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Volumn 4, Issue 3, 2016, Pages 1-14

Niacin promotes revascularization and recovery of limb function in diet-induced obese mice with peripheral ischemia

Author keywords

Inflammation; Lipotoxicity; Metabolic syndrome; Niacin; Peripheral vascular disease

Indexed keywords

NICOTINIC ACID; TRIACYLGLYCEROL;

EID: 85026615039     PISSN: None     EISSN: 20521707     Source Type: Journal    
DOI: 10.1002/prp2.233     Document Type: Article
Times cited : (9)

References (66)
  • 1
    • 84874025229 scopus 로고    scopus 로고
    • Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr(-)/(-) mice
    • Assini JM, Mulvihill EE, Sutherland BG, Telford DE, Sawyez CG, Felder SL, et al. (2013). Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr(-)/(-) mice. J Lipid Res 54: 711-724.
    • (2013) J Lipid Res , vol.54 , pp. 711-724
    • Assini, J.M.1    Mulvihill, E.E.2    Sutherland, B.G.3    Telford, D.E.4    Sawyez, C.G.5    Felder, S.L.6
  • 2
    • 17844383478 scopus 로고    scopus 로고
    • Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome
    • Biddinger SB, Almind K, Miyazaki M, Kokkotou E, Ntambi JM, Kahn CR (2005). Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes 54: 1314-1323.
    • (2005) Diabetes , vol.54 , pp. 1314-1323
    • Biddinger, S.B.1    Almind, K.2    Miyazaki, M.3    Kokkotou, E.4    Ntambi, J.M.5    Kahn, C.R.6
  • 4
    • 84891792481 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice
    • Bojic LA, Burke AC, Chhoker SS, Telford DE, Sutherland BG, Edwards JY, et al. (2014). Peroxisome proliferator-activated receptor delta agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 34: 52-60.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 52-60
    • Bojic, L.A.1    Burke, A.C.2    Chhoker, S.S.3    Telford, D.E.4    Sutherland, B.G.5    Edwards, J.Y.6
  • 5
    • 63549150420 scopus 로고    scopus 로고
    • Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replicative lifespan and enhanced angiogenic capacity in a high glucose environment
    • Borradaile NM, Pickering JG (2009). Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replicative lifespan and enhanced angiogenic capacity in a high glucose environment. Aging Cell 8: 100-112.
    • (2009) Aging Cell , vol.8 , pp. 100-112
    • Borradaile, N.M.1    Pickering, J.G.2
  • 6
    • 84855682698 scopus 로고    scopus 로고
    • Human obesity and endothelium-dependent responsiveness
    • Campia U, Tesauro M, Cardillo C (2012). Human obesity and endothelium-dependent responsiveness. Br J Pharmacol 165: 561-573.
    • (2012) Br J Pharmacol , vol.165 , pp. 561-573
    • Campia, U.1    Tesauro, M.2    Cardillo, C.3
  • 8
    • 84877069888 scopus 로고    scopus 로고
    • Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells
    • Chai JT, Digby JE, Ruparelia N, Jefferson A, Handa A, Choudhury RP (2013b). Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells. PLoS ONE 8: e62934.
    • (2013) PLoS ONE , vol.8 , pp. e62934
    • Chai, J.T.1    Digby, J.E.2    Ruparelia, N.3    Jefferson, A.4    Handa, A.5    Choudhury, R.P.6
  • 9
    • 84924763730 scopus 로고    scopus 로고
    • Arterial function in cardio-metabolic diseases: from the microcirculation to the large conduits
    • Chantler PD, Frisbee JC (2015). Arterial function in cardio-metabolic diseases: from the microcirculation to the large conduits. Prog Cardiovasc Dis 57: 489-496.
    • (2015) Prog Cardiovasc Dis , vol.57 , pp. 489-496
    • Chantler, P.D.1    Frisbee, J.C.2
  • 10
    • 84924603360 scopus 로고    scopus 로고
    • 12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction
    • Chattopadhyay R, Tinnikov A, Dyukova E, Singh NK, Kotla S, Mobley JA, et al. (2015). 12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction. J Lipid Res 56: 562-577.
