Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF

Nature Cell Biology

Volumn 19, Issue 8, 2017, Pages 974-987

  Quail, Daniela F ^a   Olson, Oakley C ^a   Bhardwaj, Priya ^b   Walsh, Logan A ^a   Akkari, Leila ^a,c,d   Quick, Marsha L ^a   Chen, I Chun ^b   Wendel, Nils ^b   Ben Chetrit, Nir ^a,b   Walker, Jeanne ^e   Holt, Peter R ^e   Dannenberg, Andrew J ^b   Joyce, Johanna A ^a,c,d  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALGRANULIN A; CCL25 CHEMOKINE; CD11B ANTIGEN; CD40 LIGAND; CD45 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR CXCR2; COLONY STIMULATING FACTOR; COLONY STIMULATING FACTOR 2; GELATINASE B; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 5; INTERLEUKIN 5 RECEPTOR ALPHA; INTERLEUKIN 6; MESSENGER RNA; SOMATOMEDIN BINDING PROTEIN 2; STROMELYSIN; UNCLASSIFIED DRUG; IL5 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BREAST CANCER; C57BL 6 MOUSE; CELL DIFFERENTIATION; CELL HOMING; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DIET INDUCED OBESITY; DOWN REGULATION; EXPERIMENTAL LUNG METASTASIS; FEMALE; GENE EXPRESSION REGULATION; HUMAN; INFLAMMATION; LEUKOCYTE ACTIVATION; LEUKOCYTE MIGRATION; MACROPHAGE; MOUSE; MYELOPOIESIS; NEUTROPHILIA; NONHUMAN; NORMAL HUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR GROWTH; UPREGULATION; WEIGHT REDUCTION; WILD TYPE; ADOPTIVE TRANSFER; ANIMAL; BAGG ALBINO MOUSE; BLOOD; BREAST TUMOR; C57BL MOUSE; COCULTURE; COMPLICATION; DIET THERAPY; DISEASE COURSE; DISEASE MODEL; GENETICS; LOW FAT DIET; LUNG; LUNG NEOPLASMS; METABOLISM; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONOBESE DIABETIC MOUSE; OBESITY; PATHOLOGY; PNEUMONIA; SCID MOUSE; SECONDARY; TIME FACTOR; TRANSGENIC MOUSE; TRANSPLANTATION; TUMOR CELL LINE; TUMOR MICROENVIRONMENT;

ADIPOSITY; ADOPTIVE TRANSFER; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; COCULTURE TECHNIQUES; DIET, FAT-RESTRICTED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-5; LUNG; LUNG NEOPLASMS; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; NEUTROPHIL INFILTRATION; NEUTROPHILS; OBESITY; PNEUMONIA; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR MICROENVIRONMENT; WEIGHT LOSS;

EID: 85026487459     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3578     Document Type: Article

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