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Volumn 593, Issue , 2017, Pages 175-198

Modeling Neurodegenerative Disorders for Developing Cannabinoid-Based Neuroprotective Therapies

Author keywords

Cannabinoids; Chronic progressive neurodegenerative disorders; Endocannabinoids; Neurodegeneration; Neuroprotection; Neurorepair

Indexed keywords

CANNABINOID; ENDOCANNABINOID; NEUROPROTECTIVE AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; CANNABINOID RECEPTOR;

EID: 85021697926     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/bs.mie.2017.06.021     Document Type: Chapter
Times cited : (13)

References (89)
  • 1
    • 84901791811 scopus 로고    scopus 로고
    • COX-2-derived endocannabinoid metabolites as novel inflammatory mediators
    • Alhouayek, M., Muccioli, G.G., COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. Trends in Pharmacological Sciences 35 (2014), 284–292.
    • (2014) Trends in Pharmacological Sciences , vol.35 , pp. 284-292
    • Alhouayek, M.1    Muccioli, G.G.2
  • 2
    • 84979258488 scopus 로고    scopus 로고
    • Why cortical neurons cannot divide, and why do they usually die in the attempt?
    • Aranda-Anzaldo, A., Dent, M.A., Why cortical neurons cannot divide, and why do they usually die in the attempt?. Journal of Neuroscience Research 95 (2017), 921–929.
    • (2017) Journal of Neuroscience Research , vol.95 , pp. 921-929
    • Aranda-Anzaldo, A.1    Dent, M.A.2
  • 4
    • 84924042444 scopus 로고    scopus 로고
    • The ongoing pursuit of neuroprotective therapies in Parkinson's disease
    • Athauda, D., Foltynie, T., The ongoing pursuit of neuroprotective therapies in Parkinson's disease. Nature Reviews. Neurology 11 (2015), 25–40.
    • (2015) Nature Reviews. Neurology , vol.11 , pp. 25-40
    • Athauda, D.1    Foltynie, T.2
  • 5
    • 84922401185 scopus 로고    scopus 로고
    • Inflammation and neurodegenerative disorders: Is there still hope for therapeutic intervention?
    • Baune, B.T., Inflammation and neurodegenerative disorders: Is there still hope for therapeutic intervention?. Current Opinion in Psychiatry 28 (2015), 148–154.
    • (2015) Current Opinion in Psychiatry , vol.28 , pp. 148-154
    • Baune, B.T.1
  • 6
    • 0348010292 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains
    • Benito, C., Nuñez, E., Tolon, R.M., et al. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of Neuroscience 23 (2003), 11136–11141.
    • (2003) The Journal of Neuroscience , vol.23 , pp. 11136-11141
    • Benito, C.1    Nuñez, E.2    Tolon, R.M.3
  • 7
  • 8
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: Effects on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno, T., Hanus, L., De Petrocellis, L., et al. Molecular targets for cannabidiol and its synthetic analogues: Effects on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. British Journal of Pharmacology 134 (2001), 845–852.
    • (2001) British Journal of Pharmacology , vol.134 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3
  • 9
    • 1842428537 scopus 로고    scopus 로고
    • Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism
    • Carrier, E.J., Kearn, C.S., Barkmeier, A.J., et al. Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. Molecular Pharmacology 65 (2004), 999–1007.
    • (2004) Molecular Pharmacology , vol.65 , pp. 999-1007
    • Carrier, E.J.1    Kearn, C.S.2    Barkmeier, A.J.3
  • 11
    • 77952926102 scopus 로고    scopus 로고
    • Clinical progression in Parkinson disease and the neurobiology of axons
    • Cheng, H.C., Ulane, C.M., Burke, R.E., Clinical progression in Parkinson disease and the neurobiology of axons. Annals of Neurology 67 (2010), 715–725.
    • (2010) Annals of Neurology , vol.67 , pp. 715-725
    • Cheng, H.C.1    Ulane, C.M.2    Burke, R.E.3
  • 12
    • 84874536805 scopus 로고    scopus 로고
    • Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury
    • Choi, I.Y., Ju, C., Anthony Jalin, A.M., et al. Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury. The American Journal of Pathology 182 (2013), 928–939.
