757 scopus 로고    scopus 로고
    • Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}
    • Rubinstein, M.P., Kovar, M., Purton, J.F., et al. Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 9166–9171.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 9166-9171
    • Rubinstein, M.P.1    Kovar, M.2    Purton, J.F.3
  • 19
    • 33750335080 scopus 로고    scopus 로고
    • Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo
    • Stoklasek, T.A., Schluns, K.S., Lefrancois, L., Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo. J. Immunol. 177 (2006), 6072–6080.
    • (2006) J. Immunol. , vol.177 , pp. 6072-6080
    • Stoklasek, T.A.1    Schluns, K.S.2    Lefrancois, L.3
  • 20
    • 42949147181 scopus 로고    scopus 로고
    • Intracellular interaction of interleukin-15 with its receptor {alpha} during production leads to mutual stabilization and increased bioactivity
    • Bergamaschi, C., Rosati, M., Jalah, R., et al. Intracellular interaction of interleukin-15 with its receptor {alpha} during production leads to mutual stabilization and increased bioactivity. J. Biol. Chem. 283 (2008), 4189–4199.
    • (2008) J. Biol. Chem. , vol.283 , pp. 4189-4199
    • Bergamaschi, C.1    Rosati, M.2    Jalah, R.3
  • 21
    • 1642581680 scopus 로고    scopus 로고
    • Transregulation of memory CD8 T-cell proliferation by IL-15R alpha(+) bone marrow-derived cells
    • Schluns, K.S., Klonowski, K.D., Lefrancois, L., Transregulation of memory CD8 T-cell proliferation by IL-15R alpha(+) bone marrow-derived cells. Blood 103 (2004), 988–994.
    • (2004) Blood , vol.103 , pp. 988-994
    • Schluns, K.S.1    Klonowski, K.D.2    Lefrancois, L.3
  • 22
    • 0037447075 scopus 로고    scopus 로고
    • IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory
    • Burkett, P.R., Koka, R., Chien, M., et al. IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory. Proc. Natl. Acad. Sci. U. S. A. 100 (2003), 4724–4729.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 4724-4729
    • Burkett, P.R.1    Koka, R.2    Chien, M.3
  • 23
    • 0037460058 scopus 로고    scopus 로고
    • Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice
    • Koka, R., Burkett, P.R., Chien, M., et al. Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice. J. Exp. Med. 197 (2003), 977–984.
    • (2003) J. Exp. Med. , vol.197 , pp. 977-984
    • Koka, R.1    Burkett, P.R.2    Chien, M.3
  • 24
    • 5444239242 scopus 로고    scopus 로고
    • Coordinate expression and trans presentation of interleukin (IL)-15R{alpha} and IL-15 supports natural killer cell and memory CD8+ t cell homeostasis
    • Burkett, P.R., Koka, R., Chien, M., et al. Coordinate expression and trans presentation of interleukin (IL)-15R{alpha} and IL-15 supports natural killer cell and memory CD8+ t cell homeostasis. J. Exp. Med. 200 (2004), 825–834.
    • (2004) J. Exp. Med. , vol.200 , pp. 825-834
    • Burkett, P.R.1    Koka, R.2    Chien, M.3
  • 25
    • 0029812542 scopus 로고    scopus 로고
    • Long-term response data for 255 patients with metastatic renal cell carcinoma treated with high-dose recombinant interleukin-2 therapy
    • Fyfe, G.A., Fisher, R.I., Rosenberg, S.A., et al. Long-term response data for 255 patients with metastatic renal cell carcinoma treated with high-dose recombinant interleukin-2 therapy. J. Clin. Oncol. 14 (1996), 2410–2411.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 2410-2411
    • Fyfe, G.A.1    Fisher, R.I.2    Rosenberg, S.A.3
  • 26
    • 48249117436 scopus 로고    scopus 로고
    • High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006
    • Klapper, J.A., Downey, S.G., Smith, F.O., et al. High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006. Cancer 113 (2008), 293–301.
