The central role of IFI204 in IFN-β release and autophagy activation during Mycobacterium bovis infection

Frontiers in Cellular and Infection Microbiology

Volumn 7, Issue MAY, 2017, Pages

  Chunfa, Liu ^a   Xin, Sun ^a   Qiang, Li ^b   Sreevatsan, Srinand ^c   Yang, Lifeng ^a   Zhao, Deming ^a   Zhou, Xiangmei ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b NINGXIA UNIVERSITY   (China)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Autophagy; DNA sensor; IFI204; IFN ; M. bovis

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON; IFI16 PROTEIN, MOUSE; INTERFERON REGULATORY FACTOR 3; IRF3 PROTEIN, MOUSE; NUCLEAR PROTEIN; PHOSPHOPROTEIN; SMALL INTERFERING RNA;

ANIMAL; AUTOPHAGY; BACTERIAL COUNT; C57BL MOUSE; CELL LINE; CYTOPLASM; DISEASE MODEL; DRUG EFFECTS; FEMALE; GENE SILENCING; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INNATE IMMUNITY; MACROPHAGE; METABOLISM; MICROBIOLOGY; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM BOVIS; PATHOGENICITY; PHAGOSOME; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; AUTOPHAGY; CELL LINE; COLONY COUNT, MICROBIAL; CYTOPLASM; DISEASE MODELS, ANIMAL; FEMALE; GENE KNOCKDOWN TECHNIQUES; IMMUNITY, INNATE; IMMUNOHISTOCHEMISTRY; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; INTERFERON-GAMMA; MACROPHAGES; MICE; MICE, INBRED C57BL; MYCOBACTERIUM BOVIS; MYCOBACTERIUM INFECTIONS; NUCLEAR PROTEINS; PHAGOSOMES; PHOSPHOPROTEINS; RNA, SMALL INTERFERING;

EID: 85027518330     PISSN: None     EISSN: 22352988     Source Type: Journal    
DOI: 10.3389/fcimb.2017.00169     Document Type: Article

References (24)

