Protective effects of orange (Citrus sinensis L.) peel aqueous extract and hesperidin on oxidative stress and peptic ulcer induced by alcohol in rat

Lipids in Health and Disease

Volumn 16, Issue 1, 2017, Pages

  Selmi, Slimen ^a   Rtibi, Kais ^a   Grami, Dhekra ^a   Sebai, Hichem ^a   Marzouki, Lamjed ^a  

^a University of Jendouba   (Tunisia)

Author keywords

Citrus sinensis peel; COX 2; Gastric ulcer; Hesperidin; Oxidative stress markers; Rat; TNF

Indexed keywords

ANTIULCER AGENT; CALCIUM; CATALASE; CITRUS SINENSIS EXTRACT; CYCLOOXYGENASE 2; FLAVONOID; GLUTATHIONE PEROXIDASE; HESPERIDIN; HYDROGEN PEROXIDE; IRON; MALONALDEHYDE; OMEPRAZOLE; PLANT EXTRACT; POLYPHENOL; SUPEROXIDE DISMUTASE; THIOL GROUP; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ALCOHOL; ANTIOXIDANT; PTGS2 PROTEIN, RAT; THIOL DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIULCER ACTIVITY; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA FRAGMENTATION; DRUG DOSE COMPARISON; ETHANOL-INDUCED GASTRIC ULCER; GENE EXPRESSION; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PEPTIC ULCER; RAT; STOMACH PROTECTION; SWEET ORANGE; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CHEMISTRY; FRUIT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; STOMACH ULCER; WISTAR RAT;

ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; CATALASE; CITRUS SINENSIS; CYCLOOXYGENASE 2; ETHANOL; FRUIT; GENE EXPRESSION REGULATION; GLUTATHIONE PEROXIDASE; HESPERIDIN; HYDROGEN PEROXIDE; MALE; MALONDIALDEHYDE; OMEPRAZOLE; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, WISTAR; STOMACH ULCER; SULFHYDRYL COMPOUNDS; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85027394268     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/s12944-017-0546-y     Document Type: Article

References (65)