    • (2015) J Lipid Res , vol.56 , pp. 562-577
    • Chattopadhyay, R.1    Tinnikov, A.2    Dyukova, E.3    Singh, N.K.4    Kotla, S.5    Mobley, J.A.6
  • 11
    • 84897398609 scopus 로고    scopus 로고
    • Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor delta pathway
    • Cheang WS, Tian XY, Wong WT, Lau CW, Lee SS, Chen ZY, et al. (2014). Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor delta pathway. Arterioscler Thromb Vasc Biol 34: 830-836.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 830-836
    • Cheang, W.S.1    Tian, X.Y.2    Wong, W.T.3    Lau, C.W.4    Lee, S.S.5    Chen, Z.Y.6
  • 12
    • 34547738951 scopus 로고    scopus 로고
    • Niaspan increases angiogenesis and improves functional recovery after stroke
    • Chen J, Cui X, Zacharek A, Jiang H, Roberts C, Zhang C, et al. (2007). Niaspan increases angiogenesis and improves functional recovery after stroke. Ann Neurol 62: 49-58.
    • (2007) Ann Neurol , vol.62 , pp. 49-58
    • Chen, J.1    Cui, X.2    Zacharek, A.3    Jiang, H.4    Roberts, C.5    Zhang, C.6
  • 13
    • 65549168338 scopus 로고    scopus 로고
    • Niaspan treatment increases tumor necrosis factor-alpha-converting enzyme and promotes arteriogenesis after stroke
    • Chen J, Cui X, Zacharek A, Ding GL, Shehadah A, Jiang Q, et al. (2009). Niaspan treatment increases tumor necrosis factor-alpha-converting enzyme and promotes arteriogenesis after stroke. J Cereb Blood Flow Metab 29: 911-920.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 911-920
    • Chen, J.1    Cui, X.2    Zacharek, A.3    Ding, G.L.4    Shehadah, A.5    Jiang, Q.6
  • 14
    • 33845875499 scopus 로고    scopus 로고
    • Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats
    • Chinen I, Shimabukuro M, Yamakawa K, Higa N, Matsuzaki T, Noguchi K, et al. (2007). Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats. Endocrinology 148: 160-165.
    • (2007) Endocrinology , vol.148 , pp. 160-165
    • Chinen, I.1    Shimabukuro, M.2    Yamakawa, K.3    Higa, N.4    Matsuzaki, T.5    Noguchi, K.6
  • 15
    • 84901293971 scopus 로고    scopus 로고
    • Niacin in pharmacological doses alters microRNA expression in skeletal muscle of obese Zucker rats
    • Couturier A, Keller J, Most E, Ringseis R, Eder K (2014). Niacin in pharmacological doses alters microRNA expression in skeletal muscle of obese Zucker rats. PLoS ONE 9: e98313.
    • (2014) PLoS ONE , vol.9 , pp. e98313
    • Couturier, A.1    Keller, J.2    Most, E.3    Ringseis, R.4    Eder, K.5
  • 16
    • 84865215836 scopus 로고    scopus 로고
    • Niacin: another look at an underutilized lipid-lowering medication
    • Creider JC, Hegele RA, Joy TR (2012). Niacin: another look at an underutilized lipid-lowering medication. Nat Rev Endocrinol 8: 517-528.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 517-528
    • Creider, J.C.1    Hegele, R.A.2    Joy, T.R.3
  • 17
    • 0035933369 scopus 로고    scopus 로고
    • Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells
    • Dagher Z, Ruderman N, Tornheim K, Ido Y (2001). Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circ Res 88: 1276-1282.
    • (2001) Circ Res , vol.88 , pp. 1276-1282
    • Dagher, Z.1    Ruderman, N.2    Tornheim, K.3    Ido, Y.4
  • 18
    • 84857648400 scopus 로고    scopus 로고
    • Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms
    • Digby JE, Martinez F, Jefferson A, Ruparelia N, Chai J, Wamil M, et al. (2012). Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms. Arterioscler Thromb Vasc Biol 32: 669-676.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 669-676
    • Digby, J.E.1    Martinez, F.2    Jefferson, A.3    Ruparelia, N.4    Chai, J.5    Wamil, M.6
  • 19
    • 84894519880 scopus 로고    scopus 로고
    • Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD
    • Dokun AO, Chen L, Lanjewar SS, Lye RJ, Annex BH (2014). Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD. Cardiovasc Res 101: 364-372.
    • (2014) Cardiovasc Res , vol.101 , pp. 364-372
    • Dokun, A.O.1    Chen, L.2    Lanjewar, S.S.3    Lye, R.J.4    Annex, B.H.5
  • 20
    • 80054870690 scopus 로고    scopus 로고
    • Obesity-associated insulin resistance in skeletal muscle: role of lipid accumulation and physical inactivity
    • Eckardt K, Taube A, Eckel J (2011). Obesity-associated insulin resistance in skeletal muscle: role of lipid accumulation and physical inactivity. Rev Endocr Metab Disord 12: 163-172.