    • (2013) The American Journal of Pathology , vol.182 , pp. 928-939
    • Choi, I.Y.1    Ju, C.2    Anthony Jalin, A.M.3
  • 13
    • 41249085808 scopus 로고    scopus 로고
    • Molecular mechanism of PPAR in the regulation of age-related inflammation
    • Chung, J.H., Seo, A.Y., Chung, S.W., et al. Molecular mechanism of PPAR in the regulation of age-related inflammation. Ageing Research Reviews 7 (2008), 126–136.
    • (2008) Ageing Research Reviews , vol.7 , pp. 126-136
    • Chung, J.H.1    Seo, A.Y.2    Chung, S.W.3
  • 18
    • 33846572874 scopus 로고    scopus 로고
    • Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030
    • Dorsey, E.R., Constantinescu, R., Thompson, J.P., Biglan, K.M., Holloway, R.G., Kieburtz, K., et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 68 (2007), 384–386.
    • (2007) Neurology , vol.68 , pp. 384-386
    • Dorsey, E.R.1    Constantinescu, R.2    Thompson, J.P.3    Biglan, K.M.4    Holloway, R.G.5    Kieburtz, K.6
  • 19
    • 83455224661 scopus 로고    scopus 로고
    • CB₁ receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus
    • Duarte, J.M., Ferreira, S.G., Carvalho, R.A., Cunha, R.A., Köfalvi, A., CB₁ receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus. Neurochemistry International 60 (2012), 1–8.
    • (2012) Neurochemistry International , vol.60 , pp. 1-8
    • Duarte, J.M.1    Ferreira, S.G.2    Carvalho, R.A.3    Cunha, R.A.4    Köfalvi, A.5
  • 20
    • 85017109840 scopus 로고    scopus 로고
    • Bridging the gap: Large animal models in neurodegenerative research
    • in press
    • Eaton, S.L., Wishart, T.M., Bridging the gap: Large animal models in neurodegenerative research. Mammalian Genome, 2017, 10.1007/s00335-017-9687-6 in press.
    • (2017) Mammalian Genome
    • Eaton, S.L.1    Wishart, T.M.2
  • 21
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in β-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement
    • Esposito, G., De Filippis, D., Maiuri, M.C., et al. Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in β-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neuroscience Letters 399 (2006), 91–95.
    • (2006) Neuroscience Letters , vol.399 , pp. 91-95
    • Esposito, G.1    De Filippis, D.2    Maiuri, M.C.3
  • 22
    • 34547878297 scopus 로고    scopus 로고
    • Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression
    • Esposito, G., Scuderi, C., Savani, C., et al. Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression. British Journal of Pharmacology 151 (2007), 1272–1279.
    • (2007) British Journal of Pharmacology , vol.151 , pp. 1272-1279
    • Esposito, G.1    Scuderi, C.2    Savani, C.3
  • 23
    • 82655189157 scopus 로고    scopus 로고
    • Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement
    • Esposito, G., Scuderi, C., Valenza, M., et al. Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement. PLoS One, 6, 2011, e28668.
    • (2011) PLoS One , vol.6
    • Esposito, G.1    Scuderi, C.2    Valenza, M.3
  • 24
    • 84895759461 scopus 로고    scopus 로고
    • The influence of cannabinoids on generic traits of neurodegeneration
    • Fagan, S.G., Campbell, V.A., The influence of cannabinoids on generic traits of neurodegeneration. British Journal of Pharmacology 171 (2014), 1347–1360.
    • (2014) British Journal of Pharmacology , vol.171 , pp. 1347-1360
    • Fagan, S.G.1    Campbell, V.A.2
  • 25
    • 84938899365 scopus 로고    scopus 로고
    • Cannabinoids in neurodegenerative disorders and stroke/brain trauma: From preclinical models to clinical applications
    • Fernández-Ruiz, J., Moro, M.A., Martínez-Orgado, J., Cannabinoids in neurodegenerative disorders and stroke/brain trauma: From preclinical models to clinical applications. Neurotherapeutics 12 (2015), 793–806.
