-
2
-
-
85033993733
-
-
[cited 2017 Jan27], Available from
-
International Diabetes Federation. [cited 2017 Jan27]. Available from: http://www.idf.org/about-diabetes/facts-figures
-
-
-
-
3
-
-
77953821528
-
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
-
Sarwar N, Gao P, Seshasai SR, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375:2215–2222.
-
(2010)
Lancet
, vol.375
, pp. 2215-2222
-
-
Sarwar, N.1
Gao, P.2
Seshasai, S.R.3
-
4
-
-
84937216336
-
The emerging risk factors collaboration. Association of cardiometabolic multimorbidity with mortality
-
Di Angelantonio E, Kaptoge S, Wormser D, et al. The emerging risk factors collaboration. Association of cardiometabolic multimorbidity with mortality. JAMA. 2015;314(1):52–60.
-
(2015)
JAMA
, vol.314
, Issue.1
, pp. 52-60
-
-
Di Angelantonio, E.1
Kaptoge, S.2
Wormser, D.3
-
5
-
-
4644351335
-
Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus
-
Selvin E, Marinopoulos S, Berkenblit G, et al. Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med. 2004;141:421–431.
-
(2004)
Ann Intern Med
, vol.141
, pp. 421-431
-
-
Selvin, E.1
Marinopoulos, S.2
Berkenblit, G.3
-
6
-
-
84946049571
-
Excess mortality among persons with type 2 diabetes
-
Tancredi M, Rosengren A, Svensson A-M, et al. Excess mortality among persons with type 2 diabetes. N Engl J Med. 2015;373:1720–1732.
-
(2015)
N Engl J Med
, vol.373
, pp. 1720-1732
-
-
Tancredi, M.1
Rosengren, A.2
Svensson, A.-M.3
-
7
-
-
0032511583
-
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
-
UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837–853.
-
(1998)
Lancet
, vol.352
, pp. 837-853
-
-
-
8
-
-
45149133036
-
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
-
Patel A, MacMahon S, Chalmers J, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560–2572.
-
(2008)
N Engl J Med
, vol.358
, pp. 2560-2572
-
-
Patel, A.1
MacMahon, S.2
Chalmers, J.3
-
9
-
-
45149131667
-
Effects of intensive glucose lowering in type 2 diabetes
-
Gerstein HC, Miller ME, Byington RP, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358:2545–2559.
-
(2008)
N Engl J Med
, vol.358
, pp. 2545-2559
-
-
Gerstein, H.C.1
Miller, M.E.2
Byington, R.P.3
-
10
-
-
35548964739
-
Cardiovascular morbidity and mortality of the metabolic syndrome
-
Obunai K, Jani S, Dangas GD., Cardiovascular morbidity and mortality of the metabolic syndrome. Med Clin North Am. 2007;91:1169–1184.
-
(2007)
Med Clin North Am
, vol.91
, pp. 1169-1184
-
-
Obunai, K.1
Jani, S.2
Dangas, G.D.3
-
11
-
-
40749090886
-
Metabolic syndrome and stroke
-
Towfighi A, Ovbiagele B., Metabolic syndrome and stroke. Curr Diab Rep. 2008;8(1):37–41.
-
(2008)
Curr Diab Rep
, vol.8
, Issue.1
, pp. 37-41
-
-
Towfighi, A.1
Ovbiagele, B.2
-
12
-
-
84905757105
-
Metformin–mode of action and clinical implications for diabetes and cancer
-
Pernicova I, Korbonits M. Metformin–mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol. 2014;10(3):143–156.
-
(2014)
Nat Rev Endocrinol
, vol.10
, Issue.3
, pp. 143-156
-
-
Pernicova, I.1
Korbonits, M.2
-
13
-
-
0025837055
-
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects
-
Defronzo RA, Barzilai N, Simonson DC. Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. J Clin Endocrinol Metab. 1991;73(6):1294–1301.
-
(1991)
J Clin Endocrinol Metab
, vol.73
, Issue.6
, pp. 1294-1301
-
-
Defronzo, R.A.1
Barzilai, N.2
Simonson, D.C.3
-
14
-
-
84855603512
-
Cellular and molecular mechanisms of metformin: an overview
-
Mar, et al
-
Viollet B, Guigas B, Garcia NS, et al. Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond). 2012 Mar;122(6):253–270.
-
(2012)
Clin Sci (Lond)
, vol.122
, Issue.6
, pp. 253-270
-
-
Viollet, B.1
Guigas, B.2
Garcia, N.S.3
-
16
-
-
84907021154
-
Effect of metformin on metabolic improvement and gut microbiota
-
Oct
-
Lee H, Ko G. Effect of metformin on metabolic improvement and gut microbiota. Appl Environ Microbiol. 2014 Oct;80(19):5935–5943.
-
(2014)
Appl Environ Microbiol
, vol.80
, Issue.19
, pp. 5935-5943
-
-
Lee, H.1
Ko, G.2
-
17
-
-
85021320590
-
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
-
May, [Epub ahead of print], et al
-
Wu H, Esteve E, Tremaroli V, et al. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nat Med. 2017 May 22 [Epub ahead of print]. DOI:10.1038/nm.4345.
-
(2017)
Nat Med
-
-
Wu, H.1
Esteve, E.2
Tremaroli, V.3
-
18
-
-
84873733300
-
Metformin: an old but still the best treatment for type 2 diabetes
-
Rojas LB, Gomes MB. Metformin: an old but still the best treatment for type 2 diabetes. Diabetol Metab Syndr. 2013;5:6.
