Niacin improves ischemia-induced neovascularization in diabetic mice by enhancement of endothelial progenitor cell functions independent of changes in plasma lipids

Angiogenesis

Volumn 15, Issue 3, 2012, Pages 377-389

  Huang, Po Hsun ^a,b   Lin, Chih Pei ^a,b   Wang, Chao Hung ^b,c,f   Chiang, Chia Hung ^a,b   Tsai, Hsiao Ya ^b   Chen, Jia Shiong ^b   Lin, Feng Yen ^d,e   Leu, Hsin Bang ^a,b   Wu, Tao Cheng ^a,b   Chen, Jaw Wen ^a,b   Lin, Shing Jong ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Diabetes; Endothelial progenitor cells; Ischemia; Niacin; Nitric oxide

Indexed keywords

ATAXIN 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; HYDROGEN PEROXIDE; LIPID; NICOTINIC ACID; NITRATE; NITRIC OXIDE; STREPTOZOCIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW TRANSPLANTATION; CAPILLARY DENSITY; CELL AGING; CELL DIFFERENTIATION; CELL FUNCTION; CELL HOMING; CELL MOTILITY; CONTROLLED STUDY; CULTURE MEDIUM; DIABETIC ANGIOPATHY; DRUG MECHANISM; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; ENZYME DEFICIENCY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEG BLOOD FLOW; LIMB ISCHEMIA; LIMB PERFUSION; LIPID BLOOD LEVEL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; FLOW CYTOMETRY; IN SITU NICK-END LABELING; ISCHEMIA; LIPIDS; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PATHOLOGIC; NIACIN; STEM CELLS;

MUS;

EID: 84865146535     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-012-9267-z     Document Type: Article

References (33)

