메뉴 건너뛰기




Volumn 8, Issue 1, 2017, Pages

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

(34)  Medina Gomez, Carolina a   Kemp, John P b,c   Dimou, Niki L d,e   Kreiner, Eskil f   Chesi, Alessandra g   Zemel, Babette S g,h   Bønnelykke, Klaus f   Boer, Cindy G a   Ahluwalia, Tarunveer S f,i   Bisgaard, Hans f   Evangelou, Evangelos e,j   Heppe, Denise H M a   Bonewald, Lynda F k   Gorski, Jeffrey P l   Ghanbari, Mohsen a,m   Demissie, Serkalem n   Duque, Gustavo o   Maurano, Matthew T p   Kiel, Douglas P q,r,s   Hsu, Yi Hsiang q,s,t   more..


Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; WNT4 PROTEIN; CARRIER PROTEIN; SREBF1 PROTEIN, HUMAN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TOM1L2 PROTEIN, HUMAN;

EID: 85026221320     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-00108-3     Document Type: Article
Times cited : (72)

References (70)
  • 1
    • 70350219260 scopus 로고    scopus 로고
    • Is bone's response to mechanical signals dominated by muscle forces? Med
    • Robling, A. G. Is bone's response to mechanical signals dominated by muscle forces? Med. Sci. Sports. Exerc. 41, 2044-9 (2009).
    • (2009) Sci. Sports. Exerc. , vol.41 , pp. 2044-2049
    • Robling, A.G.1
  • 2
    • 1642440307 scopus 로고    scopus 로고
    • Relationship between soft tissue body composition and bone mass in perimenopausal women
    • Li, S. L., Wagner, R., Holm, K., Lehotsky, J. & Zinaman, M. J. Relationship between soft tissue body composition and bone mass in perimenopausal women. Maturitas 47, 99-105 (2004).
    • (2004) Maturitas , vol.47 , pp. 99-105
    • Li, S.L.1    Wagner, R.2    Holm, K.3    Lehotsky, J.4    Zinaman, M.J.5
  • 3
    • 84923444746 scopus 로고    scopus 로고
    • Lean mass as a total mediator of the influence of muscular fitness on bone health in schoolchildren: A mediation analysis
    • Torres-Costoso, A. et al. Lean mass as a total mediator of the influence of muscular fitness on bone health in schoolchildren: a mediation analysis. J. Sports. Sci. 33, 817-30 (2015).
    • (2015) J. Sports. Sci. , vol.33 , pp. 817-830
    • Torres-Costoso, A.1
  • 4
    • 0036828894 scopus 로고    scopus 로고
    • Association between bone mineral density (DXA), body structure, and body composition in middle-aged men
    • Van Langendonck, L. et al. Association between bone mineral density (DXA), body structure, and body composition in middle-aged men. Am. J. Hum. Biol. 14, 735-42 (2002).
    • (2002) Am. J. Hum. Biol. , vol.14 , pp. 735-742
    • Van Langendonck, L.1
  • 5
    • 84960407567 scopus 로고    scopus 로고
    • Bone and muscle endocrine functions: Unexpected paradigms of inter-organ communication
    • Karsenty, G. & Olson, E. N. Bone and muscle endocrine functions: unexpected paradigms of inter-organ communication. Cell 164, 1248-56 (2016).
    • (2016) Cell , vol.164 , pp. 1248-1256
    • Karsenty, G.1    Olson, E.N.2
  • 6
    • 84943605262 scopus 로고    scopus 로고
    • Bone and muscle: Interactions beyond mechanical
    • Brotto, M. & Bonewald, L. Bone and muscle: interactions beyond mechanical. Bone 80, 109-14 (2015).
    • (2015) Bone , vol.80 , pp. 109-114
    • Brotto, M.1    Bonewald, L.2
  • 7
    • 84896702143 scopus 로고    scopus 로고
    • Muscle-bone interactions: Basic and clinical aspects
    • Cianferotti, L. & Brandi, M. L. Muscle-bone interactions: basic and clinical aspects. Endocrine. 45, 165-177 (2014).