-
(2013)
Diabetol Metab Syndr
, vol.5
, pp. 6
-
-
Rojas, L.B.1
Gomes, M.B.2
-
19
-
-
77953929752
-
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial
-
De Jager J, Kooy A, Lehert P, et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. Bmj. 2010;340(may19 4):c2181–c2181.
-
(2010)
Bmj
, vol.340
, Issue.may19 4
, pp. c2181
-
-
De Jager, J.1
Kooy, A.2
Lehert, P.3
-
20
-
-
0026468247
-
Biguanide-associated lactic acidosis. Case report and review of the literature
-
Gan SC, Barr J, Arieff AI, et al. Biguanide-associated lactic acidosis. Case report and review of the literature. Arch Intern Med. 1992;152(11):2333–2336.
-
(1992)
Arch Intern Med
, vol.152
, Issue.11
, pp. 2333-2336
-
-
Gan, S.C.1
Barr, J.2
Arieff, A.I.3
-
21
-
-
84916940263
-
Cardiovascular safety profile of currently available diabetic drugs
-
Azimova K, Juan ZS, Mukherjee D. Cardiovascular safety profile of currently available diabetic drugs. Ochsner J. 2014;14(4):616–632.
-
(2014)
Ochsner J
, vol.14
, Issue.4
, pp. 616-632
-
-
Azimova, K.1
Juan, Z.S.2
Mukherjee, D.3
-
22
-
-
84872617193
-
Eff ectiveness of metformin on weight loss in non-diabetic individuals with obesity
-
Seifarth. Eff ectiveness of metformin on weight loss in non-diabetic individuals with obesity. Exp Clin Endocrinol Diabetes. 2013;121(121):27–31. DOI:10.1055/s-0032-1327734.
-
(2013)
Exp Clin Endocrinol Diabetes
, vol.121
, Issue.121
, pp. 27-31
-
-
-
24
-
-
0032511566
-
2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group
-
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type. 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352(9131):854–865.
-
(1998)
Lancet
, vol.352
, Issue.9131
, pp. 854-865
-
-
-
25
-
-
53749091595
-
10-year follow-up of intensive glucose control in type 2 diabetes
-
Holman RR, Paul SK, Bethel MA, et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359(15):1577–1589.
-
(2008)
N Engl J Med
, vol.359
, Issue.15
, pp. 1577-1589
-
-
Holman, R.R.1
Paul, S.K.2
Bethel, M.A.3
-
26
-
-
54949090768
-
Cardiovascular outcomes in trials of oral diabetes medications: a systematic review
-
Selvin E, Bolen S, Yeh HC, et al. Cardiovascular outcomes in trials of oral diabetes medications: a systematic review. Arch Int Med. 2008;168:2070–2080.
-
(2008)
Arch Int Med
, vol.168
, pp. 2070-2080
-
-
Selvin, E.1
Bolen, S.2
Yeh, H.C.3
-
27
-
-
2642580716
-
Mortality in type 2 diabetic subjects prescribed metformin and sulphonylurea drugs in combination: cohort study
-
May-Jun
-
Gulliford M, Latinovic R. Mortality in type 2 diabetic subjects prescribed metformin and sulphonylurea drugs in combination: cohort study. Diabetes Metab Res Rev. 2004 May-Jun;20(3):239–245.
-
(2004)
Diabetes Metab Res Rev
, vol.20
, Issue.3
, pp. 239-245
-
-
Gulliford, M.1
Latinovic, R.2
-
28
-
-
13444272949
-
Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study
-
Masoudi FA, Inzucchi SE, Wang Y, et al. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation. 2005;111(5):583–590.
-
(2005)
Circulation
, vol.111
, Issue.5
, pp. 583-590
-
-
Masoudi, F.A.1
Inzucchi, S.E.2
Wang, Y.3
-
29
-
-
77549084869
-
Metformin therapy and outcomes in patients with advanced systolic heart failure and diabetes
-
Shah DD, Fonarow GC, Horwich TB. Metformin therapy and outcomes in patients with advanced systolic heart failure and diabetes. J Cardiac Failure. 2010;16:200–206.
-
(2010)
J Cardiac Failure
, vol.16
, pp. 200-206
-
-
Shah, D.D.1
Fonarow, G.C.2
Horwich, T.B.3
-
30
-
-
84879207411
-
Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34 000 patients
-
Eurich DT, Weir DL, Majumdar SR, et al. Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34 000 patients. Circ Hear Fail. 2013;6(3):395–402.
-
(2013)
Circ Hear Fail
, vol.6
, Issue.3
, pp. 395-402
-
-
Eurich, D.T.1
Weir, D.L.2
Majumdar, S.R.3
-
31
-
-
84878018230
-
Metformin therapy and prognosis of patients with heart failure and new-onset diabetes mellitus. A propensity-matched study in the community
-
Romero SP, Andrey JL, Garcia-Egido A, et al. Metformin therapy and prognosis of patients with heart failure and new-onset diabetes mellitus. A propensity-matched study in the community. Int J Cardiol. 2013;166(2):404–412.
