Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 174, Issue 7, 2017, Pages 724-731

  Leonenko, Ganna ^a   Richards, Alexander L ^a   Walters, James T ^a   Pocklington, Andrew ^a   Chambert, Kimberly ^b   Al Eissa, Mariam M ^c   Sharp, Sally I ^c   O'Brien, Niamh L ^c   Curtis, David ^c   Bass, Nicholas J ^c   McQuillin, Andrew ^c   Hultman, Christina ^d   Moran, Jennifer L ^b   McCarroll, Steven A ^b,e   Sklar, Pamela ^f   Neale, Benjamin M ^b,g   Holmans, Peter A ^a   Owen, Michael J ^a   Sullivan, Patrick F ^d,h   O'Donovan, Michael C ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d KAROLINSKA INSTITUTE   (Sweden)

^e HARVARD MEDICAL SCHOOL   (United States)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

association; exome chip; FMRP; rare variation; schizophrenia

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; FMR1 PROTEIN, HUMAN;

ALLELE; ARTICLE; CONTROLLED STUDY; EXOME; GENE FREQUENCY; GENE MUTATION; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MINOR ALLELE FREQUENCY; PRIORITY JOURNAL; PROTEIN RNA BINDING; PROTEIN TARGETING; SCHIZOPHRENIA; SWEDEN; UNITED KINGDOM; CASE CONTROL STUDY; COHORT ANALYSIS; FOLLOW UP; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MUTATION; PROGNOSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

CASE-CONTROL STUDIES; COHORT STUDIES; EXOME; FOLLOW-UP STUDIES; FRAGILE X MENTAL RETARDATION PROTEIN; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; SCHIZOPHRENIA;

EID: 85024397206     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32560     Document Type: Article

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