    • (2014) Endocrine. , vol.45 , pp. 165-177
    • Cianferotti, L.1    Brandi, M.L.2
  • 8
    • 44449177084 scopus 로고    scopus 로고
    • Genetics of the musculoskeletal system: A pleiotropic approach
    • Karasik, D. & Kiel, D. P. Genetics of the musculoskeletal system: a pleiotropic approach. J. Bone. Miner. Res. 23, 788-802 (2008).
    • (2008) J. Bone. Miner. Res. , vol.23 , pp. 788-802
    • Karasik, D.1    Kiel, D.P.2
  • 9
    • 37149055387 scopus 로고    scopus 로고
    • Dual-energy X-ray absorptiometry is a valid tool for assessing skeletal muscle mass in older women
    • Chen, Z. et al. Dual-energy X-ray absorptiometry is a valid tool for assessing skeletal muscle mass in older women. J. Nutr. 137, 2775-80 (2007).
    • (2007) J. Nutr. , vol.137 , pp. 2775-2780
    • Chen, Z.1
  • 10
    • 70350306731 scopus 로고    scopus 로고
    • Prediction of appendicular skeletal and fat mass in children: Excellent concordance of dual-energy X-ray absorptiometry and magnetic resonance imaging
    • Bridge, P. et al. Prediction of appendicular skeletal and fat mass in children: excellent concordance of dual-energy X-ray absorptiometry and magnetic resonance imaging. J. Pediatr. Endocrinol. Metab. 22, 795-804 (2009).
    • (2009) J. Pediatr. Endocrinol. Metab. , vol.22 , pp. 795-804
    • Bridge, P.1
  • 12
    • 43249106445 scopus 로고    scopus 로고
    • Heritability of body size and muscle strength in young adulthood: A study of one million Swedish men
    • Silventoinen, K., Magnusson, P. K. E., Tynelius, P., Kaprio, J. & Rasmussen, F. Heritability of body size and muscle strength in young adulthood: a study of one million Swedish men. Genet. Epidemiol. 32, 341-349 (2008).
    • (2008) Genet. Epidemiol. , vol.32 , pp. 341-349
    • Silventoinen, K.1    Magnusson, P.K.E.2    Tynelius, P.3    Kaprio, J.4    Rasmussen, F.5
  • 13
    • 0030819269 scopus 로고    scopus 로고
    • Genetic influences on muscle strength, lean body mass, and bone mineral density: A twin study
    • Arden, N. K. & Spector, T. D. Genetic influences on muscle strength, lean body mass, and bone mineral density: a twin study. J. Bone. Miner. Res. 12, 2076-81 (1997).
    • (1997) J. Bone. Miner. Res. , vol.12 , pp. 2076-2081
    • Arden, N.K.1    Spector, T.D.2
  • 14
    • 84954480685 scopus 로고    scopus 로고
    • Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures
    • Styrkarsdottir, U. et al. Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures. Nat. Commun. 7, 10129 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 10129
    • Styrkarsdottir, U.1
  • 15
    • 84943191109 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
    • Zheng, H. F. et al. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature. 526, 112-7 (2015).
    • (2015) Nature. , vol.526 , pp. 112-117
    • Zheng, H.F.1
  • 16
    • 70350646912 scopus 로고    scopus 로고
    • Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    • Rivadeneira, F. et al. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat. Genet. 41, 1199-206 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1199-1206
    • Rivadeneira, F.1
  • 17
    • 84863897868 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
    • Medina-Gomez, C. et al. Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genet. 8, e1002718 (2012).
    • (2012) PLoS Genet. , vol.8 , pp. e1002718
    • Medina-Gomez, C.1
  • 18
    • 43049181624 scopus 로고    scopus 로고
    • Bone mineral density, osteoporosis, and osteoporotic fractures: A genome-wide association study
    • Richards, J. B. et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 371, 1505-12 (2008).
    • (2008) Lancet , vol.371 , pp. 1505-1512
    • Richards, J.B.1
  • 19
    • 84903486426 scopus 로고    scopus 로고
    • Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment
    • Kemp, J. P. et al. Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. PLoS Genet. 10, e1004423 (2014).
