메뉴 건너뛰기




Volumn 9, Issue 7, 2017, Pages 971-984

Epigenome-wide association study of chronic obstructive pulmonary disease and lung function in Koreans

Author keywords

chronic obstructive pulmonary disease; DNA methylation; epigenome wide association study; gene expression; lung function

Indexed keywords

DNA; TRANSCRIPTOME;

EID: 85021729996     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi-2017-0002     Document Type: Article
Times cited : (41)

References (58)
  • 1
    • 0033801133 scopus 로고    scopus 로고
    • Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study
    • Schunemann HJ, Dorn J, Grant BJ, Winkelstein W, Jr., Trevisan M. Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study. Chest 118(3), 656-664 (2000).
    • (2000) Chest , vol.118 , Issue.3 , pp. 656-664
    • Schunemann, H.J.1    Dorn, J.2    Grant, B.J.3    Winkelstein, W.4    Trevisan, M.5
  • 2
    • 34548222188 scopus 로고    scopus 로고
    • Global burden of COPD: Risk factors, prevalence, and future trends
    • Mannino DM, Buist AS. Global burden of COPD: risk factors, prevalence, and future trends. Lancet 370(9589), 765-773 (2007).
    • (2007) Lancet , vol.370 , Issue.9589 , pp. 765-773
    • Mannino, D.M.1    Buist, A.S.2
  • 3
    • 70350223450 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study
    • Koshiol J, Rotunno M, Consonni D et al. Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study. PLoS ONE 4(10), e7380 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.10 , pp. e7380
    • Koshiol, J.1    Rotunno, M.2    Consonni, D.3
  • 4
    • 33745797471 scopus 로고    scopus 로고
    • Negative impact of chronic obstructive pulmonary disease on the health-related quality of life of patients. Results of the EPIDEPOC study
    • Carrasco Garrido P, De Miguel Diez J, Rejas Gutierrez J et al. Negative impact of chronic obstructive pulmonary disease on the health-related quality of life of patients. Results of the EPIDEPOC study. Health Qual. Life Outcomes 4, 31 (2006).
    • (2006) Health Qual. Life Outcomes , vol.4 , pp. 31
    • Carrasco Garrido, P.1    De Miguel Diez, J.2    Rejas Gutierrez, J.3
  • 5
    • 84903637201 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies six new loci associated with forced vital capacity
    • Loth DW, Soler Artigas M, Gharib SA et al. Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat. Genet. 46(7), 669-677 (2014).
    • (2014) Nat. Genet , vol.46 , Issue.7 , pp. 669-677
    • Loth, D.W.1    Soler Artigas, M.2    Gharib, S.A.3
  • 6
    • 84856337050 scopus 로고    scopus 로고
    • A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
    • Cho MH, Castaldi PJ, Wan ES et al. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum. Mol. Genet. 21(4), 947-957 (2012).
    • (2012) Hum. Mol. Genet , vol.21 , Issue.4 , pp. 947-957
    • Cho, M.H.1    Castaldi, P.J.2    Wan, E.S.3
  • 7
    • 84886428079 scopus 로고    scopus 로고
    • The future of nature versus nurture in understanding chronic obstructive pulmonary disease
    • Boezen HM, Mannino DM. The future of nature versus nurture in understanding chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 188(8), 891-892 (2013).
    • (2013) Am. J. Respir. Crit. Care Med , vol.188 , Issue.8 , pp. 891-892
    • Boezen, H.M.1    Mannino, D.M.2
  • 8
    • 84924370678 scopus 로고    scopus 로고
    • Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD
    • Yoo S, Takikawa S, Geraghty P et al. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. 11(1), e1004898 (2015).
    • (2015) PLoS Genet , vol.11 , Issue.1 , pp. e1004898
    • Yoo, S.1    Takikawa, S.2    Geraghty, P.3
  • 9
    • 84857381360 scopus 로고    scopus 로고
    • Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function
    • Qiu W, Baccarelli A, Carey VJ et al. Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function. Am. J. Respir. Crit. Care Med. 185(4), 373-381 (2012).
    • (2012) Am. J. Respir. Crit. Care Med , vol.185 , Issue.4 , pp. 373-381
    • Qiu, W.1    Baccarelli, A.2    Carey, V.J.3
  • 10
    • 84899717434 scopus 로고    scopus 로고
    • DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways
    • Vucic EA, Chari R, Thu KL et al. DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. Am. J. Respir. Cell Mol. Biol. 50(5), 912-922 (2014).