-
(2013)
Int J Cardiol
, vol.166
, Issue.2
, pp. 404-412
-
-
Romero, S.P.1
Andrey, J.L.2
Garcia-Egido, A.3
-
33
-
-
77954467938
-
-
[cited 2017 May20], Available from
-
Food and Drug Administration. Product label approval: metformin. 2006 [cited 2017 May20]. Available from: http://packageinserts.bms.com/pi/piglucophage.pdf
-
(2006)
Product label approval: metformin
-
-
-
34
-
-
82255194231
-
Treating diabetes today: a matter of selectivity of sulphonylureas
-
Seino S, Takahashi H, Takahashi T, et al. Treating diabetes today: a matter of selectivity of sulphonylureas. Diabetes, Obes Metab. 2012;14:9–13.
-
(2012)
Diabetes, Obes Metab
, vol.14
, pp. 9-13
-
-
Seino, S.1
Takahashi, H.2
Takahashi, T.3
-
35
-
-
0029024314
-
Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion
-
Aguilar-Bryan L, Nichols CG, Wechsler SW, et al. Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science. 1995;268(5209):423–426.
-
(1995)
Science
, vol.268
, Issue.5209
, pp. 423-426
-
-
Aguilar-Bryan, L.1
Nichols, C.G.2
Wechsler, S.W.3
-
36
-
-
0031396662
-
Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus
-
Bressler R, Johnson DG. Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus. Arch Intern Med. 1997;157(8):836–848.
-
(1997)
Arch Intern Med
, vol.157
, Issue.8
, pp. 836-848
-
-
Bressler, R.1
Johnson, D.G.2
-
37
-
-
84892465849
-
The incidence of mild and severe hypoglycaemia in patients with type 2 diabetes mellitus treated with sulfonylureas: a systematic review and meta-analysis
-
Schopman JE, Simon ACR, Hoefnagel SJM, et al. The incidence of mild and severe hypoglycaemia in patients with type 2 diabetes mellitus treated with sulfonylureas: a systematic review and meta-analysis. Diabetes Metab Res Rev. 2014;30(1):11–22.
-
(2014)
Diabetes Metab Res Rev
, vol.30
, Issue.1
, pp. 11-22
-
-
Schopman, J.E.1
Simon, A.C.R.2
Hoefnagel, S.J.M.3
-
38
-
-
0026341626
-
The mode of action and clinical pharmacology of gliclazide: a review
-
Campbell DB, Lavielle R, Nathan C. The mode of action and clinical pharmacology of gliclazide: a review. Diabetes Res Clin Pr. 1991;14(Suppl 2):S21–36.
-
(1991)
Diabetes Res Clin Pr
, vol.14
, pp. S21-S36
-
-
Campbell, D.B.1
Lavielle, R.2
Nathan, C.3
-
39
-
-
84941887941
-
Effects of sulfonylureas on lipids in Type 2 diabetes mellitus: a meta-analysis of randomized controlled trials
-
Chen YH, Du L, Geng XY, et al. Effects of sulfonylureas on lipids in Type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. J Evid Based Med. 2015;8:134–148.
-
(2015)
J Evid Based Med
, vol.8
, pp. 134-148
-
-
Chen, Y.H.1
Du, L.2
Geng, X.Y.3
-
40
-
-
0032972077
-
Sulfonylureas and ischaemic preconditioning; a double-blind, placebo-controlled evaluation of glimepiride and glibenclamide
-
Mar, et al
-
Klepzig H, Kober G, Matter C, et al. Sulfonylureas and ischaemic preconditioning; a double-blind, placebo-controlled evaluation of glimepiride and glibenclamide. Eur Heart J. 1999 Mar;20(6):439–446.
-
(1999)
Eur Heart J
, vol.20
, Issue.6
, pp. 439-446
-
-
Klepzig, H.1
Kober, G.2
Matter, C.3
-
41
-
-
84879207918
-
Glimepiride treatment facilitates ischemic preconditioning in the diabetic heart
-
May, et al
-
Hausenloy DJ, Wynne AM, Mocanu MM, et al. Glimepiride treatment facilitates ischemic preconditioning in the diabetic heart. J Cardiovasc Pharmacol Ther. 2013 May;18(3):263–269.
-
(2013)
J Cardiovasc Pharmacol Ther
, vol.18
, Issue.3
, pp. 263-269
-
-
Hausenloy, D.J.1
Wynne, A.M.2
Mocanu, M.M.3
-
42
-
-
0015401059
-
A summary of criticisms of the findings and conclusions of the University Group Diabetes Program (UGDP)
-
Seltzer HS. A summary of criticisms of the findings and conclusions of the University Group Diabetes Program (UGDP). Diabetes. 1972;21:976–979.
-
(1972)
Diabetes
, vol.21
, pp. 976-979
-
-
Seltzer, H.S.1
-
43
-
-
79958197888
-
Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study
-
Schramm TK, Gislason GH, Vaag A, et al. Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study. Eur Heart J. 2011;32(15):1900–1908.
-
(2011)
Eur Heart J
, vol.32
, Issue.15
, pp. 1900-1908
-
-
Schramm, T.K.1
Gislason, G.H.2
Vaag, A.3
-
44
-
-
84864349212
-
Increase in overall mortality risk in patients with type 2 diabetes receiving glipizide, glyburide or glimepiride monotherapy versus metformin: a retrospective analysis
-
Pantalone KM, Kattan MW, Yu C, et al. Increase in overall mortality risk in patients with type 2 diabetes receiving glipizide, glyburide or glimepiride monotherapy versus metformin: a retrospective analysis. Diabetes, Obes Metab. 2012;14(9):803–809.
