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Volumn 187, Issue 1, 2011, Pages 126-132

Dichotomous effects of IFN-γ on dendritic cell function determine the extent of IL-12 - driven antitumor T cell immunity

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYLTRYPTOPHAN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 12; TRANSCRIPTION FACTOR FOXP3; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 79960420765     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100168     Document Type: Article
Times cited : (30)

References (38)
  • 4
    • 39649098678 scopus 로고    scopus 로고
    • Tumour immunity: Effector response to tumour and role of the microenvironment
    • Mantovani, A., P. Romero, A. K. Palucka, and F. M. Marincola. 2008. Tumour immunity: effector response to tumour and role of the microenvironment. Lancet 371: 771-783.
    • (2008) Lancet , vol.371 , pp. 771-783
    • Mantovani, A.1    Romero, P.2    Palucka, A.K.3    Marincola, F.M.4
  • 5
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside, T. L. 2008. The tumor microenvironment and its role in promoting tumor growth. Oncogene 27: 5904-5912.
    • (2008) Oncogene , vol.27 , pp. 5904-5912
    • Whiteside, T.L.1
  • 6
    • 45149111788 scopus 로고    scopus 로고
    • Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy
    • Peggs, K. S., S. A. Quezada, and J. P. Allison. 2008. Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy. Immunol. Rev. 224: 141-165.
    • (2008) Immunol. Rev. , vol.224 , pp. 141-165
    • Peggs, K.S.1    Quezada, S.A.2    Allison, J.P.3
  • 7
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran, M. A., W. Montalvo, H. Yagita, and J. P. Allison. 2010. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl. Acad. Sci. USA 107: 4275-4280.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 8
    • 0037115541 scopus 로고    scopus 로고
    • Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres: Coinduction of innate and adaptive antitumor immunity and cure of disseminated disease
    • Hill, H. C., T. F. Conway, Jr., M. S. Sabel, Y. S. Jong, E. Mathiowitz, R. B. Bankert, and N. K. Egilmez. 2002. Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres: coinduction of innate and adaptive antitumor immunity and cure of disseminated disease. Cancer Res. 62: 7254-7263.
    • (2002) Cancer Res. , vol.62 , pp. 7254-7263
    • Hill, H.C.1    Conway Jr., T.F.2    Sabel, M.S.3    Jong, Y.S.4    Mathiowitz, E.5    Bankert, R.B.6    Egilmez, N.K.7
  • 9
    • 33644831689 scopus 로고    scopus 로고
    • IL-12 + GM-CSF microsphere therapy induces eradication of advanced spontaneous tumors in her-2/neu transgenic mice but fails to achieve long-term cure due to the inability to maintain effector T-cell activity
    • Nair, R. E., Y. S. Jong, S. A. Jones, A. Sharma, E. Mathiowitz, and N. K. Egilmez. 2006. IL-12 + GM-CSF microsphere therapy induces eradication of advanced spontaneous tumors in her-2/neu transgenic mice but fails to achieve long-term cure due to the inability to maintain effector T-cell activity. J. Immunother. 29: 10-20.
    • (2006) J. Immunother. , vol.29 , pp. 10-20
    • Nair, R.E.1    Jong, Y.S.2    Jones, S.A.3    Sharma, A.4    Mathiowitz, E.5    Egilmez, N.K.6
  • 10
    • 75149132747 scopus 로고    scopus 로고
    • Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity
    • Gu, T., R. B. Rowswell-Turner, M. O. Kilinc, and N. K. Egilmez. 2010. Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity. Cancer Res. 70: 129-138.
    • (2010) Cancer Res. , vol.70 , pp. 129-138
    • Gu, T.1    Rowswell-Turner, R.B.2    Kilinc, M.O.3    Egilmez, N.K.4
  • 11
    • 33750802413 scopus 로고    scopus 로고
    • Reversing tumor immune suppression with intratumoral IL-12: Activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8+ T effectors
    • Kilinc, M. O., K. S. Aulakh, R. E. Nair, S. A. Jones, P. Alard, M. M. Kosiewicz, and N. K. Egilmez. 2006. Reversing tumor immune suppression with intratumoral IL-12: activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8+ T effectors. J. Immunol. 177: 6962-6973.
