Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 6, 2011, Pages 2390-2395

  Willinger, Tim ^a   Rongvaux, Anthony ^a   Takizawa, Hitoshi ^b   Yancopoulos, George D ^c   Valenzuela, David M ^c   Murphy, Andrew J ^c   Auerbach, Wojtek ^c   Eynon, Elizabeth E ^a   Stevens, Sean ^c,e   Manz, Markus G ^b,d   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c REGENERON PHARMACEUTICALS INC   (United States)

^d INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^e AnaptysBio Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CD34 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 3; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CYTOKINE PRODUCTION; FETUS; GENE EXPRESSION; GENE TARGETING; HEMATOPOIETIC CELL; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; INFLUENZA; INNATE IMMUNITY; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG ALVEOLUS PROTEINOSIS; LUNG LAVAGE; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CORD BLOOD STEM CELL TRANSPLANTATION; GENE KNOCK-IN TECHNIQUES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNITY, INNATE; IMMUNITY, MUCOSAL; INFLUENZA A VIRUS, H1N1 SUBTYPE; INTERLEUKIN-3; LUNG; MACROPHAGES, ALVEOLAR; MICE; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL; ORTHOMYXOVIRIDAE INFECTIONS; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HETEROLOGOUS;

MUS; ORTHOMYXOVIRIDAE;

EID: 79952304617     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1019682108     Document Type: Article

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