    • (2008) Cancer , vol.113 , pp. 293-301
    • Klapper, J.A.1    Downey, S.G.2    Smith, F.O.3
  • 27
    • 0022534622 scopus 로고
    • Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2
    • Rosenstein, M., Ettinghausen, S.E., Rosenberg, S.A., Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2. J. Immunol. 137 (1986), 1735–1742.
    • (1986) J. Immunol. , vol.137 , pp. 1735-1742
    • Rosenstein, M.1    Ettinghausen, S.E.2    Rosenberg, S.A.3
  • 28
    • 0024121405 scopus 로고
    • Toxicity of human recombinant interleukin-2 in the mouse is mediated by interleukin-activated lymphocytes. Separation of efficacy and toxicity by selective lymphocyte subset depletion
    • Anderson, T.D., Hayes, T.J., Gately, M.K., et al. Toxicity of human recombinant interleukin-2 in the mouse is mediated by interleukin-activated lymphocytes. Separation of efficacy and toxicity by selective lymphocyte subset depletion. Lab. Invest. 59 (1988), 598–612.
    • (1988) Lab. Invest. , vol.59 , pp. 598-612
    • Anderson, T.D.1    Hayes, T.J.2    Gately, M.K.3
  • 29
    • 33644784733 scopus 로고    scopus 로고
    • IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients
    • Ahmadzadeh, M., Rosenberg, S.A., IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients. Blood 107 (2006), 2409–2414.
    • (2006) Blood , vol.107 , pp. 2409-2414
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 30
    • 0028179054 scopus 로고
    • Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
    • Grabstein, K.H., Eisenman, J., Shanebeck, K., et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264 (1994), 965–968.
    • (1994) Science , vol.264 , pp. 965-968
    • Grabstein, K.H.1    Eisenman, J.2    Shanebeck, K.3
  • 31
    • 0038665233 scopus 로고    scopus 로고
    • IL-15 promotes the survival of naive and memory phenotype CD8+ T cells
    • Berard, M., Brandt, K., Bulfone-Paus, S., et al. IL-15 promotes the survival of naive and memory phenotype CD8+ T cells. J. Immunol. 170 (2003), 5018–5026.
    • (2003) J. Immunol. , vol.170 , pp. 5018-5026
    • Berard, M.1    Brandt, K.2    Bulfone-Paus, S.3
  • 32
    • 0034633683 scopus 로고    scopus 로고
    • IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
    • Marks-Konczalik, J., Dubois, S., Losi, J.M., et al. IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 97 (2000), 11445–11450.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 11445-11450
    • Marks-Konczalik, J.1    Dubois, S.2    Losi, J.M.3
  • 33
    • 79955950299 scopus 로고    scopus 로고
    • Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques
    • Waldmann, T.A., Lugli, E., Roederer, M., et al. Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques. Blood 117 (2011), 4787–4795.
    • (2011) Blood , vol.117 , pp. 4787-4795
    • Waldmann, T.A.1    Lugli, E.2    Roederer, M.3
  • 34
    • 70350511426 scopus 로고    scopus 로고
    • Safety and immunologic effects of IL-15 administration in nonhuman primates
    • Berger, C., Berger, M., Hackman, R.C., et al. Safety and immunologic effects of IL-15 administration in nonhuman primates. Blood 114 (2009), 2417–2426.
    • (2009) Blood , vol.114 , pp. 2417-2426
    • Berger, C.1    Berger, M.2    Hackman, R.C.3
  • 35
    • 13344278015 scopus 로고
    • Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes
    • Anderson, D.M., Kumaki, S., Ahdieh, M., et al. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J. Biol. Chem. 270 (1995), 29862–29869.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29862-29869
    • Anderson, D.M.1    Kumaki, S.2    Ahdieh, M.3
  • 36
    • 0029099146 scopus 로고
    • Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
    • Giri, J.G., Kumaki, S., Ahdieh, M., et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 14 (1995), 3654–3663.
    • (1995) EMBO J. , vol.14 , pp. 3654-3663
    • Giri, J.G.1    Kumaki, S.2    Ahdieh, M.3
  • 37
    • 84912120595 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
    • Woo, S.R., Fuertes, M.B., Corrales, L., et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 41 (2014), 830–842.