    • (2006) J. Immunol. , vol.177 , pp. 6962-6973
    • Kilinc, M.O.1    Aulakh, K.S.2    Nair, R.E.3    Jones, S.A.4    Alard, P.5    Kosiewicz, M.M.6    Egilmez, N.K.7
  • 12
    • 64249096161 scopus 로고    scopus 로고
    • Central role of tumor-associated CD8+ T effector/memory cells in restoring systemic antitumor immunity
    • Kilinc, M. O., T. Gu, J. L. Harden, L. P. Virtuoso, and N. K. Egilmez. 2009. Central role of tumor-associated CD8+ T effector/memory cells in restoring systemic antitumor immunity. J. Immunol. 182: 4217-4225.
    • (2009) J. Immunol. , vol.182 , pp. 4217-4225
    • Kilinc, M.O.1    Gu, T.2    Harden, J.L.3    Virtuoso, L.P.4    Egilmez, N.K.5
  • 13
    • 76249113522 scopus 로고    scopus 로고
    • Activated CD8+ T-effector/memory cells eliminate CD4+ CD25+ Foxp3+ T-suppressor cells from tumors via FasL mediated apoptosis
    • Kilinc, M. O., R. B. Rowswell-Turner, T. Gu, L. P. Virtuoso, and N. K. Egilmez. 2009. Activated CD8+ T-effector/memory cells eliminate CD4+ CD25+ Foxp3+ T-suppressor cells from tumors via FasL mediated apoptosis. J. Immunol. 183: 7656-7660.
    • (2009) J. Immunol. , vol.183 , pp. 7656-7660
    • Kilinc, M.O.1    Rowswell-Turner, R.B.2    Gu, T.3    Virtuoso, L.P.4    Egilmez, N.K.5
  • 14
    • 33744900085 scopus 로고    scopus 로고
    • Chronic immune therapy induces a progressive increase in intratumoral T suppressor activity and a concurrent loss of tumor-specific CD8+ T effectors in her-2/neu transgenic mice bearing advanced spontaneous tumors
    • Nair, R. E., M. O. Kilinc, S. A. Jones, and N. K. Egilmez. 2006. Chronic immune therapy induces a progressive increase in intratumoral T suppressor activity and a concurrent loss of tumor-specific CD8+ T effectors in her-2/neu transgenic mice bearing advanced spontaneous tumors. J. Immunol. 176: 7325-7334.
    • (2006) J. Immunol. , vol.176 , pp. 7325-7334
    • Nair, R.E.1    Kilinc, M.O.2    Jones, S.A.3    Egilmez, N.K.4
  • 15
    • 30744468334 scopus 로고    scopus 로고
    • Innate immune cells contribute to the IFN-γ-dependent regulation of antigen-specific CD8+ T cell homeostasis
    • Sercan, O{combining double acute accent}., G. J. Hämmerling, B. Arnold, and T. Schüler. 2006. Innate immune cells contribute to the IFN-γ-dependent regulation of antigen-specific CD8+ T cell homeostasis. J. Immunol. 176: 735-739.
    • (2006) J. Immunol. , vol.176 , pp. 735-739
    • Sercan, O.1    Hämmerling, G.J.2    Arnold, B.3    Schüler, T.4
  • 18
    • 36248965712 scopus 로고    scopus 로고
    • Dendritic cells: Understanding immunogenicity
    • Steinman, R. M. 2007. Dendritic cells: understanding immunogenicity. Eur. J. Immunol. 37(Suppl 1): S53-S60.
    • (2007) Eur. J. Immunol. , vol.37 , Issue.SUPPL. 1
    • Steinman, R.M.1
  • 19
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-γ: An overview of signals, mechanisms and functions
    • Schroder, K., P. J. Hertzog, T. Ravasi, and D. A. Hume. 2004. Interferon-γ: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75: 163-189.
    • (2004) J. Leukoc. Biol. , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 20
    • 70350433798 scopus 로고    scopus 로고
    • Interferon-γ-triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells
    • Jü rgens, B., U. Hainz, D. Fuchs, T. Felzmann, and A. Heitger. 2009. Interferon-γ-triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells. Blood 114: 3235-3243.
