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Volumn 73, Issue 2, 2008, Pages 185-187

High frequency of T130I mutation of HNF4A gene in Mexican patients with early-onset type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 4; HNF4A PROTEIN, HUMAN; UNCLASSIFIED DRUG;

EID: 38349194536     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/j.1399-0004.2007.00928.x     Document Type: Letter
Times cited : (11)

References (11)
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    • Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
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  • 2
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    • Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst
    • Duncan SA, Manova K, Chen WS et al. Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci U S A 1994: 91: 7598-7602.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 7598-7602
    • Duncan, S.A.1    Manova, K.2    Chen, W.S.3
  • 3
    • 0035807902 scopus 로고    scopus 로고
    • A transcription factor regulatory circuit in differentiated pancreatic cells
    • Boj SF, Parrizas M, Maestro MA et al. A transcription factor regulatory circuit in differentiated pancreatic cells. Proc Natl Acad Sci U S A 2001: 98: 14481-14486.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14481-14486
    • Boj, S.F.1    Parrizas, M.2    Maestro, M.A.3
  • 4
    • 0028148776 scopus 로고
    • Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos
    • Chen WS, Manova K, Weinstein DC et al. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev 1994: 8: 2466-2477.
    • (1994) Genes Dev , vol.8 , pp. 2466-2477
    • Chen, W.S.1    Manova, K.2    Weinstein, D.C.3
  • 5
    • 10544236911 scopus 로고    scopus 로고
    • Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
    • Yamagata K, Furuta H, Oda N et al. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 1996: 384: 458-460.
    • (1996) Nature , vol.384 , pp. 458-460
    • Yamagata, K.1    Furuta, H.2    Oda, N.3
  • 6
    • 0344441420 scopus 로고    scopus 로고
    • Regulation of pancreatic β-cell function by the HNF transcription network: lessons from maturity- onset diabetes of the young (MODY)
    • Yamagata K. Regulation of pancreatic β-cell function by the HNF transcription network: lessons from maturity- onset diabetes of the young (MODY). Endocr J 2003: 50: 491-499.
    • (2003) Endocr J , vol.50 , pp. 491-499
    • Yamagata, K.1
  • 7
    • 18244427111 scopus 로고    scopus 로고
    • Mutations in the hepatocyte nuclear factor-4alpha gene in Japanese with non-insulin-dependent diabetes: a nucleotide substitution in the polypyrimidine tract of intron 1b
    • Sakurai K, Seki N, Fujii R et al. Mutations in the hepatocyte nuclear factor-4alpha gene in Japanese with non-insulin-dependent diabetes: a nucleotide substitution in the polypyrimidine tract of intron 1b. Horm Metab Res 2000: 32: 316-320.
    • (2000) Horm Metab Res , vol.32 , pp. 316-320
    • Sakurai, K.1    Seki, N.2    Fujii, R.3
  • 8
    • 0030798068 scopus 로고    scopus 로고
    • Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4a in Caucasians with maturity onset NIDDM
    • Moller AM, Urhammer SA, Dalgaard LT et al. Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4a in Caucasians with maturity onset NIDDM. Diabetologia 1997: 40: 980-983.
    • (1997) Diabetologia , vol.40 , pp. 980-983
    • Moller, A.M.1    Urhammer, S.A.2    Dalgaard, L.T.3
  • 9
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    • T130I mutation in HNF4α gene is a loss-of-function mutation in hepatocytes and is associated with late-onset type 2 diabetes mellitus in Japanese subjects
    • Zhu Q, Yamagata K, Miura A et al. T130I mutation in HNF4α gene is a loss-of-function mutation in hepatocytes and is associated with late-onset type 2 diabetes mellitus in Japanese subjects. Diabetologia 2003: 46: 567-573.
    • (2003) Diabetologia , vol.46 , pp. 567-573
    • Zhu, Q.1    Yamagata, K.2    Miura, A.3
  • 10
    • 18844442012 scopus 로고    scopus 로고
    • The functional Thr130Ile and Val255Met polymorphisms of hepatocyte nuclear factor-4α (HNF4A): gene associations with type 2 diabetes or altered β-cell function among Danes
    • Ek J, Rose SC, Jensen DP et al. The functional Thr130Ile and Val255Met polymorphisms of hepatocyte nuclear factor-4α (HNF4A): gene associations with type 2 diabetes or altered β-cell function among Danes. J Clin Endocrinol Metab 2005: 90: 3054-3059.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3054-3059
    • Ek, J.1    Rose, S.C.2    Jensen, D.P.3
  • 11
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    • Standards of medical care in diabetes (Position Statement)
    • American Diabetes Association
    • American Diabetes Association. Standards of medical care in diabetes (Position Statement). Diabetes Care 2004: 27 (Suppl. 1): S15-S36.
    • (2004) Diabetes Care , vol.27 , Issue.SUPPL. 1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.