-
(2012)
Diabetes, Obes Metab
, vol.14
, Issue.9
, pp. 803-809
-
-
Pantalone, K.M.1
Kattan, M.W.2
Yu, C.3
-
45
-
-
84883741367
-
Cardiovascular safety of sulfonylureas: a meta-analysis of randomized clinical trials
-
Monami M, Genovese S, Mannucci E. Cardiovascular safety of sulfonylureas: a meta-analysis of randomized clinical trials. Diabetes Obes Metab. 2013;15(10):938–953.
-
(2013)
Diabetes Obes Metab
, vol.15
, Issue.10
, pp. 938-953
-
-
Monami, M.1
Genovese, S.2
Mannucci, E.3
-
46
-
-
84964769831
-
The association between sulfonylurea use and all-cause and cardiovascular mortality: a meta-analysis with trial sequential analysis of randomized clinical trials
-
Varvaki Rados D, Catani Pinto L, Reck Remonti L, et al. The association between sulfonylurea use and all-cause and cardiovascular mortality: a meta-analysis with trial sequential analysis of randomized clinical trials. PLoS Med. 2016;13(4):e1001992.
-
(2016)
PLoS Med
, vol.13
, Issue.4
, pp. e1001992
-
-
Varvaki Rados, D.1
Catani Pinto, L.2
Reck Remonti, L.3
-
47
-
-
85019396083
-
Sulfonylureas and the risks of cardiovascular events and death: a methodological meta-regression analysis of the observational studies
-
May
-
Azoulay L, Suissa S. Sulfonylureas and the risks of cardiovascular events and death: a methodological meta-regression analysis of the observational studies. Diabetes Care. 2017 May;40(5):706–714.
-
(2017)
Diabetes Care
, vol.40
, Issue.5
, pp. 706-714
-
-
Azoulay, L.1
Suissa, S.2
-
48
-
-
85019376667
-
Modern sulfonylureas: dangerous or wrongly accused?
-
Riddle MC. Modern sulfonylureas: dangerous or wrongly accused? Diabetes Care May. 2017;40(5):629–631.
-
(2017)
Diabetes Care May
, vol.40
, Issue.5
, pp. 629-631
-
-
Riddle, M.C.1
-
49
-
-
19244365650
-
Thiazolidinediones
-
Yki-Järvinen H. Thiazolidinediones. N Engl J Med. 2004;351(11):1106–1118.
-
(2004)
N Engl J Med
, vol.351
, Issue.11
, pp. 1106-1118
-
-
Yki-Järvinen, H.1
-
50
-
-
0034033388
-
Mechanism of troglitazone action in type 2 diabetes
-
Petersen KF, Krssak M, Inzucchi S, et al. Mechanism of troglitazone action in type 2 diabetes. Diabetes. 2000;49(5):827–831.
-
(2000)
Diabetes
, vol.49
, Issue.5
, pp. 827-831
-
-
Petersen, K.F.1
Krssak, M.2
Inzucchi, S.3
-
51
-
-
33845400193
-
Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial
-
Mazzone T, Meyer PM, Feinstein SB, et al. Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial. JAMA. 2006;296(21):2572–2581.
-
(2006)
JAMA
, vol.296
, Issue.21
, pp. 2572-2581
-
-
Mazzone, T.1
Meyer, P.M.2
Feinstein, S.B.3
-
52
-
-
33847403059
-
A randomized trial of the effects of rosiglitazone and metformin on inflammation and subclinical atherosclerosis in patients with type 2 diabetes
-
Stocker DJ, Taylor AJ, Langley RW, et al. A randomized trial of the effects of rosiglitazone and metformin on inflammation and subclinical atherosclerosis in patients with type 2 diabetes. Am Heart J. 2007;153(3):445.e1-e6.
-
(2007)
Am Heart J
, vol.153
, Issue.3
-
-
Stocker, D.J.1
Taylor, A.J.2
Langley, R.W.3
-
53
-
-
34147158489
-
Relationship between vascular reactivity and lipids in Mexican-Americans with type 2 diabetes treated with pioglitazone
-
Wajcberg E, Sriwijitkamol A, Musi N, et al. Relationship between vascular reactivity and lipids in Mexican-Americans with type 2 diabetes treated with pioglitazone. J Clin Endocrinol Metab. 2007;92(4):1256–1262.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, Issue.4
, pp. 1256-1262
-
-
Wajcberg, E.1
Sriwijitkamol, A.2
Musi, N.3
-
54
-
-
41649084422
-
Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial
-
Nissen SE, Nicholls SJ, Wolski K, et al. Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial. JAMA. 2008;299(13):1561–1573.
-
(2008)
JAMA
, vol.299
, Issue.13
, pp. 1561-1573
-
-
Nissen, S.E.1
Nicholls, S.J.2
Wolski, K.3
-
55
-
-
21544466158
-
A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia
-
Goldberg RB, Kendall DM, Deeg MA, et al. A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia. Diabetes Care. 2005;28(7):1547–1554.
-
(2005)
Diabetes Care
, vol.28
, Issue.7
, pp. 1547-1554
-
-
Goldberg, R.B.1
Kendall, D.M.2
Deeg, M.A.3
-
56
-
-
85034005320
-
-
[cited 2017 Jan27], Available from
-
Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, 2008 Guidance for industry: diabetes mellitus — evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes. [cited 2017 Jan27]. Available from: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm071627.pdf
-
-
-
-
57
-
-
85033995022
-
-
[cited 2017 Jan27], Available from
-
European Medicine Agency, Committee for Medicinal Products for Human Use, 2010 Guideline on clinical investigation of medicinal products in the treatment of diabetes mellitus. [cited 2017 Jan27]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2010/02/WC500073570.pdf
-
-
-
-
58
-
-
34548580881
-
Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis
-
Singh S, Loke YK, Furberg CD. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA. 2007;298(10):1189–1195.