    • (2015) Neurotherapeutics , vol.12 , pp. 793-806
    • Fernández-Ruiz, J.1    Moro, M.A.2    Martínez-Orgado, J.3
  • 26
    • 84942522294 scopus 로고    scopus 로고
    • Endocannabinoids and neurodegenerative disorders: Parkinson's disease, Huntington's chorea, Alzheimer's disease, and others
    • Fernández-Ruiz, J., Romero, J., Ramos, J.A., Endocannabinoids and neurodegenerative disorders: Parkinson's disease, Huntington's chorea, Alzheimer's disease, and others. Handbook of Experimental Pharmacology 231 (2015), 233–259.
    • (2015) Handbook of Experimental Pharmacology , vol.231 , pp. 233-259
    • Fernández-Ruiz, J.1    Romero, J.2    Ramos, J.A.3
  • 27
    • 33845959991 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor: A new target for controlling neural cell survival?
    • Fernández-Ruiz, J., Romero, J., Velasco, G., et al. Cannabinoid CB2 receptor: A new target for controlling neural cell survival?. Trends in Pharmacological Sciences 28 (2007), 39–45.
    • (2007) Trends in Pharmacological Sciences , vol.28 , pp. 39-45
    • Fernández-Ruiz, J.1    Romero, J.2    Velasco, G.3
  • 28
    • 84872256489 scopus 로고    scopus 로고
    • Cannabidiol for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid?
    • Fernández-Ruiz, J., Sagredo, O., Pazos, M.R., et al. Cannabidiol for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid?. British Journal of Clinical Pharmacology 75 (2013), 323–333.
    • (2013) British Journal of Clinical Pharmacology , vol.75 , pp. 323-333
    • Fernández-Ruiz, J.1    Sagredo, O.2    Pazos, M.R.3
  • 29
    • 84903688936 scopus 로고    scopus 로고
    • Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands
    • Fidaleo, M., Fanelli, F., Ceru, M.P., Moreno, S., Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands. Current Medicinal Chemistry 21 (2014), 2803–2821.
    • (2014) Current Medicinal Chemistry , vol.21 , pp. 2803-2821
    • Fidaleo, M.1    Fanelli, F.2    Ceru, M.P.3    Moreno, S.4
  • 30
    • 77953712552 scopus 로고    scopus 로고
    • Modulation of the endocannabinoid system: Neuroprotection or neurotoxicity?
    • Fowler, C.J., Rojo, M.L., Rodriguez-Gaztelumendi, A., Modulation of the endocannabinoid system: Neuroprotection or neurotoxicity?. Experimental Neurology 224 (2010), 37–47.
    • (2010) Experimental Neurology , vol.224 , pp. 37-47
    • Fowler, C.J.1    Rojo, M.L.2    Rodriguez-Gaztelumendi, A.3
  • 31
    • 84924550820 scopus 로고    scopus 로고
    • Neuronal cell cycle: The neuron itself and its circumstances
    • Frade, J.M., Ovejero-Benito, M.C., Neuronal cell cycle: The neuron itself and its circumstances. Cell Cycle 14 (2015), 712–720.
    • (2015) Cell Cycle , vol.14 , pp. 712-720
    • Frade, J.M.1    Ovejero-Benito, M.C.2
  • 32
    • 85015654999 scopus 로고    scopus 로고
    • Alzheimer's disease biomarker development: A call to funding bodies (special issue-roadmap to Alzheimer's biomarkers in the clinic)
    • Frisoni, G.B., Jack, C.R. Jr., Winblad, B., Alzheimer's disease biomarker development: A call to funding bodies (special issue-roadmap to Alzheimer's biomarkers in the clinic). Neurobiology of Aging 52 (2017), 117–118.
    • (2017) Neurobiology of Aging , vol.52 , pp. 117-118
    • Frisoni, G.B.1    Jack, C.R.2    Winblad, B.3
  • 33
    • 84902075767 scopus 로고    scopus 로고
    • Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats
    • Fujii, M., Sherchan, P., Krafft, P.R., Rolland, W.B., Soejima, Y., Zhang, J.H., Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats. Journal of the Neurological Sciences 342 (2014), 101–106.
    • (2014) Journal of the Neurological Sciences , vol.342 , pp. 101-106
    • Fujii, M.1    Sherchan, P.2    Krafft, P.R.3    Rolland, W.B.4    Soejima, Y.5    Zhang, J.H.6
  • 36
    • 84877948856 scopus 로고    scopus 로고
    • Rationally designed multi-targeted agents against neurodegenerative diseases
    • Geldenhuys, W.J., Van der Schyf, C.J., Rationally designed multi-targeted agents against neurodegenerative diseases. Current Medicinal Chemistry 20 (2013), 1662–1672.
