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Volumn 66, Issue 2, 2017, Pages 498-509

Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice

Author keywords

[No Author keywords available]

Indexed keywords

FARNESOID X RECEPTOR; FATTY ACID; GLUCOSE; HETERODIMER; INSULIN; LIPID; TRIACYLGLYCEROL; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; PROTEIN TYROSINE PHOSPHATASE SHP 1; PTPN6 PROTEIN, MOUSE;

EID: 85021372072     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.29199     Document Type: Article
Times cited : (90)

References (45)
  • 1
    • 84958206076 scopus 로고    scopus 로고
    • Nuclear receptor modulation for the treatment of nonalcoholic fatty liver disease
    • Fuchs CD, Traussnigg SA, Trauner M. Nuclear receptor modulation for the treatment of nonalcoholic fatty liver disease. Semin Liver Dis 2016;36:69-86.
    • (2016) Semin Liver Dis , vol.36 , pp. 69-86
    • Fuchs, C.D.1    Traussnigg, S.A.2    Trauner, M.3
  • 3
    • 79958243702 scopus 로고    scopus 로고
    • Role of nuclear receptor SHP in metabolism and cancer
    • Zhang Y, Hagedorn CH, Wang L. Role of nuclear receptor SHP in metabolism and cancer. Biochim Biophys Acta 2011;1812:893-908.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 893-908
    • Zhang, Y.1    Hagedorn, C.H.2    Wang, L.3
  • 4
    • 78650953014 scopus 로고    scopus 로고
    • Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis
    • Anakk S, Watanabe M, Ochsner SA, McKenna NJ, Finegold MJ, Moore DD. Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest 2011;121:86-95.
    • (2011) J Clin Invest , vol.121 , pp. 86-95
    • Anakk, S.1    Watanabe, M.2    Ochsner, S.A.3    McKenna, N.J.4    Finegold, M.J.5    Moore, D.D.6
  • 6
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 2006;116:1102-1109.
    • (2006) J Clin Invest , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 7
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000;102:731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 8
    • 81855217508 scopus 로고    scopus 로고
    • Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner
    • Park YJ, Kim SC, Kim J, Anakk S, Lee JM, Tseng HT, et al. Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res 2011;52:2234-2244.
    • (2011) J Lipid Res , vol.52 , pp. 2234-2244
    • Park, Y.J.1    Kim, S.C.2    Kim, J.3    Anakk, S.4    Lee, J.M.5    Tseng, H.T.6
  • 9
    • 34547411540 scopus 로고    scopus 로고
    • Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver
    • Huang J, Iqbal J, Saha PK, Liu J, Chan L, Hussain MM, et al. Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology 2007;46:147-157.
    • (2007) Hepatology , vol.46 , pp. 147-157
    • Huang, J.1    Iqbal, J.2    Saha, P.K.3    Liu, J.4    Chan, L.5    Hussain, M.M.6
  • 10
    • 0034059141 scopus 로고    scopus 로고
    • DNA excision in liver by an albumin-Cre transgene occurs progressively with age
    • Postic C, Magnuson MA. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis 2000;26:149-150.
    • (2000) Genesis , vol.26 , pp. 149-150
    • Postic, C.1    Magnuson, M.A.2
  • 11
    • 84947751144 scopus 로고    scopus 로고
    • ADAR1 prevents liver injury from inflammation and suppresses interferon production in hepatocytes
    • Wang G, Wang H, Singh S, Zhou P, Yang S, Wang Y, et al. ADAR1 prevents liver injury from inflammation and suppresses interferon production in hepatocytes. Am J Pathol 2015;185:3224-3237.
    • (2015) Am J Pathol , vol.185 , pp. 3224-3237
    • Wang, G.1    Wang, H.2    Singh, S.3    Zhou, P.4    Yang, S.5    Wang, Y.6
  • 12
    • 34249795488 scopus 로고    scopus 로고
    • Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus
    • Holloway MG, Cui Y, Laz EV, Hosui A, Hennighausen L, Waxman DJ. Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus. Endocrinology 2007;148:1977-1986.
    • (2007) Endocrinology , vol.148 , pp. 1977-1986
    • Holloway, M.G.1    Cui, Y.2    Laz, E.V.3    Hosui, A.4    Hennighausen, L.5    Waxman, D.J.6
  • 13
    • 84952638263 scopus 로고    scopus 로고
    • Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2
    • Kim YC, Byun S, Zhang Y, Seok S, Kemper B, Ma J, et al. Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2. Genome Biol 2015;16:268.
    • (2015) Genome Biol , vol.16 , pp. 268
    • Kim, Y.C.1    Byun, S.2    Zhang, Y.3    Seok, S.4    Kemper, B.5    Ma, J.6
