Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization

Journal of Biological Chemistry

Volumn 286, Issue 3, 2011, Pages 1836-1849

  Gorski, Jeff P ^a   Huffman, Nichole T ^a   Chittur, Sridar ^b   Midura, Ronald J ^c   Black, Claudine ^a   Oxford, Julie ^d   Seidah, Nabil G ^e  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d BOISE STATE UNIVERSITY   (United States)

^e CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

, INHIBITOR; APOPTOTIC; BONE FORMATION; CAMP-RESPONSE ELEMENT-BINDING PROTEINS; CASPASE-3; CHLOROMETHYL; EXTRACELLULAR MATRICES; IN-VITRO; IN-VIVO; OSTEOBLASTIC CELLS; OSTEOCYTES; OVER-EXPRESSION; SUBTILISIN; TRANSMEMBRANES;

CELL CULTURE; ENZYME ACTIVITY; FETAL MONITORING; GENES; KETONES; MINERALOGY; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; CASPASE 3; COLLAGEN; COLLAGEN TYPE 11A1; COLLAGEN TYPE 1A1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DENTIN MATRIX PROTEIN 1; FIBRONECTIN; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; PHOSPHATE REGULATING NEUTRAL ENDOPEPTIDASE; SCLEROPROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; SUBTILISIN; SUBTILISIN KEXIN LIKE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE FUNCTION; IN VITRO STUDY; MINERALIZATION; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; PHENOTYPE; PRIORITY JOURNAL; RAT;

ANIMALS; CALCIFICATION, PHYSIOLOGIC; CASPASE 3; CELL DIFFERENTIATION; CELL LINE; ENZYME ACTIVATION; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION; MICE; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOCYTES; PROPROTEIN CONVERTASES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SULFONES; TRANSCRIPTION FACTORS;

EID: 78751480189     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.151647     Document Type: Article

References (66)