    • (2014) Immunity , vol.41 , pp. 830-842
    • Woo, S.R.1    Fuertes, M.B.2    Corrales, L.3
  • 38
    • 0032076635 scopus 로고    scopus 로고
    • Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15
    • Zhang, X., Sun, S., Hwang, I., et al. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8 (1998), 591–599.
    • (1998) Immunity , vol.8 , pp. 591-599
    • Zhang, X.1    Sun, S.2    Hwang, I.3
  • 39
    • 84255197274 scopus 로고    scopus 로고
    • IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood
    • Sneller, M.C., Kopp, W.C., Engelke, K.J., et al. IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood. Blood 118 (2011), 6845–6848.
    • (2011) Blood , vol.118 , pp. 6845-6848
    • Sneller, M.C.1    Kopp, W.C.2    Engelke, K.J.3
  • 40
    • 78049271031 scopus 로고    scopus 로고
    • Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates
    • Lugli, E., Goldman, C.K., Perera, L.P., et al. Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates. Blood 116 (2010), 3238–3248.
    • (2010) Blood , vol.116 , pp. 3238-3248
    • Lugli, E.1    Goldman, C.K.2    Perera, L.P.3
  • 41
    • 33745202622 scopus 로고    scopus 로고
    • IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates
    • Picker, L.J., Reed-Inderbitzin, E.F., Hagen, S.I., et al. IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. J. Clin. Invest 116 (2006), 1514–1524.
    • (2006) J. Clin. Invest , vol.116 , pp. 1514-1524
    • Picker, L.J.1    Reed-Inderbitzin, E.F.2    Hagen, S.I.3
  • 42
    • 84920577302 scopus 로고    scopus 로고
    • Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer
    • Conlon, K.C., Lugli, E., Welles, H.C., et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J. Clin. Oncol. 33 (2015), 74–82.
    • (2015) J. Clin. Oncol. , vol.33 , pp. 74-82
    • Conlon, K.C.1    Lugli, E.2    Welles, H.C.3
  • 43
    • 0026684134 scopus 로고
    • Cloning of the gamma chain of the human IL-2 receptor
    • Takeshita, T., Asao, H., Ohtani, K., et al. Cloning of the gamma chain of the human IL-2 receptor. Science 257 (1992), 379–382.
    • (1992) Science , vol.257 , pp. 379-382
    • Takeshita, T.1    Asao, H.2    Ohtani, K.3
  • 44
    • 51049088214 scopus 로고    scopus 로고
    • Activity of recombinant human interleukin-15 against tumor recurrence and metastasis in mice
    • Tang, F., Zhao, L.T., Jiang, Y., et al. Activity of recombinant human interleukin-15 against tumor recurrence and metastasis in mice. Cell Mol. Immunol. 5 (2008), 189–196.
    • (2008) Cell Mol. Immunol. , vol.5 , pp. 189-196
    • Tang, F.1    Zhao, L.T.2    Jiang, Y.3
  • 45
    • 10744226452 scopus 로고    scopus 로고
    • IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells
    • Klebanoff, C.A., Finkelstein, S.E., Surman, D.R., et al. IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 1969–1974.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 1969-1974
    • Klebanoff, C.A.1    Finkelstein, S.E.2    Surman, D.R.3
  • 46
    • 11244255868 scopus 로고    scopus 로고
    • The role of trans-cellular IL-15-presentation in the activation of NK-mediated killing, which leads to enhanced tumor immunesurveillance
    • Kobayashi, H., Dubois, S., Sato, N., et al. The role of trans-cellular IL-15-presentation in the activation of NK-mediated killing, which leads to enhanced tumor immunesurveillance. Blood 105 (2005), 721–727.
