Lean mass as a total mediator of the influence of muscular fitness on bone health in schoolchildren: a mediation analysis

Journal of Sports Sciences

Volumn 33, Issue 8, 2015, Pages 817-830

  Torres Costoso, Ana ^a   Gracia Marco, Luis ^b,c   Sánchez López, Mairena ^a   García Prieto, Jorge Cañete ^a   García Hermoso, Antonio ^d   Díez Fernández, Ana ^a   Martínez Vizcaíno, Vicente ^a  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE CHILE   (Chile)

Author keywords

body composition; bone mineral content; bone mineral density; children; muscular strength

Indexed keywords

ARM; BODY COMPOSITION; BODY MASS; BONE DENSITY; CHILD; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EXERCISE TEST; HUMAN; LEG; MALE; MUSCLE STRENGTH; PHOTON ABSORPTIOMETRY; PHYSIOLOGY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE;

ABSORPTIOMETRY, PHOTON; BODY COMPOSITION; BODY MASS INDEX; BONE DENSITY; CHILD; CROSS-SECTIONAL STUDIES; EXERCISE TEST; HUMANS; LOWER EXTREMITY; MALE; MUSCLE STRENGTH; MUSCLE, SKELETAL; UPPER EXTREMITY;

EID: 84923444746     PISSN: 02640414     EISSN: 1466447X     Source Type: Journal    
DOI: 10.1080/02640414.2014.964750     Document Type: Article

References (48)