    • (2011) Rev Endocr Metab Disord , vol.12 , pp. 163-172
    • Eckardt, K.1    Taube, A.2    Eckel, J.3
  • 21
    • 36049044373 scopus 로고    scopus 로고
    • Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia
    • Emanueli C, Caporali A, Krankel N, Cristofaro B, Van Linthout S, Madeddu P (2007). Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia. Front Biosci 12: 2003-2012.
    • (2007) Front Biosci , vol.12 , pp. 2003-2012
    • Emanueli, C.1    Caporali, A.2    Krankel, N.3    Cristofaro, B.4    Van Linthout, S.5    Madeddu, P.6
  • 22
    • 84891717595 scopus 로고    scopus 로고
    • Nuclear positioning in muscle development and disease
    • Folker ES, Baylies MK (2013). Nuclear positioning in muscle development and disease. Front Physiol 4: 363.
    • (2013) Front Physiol , vol.4 , pp. 363
    • Folker, E.S.1    Baylies, M.K.2
  • 23
    • 79955760111 scopus 로고    scopus 로고
    • Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells
    • Frontini MJ, Nong Z, Gros R, Drangova M, O'Neil C, Rahman MN, et al. (2011). Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells. Nat Biotechnol 29: 421-427.
    • (2011) Nat Biotechnol , vol.29 , pp. 421-427
    • Frontini, M.J.1    Nong, Z.2    Gros, R.3    Drangova, M.4    O'Neil, C.5    Rahman, M.N.6
  • 24
    • 57649219453 scopus 로고    scopus 로고
    • Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells
    • Ganji SH, Qin S, Zhang L, Kamanna VS, Kashyap ML (2009). Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells. Atherosclerosis 202: 68-75.
    • (2009) Atherosclerosis , vol.202 , pp. 68-75
    • Ganji, S.H.1    Qin, S.2    Zhang, L.3    Kamanna, V.S.4    Kashyap, M.L.5
  • 25
    • 0000847623 scopus 로고
    • Non-esterified fatty acids in the blood of obese and lean subjects
    • Gordon ES (1960). Non-esterified fatty acids in the blood of obese and lean subjects. Am J Clin Nutr 8: 740-747.
    • (1960) Am J Clin Nutr , vol.8 , pp. 740-747
    • Gordon, E.S.1
  • 26
    • 84886000801 scopus 로고    scopus 로고
    • Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (atherothrombosis intervention in metabolic syndrome with low HDL/high triglycerides and impact on global health outcomes)
    • Guyton JR, Slee AE, Anderson T, Fleg JL, Goldberg RB, Kashyap ML, et al. (2013). Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (atherothrombosis intervention in metabolic syndrome with low HDL/high triglycerides and impact on global health outcomes). J Am Coll Cardiol 62: 1580-1584.
    • (2013) J Am Coll Cardiol , vol.62 , pp. 1580-1584
    • Guyton, J.R.1    Slee, A.E.2    Anderson, T.3    Fleg, J.L.4    Goldberg, R.B.5    Kashyap, M.L.6
  • 27
    • 84877299845 scopus 로고    scopus 로고
    • HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
    • Haynes R, Jiang L, Hopewell JC, Li J, Chen F, Parish S, et al. (2013). HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment. Eur Heart J 34: 1279-1291.
    • (2013) Eur Heart J , vol.34 , pp. 1279-1291
    • Haynes, R.1    Jiang, L.2    Hopewell, J.C.3    Li, J.4    Chen, F.5    Parish, S.6
  • 30
    • 84865146535 scopus 로고    scopus 로고
    • Niacin improves ischemia-induced neovascularization in diabetic mice by enhancement of endothelial progenitor cell functions independent of changes in plasma lipids
    • Huang PH, Lin CP, Wang CH, Chiang CH, Tsai HY, Chen JS, et al. (2012). Niacin improves ischemia-induced neovascularization in diabetic mice by enhancement of endothelial progenitor cell functions independent of changes in plasma lipids. Angiogenesis 15: 377-389.