    • (2005) Blood , vol.105 , pp. 721-727
    • Kobayashi, H.1    Dubois, S.2    Sato, N.3
  • 47
    • 78650328102 scopus 로고    scopus 로고
    • Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model
    • Yu, P., Steel, J.C., Zhang, M., et al. Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model. Clin. Cancer Res. 16 (2010), 6019–6028.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 6019-6028
    • Yu, P.1    Steel, J.C.2    Zhang, M.3
  • 48
    • 84980382605 scopus 로고    scopus 로고
    • Emerging roles for IL-15 in the activation and function of T cells during immune stimulation
    • Anthony, S.M., Schluns, K.S., Emerging roles for IL-15 in the activation and function of T cells during immune stimulation. Res. Rep. Biol. 6 (2015), 25–37.
    • (2015) Res. Rep. Biol. , vol.6 , pp. 25-37
    • Anthony, S.M.1    Schluns, K.S.2
  • 49
    • 0035862325 scopus 로고    scopus 로고
    • Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells
    • Fehniger, T.A., Suzuki, K., Ponnappan, A., et al. Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells. J. Exp. Med. 193 (2001), 219–231.
    • (2001) J. Exp. Med. , vol.193 , pp. 219-231
    • Fehniger, T.A.1    Suzuki, K.2    Ponnappan, A.3
  • 50
    • 0036436131 scopus 로고    scopus 로고
    • Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity
    • Eisenman, J., Ahdieh, M., Beers, C., et al. Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity. Cytokine 20 (2002), 121–129.
    • (2002) Cytokine , vol.20 , pp. 121-129
    • Eisenman, J.1    Ahdieh, M.2    Beers, C.3
  • 51
    • 33644975335 scopus 로고    scopus 로고
    • Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins
    • Mortier, E., Quemener, A., Vusio, P., et al. Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins. J. Biol. Chem. 281 (2006), 1612–1619.
    • (2006) J. Biol. Chem. , vol.281 , pp. 1612-1619
    • Mortier, E.1    Quemener, A.2    Vusio, P.3
  • 52
    • 84863562572 scopus 로고    scopus 로고
    • Circulating interleukin-15 (IL-15) exists as heterodimeric complex with soluble IL-15 receptor alpha (IL-15Ralpha) in human serum
    • Bergamaschi, C., Bear, J., Rosati, M., et al. Circulating interleukin-15 (IL-15) exists as heterodimeric complex with soluble IL-15 receptor alpha (IL-15Ralpha) in human serum. Blood 120 (2012), 1–8.
    • (2012) Blood , vol.120 , pp. 1-8
    • Bergamaschi, C.1    Bear, J.2    Rosati, M.3
  • 53
    • 84880078963 scopus 로고    scopus 로고
    • Characterization and favorable in vivo properties of heterodimeric soluble IL-15. IL-15Ralpha cytokine compared to IL-15 monomer
    • Chertova, E., Bergamaschi, C., Chertov, O., et al. Characterization and favorable in vivo properties of heterodimeric soluble IL-15. IL-15Ralpha cytokine compared to IL-15 monomer. J. Biol. Chem. 288 (2013), 18093–18103.
    • (2013) J. Biol. Chem. , vol.288 , pp. 18093-18103
    • Chertova, E.1    Bergamaschi, C.2    Chertov, O.3
  • 54
    • 84981306115 scopus 로고    scopus 로고
    • Efficient production and enhanced tumor delivery of engineered extracellular vesicles
    • Watson, D.C., Bayik, D., Srivatsan, A., et al. Efficient production and enhanced tumor delivery of engineered extracellular vesicles. Biomaterials 105 (2016), 195–205.
    • (2016) Biomaterials , vol.105 , pp. 195-205
    • Watson, D.C.1    Bayik, D.2    Srivatsan, A.3
  • 55
    • 42149162887 scopus 로고    scopus 로고
    • Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action
    • Dubois, S., Patel, H.J., Zhang, M., et al. Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action. J. Immunol. 180 (2008), 2099–2106.
    • (2008) J. Immunol. , vol.180 , pp. 2099-2106
    • Dubois, S.1    Patel, H.J.2    Zhang, M.3
  • 56
    • 84867065769 scopus 로고    scopus 로고
    • Fc-fusion proteins: new developments and future perspectives
    • Czajkowsky, D.M., Hu, J., Shao, Z., et al. Fc-fusion proteins: new developments and future perspectives. EMBO Mol. Med. 4 (2012), 1015–1028.