    • (2009) Blood , vol.114 , pp. 3235-3243
    • Jürgens, B.1    Hainz, U.2    Fuchs, D.3    Felzmann, T.4    Heitger, A.5
  • 21
    • 0028359368 scopus 로고
    • Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor
    • Kirberg, J., A. Baron, S. Jakob, A. Rolink, K. Karjalainen, and H. von Boehmer. 1994. Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180: 25-34.
    • (1994) J. Exp. Med. , vol.180 , pp. 25-34
    • Kirberg, J.1    Baron, A.2    Jakob, S.3    Rolink, A.4    Karjalainen, K.5    Von Boehmer, H.6
  • 23
    • 27144476792 scopus 로고    scopus 로고
    • A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation
    • Braun, D., R. S. Longman, and M. L. Albert. 2005. A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation. Blood 106: 2375-2381.
    • (2005) Blood , vol.106 , pp. 2375-2381
    • Braun, D.1    Longman, R.S.2    Albert, M.L.3
  • 24
    • 77953541634 scopus 로고    scopus 로고
    • Inflammatory cytokines as a third signal for T cell activation
    • Curtsinger, J. M., and M. F. Mescher. 2010. Inflammatory cytokines as a third signal for T cell activation. Curr. Opin. Immunol. 22: 333-340.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 333-340
    • Curtsinger, J.M.1    Mescher, M.F.2
  • 25
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3: 133-146.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 26
    • 41149108216 scopus 로고    scopus 로고
    • Enhancing the clinical activity of granulocyte-macrophage colony-stimulating factor-secreting tumor cell vaccines
    • Jinushi, M., F. S. Hodi, and G. Dranoff. 2008. Enhancing the clinical activity of granulocyte-macrophage colony-stimulating factor-secreting tumor cell vaccines. Immunol. Rev. 222: 287-298.
    • (2008) Immunol. Rev. , vol.222 , pp. 287-298
    • Jinushi, M.1    Hodi, F.S.2    Dranoff, G.3
  • 27
    • 34249741135 scopus 로고    scopus 로고
    • On watching the watchers: IDO and type I/II IFN
    • Puccetti, P. 2007. On watching the watchers: IDO and type I/II IFN. Eur. J. Immunol. 37: 876-879.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 876-879
    • Puccetti, P.1
  • 30
    • 77951737056 scopus 로고    scopus 로고
    • Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction
    • Matteoli, G., E. Mazzini, I. D. Iliev, E. Mileti, F. Fallarino, P. Puccetti, M. Chieppa, and M. Rescigno. 2010. Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction. Gut 59: 595-604.
    • (2010) Gut , vol.59 , pp. 595-604
    • Matteoli, G.1    Mazzini, E.2    Iliev, I.D.3    Mileti, E.4    Fallarino, F.5    Puccetti, P.6    Chieppa, M.7    Rescigno, M.8
  • 31
    • 77954948735 scopus 로고    scopus 로고
    • Effector T cell plasticity: Flexibility in the face of changing circumstances
    • Murphy, K. M., and B. Stockinger. 2010. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat. Immunol. 11: 674-680.
    • (2010) Nat. Immunol. , vol.11 , pp. 674-680
    • Murphy, K.M.1    Stockinger, B.2
  • 33
    • 33748162638 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells: Cytokine modulation comes of age
    • DOI 10.1182/blood-2006-03-006403
    • Rutella, S., S. Danese, and G. Leone. 2006. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 108: 1435-1440. (Pubitemid 44316106)
    • (2006) Blood , vol.108 , Issue.5 , pp. 1435-1440
    • Rutella, S.1    Danese, S.2    Leone, G.3
  • 34
    • 34547152610 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells and the quest for transplant tolerance
    • Morelli, A. E., and A. W. Thomson. 2007. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat. Rev. Immunol. 7: 610-621.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 610-621
    • Morelli, A.E.1    Thomson, A.W.2
  • 35
    • 71649109998 scopus 로고    scopus 로고
    • Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth
    • Lin, A., A. Schildknecht, L. T. Nguyen, and P. S. Ohashi. 2010. Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth. Immunol. Lett. 127: 77-84.
    • (2010) Immunol. Lett. , vol.127 , pp. 77-84
    • Lin, A.1    Schildknecht, A.2    Nguyen, L.T.3    Ohashi, P.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.