-
(2007)
JAMA
, vol.298
, Issue.10
, pp. 1189-1195
-
-
Singh, S.1
Loke, Y.K.2
Furberg, C.D.3
-
59
-
-
77955285732
-
Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
-
Nissen SE, Wolski K. Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch Intern Med. 2010;170(14):1191–1201.
-
(2010)
Arch Intern Med
, vol.170
, Issue.14
, pp. 1191-1201
-
-
Nissen, S.E.1
Wolski, K.2
-
60
-
-
26244453309
-
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
-
Dormandy JA, Charbonnel B, Eckland DJA, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet. 2005;366(9493):1279–1289.
-
(2005)
Lancet
, vol.366
, Issue.9493
, pp. 1279-1289
-
-
Dormandy, J.A.1
Charbonnel, B.2
Eckland, D.J.A.3
-
61
-
-
34548590934
-
Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials
-
Lincoff AM, Wolski K, Nicholls SJ, et al. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA. 2007;298(10):1180–1188.
-
(2007)
JAMA
, vol.298
, Issue.10
, pp. 1180-1188
-
-
Lincoff, A.M.1
Wolski, K.2
Nicholls, S.J.3
-
62
-
-
56749178443
-
Comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy
-
Winkelmayer WC, Setoguchi S, Levin R, et al. Comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy. Arch Intern Med. 2008;168(21):2368–2375.
-
(2008)
Arch Intern Med
, vol.168
, Issue.21
, pp. 2368-2375
-
-
Winkelmayer, W.C.1
Setoguchi, S.2
Levin, R.3
-
63
-
-
69949096990
-
Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study
-
Juurlink DN, Gomes T, Lipscombe LL, et al. Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study. Bmj. 2009;339(aug182):b2942–b2942.
-
(2009)
Bmj
, vol.339
, Issue.aug182
, pp. b2942
-
-
Juurlink, D.N.1
Gomes, T.2
Lipscombe, L.L.3
-
64
-
-
84962114446
-
Pioglitazone after ischemic stroke or transient ischemic attack
-
Kernan WN, Viscoli CM, Furie KL, et al. Pioglitazone after ischemic stroke or transient ischemic attack. N Engl J Med. 2016;374:1321–1331.
-
(2016)
N Engl J Med
, vol.374
, pp. 1321-1331
-
-
Kernan, W.N.1
Viscoli, C.M.2
Furie, K.L.3
-
65
-
-
35748980879
-
Pioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, independently of blood pressure
-
Nov, et al
-
Nakamura T, Yamamoto E, Kataoka K, et al. Pioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, independently of blood pressure. Stroke. 2007 Nov;38(11):3016–3022.
-
(2007)
Stroke
, vol.38
, Issue.11
, pp. 3016-3022
-
-
Nakamura, T.1
Yamamoto, E.2
Kataoka, K.3
-
66
-
-
0031027627
-
Acarbose in the treatment of type I diabetes
-
Hollander P, Pi-Sunyer X, Coniff RF. Acarbose in the treatment of type I diabetes. Diabetes Care. 1997;20(3):248–253.
-
(1997)
Diabetes Care
, vol.20
, Issue.3
, pp. 248-253
-
-
Hollander, P.1
Pi-Sunyer, X.2
Coniff, R.F.3
-
67
-
-
0033855806
-
Effect of acarbose on insulin sensitivity in elderly patients with diabetes
-
Meneilly GS, Ryan EA, Radziuk J, et al. Effect of acarbose on insulin sensitivity in elderly patients with diabetes. Diabetes Care. 2000;23(8):1162–1167.
-
(2000)
Diabetes Care
, vol.23
, Issue.8
, pp. 1162-1167
-
-
Meneilly, G.S.1
Ryan, E.A.2
Radziuk, J.3
-
68
-
-
0033046464
-
A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44)
-
Holman RR, Cull CA, Turner RC. A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44). Diabetes Care. 1999;22(6):960–964.
-
(1999)
Diabetes Care
, vol.22
, Issue.6
, pp. 960-964
-
-
Holman, R.R.1
Cull, C.A.2
Turner, R.C.3
-
69
-
-
0031460261
-
Efficacy of 24-week monotherapy with acarbose, metformin, or placebo in dietary-treated NIDDM patients: the Essen-II Study
-
Hoffmann J, Spengler M. Efficacy of 24-week monotherapy with acarbose, metformin, or placebo in dietary-treated NIDDM patients: the Essen-II Study. Am J Med. 1997;103(6):483–490.
-
(1997)
Am J Med
, vol.103
, Issue.6
, pp. 483-490
-
-
Hoffmann, J.1
Spengler, M.2
-
70
-
-
0038455703
-
Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial
-
Chiasson J-L, Josse RG, Gomis R, et al. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA. 2003;290(4):486–494.
-
(2003)
JAMA
, vol.290
, Issue.4
, pp. 486-494
-
-
Chiasson, J.-L.1
Josse, R.G.2
Gomis, R.3
-
71
-
-
11844294865
-
Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis
-
Van De Laar FA, Lucassen PL, Akkermans RP, et al. Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis. Diabetes Care. 2005;28(1):154–163.