    • (2013) Current Medicinal Chemistry , vol.20 , pp. 1662-1672
    • Geldenhuys, W.J.1    Van der Schyf, C.J.2
  • 37
    • 78649394510 scopus 로고    scopus 로고
    • The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation
    • Gómez, O., Arévalo-Martin, A., García-Ovejero, D., et al. The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation. Glia 58 (2010), 1913–1927.
    • (2010) Glia , vol.58 , pp. 1913-1927
    • Gómez, O.1    Arévalo-Martin, A.2    García-Ovejero, D.3
  • 38
    • 84999905115 scopus 로고    scopus 로고
    • Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways
    • Gómez, O., Sanchez-Rodriguez, A., Le, M., et al. Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways. British Journal of Pharmacology 163 (2011), 1520–1532.
    • (2011) British Journal of Pharmacology , vol.163 , pp. 1520-1532
    • Gómez, O.1    Sanchez-Rodriguez, A.2    Le, M.3
  • 39
    • 85019217957 scopus 로고    scopus 로고
    • Brain aging and neurodegeneration: From a mitochondrial point of view
    • in press
    • Grimm, A., Eckert, A., Brain aging and neurodegeneration: From a mitochondrial point of view. Journal of Neurochemistry, 2017, 10.1111/jnc.14037 in press.
    • (2017) Journal of Neurochemistry
    • Grimm, A.1    Eckert, A.2
  • 40
    • 0031914157 scopus 로고    scopus 로고
    • Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission
    • Hampson, A.J., Bornheim, L.M., Scanziani, M., et al. Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission. Journal of Neurochemistry 70 (1998), 671–676.
    • (1998) Journal of Neurochemistry , vol.70 , pp. 671-676
    • Hampson, A.J.1    Bornheim, L.M.2    Scanziani, M.3
  • 41
    • 84940467236 scopus 로고    scopus 로고
    • The complex modulation of lysosomal degradation pathways by cannabinoid receptors 1 and 2
    • Hiebel, C., Behl, C., The complex modulation of lysosomal degradation pathways by cannabinoid receptors 1 and 2. Life Sciences 138 (2015), 3–7.
    • (2015) Life Sciences , vol.138 , pp. 3-7
    • Hiebel, C.1    Behl, C.2
  • 42
    • 84951299418 scopus 로고    scopus 로고
    • Genetically modified pig models for neurodegenerative disorders
    • Holm, I.E., Alstrup, A.K., Luo, Y., Genetically modified pig models for neurodegenerative disorders. The Journal of Pathology 238 (2016), 267–287.
    • (2016) The Journal of Pathology , vol.238 , pp. 267-287
    • Holm, I.E.1    Alstrup, A.K.2    Luo, Y.3
  • 43
    • 84975743196 scopus 로고    scopus 로고
    • A beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies
    • Hoque, A., Hossain, M.I., Ameen, S.S., Ang, C.S., Williamson, N., Ng, D.C., et al. A beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies. Pharmacology & Therapeutics 160 (2016), 159–179.
    • (2016) Pharmacology & Therapeutics , vol.160 , pp. 159-179
    • Hoque, A.1    Hossain, M.I.2    Ameen, S.S.3    Ang, C.S.4    Williamson, N.5    Ng, D.C.6
  • 44
    • 77950692040 scopus 로고    scopus 로고
    • Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: A neuroprotective therapeutic modality
    • Hwang, J., Adamson, C., Butler, D., Janero, D.R., Makriyannis, A., Bahr, B.A., Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: A neuroprotective therapeutic modality. Life Sciences 86 (2010), 615–623.
    • (2010) Life Sciences , vol.86 , pp. 615-623
    • Hwang, J.1    Adamson, C.2    Butler, D.3    Janero, D.R.4    Makriyannis, A.5    Bahr, B.A.6
  • 46
    • 0033617527 scopus 로고    scopus 로고
    • Assessing the decade of the brain
    • Jones, E.G., Mendell, L.M., Assessing the decade of the brain. Science, 284, 1999, 739.