    • (2014) PLoS Genet. , vol.10 , pp. e1004423
    • Kemp, J.P.1
  • 20
    • 84860331458 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    • Estrada, K. et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat. Genet. 44, 491-501 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 491-501
    • Estrada, K.1
  • 21
    • 84873948030 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women
    • Koller, D. L. et al. Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women. J. Bone. Miner. Res. 28, 547-58 (2013).
    • (2013) J. Bone. Miner. Res. , vol.28 , pp. 547-558
    • Koller, D.L.1
  • 22
    • 84863888921 scopus 로고    scopus 로고
    • WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk
    • Zheng, H. F. et al. WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet. 8, e1002745 (2012).
    • (2012) PLoS Genet. , vol.8 , pp. e1002745
    • Zheng, H.F.1
  • 23
    • 79955578829 scopus 로고    scopus 로고
    • Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk
    • Duncan, E. L. et al. Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet. 7, e1001372 (2011).
    • (2011) PLoS Genet. , vol.7 , pp. e1001372
    • Duncan, E.L.1
  • 24
    • 84878143904 scopus 로고    scopus 로고
    • Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits
    • Styrkarsdottir, U. et al. Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits. Nature 497, 517-20 (2013).
    • (2013) Nature , vol.497 , pp. 517-520
    • Styrkarsdottir, U.1
  • 25
    • 84957438660 scopus 로고    scopus 로고
    • Two rare mutations in the COL1A2 gene associate with low bone mineral density and fractures in Iceland
    • Styrkarsdottir, U. et al. Two rare mutations in the COL1A2 gene associate with low bone mineral density and fractures in Iceland. J. Bone. Miner. Res. 31, 173-9 (2016).
    • (2016) J. Bone. Miner. Res. , vol.31 , pp. 173-179
    • Styrkarsdottir, U.1
  • 26
    • 84897861546 scopus 로고    scopus 로고
    • Multistage genome-wide association meta-analyses identified two new loci for bone mineral density
    • Zhang, L. et al. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum. Mol. Genet. 23, 1923-33 (2014).
    • (2014) Hum. Mol. Genet. , vol.23 , pp. 1923-1933
    • Zhang, L.1
  • 27
    • 85026271792 scopus 로고    scopus 로고
    • Large meta-analysis of genome wide association studies identifies five loci for lean body mass
    • Zillikens, M. C. et al. Large meta-analysis of genome wide association studies identifies five loci for lean body mass. Nat. Commun. (in the press).
    • Nat. Commun. (In the Press
    • Zillikens, M.C.1
  • 28
    • 78650950793 scopus 로고    scopus 로고
    • An investigation into the relationship between soft tissue body composition and bone mineral density in a young adult twin sample
    • Bogl, L. H. et al. An investigation into the relationship between soft tissue body composition and bone mineral density in a young adult twin sample. J. Bone Miner. Res. 26, 79-87 (2011).
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 79-87
    • Bogl, L.H.1
  • 30
    • 84929001104 scopus 로고    scopus 로고
    • Human genomics. The genotype-tissue expression (GTEx) pilot analysis: Multitissue gene regulation in humans
    • Consortium, G. T. Human genomics. The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348, 648-60 (2015).
    • (2015) Science , vol.348 , pp. 648-660
    • Consortium, G.T.1
  • 31
    • 84874766536 scopus 로고    scopus 로고
    • Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study
    • Guo, Y. F. et al. Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study. Hum. Genet. 132, 189-99 (2013).
    • (2013) Hum. Genet. , vol.132 , pp. 189-199
    • Guo, Y.F.1
  • 32
    • 39749096552 scopus 로고    scopus 로고
    • Bivariate whole genome linkage analyses for total body lean mass and BMD
    • Wang, X. L. et al. Bivariate whole genome linkage analyses for total body lean mass and BMD. J. Bone Miner. Res. 23, 447-52 (2008).
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 447-452
    • Wang, X.L.1
  • 33
    • 79959841853 scopus 로고    scopus 로고
    • Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease
    • Do, C. B. et al. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet. 7, e1002141 (2011).