    • (2014) Am. J. Respir. Cell Mol. Biol , vol.50 , Issue.5 , pp. 912-922
    • Vucic, E.A.1    Chari, R.2    Thu, K.L.3
  • 11
    • 84990242142 scopus 로고    scopus 로고
    • DNA methylation profiling in human lung tissue identifies genes associated with COPD
    • (Epub ahead of print)
    • Morrow JD, Cho MH, Hersh CP et al. DNA methylation profiling in human lung tissue identifies genes associated with COPD. Epigenetics doi:10.1080/15592294.2016.1226451 (2016) (Epub ahead of print).
    • (2016) Epigenetics
    • Morrow, J.D.1    Cho, M.H.2    Hersh, C.P.3
  • 12
    • 84994304843 scopus 로고    scopus 로고
    • Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations
    • Busch R, Qiu W, Lasky-Su J, Morrow J, Criner G, Demeo D. Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations. Respir. Res. 17(1), 143 (2016).
    • (2016) Respir. Res , vol.17 , Issue.1 , pp. 143
    • Busch, R.1    Qiu, W.2    Lasky-Su, J.3    Morrow, J.4    Criner, G.5    Demeo, D.6
  • 13
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister R, Pelizzola M, Dowen RH et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462(7271), 315-322 (2009).
    • (2009) Nature , vol.462 , Issue.7271 , pp. 315-322
    • Lister, R.1    Pelizzola, M.2    Dowen, R.H.3
  • 14
    • 84863386102 scopus 로고    scopus 로고
    • Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies
    • Jaffe AE, Murakami P, Lee H et al. Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies. Int. J. Epidemiol. 41(1), 200-209 (2012).
    • (2012) Int. J. Epidemiol , vol.41 , Issue.1 , pp. 200-209
    • Jaffe, A.E.1    Murakami, P.2    Lee, H.3
  • 15
    • 84973478695 scopus 로고    scopus 로고
    • Methodology of an observational cohort study for subjects with chronic obstructive pulmonary disease in dusty areas near cement plants
    • Kim WJ, Hong Y. Methodology of an observational cohort study for subjects with chronic obstructive pulmonary disease in dusty areas near cement plants. J. Pulm. Respir. Med. 04(01), 169-174 (2014).
    • (2014) J. Pulm. Respir. Med , vol.4 , Issue.1 , pp. 169-174
    • Kim, W.J.1    Hong, Y.2
  • 17
    • 85006512081 scopus 로고    scopus 로고
    • Differences in chronic obstructive pulmonary disease phenotypes between nonsmokers and smokers
    • (Epub ahead of print)
    • Ji W, Lim MN, Bak SH et al. Differences in chronic obstructive pulmonary disease phenotypes between nonsmokers and smokers. Clin. Respir. J. doi:10.1111/crj.12577 (2016) (Epub ahead of print).
    • (2016) Clin. Respir. J
    • Ji, W.1    Lim, M.N.2    Bak, S.H.3
  • 18
    • 84872564830 scopus 로고    scopus 로고
    • A betamixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
    • Teschendorff AE, Marabita F, Lechner M et al. A betamixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics 29(2), 189-196 (2013).
    • (2013) Bioinformatics , vol.29 , Issue.2 , pp. 189-196
    • Teschendorff, A.E.1    Marabita, F.2    Lechner, M.3
  • 19
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8(1), 118-127 (2007).
    • (2007) Biostatistics , vol.8 , Issue.1 , pp. 118-127
    • Johnson, W.E.1    Li, C.2    Rabinovic, A.3
  • 20
    • 84884898098 scopus 로고    scopus 로고
    • Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia
    • Nordlund J, Backlin CL, Wahlberg P et al. Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia. Genome Biol. 14(9), r105 (2013).
    • (2013) Genome Biol , vol.14 , Issue.9 , pp. r105
    • Nordlund, J.1    Backlin, C.L.2    Wahlberg, P.3
  • 21
    • 84893325381 scopus 로고    scopus 로고
    • ChAMP: 450k chip analysis methylation pipeline
    • Morris TJ, Butcher LM, Feber A et al. ChAMP: 450k chip analysis methylation pipeline. Bioinformatics 30(3), 428-430 (2014).
    • (2014) Bioinformatics , vol.30 , Issue.3 , pp. 428-430
    • Morris, T.J.1    Butcher, L.M.2    Feber, A.3
  • 22
    • 84874396923 scopus 로고    scopus 로고
    • Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array
    • Price ME, Cotton AM, Lam LL et al. Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array. Epigenetics Chromatin 6(1), 4 (2013).
