Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12

Thorax

Volumn 71, Issue 6, 2016, Pages 501-509

  Jackson, Victoria E ^a   Ntalla, Ioanna ^a,b   Sayers, Ian ^c   Morris, Richard ^d,e   Whincup, Peter ^f   Casas, Juan Pablo ^e,g   Amuzu, Antoinette ^h   Choi, Minkyoung ^h   Dale, Caroline ^h   Kumari, Meena ^e,i   Engmann, Jorgen ^e   Kalsheker, Noor ^c   Chappell, Sally ^c   Guetta Baranes, Tamar ^c   McKeever, Tricia M ^c   Palmer, Colin N A ^j   Tavendale, Roger ^j   Holloway, John W ^k,l   Sayer, Avan A ^m,n   Dennison, Elaine M ^m,o   Cooper, Cyrus ^m,n   Bafadhel, Mona ^p   Barker, Bethan ^a,q   Brightling, Chris ^a,q   Bolton, Charlotte E ^c   John, Michelle E ^c   Parker, Stuart G ^r   Moffat, Miriam F ^s   Wardlaw, Andrew J ^a,q   Connolly, Martin J ^t   Porteous, David J ^u   Smith, Blair H ^v   Padmanabhan, Sandosh ^w   Hocking, Lynne ^x   Stirrups, Kathleen E ^b,y   Deloukas, Panos ^b,z   Strachan, David P ^f   Hall, Ian P ^c   Tobin, Martin D ^a,q   Wain, Louise V ^a   more..

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^g Farr Institute of Health Informatics ^*  (United Kingdom)

^h LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

ⁱ UNIVERSITY OF ESSEX   (United Kingdom)

^j UNIVERSITY OF DUNDEE   (United Kingdom)

^k UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^l SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^m UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

ⁿ UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^o VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^p UNIVERSITY OF OXFORD   (United Kingdom)

^q GLENFIELD HOSPITAL   (United Kingdom)

^r NEWCASTLE UNIVERSITY   (United Kingdom)

^s NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^t UNIVERSITY OF AUCKLAND   (New Zealand)

^u UNIVERSITY OF EDINBURGH   (United Kingdom)

^v UNIVERSITY OF DUNDEE   (United Kingdom)

^w UNIVERSITY OF GLASGOW   (United Kingdom)

^x UNIVERSITY OF ABERDEEN   (United Kingdom)

^y UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^z KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AIRWAY OBSTRUCTION; ANCESTRY GROUP; ARTICLE; CHRNA5 GENE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; DISEASE SEVERITY; EUROPEAN; EXOME; FEMALE; FOLLOW UP; FORCED EXPIRATORY VOLUME; FUNCTIONAL ASSESSMENT; GENE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC RISK; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; GPR126 GENE; HHIP GENE; HUMAN; IFIT3 GENE; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); MMP12 GENE; MOCS3 GENE; POPULATION BASED CASE CONTROL STUDY; POPULATION RESEARCH; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; SERPINA12 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; EPIDEMIOLOGY; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MIDDLE AGED; PATHOPHYSIOLOGY;

IFIT3 PROTEIN, HUMAN; MOCS3 PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE; SERINE PROTEINASE INHIBITOR; SERPINA12 PROTEIN, HUMAN; SIGNAL PEPTIDE; SULFURTRANSFERASE;

AGED; AIRWAY OBSTRUCTION; EXOME; FEMALE; FORCED EXPIRATORY VOLUME; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; NUCLEOTIDYLTRANSFERASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RISK ASSESSMENT; SERPINS; SMOKING; SULFURTRANSFERASES;

EID: 84959273257     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2015-207876     Document Type: Article

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