    • (1999) Science , vol.284 , pp. 739
    • Jones, E.G.1    Mendell, L.M.2
  • 47
    • 4544378328 scopus 로고    scopus 로고
    • The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B (NF-kappa B)
    • Jüttler, E., Potrovita, I., Tarabin, V., et al. The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B (NF-kappa B). Neuropharmacology 47 (2004), 580–592.
    • (2004) Neuropharmacology , vol.47 , pp. 580-592
    • Jüttler, E.1    Potrovita, I.2    Tarabin, V.3
  • 48
    • 84884716351 scopus 로고    scopus 로고
    • The G protein-coupled receptor 55 ligand l-α-lysophosphatidylinositol exerts microglia-dependent neuroprotection after excitotoxic lesion
    • Kallendrusch, S., Kremzow, S., Nowicki, M., Grabiec, U., Winkelmann, R., Benz, A., et al. The G protein-coupled receptor 55 ligand l-α-lysophosphatidylinositol exerts microglia-dependent neuroprotection after excitotoxic lesion. Glia 61 (2013), 1822–1831.
    • (2013) Glia , vol.61 , pp. 1822-1831
    • Kallendrusch, S.1    Kremzow, S.2    Nowicki, M.3    Grabiec, U.4    Winkelmann, R.5    Benz, A.6
  • 49
    • 28844469924 scopus 로고    scopus 로고
    • Molecular mechanism of nrf2 activation by oxidative stress
    • Kang, K.W., Lee, S.J., Kim, S.G., Molecular mechanism of nrf2 activation by oxidative stress. Antioxidants & Redox Signaling 7 (2005), 1664–1673.
    • (2005) Antioxidants & Redox Signaling , vol.7 , pp. 1664-1673
    • Kang, K.W.1    Lee, S.J.2    Kim, S.G.3
  • 50
    • 84874113211 scopus 로고    scopus 로고
    • The role of CB1 in immune modulation by cannabinoids
    • Kaplan, B.L., The role of CB1 in immune modulation by cannabinoids. Pharmacology & Therapeutics 137 (2013), 365–374.
    • (2013) Pharmacology & Therapeutics , vol.137 , pp. 365-374
    • Kaplan, B.L.1
  • 52
    • 84875543467 scopus 로고    scopus 로고
    • The current and projected economic burden of Parkinson's disease in the United States
    • Kowal, S.L., Dall, T.M., Chakrabarti, R., Storm, M.V., Jain, A., The current and projected economic burden of Parkinson's disease in the United States. Movement Disorders 28 (2013), 311–318.
    • (2013) Movement Disorders , vol.28 , pp. 311-318
    • Kowal, S.L.1    Dall, T.M.2    Chakrabarti, R.3    Storm, M.V.4    Jain, A.5
  • 53
    • 76249095734 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-β/STAT proinflammatory pathways in BV-2 microglial cells
    • 9-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-β/STAT proinflammatory pathways in BV-2 microglial cells. The Journal of Biological Chemistry 285 (2010), 1616–1626.
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 1616-1626
    • Kozela, E.1    Pietr, M.2    Juknat, A.3
  • 56
    • 84858391237 scopus 로고    scopus 로고
    • Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
    • Leweke, F.M., Piomelli, D., Pahlisch, F., et al. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Translational Psychiatry, 2, 2012, e94.
    • (2012) Translational Psychiatry , vol.2
    • Leweke, F.M.1    Piomelli, D.2    Pahlisch, F.3
  • 59
    • 85015592755 scopus 로고    scopus 로고
    • Cre-loxP-mediated recombination: General principles and experimental considerations
    • McLellan, M.A., Rosenthal, N.A., Pinto, A.R., Cre-loxP-mediated recombination: General principles and experimental considerations. Current Protocols in Mouse Biology 7 (2017), 1–12.
    • (2017) Current Protocols in Mouse Biology , vol.7 , pp. 1-12
    • McLellan, M.A.1    Rosenthal, N.A.2    Pinto, A.R.3
  • 60
    • 38449086056 scopus 로고    scopus 로고
    • Endocannabinoids and traumatic brain injury
    • Mechoulam, R., Shohami, E., Endocannabinoids and traumatic brain injury. Molecular Neurobiology 36 (2007), 68–74.