    • (2013) Epigenetics Chromatin , vol.6 , Issue.1 , pp. 4
    • Price, M.E.1    Cotton, A.M.2    Lam, L.L.3
  • 24
    • 84860637797 scopus 로고    scopus 로고
    • DNA methylation arrays as surrogate measures of cell mixture distribution
    • Houseman EA, Accomando WP, Koestler DC et al. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics 13, 86 (2012).
    • (2012) BMC Bioinformatics , vol.13 , pp. 86
    • Houseman, E.A.1    Accomando, W.P.2    Koestler, D.C.3
  • 25
    • 84864359044 scopus 로고    scopus 로고
    • Differential DNA methylation in purified human blood cells: Implications for cell lineage and studies on disease susceptibility
    • Reinius LE, Acevedo N, Joerink M et al. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS ONE 7(7), e41361 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.7 , pp. e41361
    • Reinius, L.E.1    Acevedo, N.2    Joerink, M.3
  • 26
    • 84929147900 scopus 로고    scopus 로고
    • De novo identification of differentially methylated regions in the human genome
    • Peters TJ, Buckley MJ, Statham AL et al. De novo identification of differentially methylated regions in the human genome. Epigenetics Chromatin 8, 6 (2015).
    • (2015) Epigenetics Chromatin , vol.8 , pp. 6
    • Peters, T.J.1    Buckley, M.J.2    Statham, A.L.3
  • 27
    • 84869421697 scopus 로고    scopus 로고
    • Comb-p: Software for combining, analyzing, grouping and correcting spatially correlated p-values
    • Pedersen BS, Schwartz DA, Yang IV, Kechris KJ. Comb-p: software for combining, analyzing, grouping and correcting spatially correlated p-values. Bioinformatics 28(22), 2986-2988 (2012).
    • (2012) Bioinformatics , vol.28 , Issue.22 , pp. 2986-2988
    • Pedersen, B.S.1    Schwartz, D.A.2    Yang, I.V.3    Kechris, K.J.4
  • 28
    • 0001677717 scopus 로고
    • Controlling the false discovery rate - A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series. B Stat. Methodol. 57(1), 289-300 (1995).
    • (1995) J. R. Stat. Soc. Series. B Stat. Methodol , vol.57 , Issue.1 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 29
    • 84947402121 scopus 로고
    • Rectangular confidence regions for the means of multivariate normal distributions
    • Sidak Z. Rectangular confidence regions for the means of multivariate normal distributions. J. Am. Stat. Assoc. 62(318), 8 (1967).
    • (1967) J. Am. Stat. Assoc , vol.62 , Issue.318 , pp. 8
    • Sidak, Z.1
  • 31
    • 0036079158 scopus 로고    scopus 로고
    • The human genome browser at UCSC
    • Kent WJ, Sugnet CW, Furey TS et al. The human genome browser at UCSC. Genome Res. 12(6), 996-1006 (2002).
    • (2002) Genome Res , vol.12 , Issue.6 , pp. 996-1006
    • Kent, W.J.1    Sugnet, C.W.2    Furey, T.S.3
  • 32
    • 85021754958 scopus 로고    scopus 로고
    • UCSC Genome Browser. http://genome.ucsc.edu
  • 33
    • 84928804387 scopus 로고    scopus 로고
    • CoMET: Visualisation of regional epigenome-wide association scan results and DNA co-methylation patterns
    • Martin TC, Yet I, Tsai PC, Bell JT. coMET: visualisation of regional epigenome-wide association scan results and DNA co-methylation patterns. BMC Bioinformatics 16, 131 (2015).
    • (2015) BMC Bioinformatics , vol.16 , pp. 131
    • Martin, T.C.1    Yet, I.2    Tsai, P.C.3    Bell, J.T.4
  • 34
    • 85021753896 scopus 로고    scopus 로고
    • Roadmap Epigenomics Visualization Hub (VizHub). http://vizhub.wustl.edu/
  • 35
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Consortium EP. An integrated encyclopedia of DNA elements in the human genome. Nature 489(7414), 57-74 (2012).
    • (2012) Nature , vol.489 , Issue.7414 , pp. 57-74
    • Consortium, E.P.1
  • 36
    • 84878682420 scopus 로고    scopus 로고
    • The Genotype-Tissue Expression (GTEx) project
    • Consortium GT. The Genotype-Tissue Expression (GTEx) project. Nat. Genet. 45(6), 580-585 (2013).