1. Arden, N. K., & Spector, T. D. (1997). Genetic influences on muscle strength, lean body mass, and bone mineral density: A twin study. Journal of Bone Mineral Research, 12(12), 2076–2081.
2. Artero, E. G., España-Romero, V., Ortega, F. B., Jiménez-Pavón, D., Ruiz, J. R., Vicente-Rodríguez, G., … Castillo, M. J. (2010). Health-related fitness in adolescents: Underweight, and not only overweight, as an influencing factor. The AVENA study. Scandinavian Journal of Medicine and Science in Sports, 20(3), 418–427.
3. Baptista, F., Barrigas, C., Vieira, F., Santa-Clara, H., Homens, P. M., Fragoso, I., … Sardinha, L. B. (2012). The role of lean body mass and physical activity in bone health in children. Journal of Bone and Mineral Metabolism, 30(1), 100–108.
4. Baron, R. M., & Kenny, D. A. (1986). The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51(6), 1173–1182.
5. Baroncelli, G. I., Federico, G., Vignolo, M., Valerio, G., Del Puente, A., Maghnie, M., … Saggese, G. (2006). Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth, and pubertal development. Bone, 39(1), 159–173.
6. Bernhardt, D. T., Gomez, J., Johnson, M. D., Martin, T. J., Rowland, T. W., Small, E., … Committee on Sports Medicine and Fitness. (2001). Strength training by children and adolescents. Pediatrics, 107(6), 1470–1472.
7. Castro-Piñero, J., Ortega, F. B., Artero, E. G., Girela-Rejón, M. J., Mora, J., Sjöström, M., & Ruiz, J. R. (2010). Assessing muscular strength in youth: Usefulness of standing long jump as a general index of muscular fitness. Journal of Strength and Conditioning Research, 24(7), 1810–1817.
8. Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). New York, NY: Academic Press.
9. Crabtree, N. J., Kibirige, M. S., Fordham, J. N., Banks, L. M., Muntoni, F., Chinn, D., … Shaw, N. J. (2004). The relationship between lean body mass and bone mineral content in paediatric health and disease. Bone, 35(4), 965–972.
10. Cummings, S. R., Browner, W., Cummings, S. R., Black, D. M., Nevitt, M. C., Browner, W., … Vogt, T. M. (1993). Bone density at various sites for prediction of hip fractures. The study of osteoporotic fractures research group. TheLancet, 341(8837), 72–75.
11. Davie, M. W., & Haddaway, M. J. (1994). Bone mineral content and density in healthy subjects and in osteogenesis imperfecta. Archives of Disease in Childhood, 70(4), 331–334.
12. Díez-Fernández, A., Sanchez-Lopez, M., Mora-Rodríguez, R., Notario-Pacheco, B., Torrijos-Niño, C., & Martínez-Vizcaíno, V. (2014). Obesity as a mediator of the influence of cardiorespiratory fitness on cardiometabolic risk: A mediation analysis. Diabetes Care, 37(3), 855–862. doi:10.2337/dc13-0416
13. España-Romero, V., Artero, E. G., Santaliestra-Pasias, A. M., Gutierrez, A., Castillo, M. J., & Ruiz, J. R. (2008). Hand span influences optimal grip span in boys and girls aged 6 to 12 years. TheJournal of Hand Surgery, 33(3), 378–384.
14. Frost, H. M. (2000). Muscle, bone, and the Utah paradigm: A 1999 overview. Medicine and Science in Sports and Exercise, 32(5), 911–917.
15. Frost, H. M. (2003). Bone’s mechanostat: A 2003 update. TheAnatomical Record, 275A(2), 1081–1101.
16. Goran, M. I. (1998). Measurement issues related to studies of childhood obesity: Assessment of body composition, body fat distribution, physical activity, and food intake. Pediatrics, 101(3 Pt 2), 505–518.
17. Gracia-Marco, L., Moreno, L. A., Ortega, F. B., León, F., Sioen, I., Kafatos, A., … Vicente-Rodríguez, G. (2011). Levels of physical activity that predict optimal bone mass in adolescents: The HELENA study. American Journal of Preventive Medicine, 40(6), 599–607.
18. Gracia-Marco, L., Ortega, F. B., Jiménez-Pavón, D., Rodríguez, G., Castillo, M. J., Vicente-Rodríguez, G., & Moreno, L. A. (2012). Adiposity and bone health in Spanish adolescents. The HELENA study. Osteoporosis International, 23(3), 937–947.
19. Gracia-Marco, L., Vicente-Rodríguez, G., Casajús, J. A., Molnar, D., Castillo, M. J., & Moreno, L. A. (2011). Effect of fitness and physical activity on bone mass in adolescents: The HELENA study. European Journal of Applied Physiology, 111(11), 2671–2680.
20. Guéguen, R., Jouanny, P., Guillemin, F., Kuntz, C., Pourel, J., & Siest, G. (1995). Segregation analysis and variance components analysis of bone mineral density in healthy families. Journal of Bone and Mineral Research, 10(12), 2017–2022.
21. Jurimae, T., Hurbo, T., & Jurimae, J. (2008). Relationships between legs bone mineral density, anthropometry and jumping height in prepubertal children. Collegium Antropologicum, 32(1), 61–66.
22. Marshall, D., Johnell, O., & Wedel, H. (1996). Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. British Medical Journal, 312(7041), 1254–1259.
23. Martínez-Vizcaíno, V., Sánchez-López, M., Salcedo-Aguilar, F., Notario-Pacheco, B., Solera-Martínez, M., Moya-Martínez, P., … Rodríguez-Artalejo, F. (2012). Protocol of a randomized cluster trial to assess the effectiveness of the MOVI-2 program on overweight prevention in schoolchildren. Revista Española De Cardiología (English Edition), 65(5), 427–433.
