Desferioxamine increases iron depletion and apoptosis induced by ara-C of human myeloid leukaemic cells

British Journal of Haematology

Volumn 102, Issue 3, 1998, Pages 746-752

  Leardi, Annalisa ^a   Caraglia, Michele ^a,b   Selleri, Carmine ^a   Pepe, Stefano ^a   Pizzi, Claudia ^a   Notaro, Rosario ^a   Fabbrocini, Antonietta ^a   De Lorenzo, Sonya ^a   Musico, Manuela ^a   Abbruzzese, Alberto ^b   Bianco, Angelo Raffaele ^a   Tagliaferri, Pierosandro ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Acute myeloid leukaemia; Apoptosis; ara C; Desferioxamine; Intracellular iron

Indexed keywords

CYTARABINE; DEFEROXAMINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; HUMAN; HUMAN CELL; IRON CHELATION; IRON METABOLISM; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACUTE DISEASE; ANTIDOTES; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CELL DIVISION; CYTARABINE; DEFEROXAMINE; DRUG INTERACTIONS; DRUG SYNERGISM; HL-60 CELLS; HUMANS; IRON; LEUKEMIA, MYELOID; RECEPTORS, TRANSFERRIN; TUMOR CELLS, CULTURED;

EID: 7344242642     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00834.x     Document Type: Article

References (27)

1. Barker, K.A. & Newburger, P.E. (1990) Relationships between the cell cycle and the expression of c-myc and transferrin receptor genes during induced myeloid differentiation. Experimental Cell Research, 186, 1-5.
2. Becton, U.R. & Bryles, P. (1988) Deferoxamine inhibition of human neuroblastoma viability and proliferation. Cancer Research, 48, 7189-7192.
3. Caraglia, M., Leardi, A., Improta, S., Perin, V., Ricciardi, B., Arra, C., Ferraro, P., Fabbrocini, A., Pinto, A., Bianco, A.R. & Tagliaferri, P. (1997) Transient exposure to cytarabine increases peptide growth factor receptor expression and tumorigenicity of melanoma cells. Anticancer Research, 17, 2369-2376.
4. Caraglia, M., Leardi, A., Ricciardi, B., de Laurentiis, M., Lentini Graziano, M.L., Matano, E., De Placido, S., Blanco, A.R. & Tagliaferri, P. (1996) α-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies. International Journal of Oncology, 8, 847-850.
5. Caraglia, M., Libroia, A.M., Corradino, S., Coppola, V., Guarrasi, R., Barile, C., Genua. G., Bianco, A.R. & Tagliaferri, P. (1994) α-Interferon induces depletion of intracellular iron content and upregulation of functional transferrin receptors on human epidermoid cancer KB cells. Biochemical and Biophysical Research Communications. 203, 281-288.
6. 125I]-transferrin and enhances the in vitro targeting of human tumor cells with anti-(growth factor receptor) mAb. Cancer Immunology and Immunotherapy, 37, 150-156.
7. Crichton, R.R. (1984) Iron uptake and utilization by mammalian cells. II. Intracellular iron utilization. Trends in Biohemical Science, 9, 283-286.
8. Crichton, R.R. & Charloteaux-Wauters, M. (1987) Iron transport and storage. European Journal of Biochemistry, 164, 485-506.
9. Dickancaite, E., Cenas, N., Kalvelyte, A. & Serapiniene, N. (1997) Toxicity of daunorubicin and naphtoquinones to HL-60 cells: an involvement of oxidative stress. Biochemical and Molecular Biology International, 41, 987-994.
10. Dickson, R.B., Hanover, J.A., Willingham, M.C. & Pastan, I. (1985) Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis. Biochemistry 22, 5667-5571.
11. Estrov, Z., Tawa, A., Wang, X-H., Dubé, I.D., Sulh, H., Cohen, A., Gelfand, E.W. & Freedman, M.H. (1987) In vitro and in vivo effects of deferoxamine in neonatal acute leukemia. Blood, 69, 757-761.
12. Fontecave, M. & Pierre, J.L. (1991) Iron metabolism: the low-molecular-mass iron pool. Biology of Metals, 4, 133-135.
13. Gatter, K.C., Brown, G., Trowbridge, I.S,. Woolston, R.-E. & Mason, D.Y. (1983) Transferrin receptors in human tissues: their distribution and possible clinical relevance. Journal of Clinical Pathology, 36, 539-540.
14. Hileti, D., Panayiotidis, P. & Hoffbrand, V. (1995) Iron chelators induce apoptosis in proliferating cells. British Journal of Haematology, 89, 181-187.
15. Kemp, J.D., Thorson, J.A., Stewart, B.C. & Naumann, P.W. (1992) Inhibition of hemopoietic tumor growth by combined treatment with deferoxamine and an IgG monoclonal antibody against the transferrin receptor: evidence for a threshold model of iron deprivation toxicity. Cancer Research, 52, 4144-1148.
16. Kulp, K.S., Green, S.L. & Vulliet, P.K. (1996) Iron deprivation inhibits cyclin-dependent kinase activity and decreases cyclin D/CDK4 protein levels in asynchronous MDA-MB-453 human breast cancer cells. Experimental Cell Research, 229, 60-68.
17. Kulp, K.S. & Vulliet, P.R. (1996) Mimosine blocks cell cycle progression by chelating iron in asynchronous human breast cancer cells. Toxicology Application in Biochemistry, 139, 356-364.
18. Neilands, J.B. (1991) A brief history of iron metabolism. Biology of Metals, 4, 1-6.
19. Rouault, T.A., Tang, C.K., Kaptain, S., Burgess, W.H., Haile, D.J., Samaniego, F., McBride, O.W., Harford, J.B. & Klausner, R.D. (1990) Cloning of the cDNA encoding an mRNA regulatory protein: the human iron-responsive element-binding protein. Proceedings of the National Academy of Sciences of the United States of America, 87, 7958-7962.
20. Sarti, P., Ginobbi, P., D'Agostino, I., Arancia, G., Lendaro, E., Molinari, A., Ippoliti, R. & Citro, G. (1996) Liposomal targeting of leukaemia HL60 cells induced by transferrin-receptor endocytosis. Biotechnology Applications in Biochemistry, 24, 269-276.
21. Shindelman, J.E., Ortmeyer, A.E. & Sussman, H.H. (1981) Demonstration of the transferrin receptor in human breast cancer tissues: potential marker for identifying dividing cells. International Journal of Cancer, 27, 329-334.
22. 3H-thymidine labeling index in breast cancer. Cell Proliferation, 24, 437-445.
23. Taetle, R., Honeysett, J.M. & Bergeron, R. (1989) Combination iron depletion therapy. Journal of the National Cancer Institute, 81, 1229-1255.
24. Taetle, R., Rhyner, K., Castagnola, J., To, D. & Mendelsohn, J. (1985) Role of transferrin, Fe, and transferrin receptors in myeloid leukemia cell growth: studies with an antitransferrin receptor monoclonal antibody. Journal of Clinical Investigation, 75, 1061-1067.
25. Tagliaferri, P., Caraglia, M., Muraro, R., Budillon, A., Pinto, A. & Bianco, A.R. (1994) Pharmacological modulation of peptide growth factor receptor expression on tumor cells as a basis for cancer therapy. Anti-Cancer Drugs, 5, 379-393.
26. Theil, E.C. (1990) Regulation of ferritin and transferrin receptor mRNAs. Journal of Biological Chemistry 265, 4771-4774.
27. Trowbridge, I.S. & Shackelford, D.A. (1985) Structure and function of transferrin receptors and their relationship to cell growth. Biochemical Society Symposia, 51, 117-123.