1. Ansari, M. A., Dutta, S., Veettil, M. V., Dutta, D., Iqbal, J., Kumar, B., et al. (2015). Herpesvirus genome recognition induced acetylation of nuclear IFI16 is essential for its cytoplasmic translocation, inflammasome and IFN-β responses. PLoS Pathog. 11:e1005019. doi: 10.1371/journal.ppat.1005019
2. Castillo, E. F., Dekonenko, A., Arko-Mensah, J., Mandell, M. A., Dupont, N., Jiang, S., et al. (2012). Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc. Natl. Acad. Sci. U.S.A. 109, E3168-E3176. doi: 10.1073/pnas.1210500109
3. Collins, A. C., Cai, H., Li, T., Franco, L. H., Li, X. D., Nair, V. R., et al. (2015). Cyclic GMP-AMP synthase is an innate immune DNA sensor for Mycobacterium tuberculosis. Cell Host Microbe 17, 820-828. doi: 10.1016/j.chom.2015.05.005
4. Dauffy, J., Mouchiroud, G., and Bourette, R. P. (2006). the interferon-inducible gene, Ifi204, is transcriptionally activated in response to M-CSF, and its expression favors macrophage differentiation in myeloid progenitor cells. J. Leukoc. Biol. 79, 173-183. doi: 10.1189/jlb.0205083
5. Dey, B., Dey, R. J., Cheung, L. S., Pokkali, S., Guo, H., Lee, J. H., et al. (2015). A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis. Nat. Med. 21, 401-406. doi: 10.1038/nm.3813
6. Gray, E. E., Winship, D., Snyder, J. M., Child, S. J., Geballe, A. P., and Stetson, D. B. (2016). The AIM2-like receptors are dispensable for the interferon response to intracellular DNA. Immunity 45, 255-266. doi: 10.1016/j.immuni.2016.06.015
7. Hansen, K., Prabakaran, T., Laustsen, A., Jorgensen, S. E., Rahbaek, S. H., Jensen, S. B., et al. (2014). Listeria monocytogenes induces IFNbeta expression through an IFI16-, cGAS-and STING-dependent pathway. EMBO J. 33, 1654-1666. doi: 10.15252/embj.201488029
8. Kerur, N., Veettil, M. V., Sharma-Walia, N., Bottero, V., Sadagopan, S., Otageri, P., et al. (2011). IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 9, 363-375. doi: 10.1016/j.chom.2011.04.008
9. Liang, Q., Seo, G. J., Choi, Y. J., Kwak, M. J., Ge, J., Rodgers, M. A., et al. (2014). Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses. Cell Host Microbe 15, 228-238. doi: 10.1016/j.chom.2014.01.009
10. Liu, C., Yue, R., Yang, Y., Cui, Y., Yang, L., Zhao, D., et al. (2016). AIM2 inhibits autophagy and IFN-β production during M. bovis infection. Oncotarget 7, 46972-46987. doi: 10.18632/oncotarget.10503
11. Majlessi, L., and Brosch, R. (2015). Mycobacterium tuberculosis meets the cytosol: the role of cGAS in anti-mycobacterial immunity. Cell Host Microbe 17, 733-735. doi: 10.1016/j.chom.2015.05.017
12. Manzanillo, P. S., Shiloh, M. U., Portnoy, D. A., and Cox, J. S. (2012). Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages. Cell Host Microbe 11, 469-480. doi: 10.1016/j.chom.2012.03.007
13. O'Garra, A., Redford, P. S., McNab, F. W., Bloom, C. I., Wilkinson, R. J., and Berry, M. P. (2013). The immune response in tuberculosis. Annu. Rev. Immunol. 31, 475-527. doi: 10.1146/annurev-immunol-032712-095939
14. Pandey, A. K., Yang, Y., Jiang, Z., Fortune, S. M., Coulombe, F., Behr, M. A., et al. (2009). NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog. 5:e1000500. doi: 10.1371/journal.ppat.1000500
15. Pilli, M., Arko-Mensah, J., Ponpuak, M., Roberts, E., Master, S., Mandell, M. A., et al. (2012). TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. Immunity 37, 223-234. doi: 10.1016/j.immuni.2012.04.015
16. Saiga, H., Kitada, S., Shimada, Y., Kamiyama, N., Okuyama, M., Makino, M., et al. (2012). Critical role of AIM2 in Mycobacterium tuberculosis infection. Int. Immunol. 24, 637-644. doi: 10.1093/intimm/dxs062
17. Scott, C., Cavanaugh, J. S., Pratt, R., Silk, B. J., LoBue, P., and Moonan, P. K. (2016). Human tuberculosis caused by Mycobacterium bovis in the United States, 2006-2013. Clin. Infect. Dis. 63, 594-601. doi: 10.1093/cid/ciw371
18. Storek, K. M., Gertsvolf, N. A., Ohlson, M. B., and Monack, D. M. (2015). cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection. J. Immunol. 194, 3236-3245. doi: 10.4049/jimmunol.1402764
19. Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., et al. (2010). IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 11, 997-1004. doi: 10.1038/ni.1932
20. Wassermann, R., Gulen, M. F., Sala, C., Perin, S. G., Lou, Y., Rybniker, J., et al. (2015). Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-dependent intracellular immune responses through ESX-1. Cell Host Microbe 17, 799-810. doi: 10.1016/j.chom.2015.05.003
21. Watson, R. O., Bell, S. L., MacDuff, D. A., Kimmey, J. M., Diner, E. J., Olivas, J., et al. (2015). The cytosolic sensor cGAS detects Mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy. Cell Host Microbe 17, 811-819. doi: 10.1016/j.chom.2015.05.004
22. Watson, R. O., Manzanillo, P. S., and Cox, J. S. (2012). Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. Cell 150, 803-815. doi: 10.1016/j.cell.2012.06.040
23. Wiens, K. E., and Ernst, J. D. (2016). The mechanism for type I interferon induction by Mycobacterium tuberculosis is bacterial strain-dependent. PLoS Pathog. 12:e1005809. doi: 10.1371/journal.ppat.1005809
24. Yang, Y., Zhou, X., Kouadir, M., Shi, F., Ding, T., Liu, C., et al. (2013). the AIM2 inflammasome is involved in macrophage activation during infection with virulent Mycobacterium bovis strain. J. Infect. Dis. 208, 1849-1858. doi: 10.1093/infdis/jit347