Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 16, 2012, Pages 6130-6135

  Malik, Mariam ^a   Jividen, Kasey ^a   Padmakumar, V C ^a   Cataisson, Christophe ^a   Li, Luowei ^a   Lee, Jessica ^a   Howard, O M Zack ^a   Yuspa, Stuart H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

IL 1beta; Phagocytosis; Protein nitrosylation

Indexed keywords

CHLORIDE INTRACELLULAR CHANNEL 4; CXCL1 CHEMOKINE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNE RESPONSE; IN VIVO STUDY; MOUSE; NITROSYLATION; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; CHLORIDE CHANNELS; GENE EXPRESSION; IMMUNOBLOTTING; INTERFERON-GAMMA; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84859949720     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1201351109     Document Type: Article

References (35)

1. Qian Z, Okuhara D, Abe MK, Rosner MR (1999) Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. J Biol Chem 274:1621-1627.
2. Tulk BM, Kapadia S, Edwards JC (2002) CLIC1 inserts from the aqueous phase into phospholipid membranes, where it functions as an anion channel. Am J Physiol Cell Physiol 282:C1103-C1112. (Pubitemid 34663119)
3. Berryman M, Bruno J, Price J, Edwards JC (2004) CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo. J Biol Chem 279:34794-34801. (Pubitemid 39318112)
4. Fernández-Salas E, et al. (2002) mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53. Mol Cell Biol 22:3610-3620. (Pubitemid 34525205)
5. Shiio Y, et al. (2006) Quantitative proteomic analysis of myc-induced apoptosis: A direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4. J Biol Chem 281:2750-2756. (Pubitemid 43845738)
6. Suh KS, et al. (2007) CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation. J Cell Sci 120:2631-2640. (Pubitemid 47323871)
7. Rønnov-Jessen L, Villadsen R, Edwards JC, Petersen OW (2002) Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts. Am J Pathol 161:471-480. (Pubitemid 36142156)
8. Shukla A, et al. (2009) TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3. Nat Cell Biol 11:777-784.
9. Yao Q, Qu X, Yang Q, Wei M, Kong B (2009) CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. Oncol Rep 22:541-548.
10. Suh KS, et al. (2004) The organellular chloride channel protein CLIC4/mtCLIC translocates to the nucleus in response to cellular stress and accelerates apoptosis. J Biol Chem 279:4632-4641. (Pubitemid 38199055)
11. Littler DR, et al. (2005) Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4. FEBS J 272:4996-5007. (Pubitemid 41415122)
12. Greco TM, et al. (2006) Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells. Proc Natl Acad Sci USA 103:7420-7425. (Pubitemid 43727848)
13. Malik M, et al. (2010) S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein CLIC4. J Biol Chem 285:23818-23828.
14. Ogawa S, et al. (2005) Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 122:707-721. (Pubitemid 41242636)
15. He G, et al. (2011) Role of CLIC4 in the host innate responses to bacterial lipopolysaccharide. Eur J Immunol 41:1221-1230.
16. Nacy CA, Meltzer MS (1991) T-cell-mediated activation of macrophages. Curr Opin Immunol 3:330-335.
17. Tsunawaki S, Sporn M, Ding A, Nathan C (1988) Deactivation of macrophages by transforming growth factor-beta. Nature 334:260-262.
18. Gao J, Morrison DC, Parmely TJ, Russell SW, Murphy WJ (1997) An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide. J Biol Chem 272:1226-1230. (Pubitemid 27034621)
19. Berton G, Gordon S (1983) Superoxide release by peritoneal and bone marrow-derived mouse macrophages. Modulation by adherence and cell activation. Immunology 49:693-704.
20. Okamoto T, et al. (2004) Multiple contributing roles for NOS2 in LPS-induced acute airway inflammation in mice. Am J Physiol Lung Cell Mol Physiol 286:L198-L209. (Pubitemid 38055876)
21. MacMicking J, Xie QW, Nathan C (1997) Nitric oxide and macrophage function. Annu Rev Immunol 15:323-350. (Pubitemid 27169284)
22. Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117:3720-3732.
23. Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8:958-969.
24. Gordon S, Hamann J, Lin HH, Stacey M (2011) F4/80 and the related adhesion-GPCRs. Eur J Immunol 41:2472-2476.
25. Imai K, Takeshita A, Hanazawa S (2000) Transforming growth factor-beta inhibits lipopolysaccharide-stimulated expression of inflammatory cytokines in mouse macrophages through downregulation of activation protein 1 and CD14 receptor expression. Infect Immun 68:2418-2423. (Pubitemid 30253807)
26. Vodovotz Y, Bogdan C, Paik J, Xie QW, Nathan C (1993) Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. J Exp Med 178:605-613. (Pubitemid 23218209)
27. Werner F, et al. (2000) Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3. J Biol Chem 275:36653-36658. (Pubitemid 32002067)
28. McCartney-Francis N, Jin W, Wahl SM (2004) Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway. J Immunol 172:3814-3821. (Pubitemid 38337967)
29. Pan H, et al. (2010) SMAD4 is required for development of maximal endotoxin tolerance. J Immunol 184:5502-5509.
30. Perdiguero E, et al. (2011) p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair. J Cell Biol 195:307-322.
31. Suh KS, et al. (2007) Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. Clin Cancer Res 13:121-131. (Pubitemid 46121860)
32. Hussain SP, et al. (2004) Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Res 64:6849-6853. (Pubitemid 39330989)
33. Cataisson C, et al. (2006) CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation. J Clin Invest 116:2757-2766. (Pubitemid 44511639)
34. Jaffrey SR, Snyder SH (2001) The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE 2001:pl1.
35. Medina E, Goldmann O (2011) In vivo and ex vivo protocols for measuring the killing of extracellular pathogens by macrophages. Current Protoc Immunol Chapter 14: Unit 14.19.1-17.