    • (2011) PLoS Genet. , vol.7 , pp. e1002141
    • Do, C.B.1
  • 34
    • 84982091074 scopus 로고    scopus 로고
    • MIR-33-5p, a novel mechano-sensitive microRNA promotes osteoblast differentiation by targeting Hmga2
    • Wang, H. et al. MIR-33-5p, a novel mechano-sensitive microRNA promotes osteoblast differentiation by targeting Hmga2. Sci. Rep. 6, 23170 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 23170
    • Wang, H.1
  • 35
    • 78751567960 scopus 로고    scopus 로고
    • Dysregulation and cellular mislocalization of specific MIRNAs in myotonic dystrophy type 1
    • Perbellini, R. et al. Dysregulation and cellular mislocalization of specific MIRNAs in myotonic dystrophy type 1. Neuromusc. Disord. 21, 81-88 (2011).
    • (2011) Neuromusc. Disord. , vol.21 , pp. 81-88
    • Perbellini, R.1
  • 36
    • 79955016827 scopus 로고    scopus 로고
    • MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
    • Eskildsen, T. et al. MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo. Proc. Natl Acad. Sci. USA 108, 6139-44 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 6139-6144
    • Eskildsen, T.1
  • 37
    • 84936985198 scopus 로고    scopus 로고
    • MIR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1
    • Xu, J., Li, L., Yun, H. F. & Han, Y. S. MIR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1. Biochem. Biophys. Res. Commun. 463, 1159-1164 (2015).
    • (2015) Biochem. Biophys. Res. Commun. , vol.463 , pp. 1159-1164
    • Xu, J.1    Li, L.2    Yun, H.F.3    Han, Y.S.4
  • 38
    • 79957938660 scopus 로고    scopus 로고
    • Expression of MIR-1, MIR-133a, MIR-133b and MIR-206 increases during development of human skeletal muscle
    • Koutsoulidou, A., Mastroyiannopoulos, N. P., Furling, D., Uney, J. B. & Phylactou, L. A. Expression of MIR-1, MIR-133a, MIR-133b and MIR-206 increases during development of human skeletal muscle. BMC Dev. Biol. 11, 34 (2011).
    • (2011) BMC Dev. Biol. , vol.11 , pp. 34
    • Koutsoulidou, A.1    Mastroyiannopoulos, N.P.2    Furling, D.3    Uney, J.B.4    Phylactou, L.A.5
  • 39
    • 84885018609 scopus 로고    scopus 로고
    • Systematic identification of trans eQTLs as putative drivers of known disease associations
    • Westra, H. J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238-U195 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. U195-U1238
    • Westra, H.J.1
  • 40
    • 84961927084 scopus 로고    scopus 로고
    • Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
    • Zhu, Z. et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat. Genet. 48, 481-7 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 481-487
    • Zhu, Z.1
  • 41
    • 84870604901 scopus 로고    scopus 로고
    • SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors
    • Dessalle, K. et al. SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors. PLoS ONE 7, e50878 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e50878
    • Dessalle, K.1
  • 42
    • 78751480189 scopus 로고    scopus 로고
    • Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization
    • Gorski, J. P. et al. Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization. J. Biol. Chem. 286, 1836-49 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 1836-1849
    • Gorski, J.P.1
  • 43
    • 76749161934 scopus 로고    scopus 로고
    • A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation
    • Lecomte, V. et al. A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation. Mol. Cell Biol. 30, 1182-98 (2010).
    • (2010) Mol. Cell Biol. , vol.30 , pp. 1182-1198
    • Lecomte, V.1
  • 44
    • 0036537888 scopus 로고    scopus 로고
    • A novel interaction between lamin A and SREBP1: Implications for partial lipodystrophy and other laminopathies
    • Lloyd, D. J., Trembath, R. C. & Shackleton, S. A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. Hum. Mol. Genet. 11, 769-77 (2002).