24. Morales, P. F., Sánchez-López, M., Moya-Martínez, P., García-Prieto, J. C., Martínez-Andrés, M., García, N. L., & Martínez-Vizcaíno, V. (2013). Health-related quality of life, obesity, and fitness in schoolchildren: The Cuenca study. Quality of Life Research, 22(7), 1515–1523.
25. Ortega, F. B., Artero, E. G., Ruiz, J. R., Vicente-Rodríguez, G., Bergman, P., Hagströmer, M., … Castillo, M. J. (2008). Reliability of health-related physical fitness tests in European adolescents. The HELENA study. International Journal of Obesity, 32(Suppl. 5), SS49–SS57.
26. Ortega, F. B., Ruiz, J. R., Castillo, M. J., & Sjöström, M. (2008). Physical fitness in childhood and adolescence: A powerful marker of health. International Journal of Obesity, 32(1), 1–11.
27. Ortega, F. B., Sanchez-Lopez, M., Solera-Martinez, M., Fernandez-Sanchez, A., Sjostrom, M., & Martinez-Vizcaino, V. (2013). Self-reported and measured cardiorespiratory fitness similarly predict cardiovascular disease risk in young adults. Scandinavian Journal of Medicine and Science in Sports, 23, 749–757. doi:10.1111/j.1600-0838.2012.01454.x0838.2012.01454.x
28. Pietrobelli, A., Faith, M. S., Wang, J., Brambilla, P., Chiumello, G., & Heymsfield, S. B. (2002). Association of lean tissue and fat mass with bone mineral content in children and adolescents. Obesity Research, 10(1), 56–60.
29. Pocock, N., Eisman, J., Gwinn, T., Sambrook, P., Kelly, P., Freund, J., & Yeates, M. (1989). Muscle strength, physical fitness, and weight but not age predict femoral neck bone mass. Journal of Bone and Mineral Research, 4(3), 441–448.
30. Pocock, N. A., Eisman, J. A., Hopper, J. L., Yeates, M. G., Sambrook, P. N., & Eberl, S. (1987). Genetic determinants of bone mass in adults. A twin study. Journal of Clinical Investigation, 80(3), 706–710.
31. Preacher, K. J., & Hayes, A. F. (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behavior Research Methods, 40(3), 879–891.
32. Rauch, F., Bailey, D. A., Baxter-Jones, A., Mirwald, R., & Faulkner, R. (2004). The ‘muscle-bone unit’ during the pubertal growth spurt. Bone, 34(5), 771–775.
33. Reid, I. R. (2002). Relationships among body mass, its components, and bone. Bone, 31(5), 547–555.
34. Rizzoli, R., Bianchi, M. L., Garabédian, M., McKay, H. A., & Moreno, L. A. (2010). Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly. Bone, 46(2), 294–305.
35. Rizzoli, R., Bonjour, J. P., & Ferrari, S. L. (2001). Osteoporosis, genetics and hormones. Journal of Molecular Endocrinology, 26(2), 79–94.
36. Rowlands, A. V. (2007). Accelerometer assessment of physical activity in children: An update. Pediatric Exercise Science, 19(3), 252–266.
37. Schoenau, E., Neu, C. M., Beck, B., Manz, F., & Rauch, F. (2002). Bone mineral content per muscle cross-sectional area as an index of the functional muscle-bone unit. Journal of Bone and Mineral Research, 17(6), 1095–1101.
38. Seeman, E. (2001). Clinical review 137: Sexual dimorphism in skeletal size, density, and strength. TheJournal of Clinical Endocrinology & Metabolism, 86(10), 4576–4584.
39. Seeman, E., Hopper, J. L., Young, N. R., Formica, C., Goss, P., & Tsalamandris, C. (1996). Do genetic factors explain associations between muscle strength, lean mass, and bone density? A twin study. American Journal of Physiology, 270(2 Pt 1), E320–E327.
40. Snow-Harter, C., Bouxsein, M., Lewis, B., Charette, S., Weinstein, P., & Marcus, R. (1990). Muscle strength as a predictor of bone mineral density in young women. Journal of Bone and Mineral Research, 5(6), 589–595.
41. Sobel, M. (1982). Asymptotic confidence intervals for indirect effects in structural equation models. In S. Leinhardt (Ed.), Sociological methodology (pp. 290–312). Washington, DC: American Sociological Association.
42. Southard, R. N., Morris, J. D., Mahan, J. D., Hayes, J. R., Torch, M. A., Sommer, A., & Zipf, W. B. (1991). Bone mass in healthy children: Measurement with quantitative DXA. Radiology, 179(3), 735–738.
43. Valtuena, J., Valtueña, J., Gracia-Marco, L., Vicente-Rodríguez, G., González-Gross, M., Huybrechts, I., … Moreno, L. A. (2012). Vitamin D status and physical activity interact to improve bone mass in adolescents. The HELENA study. Osteoporosis International, 23(8), 2227–2237.
44. Vicente-Rodríguez, G. (2006). How does exercise affect bone development during growth? Sports Medicine, 36(7), 561–569.
45. Vicente-Rodríguez, G., Ara, I., Perez-Gomez, J., Dorado, C., & Calbet, J. A. (2005). Muscular development and physical activity as major determinants of femoral bone mass acquisition during growth. British Journal of Sports Medicine, 39(9), 611–616.
46. Vicente-Rodríguez, G., Ara, I., Perez-Gomez, J., Serrano-Sanchez, J. A., Dorado, C., & Calbet, J. (2004). High femoral bone mineral density accretion in prepubertal soccer players. Medicine and Science in Sports Exercise, 36(10), 1789–1795.
47. Wetzsteon, R. J., Zemel, B. S., Shults, J., Howard, K. M., Kibe, L. W., & Leonard, M. B. (2011). Mechanical loads and cortical bone geometry in healthy children and young adults. Bone, 48(5), 1103–1108.
48. Xu, L., Nicholson, P., Wang, Q., Alén, M., & Cheng, S. (2009). Bone and muscle development during puberty in girls: A seven-year longitudinal study. Journal of Bone and Mineral Research, 24(10), 1693–1698.