Darwinian dynamics of intratumoral heterogeneity: Not solely random mutations but also variable environmental selection forces

Cancer Research

Volumn 76, Issue 11, 2016, Pages 3136-3144

  Lloyd, Mark C ^a,b   Cunningham, Jessica J ^c   Bui, Marilyn M ^c   Gillies, Robert J ^c   Brown, Joel S ^b   Gatenby, Robert A ^c  

^a Inspirata Inc   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; CASPASE 3; CD34 ANTIGEN; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KI 67 ANTIGEN; SLC2A1 PROTEIN, HUMAN; TUMOR MARKER;

ALGORITHM; ANGIOGENESIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER RESEARCH; CANCER STAGING; CARCINOGENESIS; CELL POPULATION; CLINICAL ARTICLE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MATHEMATICAL MODEL; MOLECULAR EVOLUTION; ONCOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; TUMOR BLOOD FLOW; TUMOR INVASION; TUMOR MICROENVIRONMENT; UPREGULATION; BREAST TUMOR; ENZYME IMMUNOASSAY; FEMALE; GENETICS; METABOLISM; MUTATION; NEOVASCULARIZATION (PATHOLOGY); PAGET NIPPLE DISEASE; PATHOLOGY; RETROSPECTIVE STUDY; THEORETICAL MODEL;

BIOMARKERS, TUMOR; BREAST NEOPLASMS; CARBONIC ANHYDRASE IX; CARCINOMA, DUCTAL, BREAST; FEMALE; GLUCOSE TRANSPORTER TYPE 1; HUMANS; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; MODELS, THEORETICAL; MUTATION; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; RETROSPECTIVE STUDIES; TUMOR MICROENVIRONMENT;

EID: 84975093395     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-2962     Document Type: Article

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