1. Lian, J. B., and Stein, G. S. (1992) Crit. Rev. Oral Biol. Med. 3, 269-305
2. Ruchon, A. F., Tenenhouse, H. S., Marcinkiewicz, M., Siegfried, G., Aubin, J. E., DesGroseillers, L., Crine, P., and Boileau, G. (2000) J. Bone Miner. Res. 15, 1440-1450
3. The HYP Consortium (1995) Nat. Genet. 11, 130-136
4. Lorenz-Depiereux, B., Bastepe, M., Benet-Pagès, A., Amyere, M., Wagenstaller, J., Müller-Barth, U., Badenhoop, K., Kaiser, S. M., Rittmaster, R. S., Shlossberg, A. H., Olivares, J. L., Loris, C., Ramos, F. J., Glorieux, F., Vikkula, M., Jüppner, H., and Strom, T. M. (2006) Nat. Genet. 38, 1248-1250
5. Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., Rios, H., Drezner, M. K., Quarles, L. D., Bonewald, L. F., and White, K. E. (2006) Nat. Genet. 38, 1310-1315
6. Hansen, U., and Bruckner, P. (2003) J. Biol. Chem. 278, 37352-37359
7. Li, Y., Lacerda, D. A., Warman, M. L., Beier, D. R., Yoshioka, H., Ninomiya, Y., Oxford, J. T., Morris, N. P., Andrikopoulos, K., and Ramirez, F. (1995) Cell 80, 423-430
8. Richards, A. J., Yates, J. R., Williams, R., Payne, S. J., Pope, F. M., Scott, J. D., and Snead, M. P. (1996) Hum. Mol. Genet. 5, 1339-1343
9. Schneider, G. B., Zaharias, R., and Stanford ,C. (2001) J. Dent. Res. 80, 1540-1544
10. Moursi, A. M., Damsky, C. H., Lull, J., Zimmerman, D., Doty, S. B., Aota, S., and Globus, R. K. (1996) J. Cell Sci. 109, 1369-1380
11. Moursi, A. M., Globus, R. K., and Damsky, C. H. (1997) J. Cell Sci. 110, 2187-2196
12. Stanford, C. M., Jacobson, P. A., Eanes, E. D., Lembke, L. A., and Midura, R. J. (1995) J. Biol. Chem. 270, 9420-9428
13. Wang, A., Martin, J. A., Lembke, L. A., and Midura, R. J. (2000) J. Biol. Chem. 275, 11082-11091
14. Gorski, J. P., Wang, A., Lovitch, D., Law, D., Powell, K., and Midura, R. J. (2004) J. Biol. Chem. 279, 25455-25463
15. Midura, R. J., Wang, A., Lovitch, D., Law, D., Powell, K., and Gorski, J. P. (2004) J. Biol. Chem. 279, 25464-25473
16. Huffman, N. T., Keightley, J. A., Chaoying, C., Midura, R. J., Lovitch, D., Veno, P. A., Dallas, S. L., and Gorski, J. P. (2007) J. Biol. Chem. 282, 26002-26013
17. Wang, C., Wang, Y., Huffman, N. T., Cui, C., Yao, X., Midura, S., Midura, R. J., and Gorski, J. P. (2009) J. Biol. Chem. 284, 7100-7113
18. Gorski, J. P., Huffman, N. T., Cui, C., Henderson, E. P., Midura, R. J., and Seidah, N. G. (2009) Cells Tissues Organs 189, 25-32
19. Seidah, N. G., Mayer, G., Zaid, A., Rousselet, E., Nassoury, N., Poirier, S., Essalmani, R., and Prat, A. (2008) Int. J. Biochem. Cell Biol. 40, 1111-1125
20. Wang, X., Pai, J. T., Wiedenfeld, E. A., Medina, J. C., Slaughter, C. A., Goldstein, J. L., and Brown, M. S. (1995) J. Biol. Chem. 270, 18044-18050
21. Wang, X., Zelenski, N. G., Yang, J., Sakai, J., Brown, M. S., and Goldstein, J. L. (1996) EMBO J. 15, 1012-1020
22. Higgins, M. E., and Ioannou, Y. A. (2001) J. Lipid Res. 42, 1939-1946
23. Guan, G., Dai, P. H., Osborne, T. F., Kim, J. B., and Shechter, I. (1997) J. Biol. Chem. 272, 10295-10302
24. Schröder, M. (2008) Cell. Mol. Life Sci. 65, 862-894
25. Murakami, T., Kondo, S., Ogata, M., Kanemoto, S., Saito, A., Wanaka, A., and Imaizumi, K. (2006) J. Neurochem. 96, 1090-1100
26. Murakami, T., Saito, A., Hino, S., Kondo, S., Kanemoto, S., Chihara, K., Sekiya, H., Tsumagari, K., Ochiai, K., Yoshinaga, K., Saitoh, M., Nishimura, R., Yoneda, T., Kou, I., Furuichi, T., Ikegawa, S., Ikawa, M., Okabe, M., Wanaka, A., and Imaizumi, K. (2009) Nat. Cell Biol. 11, 1205-1211
27. Chandhoke, T. K., Huang, Y. F., Liu, F., Gronowicz, G. A., Adams, D. J., Harrison, J. R., and Kream, B. E. (2008) Bone 43, 101-109
28. Schlombs, K., Wagner, T., and Scheel, J. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 14024-14029
29. Patra, D., Xing, X., Davies, S., Bryan, J., Franz, C., Hunziker, E. B., and Sandell, L. J. (2007) J. Cell Biol. 179, 687-700
30. Laemmli, U. K. (1970) Nature 227, 680-685
31. Pullikotil, P., Vincent, M., Nichol, S. T., and Seidah, N. G. (2004) J. Biol. Chem. 279, 17338-17347
32. Pullikotil, P., Benjannet, S., Mayne, J., and Seidah, N. G. (2007) J. Biol. Chem. 282, 27402-27413
33. Zhang, K., Shen, X., Wu, J., Sakaki, K., Saunders, T., Rutkowski, D. T., Back, S. H., and Kaufman, R. J. (2006) Cell 124, 587-599
34. Kalajzic, I., Braut, A., Guo, D., Jiang, X., Kronenberg, M. S., Mina, M., Harris, M. A., Harris, S. E., and Rowe, D. W. (2004) Bone 35, 74-82