    • (2007) Molecular Neurobiology , vol.36 , pp. 68-74
    • Mechoulam, R.1    Shohami, E.2
  • 62
    • 0041842648 scopus 로고    scopus 로고
    • Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia
    • Molina-Holgado, F., Pinteaux, E., Moore, J.D., et al. Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia. The Journal of Neuroscience 23 (2003), 6470–6474.
    • (2003) The Journal of Neuroscience , vol.23 , pp. 6470-6474
    • Molina-Holgado, F.1    Pinteaux, E.2    Moore, J.D.3
  • 63
    • 0037111841 scopus 로고    scopus 로고
    • Cannabinoids promote oligodendrocyte progenitor survival: Involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    • Molina-Holgado, E., Vela, J.M., Arevalo-Martin, A., et al. Cannabinoids promote oligodendrocyte progenitor survival: Involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling. The Journal of Neuroscience 22 (2002), 9742–9753.
    • (2002) The Journal of Neuroscience , vol.22 , pp. 9742-9753
    • Molina-Holgado, E.1    Vela, J.M.2    Arevalo-Martin, A.3
  • 65
    • 77951499518 scopus 로고    scopus 로고
    • Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NFκB activation in BV2 murine microglial cells
    • Oh, Y.T., Lee, J.Y., Lee, J., et al. Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NFκB activation in BV2 murine microglial cells. Neuroscience Letters 474 (2010), 148–153.
    • (2010) Neuroscience Letters , vol.474 , pp. 148-153
    • Oh, Y.T.1    Lee, J.Y.2    Lee, J.3
  • 66
    • 84898872648 scopus 로고    scopus 로고
    • Endocannabinoid-mediated retrograde modulation of synaptic transmission
    • Ohno-Shosaku, T., Kano, M., Endocannabinoid-mediated retrograde modulation of synaptic transmission. Current Opinion in Neurobiology 29C (2014), 1–8.
    • (2014) Current Opinion in Neurobiology , vol.29C , pp. 1-8
    • Ohno-Shosaku, T.1    Kano, M.2
  • 67
    • 79952198989 scopus 로고    scopus 로고
    • Is lipid signaling through cannabinoid 2 receptors part of a protective system?
    • Pacher, P., Mechoulam, R., Is lipid signaling through cannabinoid 2 receptors part of a protective system?. Progress in Lipid Research 50 (2011), 193–211.
    • (2011) Progress in Lipid Research , vol.50 , pp. 193-211
    • Pacher, P.1    Mechoulam, R.2
  • 68
    • 84931009752 scopus 로고    scopus 로고
    • Neuroprotection in experimental autoimmune encephalomyelitis and progressive multiple sclerosis by cannabis-based cannabinoids
    • Pryce, G., Riddall, D.R., Selwood, D.L., Giovannoni, G., Baker, D., Neuroprotection in experimental autoimmune encephalomyelitis and progressive multiple sclerosis by cannabis-based cannabinoids. Journal of Neuroimmune Pharmacology 10 (2015), 281–292.
    • (2015) Journal of Neuroimmune Pharmacology , vol.10 , pp. 281-292
    • Pryce, G.1    Riddall, D.R.2    Selwood, D.L.3    Giovannoni, G.4    Baker, D.5
  • 69
    • 84895752653 scopus 로고    scopus 로고
    • Changes in CB1 and CB2 receptors in the post-mortem cerebellum of humans affected by spinocerebellar ataxias
    • Rodríguez-Cueto, C., Benito, C., Fernández-Ruiz, J., et al. Changes in CB1 and CB2 receptors in the post-mortem cerebellum of humans affected by spinocerebellar ataxias. British Journal of Pharmacology 171 (2014), 1472–1489.
    • (2014) British Journal of Pharmacology , vol.171 , pp. 1472-1489
    • Rodríguez-Cueto, C.1    Benito, C.2    Fernández-Ruiz, J.3
  • 70
    • 84895933029 scopus 로고    scopus 로고
    • Endocannabinoid-hydrolysing enzymes in the post-mortem cerebellum of humans affected by hereditary autosomal dominant ataxias
    • Rodríguez-Cueto, C., Benito, C., Romero, J., Hernández-Gálvez, M., Gómez-Ruiz, M., Fernández-Ruiz, J., Endocannabinoid-hydrolysing enzymes in the post-mortem cerebellum of humans affected by hereditary autosomal dominant ataxias. Pathobiology 81 (2014), 149–159.