1. Feinstein LB, Holman RC, Christensen KL, Steiner CA, Swerdlow DL. Swerdlow Trends in Hospitalizations for Peptic Ulcer Disease, United States, 1998-2005. Emerg Infect Dis. 2010;16(9):1410-8.
2. Thorsen K, Søreide JA, Kvaløy JT, Glomsaker T, Søreide K. Epidemiology of perforated peptic ulcer: age- and gender-adjusted analysis of incidence and mortality. World J Gastroenterol. 2013;19:347-54.
3. Mota KSL, Dias GEN, Pinto MEF, Luiz-Ferreira A, Souza-Brito ARM, Hiruma-Lima CA, Barbosa-Filho JM, Batista LM. Flavonoids with gastroprotective activity. Molecules. 2009;14:979-1012.
4. Paguigan ND, Castillo DHB, Chichioco-Hernandez CL. Anti-ulcer activity of leguminosae plants. Arq Gastroenterol. 2014;51:815-29.
5. Hunt RH, Camilleri M, Crowe SE, El-Omar EM, Fox JG, Kuipers EJ, Malfertheiner P, McColl KEL, Pritchard DM, Rugge M, Sonnenberg A, Sugano K, Tack J. The stomach in health and disease. Recent Adv Clin Pract. 2015;64(10):1650-68.
6. Oliveira CP, Kassab P, Lopasso FP, Souza HP, Janiszewski M, Laurindo FR. Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress. World J Gastroenterol. 2003;9:446-8.
7. Kountouras J, Chatzopoulos D, Zavos C. Reactive oxygen metabolites and upper gastrointestinal diseases. Hepato-Gastroenterol. 2001;8:743-51.
8. Guslandi M. Effects of ethanol on the gastric mucosa. Digest Dis Sci. 1987;5:21-32.
9. Kangwan N, Park JM, Hahm KB. Development of GI-safe NSAID: progression from the bark of willow tree to modern pharmacology. Curr Opin Pharmacol. 2014;19:17-23.
10. Jaime AR, Cristina T, Tania Y, Jose B, Guillermo S. Gastroprotective and ulcer healing effect of ferruginol in mice and rats: Assessment of its mechanism of actionusing in vitro models. Life Sci. 2006;78:2503-9.
11. Fathiazad F, Afshar J. An investigation of methylation methods of hesperidin. Daru. 2004;12:67-70.
12. Aghel N, Ramezani Z, Beiranvand S. Hesperidine from citrus sinensis cultivated in dezful. Iran Pak J Biol Sci. 2008;20:2451-3.
13. Rotelli AE, Guardia T, Juárez AO, De L, Pelzer LE. Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res. 2003;48:601-6.
14. Navarri-Izzo F, Pinzino C, Quartacci MF, Sgherri CLM. Intracellular membranes: kinetics of superoxide production and changes in thylakoids of resurrection plants upon dehydration and rehydration. Proc R Soc Edinburgh Sec B. 1994;102 B:187-91.
15. Bernatova I, Pechanova O, Babal P, Kysela S, Stvrtina S, Andriantsitohaina R. Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol. 2002;282:H942-8.
16. Knekt P, Kumpulainen J, Jarvinen R, Rissanen H, Heliovaara M, Reunanen A, Hakulinen T, Aromaa A. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr. 2002;76:560-8.
17. Anila L, Vijayalakshmi NR. Antioxidant action of flavonoids from Mangifear indica and Emblica officinalis in hypercholesterolemic rats. Food Chem. 2003;83:569-74.
18. Hitzenberger G. Therapeutic effectiveness of flavonoids illustrated by daflon 500 mg. Wein Med Wochenschr. 1997;174:409-12.
19. Manthey JA, Grohmann K. Concentrations of hesperidin and other orange peel flavonoids in citrus processing byproducts. J Agric Food Chem. 1996;44:811-4.
20. Haseeb N, John S, Gauri M, Yukio K. Extraction of polyphenols from grape seeds and concentration by ultrafiltration. Sep Purif Technol. 2006;48:176-81.
21. Chang CY, Kuan YH, Li JR, Chen WY, Ou YC, Pan HC. Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. J Nutr Biochem. 2013;24:2127-37.
22. Grzegorczyk I, Matkowski A, Wysokinska H. Antioxidant activity of extracts from in vitro cultures of Salvia officinalis L. Food Chem. 2007;104:536-41.
23. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47:469-74.
24. Maskos K, Fernandez-Catalan C, Huber R, Bourenkov GP, Bartunik H, Ellestad GA, Reddy P, Wolfson MF, Rauch CT, Castner BJ, Davis R, Clarke HR, Petersen M, Fitzner JN, Cerretti DP, March CJ, Paxton RJ, Black RA, Bode W. Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. Proc Natl Acad Sci U S A. 1998;95:3408-12.
25. Walch L, Morris PL. Cyclooxygenase 2 pathway mediates IL-1beta regulation of IL-1alpha-1beta, and IL-6 mRNA levels in Leydig cell progenitors. Endocrinology. 2002;143:3276-83.
26. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 1990;186:421-31.
27. Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate antioxidant activity. LWT Food Sci Technol. 1995;28:25-30.
28. Misra HP, Fridovich I. The role of superoxide anion in autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247:3170-5.
29. Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121-6.
30. Flohé L, Günzler WA. Assays of glutathione peroxidase. Methods Enzymol. 1984;105:114-21.
31. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82:70-7.
32. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and non-protein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968;25:192-205.
33. Dingeon B, Ferry JP, Roullet A. Automatic assay of blood sugar by Trinder's method. Ann Biol Clin. 1975;33:3-13.