35. Kalajzic, I., Kalajzic, Z., Kaliterna, M., Gronowicz, G., Clark, S. H., Lichtler, A. C., and Rowe, D. (2002) J. Bone Miner. Res. 17, 15-25
36. Kalajzic, I., Staal, A., Yang, W. P., Wu, Y., Johnson, S. E., Feyen, J. H., Krueger, W., Maye, P., Yu, F., Zhao, Y., Kuo, L., Gupta, R. R., Achenie, L. E., Wang, H. W., Shin, D. G., and Rowe, D. W. (2005) J. Biol. Chem. 280, 24618-24626
37. Pasquato, A., Pullikotil, P., Asselin, M. C., Vacatello, M., Paolillo, L., Ghezzo, F., Basso, F., Di Bello, C., Dettin, M., and Seidah, N. G. (2006) J. Biol. Chem. 281, 23471-23481
38. Seidah, N. G., Mowla, S. J., Hamelin, J., Mamarbachi, A. M., Benjannet, S., Touré, B. B., Basak, A., Munzer, J. S., Marcinkiewicz, J., Zhong, M., Barale, J. C., Lazure, C., Murphy, R. A., Chrétien, M., and Marcinkiewicz, M. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 1321-1326
39. Elagoz, A., Benjannet, S., Mammarbassi, A., Wickham, L., and Seidah, N. G. (2002) J. Biol. Chem. 277, 11265-11275
40. Henrich, S., Cameron, A., Bourenkov, G. P., Kiefersauer, R., Huber, R., Lindberg, I., Bode, W., and Than, M. E. (2003) Nat. Struct. Biol. 10, 520-526
41. Nohturfft, A., Yabe, D., Goldstein, J. L., Brown, M. S., and Espenshade, P. J. (2000) Cell 102, 315-323
42. Dooley, K. A., Bennett, M. K., and Osborne, T. F. (1999) J. Biol. Chem. 274, 5285-5291
43. Inoue, J., Sato, R., and Maeda, M. (1998) J Biochem. 123, 1191-1198
44. Chandler, J. M., Cohen, G. M., and MacFarlane, M. (1998) J. Biol. Chem. 273, 10815-10818
45. Liu, X., Kim, C. N., Pohl, J., and Wang, X. (1996) J. Biol. Chem. 271, 13371-13376
46. Omori, Y., Imai, J., Suzuki, Y., Watanabe, S., Tanigami, A., and Sugano, S. (2002) Biochem. Biophys. Res. Commun. 293, 470-477
47. Dixon, P. H., Christie, P. T., Wooding, C., Trump, D., Grieff, M., Holm, I., Gertner, J. M., Schmidtke, J., Shah, B., Shaw, N., Smith, C., Tau, C., Schlessinger, D., Whyte, M. P., and Thakker, R. V. (1998) J. Clin. Endocrinol. Metab. 83, 3615-3623
48. Pihlajaniemi, T., Dickson, L. A., Pope, F. M., Korhonen, V. R., Nicholls, A., Prockop, D. J., and Myers, J. C. (1984) J Biol. Chem. 259, 12941-12944
49. Singh, L. P., Andy, J., Anyamale, V., Greene, K., Alexander, M., and Crook, E. D. (2001) Diabetes 50, 2355-2362
50. Michaelson, J. E., Ritzenthaler, J. D., and Roman, J. (2002) Am. J. Physiol. Lung Cell. Mol. Physiol. 282, L291-L301
51. Miura, M., Chen, X. D., Allen, M. R., Bi, Y., Gronthos, S., Seo, B. M., Lakhani, S., Flavell, R. A., Feng, X. H., Robey, P. G., Young, M., and Shi, S. (2004) J. Clin. Invest. 114, 1704-1713
52. Mogi, M., and Togari, A. (2003) J. Biol. Chem. 278, 47477-47482
53. Hirano, Y., Yoshida, M., Shimizu, M., and Sato, R. (2001) J. Biol. Chem. 276, 36431-36437
54. Costes, S., Vandewalle, B., Tourrel-Cuzin, C., Broca, C., Linck, N., Bertrand, G., Kerr-Conte, J., Portha, B., Pattou, F., Bockaert, J., and Dalle, S. (2009) Diabetes 58, 1105-1115
55. Punga, T., Bengoechea-Alonso, M. T., and Ericsson, J. (2006) J. Biol. Chem. 281, 25278-25286
56. Bengoechea-Alonso, M. T., and Ericsson, J. (2009) J. Biol. Chem. 284, 5885-5895
57. Meares, G. P., and Jope, R. S. (2007) J. Biol. Chem. 282, 16989-17001
58. Webb, S. J., Nicholson, D., Bubb, V. J., and Wyllie, A. H. (1999) FASEB J. 13, 339-346
59. Hunter, I., McGregor, D., and Robins, S. P. (2001) J. Bone Miner. Res. 16, 466-477
60. Farr, G. H., 3rd, Ferkey, D. M., Yost, C., Pierce, S. B., Weaver, C., and Kimelman, D. (2000) J. Cell Biol. 148, 691-702
61. Gupta, S., Hastak, K., Afaq, F., Ahmad, N., and Mukhtar, H. (2004) Oncogene 23, 2507-2522
62. Park, I. C., Park, M. J., Choe, T. B., Jang, J. J., Hong, S. I., and Lee, S. H. (2000) Int. J. Oncol. 16, 1243-1248
63. Castoreno, A. B., Wang, Y., Stockinger, W., Jarzylo, L. A., Du, H., Pagnon, J. C., Shieh, E. C., and Nohturfft, A. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 13129-13134
64. Amemiya-Kudo, M., Oka, J., Ide, T., Matsuzaka, T., Sone, H., Yoshikawa, T., Yahagi, N., Ishibashi, S., Osuga, J., Yamada, N., Murase, T., and Shimano, H. (2005) J. Biol. Chem. 280, 34577-34589
65. Liu, Y., Chen, B. P., Lu, M., Zhu, Y., Stemerman, M. B., Chien, S., and Shyy, J. Y. (2002) Arterioscler. Thromb. Vasc. Biol. 22, 76-81
66. Gondret, F., Ferré, P., and Dugail, I. (2001) J. Lipid Res. 42, 106-113