    • (2012) Angiogenesis , vol.15 , pp. 377-389
    • Huang, P.H.1    Lin, C.P.2    Wang, C.H.3    Chiang, C.H.4    Tsai, H.Y.5    Chen, J.S.6
  • 31
    • 84910091883 scopus 로고    scopus 로고
    • Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity
    • Hughes-Large JM, Pang DK, Robson DL, Chan P, Toma J, Borradaile NM (2014). Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity. Atherosclerosis 237: 696-704.
    • (2014) Atherosclerosis , vol.237 , pp. 696-704
    • Hughes-Large, J.M.1    Pang, D.K.2    Robson, D.L.3    Chan, P.4    Toma, J.5    Borradaile, N.M.6
  • 32
    • 76049123402 scopus 로고    scopus 로고
    • Insulin resistance, lipotoxicity and endothelial dysfunction
    • Imrie H, Abbas A, Kearney M (2010). Insulin resistance, lipotoxicity and endothelial dysfunction. Biochim Biophys Acta 1801: 320-326.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 320-326
    • Imrie, H.1    Abbas, A.2    Kearney, M.3
  • 33
    • 84892911549 scopus 로고    scopus 로고
    • Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults
    • 1985.
    • Kaplon RE, Gano LB, Seals DR (2014). Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults. J Appl Physiol (1985) 116: 156-163.
    • (2014) J Appl Physiol , vol.116 , pp. 156-163
    • Kaplon, R.E.1    Gano, L.B.2    Seals, D.R.3
  • 34
    • 34250169823 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
    • Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, et al. (2007). Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res 100: 1589-1596.
    • (2007) Circ Res , vol.100 , pp. 1589-1596
    • Kim, F.1    Pham, M.2    Luttrell, I.3    Bannerman, D.D.4    Tupper, J.5    Thaler, J.6
  • 36
    • 84860845827 scopus 로고    scopus 로고
    • The use of animal models in diabetes research
    • King AJ (2012). The use of animal models in diabetes research. Br J Pharmacol 166: 877-894.
    • (2012) Br J Pharmacol , vol.166 , pp. 877-894
    • King, A.J.1
  • 37
    • 84858698955 scopus 로고    scopus 로고
    • Nifedipine ameliorates ischemia-induced revascularization in diet-induced obese mice
    • Kito T, Shibata R, Kondo M, Yamamoto T, Suzuki H, Ishii M, et al. (2012). Nifedipine ameliorates ischemia-induced revascularization in diet-induced obese mice. Am J Hypertens 25: 401-406.
    • (2012) Am J Hypertens , vol.25 , pp. 401-406
    • Kito, T.1    Shibata, R.2    Kondo, M.3    Yamamoto, T.4    Suzuki, H.5    Ishii, M.6
  • 38
    • 84940989761 scopus 로고    scopus 로고
    • Dosing Profile Profoundly Influences Nicotinic Acid's Ability to Improve Metabolic Control in Rats
    • Kroon T, Kjellstedt A, Thalen P, Gabrielsson J, Oakes ND (2015). Dosing Profile Profoundly Influences Nicotinic Acid's Ability to Improve Metabolic Control in Rats. J Lipid Res 56: 1679-1690.
    • (2015) J Lipid Res , vol.56 , pp. 1679-1690
    • Kroon, T.1    Kjellstedt, A.2    Thalen, P.3    Gabrielsson, J.4    Oakes, N.D.5
  • 41
    • 84872679028 scopus 로고    scopus 로고
    • The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression
    • Lavigne PM, Karas RH (2013). The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression. J Am Coll Cardiol 61: 440-446.
    • (2013) J Am Coll Cardiol , vol.61 , pp. 440-446
    • Lavigne, P.M.1    Karas, R.H.2
  • 42
    • 33847400644 scopus 로고    scopus 로고
    • In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia
    • Li Y, Hazarika S, Xie D, Pippen AM, Kontos CD, Annex BH (2007). In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia. Diabetes 56: 656-665.
    • (2007) Diabetes , vol.56 , pp. 656-665
    • Li, Y.1    Hazarika, S.2    Xie, D.3    Pippen, A.M.4    Kontos, C.D.5    Annex, B.H.6
  • 43
    • 79952240405 scopus 로고    scopus 로고
    • Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
    • Lukasova M, Malaval C, Gille A, Kero J, Offermanns S (2011). Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest 121: 1163-1173.