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 769-777
    • Lloyd, D.J.1    Trembath, R.C.2    Shackleton, S.3
  • 45
    • 77953787211 scopus 로고    scopus 로고
    • MIR-33 contributes to the regulation of cholesterol homeostasis
    • Rayner, K. J. et al. MIR-33 contributes to the regulation of cholesterol homeostasis. Science 328, 1570-3 (2010).
    • (2010) Science , vol.328 , pp. 1570-1573
    • Rayner, K.J.1
  • 46
    • 84978682985 scopus 로고    scopus 로고
    • Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank
    • Muñoz, M. et al. Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank. Nat. Genet. 48, 980-983 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 980-983
    • Muñoz, M.1
  • 47
    • 84878502589 scopus 로고    scopus 로고
    • Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits
    • Zaitlen, N. et al. Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. PLoS Genet. 9, e1003520 (2013).
    • (2013) PLoS Genet. , vol.9 , pp. e1003520
    • Zaitlen, N.1
  • 48
    • 84903288901 scopus 로고    scopus 로고
    • High-resolution genome screen for bone mineral density in heterogeneous stock rat
    • Alam, I. et al. High-resolution genome screen for bone mineral density in heterogeneous stock rat. J. Bone Miner. Res. 29, 1619-26 (2014).
    • (2014) J. Bone Miner. Res. , vol.29 , pp. 1619-1626
    • Alam, I.1
  • 49
    • 17744388353 scopus 로고    scopus 로고
    • Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome
    • Bi, W. et al. Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome. Hum. Mol. Genet. 14, 983-95 (2005).
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 983-995
    • Bi, W.1
  • 51
    • 84861095603 scopus 로고    scopus 로고
    • Topological domains in mammalian genomes identified by analysis of chromatin interactions
    • Dixon, J. R. et al. Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature 485, 376-80 (2012).
    • (2012) Nature , vol.485 , pp. 376-380
    • Dixon, J.R.1
  • 52
    • 42449119665 scopus 로고    scopus 로고
    • Tom1l2 hypomorphic mice exhibit increased incidence of infections and tumors and abnormal immunologic response
    • Girirajan, S. et al. Tom1l2 hypomorphic mice exhibit increased incidence of infections and tumors and abnormal immunologic response. Mamm. Genome 19, 246-62 (2008).
    • (2008) Mamm. Genome , vol.19 , pp. 246-262
    • Girirajan, S.1
  • 53
    • 0028225462 scopus 로고
    • SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
    • Wang, X., Sato, R., Brown, M. S., Hua, X. & Goldstein, J. L. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77, 53-62 (1994).
    • (1994) Cell , vol.77 , pp. 53-62
    • Wang, X.1    Sato, R.2    Brown, M.S.3    Hua, X.4    Goldstein, J.L.5
  • 54
    • 84888587567 scopus 로고    scopus 로고
    • Estimation and partition of heritability in human populations using wholegenome analysis methods
    • Vinkhuyzen, A. A., Wray, N. R., Yang, J., Goddard, M. E. & Visscher, P. M. Estimation and partition of heritability in human populations using wholegenome analysis methods. Annu. Rev. Genet. 47, 75-95 (2013).
    • (2013) Annu. Rev. Genet. , vol.47 , pp. 75-95
    • Vinkhuyzen, A.A.1    Wray, N.R.2    Yang, J.3    Goddard, M.E.4    Visscher, P.M.5
  • 55
    • 84867284056 scopus 로고    scopus 로고
    • Estimation of pleiotropy between complex diseases using single-nucleotide polymorphismderived genomic relationships and restricted maximum likelihood
    • Lee, S. H., Yang, J., Goddard, M. E., Visscher, P. M. & Wray, N. R. Estimation of pleiotropy between complex diseases using single-nucleotide polymorphismderived genomic relationships and restricted maximum likelihood. Bioinformatics. 28, 2540-2 (2012).
    • (2012) Bioinformatics. , vol.28 , pp. 2540-2542
    • Lee, S.H.1    Yang, J.2    Goddard, M.E.3    Visscher, P.M.4    Wray, N.R.5
  • 56
    • 84863981000 scopus 로고    scopus 로고
    • Estimating kinship in admixed populations
    • Thornton, T. et al. Estimating kinship in admixed populations. Am. J. Hum. Genet. 91, 122-38 (2012).