    • (2012) EMBO Mol. Med. , vol.4 , pp. 1015-1028
    • Czajkowsky, D.M.1    Hu, J.2    Shao, Z.3
  • 57
    • 78650737758 scopus 로고    scopus 로고
    • Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes
    • Elpek, K.G., Rubinstein, M.P., Bellemare-Pelletier, A., et al. Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 21647–21652.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 21647-21652
    • Elpek, K.G.1    Rubinstein, M.P.2    Bellemare-Pelletier, A.3
  • 58
    • 42349091974 scopus 로고    scopus 로고
    • Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells
    • Epardaud, M., Elpek, K.G., Rubinstein, M.P., et al. Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells. Cancer Res. 68 (2008), 2972–2983.
    • (2008) Cancer Res. , vol.68 , pp. 2972-2983
    • Epardaud, M.1    Elpek, K.G.2    Rubinstein, M.P.3
  • 59
    • 70349482330 scopus 로고    scopus 로고
    • High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor alpha fusion protein, in metastatic melanoma and colorectal cancer
    • Bessard, A., Sole, V., Bouchaud, G., et al. High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor alpha fusion protein, in metastatic melanoma and colorectal cancer. Mol. Cancer Ther. 8 (2009), 2736–2745.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2736-2745
    • Bessard, A.1    Sole, V.2    Bouchaud, G.3
  • 60
    • 84877865939 scopus 로고    scopus 로고
    • Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor alphaSu/Fc fusion complex in syngeneic murine models of multiple myeloma
    • Xu, W., Jones, M., Liu, B., et al. Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor alphaSu/Fc fusion complex in syngeneic murine models of multiple myeloma. Cancer Res. 73 (2013), 3075–3086.
    • (2013) Cancer Res. , vol.73 , pp. 3075-3086
    • Xu, W.1    Jones, M.2    Liu, B.3
  • 61
    • 84971667832 scopus 로고    scopus 로고
    • IL-15 superagonist/IL-15RalphaSushi-Fc fusion complex (IL-15SA/IL-15RalphaSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas
    • Kim, P.S., Kwilas, A.R., Xu, W., et al. IL-15 superagonist/IL-15RalphaSushi-Fc fusion complex (IL-15SA/IL-15RalphaSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas. Oncotarget 7 (2016), 16130–16145.
    • (2016) Oncotarget , vol.7 , pp. 16130-16145
    • Kim, P.S.1    Kwilas, A.R.2    Xu, W.3
  • 62
    • 84944280347 scopus 로고    scopus 로고
    • Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model
    • Mathios, D., Park, C.K., Marcus, W.D., et al. Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model. Int. J. Cancer 138 (2016), 187–194.
    • (2016) Int. J. Cancer , vol.138 , pp. 187-194
    • Mathios, D.1    Park, C.K.2    Marcus, W.D.3
  • 63
    • 84960166465 scopus 로고    scopus 로고
    • Comparison of the superagonist complex ALT-803, to IL15 as cancer immunotherapeutics in animal models
    • Rhode, P.R., Egan, J.O., Xu, W., et al. Comparison of the superagonist complex ALT-803, to IL15 as cancer immunotherapeutics in animal models. Cancer Immunol. Res. 4 (2016), 49–60.
    • (2016) Cancer Immunol. Res. , vol.4 , pp. 49-60
    • Rhode, P.R.1    Egan, J.O.2    Xu, W.3
  • 64
    • 84902438193 scopus 로고    scopus 로고
    • Intravesical ALT-803 and BCG treatment reduces tumor burden in a carcinogen induced bladder cancer rat model; a role for cytokine production and NK cell expansion
    • Gomes-Giacoia, E., Miyake, M., Goodison, S., et al. Intravesical ALT-803 and BCG treatment reduces tumor burden in a carcinogen induced bladder cancer rat model; a role for cytokine production and NK cell expansion. PLoS One, 9, 2014, e96705-.