34. Leardi A, Caraglia M, Selleri C, Pepe S, Pizzi C, Notaro R. Desferioxamine increases iron depletion and apoptosis induced by ara-C of human myeloid leukaemic cells. Br J Haematol. 1998;102:746-52.
35. Stern J, Lewis WH. The colorimetric estimation of calcium in serum with ocresolphthalein complexone. Clin Chim Acta. 1957;2:576-80.
36. Hartree EF. Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal Biochem. 1972;48:422-7.
37. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-75.
38. Maurya RC, Srivastava UC. Cytoarchitecture of the cerebral hemisphere of Indian Wall Lizard, Hemidactylus flaviviridis (Rüppell). Nat Acad Sci Lett. 2011;34(11 & 12):431-6.
39. Kelebek H, Selli S, Canbas A, Cabaroglu T. HPLC determination of organic acids, sugars, phenolic compositions and antioxidant capacity of orange juice and orange wine made from a Turkish cv. Kozan Microchem J. 2009;91:187-92.
40. Zhao JH, Wojtek PM, Catherine W, Li L, Xu H-S, Peter RL, Scott J, Yan MZ, Xiujuan JD. Controlling cell growth on titanium by surface functionalization of heptylamine using a novel combined plasma polymerization mode. J Biomed Mater Res A. 2011;97(2):127-34.
41. Hichem S, Abdelaziz S, Latifa C, Kais R, Mohamed A, Jamel EB, et al. In vitro and in vivo antioxidant properties of Tunisian carob (Ceratonia siliqua L.). J Med Food Res. 2013;7:85-90.
42. Rodrigo R, Bosco C. Oxidative stress and protective effects of polyphenols: comparative studies in human and rodent kidney. A review. Comp Biochem Physiol C Toxicol Pharmacol. 2006;142:317-27.
43. Awaad AS, Al-Jaber NA, Moses JE, El-Meligy RM, Zain ME. Antiulcerogenic Activities of the Extracts and Isolated Flavonoids of Euphorbia cuneata Vahl. Phytother Res. 2013;27(1):126-30.
44. Bode C, Bode JC. Alcohol's Role in Gastrointestinal Tract Disorders. Alcohol Res Health. 1997;21:76-83.
45. Soojin P, Ki-baik H, Tae-young OH, Joo-hyun Jin BS, Ryowon C. Preventive Effect of the Flavonoid, Wogonin, Against Ethanol-Induced Gastric Mucosal Damage in Rats. Digest Dis Sci. 2004;49:384-94.
46. Park JH, Jang KJ, Kim CH, Kim JH, Kim YK, Yoon HM. Ganoderma Lucidum Pharmacopuncture for Teating Ethanol-induced Chronic Gastric Ulcers in Rats. Aust J Pharm. 2015;18:72-8.
47. Park JH, Jang KJ, Kim CH, Kim JH, Kim YK, Yoon HM. Ganoderma lucidum pharmacopuncture for teating ethanol-induced chronic gastric ulcers in rats. J Pharmacopuncture. 2015;18:72-8.
48. Pan JS, He SZ, Xu HZ, Zhan XJ, Yang XN, Xiao HM, et al. Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury. World J Gastroenterol. 2008;14:5857-67.
49. Zhao M, Du YQ, Yuan L, Wang NN. Protective effect of puerarin on acute alcoholic liver injury. Am J Chin Med. 2010;38:241-9.
50. Calivarathan L, Laura EN, Thomas MM. Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation. Free Radical Bio Med. 2014;69:403-16.
51. Kannan M, Wang L, Kang YJ. Myocardial oxidative stress and toxicity induced by acute ethanol exposure in mice. Exp Biol Med (Maywood). 2004;229:553-9.
52. Haorah J, Knipe B, Leibhart J, Ghorpade A, Persidsky Y. Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. J Leukoc Biol. 2005;78:1223-32.
53. Zima T, Kalousov'a M. Oxidative stress and signal transduction pathways in alcoholic liver disease. Alcoholism: Clin Exp Res. 2005;29:110S-5S.
54. Sairam K, Rao CV, Dora BM, Agrawal VK, Goel RK. Antiulcerogenic activity of methanolic extract of Emblica officinalis. J Ethnopharmacol. 2002;82:1-9.
55. Kumazawa S, Taniguchi M, Suzuki Y, Shimura M, Kwon MS, Nakayama T. Antioxidant activity of polyphenols in carob pods. J Agric Food Chem. 2002;50:373-7.
56. Chen ZT, Chu HL, Chyau CC, Chu CC, Duh PD. Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress. Food Chem. 2012;135:2119-212.
57. Abd El-aal HA and Halaweish FT. Food preservative activity of phenolic compounds in orange peel extracts (Citrus sinensis L.). Lucrari Stiintifice. 2015;53:233-40.Seria Zootehnie.
58. Kogiannou DAA, Kalogeropoulos N, Kefalas P, Polissiou MG, Kaliora AC. Herbal infusions; their phenolic profile, antioxidant and anti-inflammatory effects in HT29 and PC3 cells. Food Chem Toxicol. 2013;61:152-9.
59. Szabo S. Role of sulfhydryls and early vascular lesions in gastric mucosal injury. Acta Physiol Hung. 1984;64:203-14.
60. Szabo S, Vattay P. Experimental gastric and duodenal ulcers. Advances in pathogenesis. Gastroenterol. Clin. North Am. 1990;19:67-85.
61. Davidson SM, Duchen MR. Calcium microdomains and oxidative stress. Cell Calcium. 2006;40:561-74.
62. Ermak G, Davies KJA. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol. 2002;38:713-21.
63. Li YM, Li ZS, Zhou XP, Xie XF, Zhan XB. Effect of acid inhibitor on the function and ultra structure of gastric parietal cells in rats under stress. Jiefanjun Yixue Zazhi. 2002;27:1078-80.
64. Nobushi Y, Uchikura K. Selective detection of hydroxyl radical scavenging capacity based on electrogenerated chemiluminescence detection using tris(2,2′- bipyridine) ruthenium(III) by flow injection analysis. Chem Pharm Bull. 2010;58:117-20.
65. Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology. 2011;283:65-87.