    • (2012) Am. J. Hum. Genet. , vol.91 , pp. 122-138
    • Thornton, T.1
  • 57
    • 85000692305 scopus 로고    scopus 로고
    • An atlas of genetic correlations across human diseases and traits
    • Bulik-Sullivan, B. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236-41 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 1236-1241
    • Bulik-Sullivan, B.1
  • 58
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-75 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1
  • 60
    • 84956920246 scopus 로고    scopus 로고
    • Estimating within-study covariances in multivariate meta-analysis with multiple outcomes
    • Wei, Y. & Higgins, J. P. Estimating within-study covariances in multivariate meta-analysis with multiple outcomes. Stat. Med. (2012).
    • (2012) Stat. Med.
    • Wei, Y.1    Higgins, J.P.2
  • 61
    • 68149160854 scopus 로고    scopus 로고
    • Multivariate random-effects meta-analysis
    • White, I. R. Multivariate random-effects meta-analysis. Stata J. 9, 40-56 (2009).
    • (2009) Stata J. , vol.9 , pp. 40-56
    • White, I.R.1
  • 62
    • 84928985369 scopus 로고    scopus 로고
    • EasyStrata: Evaluation and visualization of stratified genome-wide association meta-analysis data
    • Winkler, T. W. et al. EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data. Bioinformatics 31, 259-61 (2015).
    • (2015) Bioinformatics , vol.31 , pp. 259-261
    • Winkler, T.W.1
  • 63
    • 84858779229 scopus 로고    scopus 로고
    • HaploReg: A resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
    • Ward, L. D. & Kellis, M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 40, D930-4 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. D930-D934
    • Ward, L.D.1    Kellis, M.2
  • 64
    • 84891790401 scopus 로고    scopus 로고
    • The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
    • Welter, D. et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 42, D1001-6 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. D1001-D1006
    • Welter, D.1
  • 65
    • 84857691987 scopus 로고    scopus 로고
    • Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis
    • Gong, J. et al. Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Hum. Mutat. 33, 254-63 (2012).
    • (2012) Hum. Mutat. , vol.33 , pp. 254-263
    • Gong, J.1
  • 66
    • 84891770518 scopus 로고    scopus 로고
    • PolyMIRTS Database 3. 0: Linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways
    • Bhattacharya, A., Ziebarth, J. D. & Cui, Y. PolyMIRTS Database 3. 0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways. Nucleic Acids Res. 42, D86-91 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. D86-91
    • Bhattacharya, A.1    Ziebarth, J.D.2    Cui, Y.3
  • 67
    • 84891818318 scopus 로고    scopus 로고
    • MIRBase: Annotating high confidence microRNAs using deep sequencing data
    • Kozomara, A. & Griffiths-Jones, S. MIRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 42, D68-D73 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. D68-D73
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 68
    • 84940502214 scopus 로고    scopus 로고
    • Predicting effective microRNA target sites in mammalian mRNAs
    • Agarwal, V., Bell, G. W., Nam, J.-W. & Bartel, D. P. Predicting effective microRNA target sites in mammalian mRNAs. eLife 4, e05005 (2015).
    • (2015) ELife , vol.4 , pp. e05005
    • Agarwal, V.1    Bell, G.W.2    Nam, J.-W.3    Bartel, D.P.4
  • 69
    • 79960653147 scopus 로고    scopus 로고
    • Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype
    • Jemtland, R. et al. Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype. J. Bone Miner. Res. 26, 1793-801 (2011).
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 1793-1801
    • Jemtland, R.1
  • 70
    • 77649179580 scopus 로고    scopus 로고
    • Eight genes are highly associated with BMD variation in postmenopausal Caucasian women
    • Reppe, S. et al. Eight genes are highly associated with BMD variation in postmenopausal Caucasian women. Bone 46, 604-12 (2010).
    • (2010) Bone , vol.46 , pp. 604-612
    • Reppe, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.