-
(2005)
Diabetes Care
, vol.28
, Issue.1
, pp. 154-163
-
-
Van De Laar, F.A.1
Lucassen, P.L.2
Akkermans, R.P.3
-
72
-
-
84929992530
-
Switching α-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients
-
Hariya N, Mochizuki K, Inoue S, et al. Switching α-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients. Drugs R D. 2014;14(3):177–184.
-
(2014)
Drugs R D
, vol.14
, Issue.3
, pp. 177-184
-
-
Hariya, N.1
Mochizuki, K.2
Inoue, S.3
-
73
-
-
0031892659
-
Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes
-
Fuhlendorff J, Rorsman P, Kofod H, et al. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes. 1998;47(3):345–351.
-
(1998)
Diabetes
, vol.47
, Issue.3
, pp. 345-351
-
-
Fuhlendorff, J.1
Rorsman, P.2
Kofod, H.3
-
74
-
-
0038060676
-
Comparison of glycaemic control and cardiovascular risk profile in patients with type 2 diabetes during treatment with either repaglinide or metformin
-
Derosa G, Mugellini A, Ciccarelli L, et al. Comparison of glycaemic control and cardiovascular risk profile in patients with type 2 diabetes during treatment with either repaglinide or metformin. Diabetes Res Clin Pract. 2003;60(3):161–169.
-
(2003)
Diabetes Res Clin Pract
, vol.60
, Issue.3
, pp. 161-169
-
-
Derosa, G.1
Mugellini, A.2
Ciccarelli, L.3
-
75
-
-
77951473452
-
Effect of nateglinide on the incidence of diabetes and cardiovascular events
-
NAVIGATOR Study Group, Holman RR, Haffner SM, et al. Effect of nateglinide on the incidence of diabetes and cardiovascular events. N Engl J Med. 2010;362(16):1463–1476.
-
(2010)
N Engl J Med
, vol.362
, Issue.16
, pp. 1463-1476
-
-
Holman, R.R.1
Haffner, S.M.2
-
76
-
-
58149090676
-
The role of incretins in glucose homeostasis and diabetes treatment
-
Kim W, Egan J. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev. 2008;60:470–512.
-
(2008)
Pharmacol Rev
, vol.60
, pp. 470-512
-
-
Kim, W.1
Egan, J.2
-
78
-
-
79952694840
-
Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes
-
Ratner R, Han J, Nicewarner D, et al. Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes. Cardiovasc Diabetol. 2011;10:22.
-
(2011)
Cardiovasc Diabetol
, vol.10
, pp. 22
-
-
Ratner, R.1
Han, J.2
Nicewarner, D.3
-
79
-
-
84978839381
-
Liraglutide and cardiovascular outcomes in type 2 diabetes
-
Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375(4):311–322.
-
(2016)
N Engl J Med
, vol.375
, Issue.4
, pp. 311-322
-
-
Marso, S.P.1
Daniels, G.H.2
Brown-Frandsen, K.3
-
80
-
-
84994813253
-
Semaglutide and cardiovascular outcomes in patients with type 2 diabetes
-
Marso SP, Bain SC, Consoli A, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375:1834–1844.
-
(2016)
N Engl J Med
, vol.375
, pp. 1834-1844
-
-
Marso, S.P.1
Bain, S.C.2
Consoli, A.3
-
81
-
-
84880688845
-
GLP-1 receptor agonists: effects on cardiovascular risk reduction
-
Lorber D. GLP-1 receptor agonists: effects on cardiovascular risk reduction. Cardiovasc Ther. 2013;31:238–249.
-
(2013)
Cardiovasc Ther
, vol.31
, pp. 238-249
-
-
Lorber, D.1
-
82
-
-
33846006173
-
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
-
Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368:1696–1770.
-
(2006)
Lancet
, vol.368
, pp. 1696-1770
-
-
Drucker, D.J.1
Nauck, M.A.2
-
83
-
-
84860807487
-
Exenatide reduces final infarct size in patients with ST-segment-elevation myocardial infarction and short-duration of ischemia
-
Lonborg J, Kelbæk H, Vejlstrup N, et al. Exenatide reduces final infarct size in patients with ST-segment-elevation myocardial infarction and short-duration of ischemia. Circ Cardiovasc Interv. 2012;5:288–295.
-
(2012)
Circ Cardiovasc Interv
, vol.5
, pp. 288-295
-
-
Lonborg, J.1
Kelbæk, H.2
Vejlstrup, N.3
-
84
-
-
84862521094
-
Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety
-
Nathanson D, Ullman B, Lofstrom U, et al. Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety. Diabetologia. 2012;55:926–935.
-
(2012)
Diabetologia
, vol.55
, pp. 926-935
-
-
Nathanson, D.1
Ullman, B.2
Lofstrom, U.3
-
85
-
-
84890536384
-
Effect of GLP-1 mimetics on blood pressure and relationship to weight loss and glycemia lowering: results of a systematic meta-analysis and meta-regression
-
Katout M, Zhu H, Rutsky J, et al. Effect of GLP-1 mimetics on blood pressure and relationship to weight loss and glycemia lowering: results of a systematic meta-analysis and meta-regression. Am J Hypertens. 2014;27:130–139.