    • (2014) Pathobiology , vol.81 , pp. 149-159
    • Rodríguez-Cueto, C.1    Benito, C.2    Romero, J.3    Hernández-Gálvez, M.4    Gómez-Ruiz, M.5    Fernández-Ruiz, J.6
  • 71
    • 84992735493 scopus 로고    scopus 로고
    • Dysregulation of the endocannabinoid signaling system in the cerebellum and brainstem in a transgenic mouse model of spinocerebellar ataxia type-3
    • Rodríguez-Cueto, C., Hernández-Gálvez, M., Hillard, C.J., Maciel, P., García-García, L., Valdeolivas, S., et al. Dysregulation of the endocannabinoid signaling system in the cerebellum and brainstem in a transgenic mouse model of spinocerebellar ataxia type-3. Neuroscience 339 (2016), 191–209.
    • (2016) Neuroscience , vol.339 , pp. 191-209
    • Rodríguez-Cueto, C.1    Hernández-Gálvez, M.2    Hillard, C.J.3    Maciel, P.4    García-García, L.5    Valdeolivas, S.6
  • 72
    • 84999204603 scopus 로고    scopus 로고
    • Imaging in neurodegenerative disorders
    • Oxford University Press USA
    • Saba, L., Imaging in neurodegenerative disorders. 2015, Oxford University Press, USA.
    • (2015)
    • Saba, L.1
  • 73
    • 84907923806 scopus 로고    scopus 로고
    • Clinical trials in Huntington's disease: Interventions in early clinical development and newer methodological approaches
    • Sampaio, C., Borowsky, B., Reilmann, R., Clinical trials in Huntington's disease: Interventions in early clinical development and newer methodological approaches. Movement Disorders 29 (2014), 1419–1428.
    • (2014) Movement Disorders , vol.29 , pp. 1419-1428
    • Sampaio, C.1    Borowsky, B.2    Reilmann, R.3
  • 75
    • 0033819840 scopus 로고    scopus 로고
    • A non-psychotropic cannabinoid with neuroprotective properties
    • Shohami, E., Mechoulam, R., A non-psychotropic cannabinoid with neuroprotective properties. Drug Development Research 50 (2000), 211–215.
    • (2000) Drug Development Research , vol.50 , pp. 211-215
    • Shohami, E.1    Mechoulam, R.2
  • 76
    • 0034069673 scopus 로고    scopus 로고
    • Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice
    • Smith, S.R., Terminelli, C., Denhardt, G., Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice. The Journal of Pharmacology and Experimental Therapeutics 293 (2000), 136–150.
    • (2000) The Journal of Pharmacology and Experimental Therapeutics , vol.293 , pp. 136-150
    • Smith, S.R.1    Terminelli, C.2    Denhardt, G.3
  • 77
    • 43949146665 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: “Key” regulators of neuroinflammation after traumatic brain injury
    • Stahel, P.F., Smith, W.R., Bruchis, J., Rabb, C.H., Peroxisome proliferator-activated receptors: “Key” regulators of neuroinflammation after traumatic brain injury. PPAR Research, 2008, 2008, 538141.
    • (2008) PPAR Research , vol.2008 , pp. 538141
    • Stahel, P.F.1    Smith, W.R.2    Bruchis, J.3    Rabb, C.H.4
  • 78
    • 77954406421 scopus 로고    scopus 로고
    • Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas
    • Stella, N., Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. Glia 58 (2010), 1017–1030.
    • (2010) Glia , vol.58 , pp. 1017-1030
    • Stella, N.1
  • 79
    • 85025474935 scopus 로고    scopus 로고
    • Available at:
    • United Nations, Available at: esa.un.org/unpd/wpp/publications/files/key_findings_wpp_2015.pdf, 2015.
    • (2015)
    • United Nations1
  • 80
    • 84887495462 scopus 로고    scopus 로고
    • The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: A potential role of cyclooxygenase-2-dependent metabolism of 2-AG
    • Valdeolivas, S., Pazos, M.R., Bisogno, T., Piscitelli, F., Iannotti, F.A., Allarà, M., et al. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: A potential role of cyclooxygenase-2-dependent metabolism of 2-AG. Cell Death & Disease, 4, 2013, e862.