    • (2013) Nat. Genet , vol.45 , Issue.6 , pp. 580-585
    • Consortium, G.T.1
  • 38
    • 84925310744 scopus 로고    scopus 로고
    • Comprehensive analysis of transcriptome sequencing data in the lung tissues of COPD subjects
    • Kim WJ, Lim JH, Lee JS, Lee SD, Kim JH, Oh YM. Comprehensive analysis of transcriptome sequencing data in the lung tissues of COPD subjects. Int. J. Genomics 2015, 206937 (2015).
    • (2015) Int. J. Genomics , vol.2015 , pp. 206937
    • Kim, W.J.1    Lim, J.H.2    Lee, J.S.3    Lee, S.D.4    Kim, J.H.5    Oh, Y.M.6
  • 41
    • 80051702878 scopus 로고    scopus 로고
    • Combinatorial effect of TIMP-1 and alpha1AT gene polymorphisms on development of chronic obstructive pulmonary disease
    • Kumar M, Bhadoria DP, Dutta K et al. Combinatorial effect of TIMP-1 and alpha1AT gene polymorphisms on development of chronic obstructive pulmonary disease. Clin. Biochem. 44(13), 1067-1073 (2011).
    • (2011) Clin. Biochem , vol.44 , Issue.13 , pp. 1067-1073
    • Kumar, M.1    Bhadoria, D.P.2    Dutta, K.3
  • 42
    • 84921553409 scopus 로고    scopus 로고
    • Prevalence of alpha-1 antitrypsin high-risk variants in Mexican mestizo population and their association with lung function values
    • Perez-Rubio G, Jimenez-Valverde LO, Ramirez-Venegas A et al. Prevalence of alpha-1 antitrypsin high-risk variants in Mexican mestizo population and their association with lung function values. Arch. Bronconeumol. 51(2), 80-85 (2015).
    • (2015) Arch. Bronconeumol , vol.51 , Issue.2 , pp. 80-85
    • Perez-Rubio, G.1    Jimenez-Valverde, L.O.2    Ramirez-Venegas, A.3
  • 43
    • 84959273257 scopus 로고    scopus 로고
    • Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12
    • Jackson VE, Ntalla I, Sayers I et al. Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax 71(6), 501-509 (2016).
    • (2016) Thorax , vol.71 , Issue.6 , pp. 501-509
    • Jackson, V.E.1    Ntalla, I.2    Sayers, I.3
  • 44
    • 80055008094 scopus 로고    scopus 로고
    • Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
    • Soler Artigas M, Loth DW, Wain LV et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat. Genet. 43(11), 1082-1090 (2011).
    • (2011) Nat. Genet , vol.43 , Issue.11 , pp. 1082-1090
    • Soler Artigas, M.1    Loth, D.W.2    Wain, L.V.3
  • 45
    • 73349111257 scopus 로고    scopus 로고
    • Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
    • Hancock DB, Eijgelsheim M, Wilk JB et al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat. Genet. 42(1), 45-52 (2010).
    • (2010) Nat. Genet , vol.42 , Issue.1 , pp. 45-52
    • Hancock, D.B.1    Eijgelsheim, M.2    Wilk, J.B.3
  • 46
    • 84891747469 scopus 로고    scopus 로고
    • Genome-wide association study of lung function phenotypes in a founder population
    • e241-e210
    • Yao TC, Du G, Han L et al. Genome-wide association study of lung function phenotypes in a founder population. J. Allergy Clin. Immunol. 133(1), 248-255; e241-e210 (2014).
    • (2014) J. Allergy Clin. Immunol , vol.133 , Issue.1 , pp. 248-255
    • Yao, T.C.1    Du, G.2    Han, L.3
  • 47
    • 84881156244 scopus 로고    scopus 로고
    • Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
    • Li X, Hawkins GA, Ampleford EJ et al. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J. Allergy Clin. Immunol. 132(2), 313e315-320e315 (2013).
    • (2013) J. Allergy Clin. Immunol , vol.132 , Issue.2 , pp. 313e315-320e315
    • Li, X.1    Hawkins, G.A.2    Ampleford, E.J.3
  • 48
    • 20244379268 scopus 로고    scopus 로고
    • Polymorphisms of TNFalpha, IL1beta, and IL1RN genes in chronic obstructive pulmonary disease
    • Hegab AE, Sakamoto T, Saitoh W et al. Polymorphisms of TNFalpha, IL1beta, and IL1RN genes in chronic obstructive pulmonary disease. Biochem. Biophys. Res. Commun. 329(4), 1246-1252 (2005).