    • (2011) J Clin Invest , vol.121 , pp. 1163-1173
    • Lukasova, M.1    Malaval, C.2    Gille, A.3    Kero, J.4    Offermanns, S.5
  • 44
    • 69849111863 scopus 로고    scopus 로고
    • Activation of NF-κB by Palmitate in Endothelial Cells. A Key Role for NADPH Oxidase-Derived Superoxide in Response to TLR4 Activation
    • Maloney E, Sweet IR, Hockenbery DM, Pham M, Rizzo NO, Tateya S, et al. (2009). Activation of NF-κB by Palmitate in Endothelial Cells. A Key Role for NADPH Oxidase-Derived Superoxide in Response to TLR4 Activation. Arterioscler Thromb Vasc Biol 29: 1370-1375.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1370-1375
    • Maloney, E.1    Sweet, I.R.2    Hockenbery, D.M.3    Pham, M.4    Rizzo, N.O.5    Tateya, S.6
  • 46
    • 34249034223 scopus 로고    scopus 로고
    • Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites
    • Menon RM, Gonzalez MA, Adams MH, Tolbert DS, Leu JH, Cefali EA (2007b). Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites. J Clin Pharmacol 47: 681-688.
    • (2007) J Clin Pharmacol , vol.47 , pp. 681-688
    • Menon, R.M.1    Gonzalez, M.A.2    Adams, M.H.3    Tolbert, D.S.4    Leu, J.H.5    Cefali, E.A.6
  • 48
    • 84897031074 scopus 로고    scopus 로고
    • Cardiovascular drugs that increase the risk of new-onset diabetes
    • Ong KL, Barter PJ, Waters DD (2014). Cardiovascular drugs that increase the risk of new-onset diabetes. Am Heart J 167: 421-428.
    • (2014) Am Heart J , vol.167 , pp. 421-428
    • Ong, K.L.1    Barter, P.J.2    Waters, D.D.3
  • 49
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw S, Nihal M, Ahmad N (2008). Dose translation from animal to human studies revisited. FASEB J 22: 659-661.
    • (2008) FASEB J , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 50
    • 34249326588 scopus 로고    scopus 로고
    • The chemokine system in arteriogenesis and hind limb ischemia
    • Shireman PK (2007). The chemokine system in arteriogenesis and hind limb ischemia. J Vasc Surg 45: A48-A56.
    • (2007) J Vasc Surg , vol.45 , pp. A48-A56
    • Shireman, P.K.1
  • 52
    • 84874667392 scopus 로고    scopus 로고
    • Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide
    • Symons JD, Abel ED (2013). Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide. Rev Endocr Metab Disord 14: 59-68.
    • (2013) Rev Endocr Metab Disord , vol.14 , pp. 59-68
    • Symons, J.D.1    Abel, E.D.2
  • 53
    • 0037352280 scopus 로고    scopus 로고
    • PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
    • Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, et al. (2003). PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 9: 352-355.
    • (2003) Nat Med , vol.9 , pp. 352-355
    • Tunaru, S.1    Kero, J.2    Schaub, A.3    Wufka, C.4    Blaukat, A.5    Pfeffer, K.6
  • 54
    • 79952103415 scopus 로고    scopus 로고
    • Niacin results in reduced monocyte adhesion in patients with type 2 diabetes mellitus
    • Tavintharan S, Woon K, Pek LT, Jauhar N, Dong X, Lim SC, et al. (2011). Niacin results in reduced monocyte adhesion in patients with type 2 diabetes mellitus. Atherosclerosis 215: 176-179.
    • (2011) Atherosclerosis , vol.215 , pp. 176-179
    • Tavintharan, S.1    Woon, K.2    Pek, L.T.3    Jauhar, N.4    Dong, X.5    Lim, S.C.6
  • 55
    • 35348902493 scopus 로고    scopus 로고
    • The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome
    • Thoenes M, Oguchi A, Nagamia S, Vaccari CS, Hammoud R, Umpierrez GE, et al. (2007). The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome. Int J Clin Pract 61: 1942-1948.
    • (2007) Int J Clin Pract , vol.61 , pp. 1942-1948
    • Thoenes, M.1    Oguchi, A.2    Nagamia, S.3    Vaccari, C.S.4    Hammoud, R.5    Umpierrez, G.E.6
  • 56
    • 84860758607 scopus 로고    scopus 로고
    • Uncoupling protein-2 protects endothelial function in diet-induced obese mice
    • Tian XY, Wong WT, Xu A, Lu Y, Zhang Y, Wang L, et al. (2012). Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circ Res 110: 1211-1216.