    • (2014) PLoS One , vol.9 , pp. e96705-
    • Gomes-Giacoia, E.1    Miyake, M.2    Goodison, S.3
  • 65
    • 85013456449 scopus 로고    scopus 로고
    • IL-15 super-agonist (ALT-803) enhances natural killer (NK) cell function against ovarian cancer
    • Felices, M., Chu, S., Kodal, B., et al. IL-15 super-agonist (ALT-803) enhances natural killer (NK) cell function against ovarian cancer. Gynecol. Oncol. 145 (2007), 453–461.
    • (2007) Gynecol. Oncol. , vol.145 , pp. 453-461
    • Felices, M.1    Chu, S.2    Kodal, B.3
  • 66
    • 85021796428 scopus 로고    scopus 로고
    • New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity
    • Bailey, C.P., Budak-Alpdogan, T., Sauter, C.T., et al. New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity. Oncotarget 8 (2017), 44366–44378.
    • (2017) Oncotarget , vol.8 , pp. 44366-44378
    • Bailey, C.P.1    Budak-Alpdogan, T.2    Sauter, C.T.3
  • 67
    • 84975299077 scopus 로고    scopus 로고
    • IL-15 trans-Signaling with the superagonist RLI promotes Effector/Memory CD8+ t cell responses and enhances antitumor activity of PD-1 antagonists
    • Desbois, M., Le, V.P., Coutzac, C., et al. IL-15 trans-Signaling with the superagonist RLI promotes Effector/Memory CD8+ t cell responses and enhances antitumor activity of PD-1 antagonists. J. Immunol. 197 (2016), 168–178.
    • (2016) J. Immunol. , vol.197 , pp. 168-178
    • Desbois, M.1    Le, V.P.2    Coutzac, C.3
  • 68
    • 0031563157 scopus 로고    scopus 로고
    • IL-15 mediates anti-tumor effects after cyclophosphamide injection of tumor-bearing mice and enhances adoptive immunotherapy: the potential role of NK cell subpopulations
    • Evans, R., Fuller, J.A., Christianson, G., et al. IL-15 mediates anti-tumor effects after cyclophosphamide injection of tumor-bearing mice and enhances adoptive immunotherapy: the potential role of NK cell subpopulations. Cell. Immunol. 179 (1997), 66–73.
    • (1997) Cell. Immunol. , vol.179 , pp. 66-73
    • Evans, R.1    Fuller, J.A.2    Christianson, G.3
  • 69
    • 0032534579 scopus 로고    scopus 로고
    • Combination chemotherapy and IL-15 administration induce permanent tumor regression in a mouse lung tumor model: NK and T cell-mediated effects antagonized by B cells
    • Chapoval, A.I., Fuller, J.A., Kremlev, S.G., et al. Combination chemotherapy and IL-15 administration induce permanent tumor regression in a mouse lung tumor model: NK and T cell-mediated effects antagonized by B cells. J. Immunol. 161 (1998), 6977–6984.
    • (1998) J. Immunol. , vol.161 , pp. 6977-6984
    • Chapoval, A.I.1    Fuller, J.A.2    Kremlev, S.G.3
  • 70
    • 84953425816 scopus 로고    scopus 로고
    • IL-15/sIL-15Ralpha gene transfer suppresses Lewis lung cancer growth in the lungs, liver and kidneys
    • Sun, H., Liu, D., IL-15/sIL-15Ralpha gene transfer suppresses Lewis lung cancer growth in the lungs, liver and kidneys. Cancer Gene Ther. 23 (2016), 54–60.
    • (2016) Cancer Gene Ther. , vol.23 , pp. 54-60
    • Sun, H.1    Liu, D.2
  • 71
    • 0031042456 scopus 로고    scopus 로고
    • Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis
    • McInnes, I.B., Leung, B.P., Sturrock, R.D., et al. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nat. Med. 3 (1997), 189–195.