1. The DCCT/EDIC Study Research Group (2005) Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 353:2643-2653 (Pubitemid 41817713)
2. Adeghate E (2004) Molecular and cellular basis of the etiology and management of diabetic cardiomyopathy: a short review. Mol Cell Biochem 261:187-191 (Pubitemid 39004531)
3. Federman DG, Bravata DM, Kirsner RS (2004) Peripheral arterial disease. A systemic disease extending beyond the affected extremity. Geriatrics 59:29-30
4. Asahara T, Murohara T, Sullivan A et al (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964-967 (Pubitemid 27087709)
5. Vasa M, Fichtlscherer S, Aicher A et al (2001) Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 89:1-7
6. Fadini GP, de Kreutzenberg S, Albiero M et al (2008) Gender differences in endothelial progenitor cells and cardiovascular risk profile: the role of female estrogens. Arterioscler Thromb Vasc Biol 28:997-1004 (Pubitemid 351544119)
7. Chen YH, Lin SJ, Lin FY et al (2007) High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes 56:1559-1568 (Pubitemid 46842612)
8. Meyers CD, Kamanna VS, Kashyap ML (2004) Niacin therapy in atherosclerosis. Curr Opin Lipidol 15:659-665 (Pubitemid 39612984)
9. Kamanna VS, Kashyap ML (2007) Nicotinic acid (niacin) receptor agonists: will they be useful therapeutic agents? Am J Cardiol 100:53-61 (Pubitemid 350161785)
10. Brown BG, Zhao XQ, Chait A et al (2001) Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 345:1583-1592 (Pubitemid 33126837)
11. Taylor AJ, Sullenberger LE, Lee HJ, Lee JK, Grace KA (2004) Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation 110:3512-3517 (Pubitemid 39612564)
12. Vittone F, Chait A, Morse JS, Fish B, Brown BG, Zhao XQ (2007) Niacin plus simvastatin reduces coronary stenosis progression among patients with metabolic syndrome despite a modest increase in insulin resistance: a subgroup analysis of the HDL-Atherosclerosis Treatment Study (HATS). J Clin Lipidol 1:203-210 (Pubitemid 47055291)
13. Kuvin JT, Rämet ME, Patel AR, Pandian NG, Mendelsohn ME, Karas RH (2002) A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expression. Am Heart J 144:165-172 (Pubitemid 34734771)
14. Warnholtz A, Wild P, Ostad MA et al (2009) Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: results of the randomized, double-blind, placebo-controlled INEF study. Atherosclerosis 204:216-221
15. Kuvin JT, Dave DM, Sliney KA et al (2006) Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease. Am J Cardiol 98:743-745 (Pubitemid 44301006)
16. Ganji SH, Qin S, Zhang L, Kamanna VS, Kashyap ML (2009) Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells. Atherosclerosis 202:68-75
17. Tavintharan S, Lim SC, Sum CF (2009) Effects of niacin on cell adhesion and early atherogenesis: biochemical and functional findings in endothelial cells. Basic Clin Pharmacol Toxicol 104:206-210
18. Rosenson RS (2003) Antiatherothrombotic effects of nicotinic acid. Atherosclerosis 171:87-96 (Pubitemid 37464633)
19. Huang PH, Tsai HY, Wang CH et al (2010) Moderate intake of red wine improves ischemia-induced neovascularization in diabetic mice-roles of endothelial progenitor cells and nitric oxide. Atherosclerosis 212:426-435
20. Huang PH, Chen YH, Wang CH et al (2009) Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 29:1179-1184
21. Huang PH, Huang SS, Chen YH et al (2010) Increased circulating CD31 +/annexin V + apoptotic microparticles and decreased circulating endothelial progenitor cell levels in hypertensive patients with microalbuminuria. J Hypertens 28:1655-1665
22. Matoba T, Shimokawa H, Nakashima M et al (2000) Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice. J Clin Invest 106:1521-1530 (Pubitemid 32040953)
23. Loomans CJ, de Koning EJ, Staal FJ et al (2004) Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 53:195-199 (Pubitemid 38044715)
24. Tepper OM, Galiano RD, Capla JM et al (2002) Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 106:2781-2786 (Pubitemid 35396976)
25. Fadini GP, Sartore S, Albiero M et al (2006) Number and function of endothelial progenitor cells as a marker of severity for diabetic vasculopathy. Arterioscler Thromb Vasc Biol 26:2140-2146 (Pubitemid 44253800)
26. Fadini GP, Sartore S, Schiavon M et al (2006) Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia-reperfusion injury in rats. Diabetologia 49:3075-3084 (Pubitemid 44730312)
27. Thoenes M, Oguchi A, Nagamia S et al (2007) The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome. Int J Clin Pract 61:1942-1948 (Pubitemid 47573105)
28. Wu BJ, Yan L, Charlton F, Witting P, Barter PJ, Rye KA (2010) Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids. Arterioscler Thromb Vasc Biol 30:968-975
29. Yan Q, Briehl M, Crowley CL, Payne CM, Bernstein H, Bernstein C (1999) The NAD+ precursors, nicotinic acid and nicotinamide upregulate glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphate dehydrogenase mRNA in Jurkat cells. Biochem Biophys Res Commun 255:133-136 (Pubitemid 29292077)
30. Meister A, Anderson ME (1983) Glutathione. Annu Rev Biochem 52:711-760 (Pubitemid 13030692)
31. Avogaro A, Fadini GP (2006) The Janus face of nicotinic angiogenesis. J Am Coll Cardiol 48:2561-2563 (Pubitemid 44881228)
32. Harwood DT, Kettle AJ, Winterbourn CC (2006) Production of glutathione sulfonamide and dehydroglutathione from GSH by myeloperoxidase-derived oxidants and detection using a novel LC-MS/MS method. Biochem J 399:161-168 (Pubitemid 44505417)
33. Sugiyama S, Kugiyama K, Aikawa M, Nakamura S, Ogawa H, Libby P (2004) Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis. Arterioscler Thromb Vasc Biol 24:1309-1314 (Pubitemid 38880026)