    • (2012) Circ Res , vol.110 , pp. 1211-1216
    • Tian, X.Y.1    Wong, W.T.2    Xu, A.3    Lu, Y.4    Zhang, Y.5    Wang, L.6
  • 57
    • 84942616003 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptorbeta/delta agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity
    • Toral M, Gomez-Guzman M, Jimenez R, Romero M, Zarzuelo MJ, Utrilla MP, et al. (2015). Chronic peroxisome proliferator-activated receptorbeta/delta agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. J Hypertens 33: 1831-1844.
    • (2015) J Hypertens , vol.33 , pp. 1831-1844
    • Toral, M.1    Gomez-Guzman, M.2    Jimenez, R.3    Romero, M.4    Zarzuelo, M.J.5    Utrilla, M.P.6
  • 59
    • 22144459034 scopus 로고    scopus 로고
    • Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation
    • van der Veer E, Nong Z, O'Neil C, Urquhart B, Freeman D, Pickering JG (2005). Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation. Circ Res 97: 25-34.
    • (2005) Circ Res , vol.97 , pp. 25-34
    • van der Veer, E.1    Nong, Z.2    O'Neil, C.3    Urquhart, B.4    Freeman, D.5    Pickering, J.G.6
  • 60
    • 34249696938 scopus 로고    scopus 로고
    • Extension of human cell lifespan by nicotinamide phosphoribosyltransferase
    • van der Veer E, Ho C, O'Neil C, Barbosa N, Scott R, Cregan SP, et al. (2007). Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J Biol Chem 282: 10841-10845.
    • (2007) J Biol Chem , vol.282 , pp. 10841-10845
    • van der Veer, E.1    Ho, C.2    O'Neil, C.3    Barbosa, N.4    Scott, R.5    Cregan, S.P.6
  • 61
    • 77952752103 scopus 로고    scopus 로고
    • Does endothelial dysfunction contribute to the clinical status of patients with peripheral arterial disease?
    • Vita JA, Hamburg NM (2010). Does endothelial dysfunction contribute to the clinical status of patients with peripheral arterial disease? Can J Cardiol 26(Suppl A): 45A-50A.
    • (2010) Can J Cardiol , vol.26 , pp. 45A-50A
    • Vita, J.A.1    Hamburg, N.M.2
  • 62
    • 66149107054 scopus 로고    scopus 로고
    • Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR
    • Wang CY, Kim HH, Hiroi Y, Sawada N, Salomone S, Benjamin LE, et al. (2009). Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal 2: ra11.
    • (2009) Sci Signal , vol.2 , pp. ra11
    • Wang, C.Y.1    Kim, H.H.2    Hiroi, Y.3    Sawada, N.4    Salomone, S.5    Benjamin, L.E.6
  • 63
    • 84870542800 scopus 로고    scopus 로고
    • Mechanisms of lipotoxicity in the cardiovascular system
    • Wende AR, Symons JD, Abel ED (2012). Mechanisms of lipotoxicity in the cardiovascular system. Curr Hypertens Rep 14: 517-531.
    • (2012) Curr Hypertens Rep , vol.14 , pp. 517-531
    • Wende, A.R.1    Symons, J.D.2    Abel, E.D.3
  • 64
    • 77951483195 scopus 로고    scopus 로고
    • Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids
    • Wu BJ, Yan L, Charlton F, Witting P, Barter PJ, Rye KA (2010). Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids. Arterioscler Thromb Vasc Biol 30: 968-975.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 968-975
    • Wu, B.J.1    Yan, L.2    Charlton, F.3    Witting, P.4    Barter, P.J.5    Rye, K.A.6
  • 65
    • 84855381655 scopus 로고    scopus 로고
    • Niacin inhibits vascular inflammation via the induction of heme oxygenase-1
    • Wu BJ, Chen K, Barter PJ, Rye KA (2012). Niacin inhibits vascular inflammation via the induction of heme oxygenase-1. Circulation 125: 150-158.
    • (2012) Circulation , vol.125 , pp. 150-158
    • Wu, B.J.1    Chen, K.2    Barter, P.J.3    Rye, K.A.4
  • 66
    • 77953961808 scopus 로고    scopus 로고
    • Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib
    • Yvan-Charvet L, Kling J, Pagler T, Li H, Hubbard B, Fisher T, et al. (2010). Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib. Arterioscler Thromb Vasc Biol 30: 1430-1438.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1430-1438
    • Yvan-Charvet, L.1    Kling, J.2    Pagler, T.3    Li, H.4    Hubbard, B.5    Fisher, T.6


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