    • (1997) Nat. Med. , vol.3 , pp. 189-195
    • McInnes, I.B.1    Leung, B.P.2    Sturrock, R.D.3
  • 72
    • 0028818320 scopus 로고
    • Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro
    • Carson, W.E., Ross, M.E., Baiocchi, R.A., et al. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. J. Clin. Invest. 96 (1995), 2578–2582.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2578-2582
    • Carson, W.E.1    Ross, M.E.2    Baiocchi, R.A.3
  • 73
    • 0032522473 scopus 로고    scopus 로고
    • Interleukin 15 protects against toxicity and potentiates antitumor activity of 5-fluorouracil alone and in combination with leucovorin in rats bearing colorectal cancer
    • Cao, S., Troutt, A.B., Rustum, Y.M., Interleukin 15 protects against toxicity and potentiates antitumor activity of 5-fluorouracil alone and in combination with leucovorin in rats bearing colorectal cancer. Cancer Res. 58 (1998), 1695–1699.
    • (1998) Cancer Res. , vol.58 , pp. 1695-1699
    • Cao, S.1    Troutt, A.B.2    Rustum, Y.M.3
  • 74
    • 25144466458 scopus 로고    scopus 로고
    • Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • Suzuki, E., Kapoor, V., Jassar, A.S., et al. Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin. Cancer Res. 11 (2005), 6713–6721.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3
  • 75
    • 34547630506 scopus 로고    scopus 로고
    • A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model
    • Ko, H.J., Kim, Y.J., Kim, Y.S., et al. A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model. Cancer Res. 67 (2007), 7477–7486.
    • (2007) Cancer Res. , vol.67 , pp. 7477-7486
    • Ko, H.J.1    Kim, Y.J.2    Kim, Y.S.3
  • 76
    • 84859939817 scopus 로고    scopus 로고
    • Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
    • Yu, P., Steel, J.C., Zhang, M., et al. Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 6187–6192.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 6187-6192
    • Yu, P.1    Steel, J.C.2    Zhang, M.3
  • 78
    • 66149114495 scopus 로고    scopus 로고
    • Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer
    • Zhang, M., Yao, Z., Dubois, S., et al. Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 7513–7518.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 7513-7518
    • Zhang, M.1    Yao, Z.2    Dubois, S.3
  • 79
    • 84862628705 scopus 로고    scopus 로고
    • Augmented IL-15Ralpha expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice
    • Zhang, M., Ju, W., Yao, Z., et al. Augmented IL-15Ralpha expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice. J. Immunol. 188 (2012), 6156–6164.
    • (2012) J. Immunol. , vol.188 , pp. 6156-6164
    • Zhang, M.1    Ju, W.2    Yao, Z.3
  • 80
    • 84871947763 scopus 로고    scopus 로고
    • Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein
    • Ochoa, M.C., Fioravanti, J., Rodriguez, I., et al. Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein. Cancer Res. 73 (2013), 139–149.
    • (2013) Cancer Res. , vol.73 , pp. 139-149
    • Ochoa, M.C.1    Fioravanti, J.2    Rodriguez, I.3
  • 81
    • 84877964989 scopus 로고    scopus 로고
    • Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency
    • Vincent, M., Bessard, A., Cochonneau, D., et al. Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. Int. J. Cancer 133 (2013), 757–765.
    • (2013) Int. J. Cancer , vol.133 , pp. 757-765
    • Vincent, M.1    Bessard, A.2    Cochonneau, D.3
  • 82
    • 84892574356 scopus 로고    scopus 로고
    • Combining antibody-directed presentation of IL-15 and 4-1BBL in a trifunctional fusion protein for cancer immunotherapy
    • Kermer, V., Hornig, N., Harder, M., et al. Combining antibody-directed presentation of IL-15 and 4-1BBL in a trifunctional fusion protein for cancer immunotherapy. Mol. Cancer Ther. 13 (2014), 112–121.
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 112-121
    • Kermer, V.1    Hornig, N.2    Harder, M.3
  • 83
    • 84885104733 scopus 로고    scopus 로고
    • Recombinant human IL-15 trans-presentation by B leukemic cells from chronic lymphocytic leukemia induces autologous NK cell proliferation leading to improved anti-CD20 immunotherapy
    • Laprevotte, E., Voisin, G., Ysebaert, L., et al. Recombinant human IL-15 trans-presentation by B leukemic cells from chronic lymphocytic leukemia induces autologous NK cell proliferation leading to improved anti-CD20 immunotherapy. J. Immunol. 191 (2013), 3634–3640.