    • (2005) Biochem. Biophys. Res. Commun , vol.329 , Issue.4 , pp. 1246-1252
    • Hegab, A.E.1    Sakamoto, T.2    Saitoh, W.3
  • 49
    • 84906084215 scopus 로고    scopus 로고
    • Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations
    • Plate M, Lawson PJ, Hill MR et al. Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations. Am. J. Physiol. Lung Cell Mol. Physiol. 307(4), L311-L316 (2014).
    • (2014) Am. J. Physiol. Lung Cell Mol. Physiol , vol.307 , Issue.4 , pp. L311-L316
    • Plate, M.1    Lawson, P.J.2    Hill, M.R.3
  • 50
    • 77954814332 scopus 로고    scopus 로고
    • Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population
    • Lee SY, Kim MJ, Kang HG et al. Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population. Respiration 80(2), 133-138 (2010).
    • (2010) Respiration , vol.80 , Issue.2 , pp. 133-138
    • Lee, S.Y.1    Kim, M.J.2    Kang, H.G.3
  • 51
    • 80052832530 scopus 로고    scopus 로고
    • Genetics of sputum gene expression in chronic obstructive pulmonary disease
    • Qiu W, Cho MH, Riley JH et al. Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS ONE 6(9), e24395 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.9 , pp. e24395
    • Qiu, W.1    Cho, M.H.2    Riley, J.H.3
  • 52
    • 84925424005 scopus 로고    scopus 로고
    • The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc
    • Sun XX, He X, Yin L, Komada M, Sears RC, Dai MS. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proc. Natl Acad. Sci. USA 112(12), 3734-3739 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , Issue.12 , pp. 3734-3739
    • Sun, X.X.1    He, X.2    Yin, L.3    Komada, M.4    Sears, R.C.5    Dai, M.S.6
  • 53
    • 84872034012 scopus 로고    scopus 로고
    • Genomewide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function
    • Hancock DB, Soler Artigas M, Gharib SA et al. Genomewide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet. 8(12), e1003098 (2012).
    • (2012) PLoS Genet , vol.8 , Issue.12 , pp. e1003098
    • Hancock, D.B.1    Soler Artigas, M.2    Gharib, S.A.3
  • 54
    • 84871797748 scopus 로고    scopus 로고
    • Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease
    • Kim DK, Cho MH, Hersh CP et al. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 186(12), 1238-1247 (2012).
    • (2012) Am. J. Respir. Crit. Care Med , vol.186 , Issue.12 , pp. 1238-1247
    • Kim, D.K.1    Cho, M.H.2    Hersh, C.P.3
  • 55
    • 84975129723 scopus 로고    scopus 로고
    • Bridging lung development with chronic obstructive pulmonary disease. Relevance of developmental pathways in chronic obstructive pulmonary disease pathogenesis
    • Boucherat O, Morissette MC, Provencher S, Bonnet S, Maltais F. Bridging lung development with chronic obstructive pulmonary disease. Relevance of developmental pathways in chronic obstructive pulmonary disease pathogenesis. Am. J. Respir. Crit. Care Med. 193(4), 362-375 (2016).
    • (2016) Am. J. Respir. Crit. Care Med , vol.193 , Issue.4 , pp. 362-375
    • Boucherat, O.1    Morissette, M.C.2    Provencher, S.3    Bonnet, S.4    Maltais, F.5
  • 56
    • 84985911227 scopus 로고    scopus 로고
    • Early-life origins of chronic obstructive pulmonary disease
    • Martinez FD. Early-life origins of chronic obstructive pulmonary disease. N. Engl. J. Med. 375(9), 871-878 (2016).
    • (2016) N. Engl. J. Med , vol.375 , Issue.9 , pp. 871-878
    • Martinez, F.D.1
  • 57
    • 84880617636 scopus 로고    scopus 로고
    • WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): Update 2013
    • Wang J, Duncan D, Shi Z, Zhang B. WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013. Nucleic Acids Res. 41, W77-W83 (2013).
    • (2013) Nucleic Acids Res , vol.41 , pp. W77-W83
    • Wang, J.1    Duncan, D.2    Shi, Z.3    Zhang, B.4
  • 58
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio TA, Collins FS, Cox NJ et al. Finding the missing heritability of complex diseases. Nature 461(7265), 747-753 (2009).
    • (2009) Nature , vol.461 , Issue.7265 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.