Single-molecule analysis of ligand efficacy in β2AR-G-protein activation

Nature

Volumn 547, Issue 7661, 2017, Pages 68-73

  Gregorio, G Glenn ^a   Masureel, Matthieu ^b   Hilger, Daniel ^b   Terry, Daniel S ^a   Juette, Manuel ^a   Zhao, Hong ^a   Zhou, Zhou ^a   Perez Aguilar, Jose Manuel ^a,f   Hauge, Maria ^c,d,e   Mathiasen, Signe ^c,d   Javitch, Jonathan A ^c,d   Weinstein, Harel ^a   Kobilka, Brian K ^b   Blanchard, Scott C ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Columbia University College of Physicians and Surg ^*  (United States)

^d NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f IBM T J WATSON RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; FLUORESCENT DYE; G PROTEIN COUPLED RECEPTOR; NUCLEOTIDE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLENBUTEROL; EPINEPHRINE; GUANOSINE DIPHOSPHATE; LIGAND; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

BIOENERGETICS; DISEASE TREATMENT; GENE EXPRESSION; LIGAND; MOLECULAR ANALYSIS; PHYSIOLOGY; PROTEIN;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PRIORITY JOURNAL; QUANTUM YIELD; SIGNAL TRANSDUCTION; SINGLE MOLECULE IMAGING; STEADY STATE; ALLOSTERIC SITE; CELL MEMBRANE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; HUMAN; KINETICS; METABOLISM; MOLECULAR MODEL; MOVEMENT (PHYSIOLOGY); PROTEIN STABILITY;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALLOSTERIC SITE; CELL MEMBRANE; CLENBUTEROL; ENZYME ACTIVATION; EPINEPHRINE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GUANOSINE DIPHOSPHATE; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOVEMENT; PROTEIN STABILITY; RECEPTORS, ADRENERGIC, BETA-2; SINGLE MOLECULE IMAGING;

EID: 85022054938     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature22354     Document Type: Article

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