    • (2013) J. Immunol. , vol.191 , pp. 3634-3640
    • Laprevotte, E.1    Voisin, G.2    Ysebaert, L.3
  • 84
    • 84903759006 scopus 로고    scopus 로고
    • Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse
    • Vincent, M., Teppaz, G., Lajoie, L., et al. Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse. MAbs 6 (2014), 1026–1037.
    • (2014) MAbs , vol.6 , pp. 1026-1037
    • Vincent, M.1    Teppaz, G.2    Lajoie, L.3
  • 85
    • 84994761943 scopus 로고    scopus 로고
    • A novel fusion of ALT-803 (Interleukin (IL)-15 superagonist) with an antibody demonstrates antigen-specific antitumor responses
    • Liu, B., Kong, L., Han, K., et al. A novel fusion of ALT-803 (Interleukin (IL)-15 superagonist) with an antibody demonstrates antigen-specific antitumor responses. J. Biol. Chem. 291 (2016), 23869–23881.
    • (2016) J. Biol. Chem. , vol.291 , pp. 23869-23881
    • Liu, B.1    Kong, L.2    Han, K.3
  • 86
    • 84959036947 scopus 로고    scopus 로고
    • The IL-15-Based ALT-803 complex enhances fcgammaRIIIa-Triggered NK cell responses and In vivo clearance of B cell lymphomas
    • Rosario, M., Liu, B., Kong, L., et al. The IL-15-Based ALT-803 complex enhances fcgammaRIIIa-Triggered NK cell responses and In vivo clearance of B cell lymphomas. Clin. Cancer Res. 22 (2016), 596–608.
    • (2016) Clin. Cancer Res. , vol.22 , pp. 596-608
    • Rosario, M.1    Liu, B.2    Kong, L.3
  • 87
    • 85020313057 scopus 로고    scopus 로고
    • Intravesical ALT-803 for BCG-unresponsive bladder cancer – a case report
    • Huang, J., Schisler, J., Wong, H.C., et al. Intravesical ALT-803 for BCG-unresponsive bladder cancer – a case report. Urol. Case Rep. 14 (2017), 15–17.
    • (2017) Urol. Case Rep. , vol.14 , pp. 15-17
    • Huang, J.1    Schisler, J.2    Wong, H.C.3
  • 88
    • 0030008255 scopus 로고    scopus 로고
    • Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region/IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation
    • Bamford, R.N., Battiata, A.P., Burton, J.D., et al. Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region/IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation. Proc. Natl. Acad. Sci. U. S. A. 93 (1996), 2897–2902.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 2897-2902
    • Bamford, R.N.1    Battiata, A.P.2    Burton, J.D.3
  • 89
    • 2642629701 scopus 로고    scopus 로고
    • Interleukin-15 is an autocrine/paracrine viability factor for cutaneous T-cell lymphoma cells
    • Dobbeling, U., Dummer, R., Laine, E., et al. Interleukin-15 is an autocrine/paracrine viability factor for cutaneous T-cell lymphoma cells. Blood 92 (1998), 252–258.
    • (1998) Blood , vol.92 , pp. 252-258
    • Dobbeling, U.1    Dummer, R.2    Laine, E.3
  • 90
    • 3042548953 scopus 로고    scopus 로고
    • IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques
    • Villinger, F., Miller, R., Mori, K., et al. IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques. Vaccine 22 (2004), 3510–3521.
    • (2004) Vaccine , vol.22 , pp. 3510-3521
    • Villinger, F.1    Miller, R.2    Mori, K.3
  • 91
    • 20144386847 scopus 로고    scopus 로고
    • Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques
    • Mueller, Y.M., Petrovas, C., Bojczuk, P.M., et al. Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques. J. Virol. 79 (2005), 4877–4885.
    • (2005) J. Virol. , vol.79 , pp. 4877-4885
    • Mueller, Y.M.1    Petrovas, C.2    Bojczuk, P.M.3


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