    • (2013) Cell Death & Disease , vol.4
    • Valdeolivas, S.1    Pazos, M.R.2    Bisogno, T.3    Piscitelli, F.4    Iannotti, F.A.5    Allarà, M.6
  • 81
    • 26844504226 scopus 로고    scopus 로고
    • Identification and functional characterization of brainstem cannabinoid CB2 receptors
    • Van Sickle, M.D., Duncan, M., Kingsley, P.J., et al. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science 310 (2005), 329–332.
    • (2005) Science , vol.310 , pp. 329-332
    • Van Sickle, M.D.1    Duncan, M.2    Kingsley, P.J.3
  • 82
    • 84906076125 scopus 로고    scopus 로고
    • Functions of the CB1 and CB 2 receptors in neuroprotection at the level of the blood-brain barrier
    • Vendel, E., de Lange, E.C., Functions of the CB1 and CB 2 receptors in neuroprotection at the level of the blood-brain barrier. Neuromolecular Medicine 16 (2014), 620–642.
    • (2014) Neuromolecular Medicine , vol.16 , pp. 620-642
    • Vendel, E.1    de Lange, E.C.2
  • 83
    • 0037442829 scopus 로고    scopus 로고
    • Nonpsychotropic cannabinoid receptors regulate microglial cell migration
    • Walter, L., Franklin, A., Witting, A., et al. Nonpsychotropic cannabinoid receptors regulate microglial cell migration. The Journal of Neuroscience 23 (2003), 1398–1405.
    • (2003) The Journal of Neuroscience , vol.23 , pp. 1398-1405
    • Walter, L.1    Franklin, A.2    Witting, A.3
  • 84
    • 84893808684 scopus 로고    scopus 로고
    • Effects of cannabinoid receptor type 2 on endogenous myocardial regeneration by activating cardiac progenitor cells in mouse infarcted heart
    • Wang, Y., Ma, S., Wang, Q., et al. Effects of cannabinoid receptor type 2 on endogenous myocardial regeneration by activating cardiac progenitor cells in mouse infarcted heart. Science China. Life Sciences 57 (2014), 201–208.
    • (2014) Science China. Life Sciences , vol.57 , pp. 201-208
    • Wang, Y.1    Ma, S.2    Wang, Q.3
  • 86
    • 85019991853 scopus 로고    scopus 로고
    • Aging and life course
    • Available at:
    • World Health Organization, Aging and life course. Available at: www.who.int/ageing/about/facts/en, 2013.
    • (2013)
    • World Health Organization1
  • 87
    • 84971330670 scopus 로고    scopus 로고
    • CRISPR/Cas9: Implications for modeling and therapy of neurodegenerative diseases
    • Yang, W., Tu, Z., Sun, Q., Li, X.J., CRISPR/Cas9: Implications for modeling and therapy of neurodegenerative diseases. Frontiers in Molecular Neuroscience, 9, 2016, 30.
    • (2016) Frontiers in Molecular Neuroscience , vol.9 , pp. 30
    • Yang, W.1    Tu, Z.2    Sun, Q.3    Li, X.J.4
  • 88
    • 84960173074 scopus 로고    scopus 로고
    • Pathology of the aging brain in domestic and laboratory animals, and animal models of human neurodegenerative diseases
    • Youssef, S.A., Capucchio, M.T., Rofina, J.E., Chambers, J.K., Uchida, K., Nakayama, H., et al. Pathology of the aging brain in domestic and laboratory animals, and animal models of human neurodegenerative diseases. Veterinary Pathology 53 (2016), 327–348.
    • (2016) Veterinary Pathology , vol.53 , pp. 327-348
    • Youssef, S.A.1    Capucchio, M.T.2    Rofina, J.E.3    Chambers, J.K.4    Uchida, K.5    Nakayama, H.6
  • 89
    • 84874548398 scopus 로고    scopus 로고
    • Endogenous neurogenesis induced by ischemic brain injury or neurodegenerative diseases in adults
    • Ziemka-Nałęcz, M., Zalewska, T., Endogenous neurogenesis induced by ischemic brain injury or neurodegenerative diseases in adults. Acta Neurobiologiae Experimentalis 72 (2012), 309–324.
    • (2012) Acta Neurobiologiae Experimentalis , vol.72 , pp. 309-324
    • Ziemka-Nałęcz, M.1    Zalewska, T.2


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