-
(2014)
Am J Hypertens
, vol.27
, pp. 130-139
-
-
Katout, M.1
Zhu, H.2
Rutsky, J.3
-
86
-
-
84920855422
-
Effect of glucagonlike peptide-1 receptor agonists on lipid profiles among type 2 diabetes: a systematic review and network meta-analysis
-
Sun F, Wu S, Wang J, et al. Effect of glucagonlike peptide-1 receptor agonists on lipid profiles among type 2 diabetes: a systematic review and network meta-analysis. Clin Ther. 2015;37:225–241.
-
(2015)
Clin Ther
, vol.37
, pp. 225-241
-
-
Sun, F.1
Wu, S.2
Wang, J.3
-
87
-
-
84948740668
-
Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
-
Pfeffer MA, Claggett B, Diaz R, et al. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med. 2015;373:2247–2257.
-
(2015)
N Engl J Med
, vol.373
, pp. 2247-2257
-
-
Pfeffer, M.A.1
Claggett, B.2
Diaz, R.3
-
88
-
-
85011655558
-
Lessons from a cardiovascular outcome trial with liraglutide in type 2 diabetes
-
Dec, [Epub ahead of print
-
Kim HJ, Kim DJ. Lessons from a cardiovascular outcome trial with liraglutide in type 2 diabetes. J Diabetes Investig. 2016 Dec 8 [Epub ahead of print]. DOI:10.1111/jdi.12607.
-
(2016)
J Diabetes Investig
-
-
Kim, H.J.1
Kim, D.J.2
-
89
-
-
84926433000
-
Cardiovascular effects of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes
-
Koska J, Sands M, Burciu C, et al. Cardiovascular effects of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes. Diab Vasc Dis Res. 2015;12:154–163.
-
(2015)
Diab Vasc Dis Res
, vol.12
, pp. 154-163
-
-
Koska, J.1
Sands, M.2
Burciu, C.3
-
90
-
-
84875054251
-
Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors
-
Barbieri M, Rizzo MR, Marfella R, et al. Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors. Atherosclerosis. 2013;227:349–354.
-
(2013)
Atherosclerosis
, vol.227
, pp. 349-354
-
-
Barbieri, M.1
Rizzo, M.R.2
Marfella, R.3
-
91
-
-
84857903646
-
DPP-4 inhibitors and lipids: systematic review and meta-analysis
-
Monami M, Lamanna C, Desideri CM, et al. DPP-4 inhibitors and lipids: systematic review and meta-analysis. Adv Ther. 2012;29:14–25.
-
(2012)
Adv Ther
, vol.29
, pp. 14-25
-
-
Monami, M.1
Lamanna, C.2
Desideri, C.M.3
-
92
-
-
84883765959
-
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
-
Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. 2013;369:1317–1326.
-
(2013)
N Engl J Med
, vol.369
, pp. 1317-1326
-
-
Scirica, B.M.1
Bhatt, D.L.2
Braunwald, E.3
-
93
-
-
84883745765
-
Alogliptin after acute coronary syndrome in patients with type 2 diabetes
-
White WB, Cannon CP, Heller SR, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med. 2013;369:1327–1335.
-
(2013)
N Engl J Med
, vol.369
, pp. 1327-1335
-
-
White, W.B.1
Cannon, C.P.2
Heller, S.R.3
-
94
-
-
84926477579
-
Cardiovascular outcomes with alogliptin in patients with type 2 diabetes mellitus and recent acute coronary syndromes
-
Sep, Barcelona, Spain:. In:,. Diabetologia. 2013 Sep;56 Suppl 1:1–566
-
White WB. Cardiovascular outcomes with alogliptin in patients with type 2 diabetes mellitus and recent acute coronary syndromes. In: Presented at European Association for the Study of Diabetes; 2013 Sep 23–27; Barcelona, Spain. Diabetologia. 2013 Sep;56 Suppl 1:1–566.
-
(2013)
Presented at European Association for the Study of Diabetes
-
-
White, W.B.1
-
95
-
-
84937053742
-
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
-
Green JB, Bethel MA, Armstrong PW, et al. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2015;373:232–242.
-
(2015)
N Engl J Med
, vol.373
, pp. 232-242
-
-
Green, J.B.1
Bethel, M.A.2
Armstrong, P.W.3
-
96
-
-
84931264841
-
Cardiovascular safety of linagliptin in type 2 diabetes: a comprehensive patient-level pooled analysis of prospectively adjudicated cardiovascular events
-
Rosenstock J, Marx N, Neubacher D, et al. Cardiovascular safety of linagliptin in type 2 diabetes: a comprehensive patient-level pooled analysis of prospectively adjudicated cardiovascular events. Cardiovasc Diabetol. 2015;14:57.
-
(2015)
Cardiovasc Diabetol
, vol.14
, pp. 57
-
-
Rosenstock, J.1
Marx, N.2
Neubacher, D.3
-
97
-
-
84962323033
-
A multicenter observational study of incretin-based drugs and heart failure
-
Filion KB, Azoulay L, Platt RW, et al. A multicenter observational study of incretin-based drugs and heart failure. N Engl J Med. 2016;374:1145–1154.
-
(2016)
N Engl J Med
, vol.374
, pp. 1145-1154
-
-
Filion, K.B.1
Azoulay, L.2
Platt, R.W.3
-
98
-
-
84962810190
-
Effect of dipeptidyl peptidase-4 inhibitors on heart failure: a meta-analysis of randomized clinical trials
-
May, et al
-
Kongwatcharapong J, Dilokthornsakul P, Nathisuwan S, et al. Effect of dipeptidyl peptidase-4 inhibitors on heart failure: a meta-analysis of randomized clinical trials. Int J Cardiol. 2016 May 15;211:88–95.
