A composite of multiple signals distinguishes causal variants in regions of positive selection

Science

Volumn 327, Issue 5967, 2010, Pages 883-886

  Grossman, Sharon R ^a,b   Shylakhter, Ilya ^a,b   Karlsson, Elinor K ^a,b   Byrne, Elizabeth H ^a,b   Morales, Shannon ^a,b,c   Frieden, Gabriel ^a   Hostetter, Elizabeth ^a,b   Angelino, Elaine ^a,d   Garber, Manuel ^b   Zuk, Or ^b   Lander, Eric S ^b,d,e   Schaffner, Stephen F ^b   Sabeti, Pardis C ^b,d  

^a HARVARD UNIVERSITY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; GENETIC VARIATION; GENOMICS; GENOTYPE; HOMINID; MUTATION; NATURAL SELECTION;

ACCURACY; ARTICLE; COMPOSITE OF MULTIPLE SIGNAL; EVOLUTION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENE TECHNOLOGY; GENETIC SELECTION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; NATURAL SELECTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

COMPUTATIONAL BIOLOGY; DNA, INTERGENIC; EVOLUTION, MOLECULAR; GENETIC LOCI; GENETIC VARIATION; GENOME, HUMAN; HAPLOTYPES; HUMANS; POLYMORPHISM, GENETIC; POPULATION GROUPS; REGULATORY SEQUENCES, NUCLEIC ACID; SELECTION, GENETIC; SOFTWARE;

EID: 76749155514     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1183863     Document Type: Article

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18. www.1000genomes.org We thank K. Andersen, J. Lohmueller, B. Stranger, S. McCarroll, K. Lohmueller, K. Lindblad-Toh, M. Guttman, and J. Rinn for functional guidance, and E. Phelan, D. Altshuler, and the Sabeti Lab for helpful discussions throughout. P.C.S. is supported by the Burroughs Wellcome and Packard foundations. E.K.K. is supported by the American Cancer Society.