-
(2016)
Int J Cardiol
, vol.211
, pp. 88-95
-
-
Kongwatcharapong, J.1
Dilokthornsakul, P.2
Nathisuwan, S.3
-
99
-
-
85034011633
-
-
[cited 2017 May20], Available from
-
Diabetes Medications Containing Saxagliptin and Alogliptin: Drug Safety Communication - Risk of Heart Failure. [cited 2017 May20]. Available from: https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm494252.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery
-
-
-
-
100
-
-
84923448295
-
SGLT-2 inhibitors and cardiovascular risk: proposed pathways and review of ongoing outcome trials
-
Inzucchi SE, Zinman B, Wanner C, et al. SGLT-2 inhibitors and cardiovascular risk: proposed pathways and review of ongoing outcome trials. Diab Vasc Dis Res. 2015;12:90–110.
-
(2015)
Diab Vasc Dis Res
, vol.12
, pp. 90-110
-
-
Inzucchi, S.E.1
Zinman, B.2
Wanner, C.3
-
101
-
-
84910055228
-
Cardiovascular impact of drugs used in the treatment of diabetes
-
Triggle CR, Ding H. Cardiovascular impact of drugs used in the treatment of diabetes. Ther Adv Chronic Dis. 2014;5(6):245–268.
-
(2014)
Ther Adv Chronic Dis
, vol.5
, Issue.6
, pp. 245-268
-
-
Triggle, C.R.1
Ding, H.2
-
103
-
-
84898854471
-
Effects of sodium- glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis
-
Baker WL, Smyth LR, Riche DM, et al. Effects of sodium- glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis. J Am Soc Hypertens. 2014;8:262–275.
-
(2014)
J Am Soc Hypertens
, vol.8
, pp. 262-275
-
-
Baker, W.L.1
Smyth, L.R.2
Riche, D.M.3
-
104
-
-
84901198078
-
Blood pressure effects of sodium-glucose co-transport 2 (SGLT2) inhibitors
-
Oliva RV, Bakris GL. Blood pressure effects of sodium-glucose co-transport 2 (SGLT2) inhibitors. J Am Soc Hypertens. 2014;8:330–333.
-
(2014)
J Am Soc Hypertens
, vol.8
, pp. 330-333
-
-
Oliva, R.V.1
Bakris, G.L.2
-
105
-
-
84964240560
-
Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetes
-
Bode B, Stenlöf K, Harris S, et al. Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetes. Diabetes Obes Metab. 2015;17:294–303.
-
(2015)
Diabetes Obes Metab
, vol.17
, pp. 294-303
-
-
Bode, B.1
Stenlöf, K.2
Harris, S.3
-
106
-
-
84944800184
-
Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
-
Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117–2128.
-
(2015)
N Engl J Med
, vol.373
, pp. 2117-2128
-
-
Zinman, B.1
Wanner, C.2
Lachin, J.M.3
-
107
-
-
85021849793
-
Canagliflozin slows progression of renal function decline independently of glycemic effects
-
Heerspink HJ, Desai M, Jardine M, et al. Canagliflozin slows progression of renal function decline independently of glycemic effects. J Am Soc Nephrol. 2016. DOI:10.1681/ASN.2016030278.
-
(2016)
J Am Soc Nephrol
-
-
Heerspink, H.J.1
Desai, M.2
Jardine, M.3
-
108
-
-
84979895487
-
Empagliflozin and progression of kidney disease in type 2 diabetes
-
Wanner SE, Inzucchi JM, Lachin D, et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med. 2016;375:323–334.
-
(2016)
N Engl J Med
, vol.375
, pp. 323-334
-
-
Wanner, S.E.1
Inzucchi, J.M.2
Lachin, D.3
-
111
-
-
85034008094
-
-
Cardiovascular Outcomes Following Treatment With Ertugliflozin in Participants With Type 2 Diabetes Mellitus and Established Vascular Disease (clinicaltrials.gov identifier: NCT01986881).
-
(clinicaltrials.gov identifier: NCT01986881)
-
-
-
112
-
-
85033975473
-
Lower rates of hospitalization for heart failure and all-cause death in new users of sglt-2 inhibitors versus other glucose lowering drugs–real world data from six countries and more than 300,000 patients: the cvd-real study
-
Mar, [cited 2017 May20], Washington (DC): Available from:, et al,. In
-
Kosiborod M, Cavender M, Norhammar A, et al. Lower rates of hospitalization for heart failure and all-cause death in new users of sglt-2 inhibitors versus other glucose lowering drugs–real world data from six countries and more than 300,000 patients: the cvd-real study. In: Presented at American College of Cardiology Scientific Sessions; 2017 Mar [cited 2017 May20]; Washington (DC). Available from: https://www.acc.org/latest-in-cardiology/articles/2017/03/13/17/58/sun-2pm-cvd-real-study-lower-rates-of-hospitalization-for-hf-in-new-users-of-sglt-2-inhibitors-vs-other-glucose-lowering-drugs-acc-2017#sthash.ZrcVp77F.dpuf
-
(2017)
Presented at American College of Cardiology Scientific Sessions
-
-
Kosiborod, M.1
Cavender, M.2
Norhammar, A.3
|