  • 14
    • 84923031534 scopus 로고    scopus 로고
    • Nutrient-sensing nuclear receptors coordinate autophagy
    • Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, et al. Nutrient-sensing nuclear receptors coordinate autophagy. Nature 2014;516:112-115.
    • (2014) Nature , vol.516 , pp. 112-115
    • Lee, J.M.1    Wagner, M.2    Xiao, R.3    Kim, K.H.4    Feng, D.5    Lazar, M.A.6
  • 18
    • 84904889636 scopus 로고    scopus 로고
    • Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice
    • Park JH, Chung HY, Kim M, Lee JH, Jung M, Ha H. Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice. Aging Cell 2014;13:709-718.
    • (2014) Aging Cell , vol.13 , pp. 709-718
    • Park, J.H.1    Chung, H.Y.2    Kim, M.3    Lee, J.H.4    Jung, M.5    Ha, H.6
  • 19
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • Perry RJ, Samuel VT, Petersen KF, Shulman GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 2014;510:84-91.
    • (2014) Nature , vol.510 , pp. 84-91
    • Perry, R.J.1    Samuel, V.T.2    Petersen, K.F.3    Shulman, G.I.4
  • 20
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 2010;11:467-478.
    • (2010) Cell Metab , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 21
    • 84857185764 scopus 로고    scopus 로고
    • Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
    • Potthoff MJ, Kliewer SA, Mangelsdorf DJ. Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev 2012;26:312-324.
    • (2012) Genes Dev , vol.26 , pp. 312-324
    • Potthoff, M.J.1    Kliewer, S.A.2    Mangelsdorf, D.J.3
  • 23
    • 84907386500 scopus 로고    scopus 로고
    • Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease
    • Shulman GI. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 2014;371:1131-1141.
    • (2014) N Engl J Med , vol.371 , pp. 1131-1141
    • Shulman, G.I.1
  • 24
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ. The genetics of ageing. Nature 2010;464:504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 25
    • 84896388318 scopus 로고    scopus 로고
    • Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice
    • Xiong X, Wang X, Lu Y, Wang E, Zhang Z, Yang J, et al. Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice. J Hepatol 2014;60:847-854.
    • (2014) J Hepatol , vol.60 , pp. 847-854
    • Xiong, X.1    Wang, X.2    Lu, Y.3    Wang, E.4    Zhang, Z.5    Yang, J.6
  • 26
    • 79960838523 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity
    • Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, Duez H, Velagapudi VR, et al. Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes 2011;60:1861-1871.
    • (2011) Diabetes , vol.60 , pp. 1861-1871
    • Prawitt, J.1    Abdelkarim, M.2    Stroeve, J.H.3    Popescu, I.4    Duez, H.5    Velagapudi, V.R.6
  • 27
    • 27844551588 scopus 로고    scopus 로고
    • The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes
    • Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, et al. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab 2005;2:227-238.
    • (2005) Cell Metab , vol.2 , pp. 227-238
    • Wang, L.1    Liu, J.2    Saha, P.3    Huang, J.4    Chan, L.5    Spiegelman, B.6
  • 28
    • 84876477803 scopus 로고    scopus 로고
    • Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance
    • Ma Y, Huang Y, Yan L, Gao M, Liu D. Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance. Pharm Res 2013;30:1447-1457.
    • (2013) Pharm Res , vol.30 , pp. 1447-1457
    • Ma, Y.1    Huang, Y.2    Yan, L.3    Gao, M.4    Liu, D.5
  • 29
    • 79960695556 scopus 로고    scopus 로고
    • Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure
    • Watanabe M, Horai Y, Houten SM, Morimoto K, Sugizaki T, Arita E, et al. Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem 2011;286:26913-26920.
    • (2011) J Biol Chem , vol.286 , pp. 26913-26920
    • Watanabe, M.1    Horai, Y.2    Houten, S.M.3    Morimoto, K.4    Sugizaki, T.5    Arita, E.6
  • 30
    • 78649818490 scopus 로고    scopus 로고
    • Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity
    • Zadravec D, Brolinson A, Fisher RM, Carneheim C, Csikasz RI, Bertrand-Michel J, et al. Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity. FASEB J 2010;24:4366-4377.
    • (2010) FASEB J , vol.24 , pp. 4366-4377
    • Zadravec, D.1    Brolinson, A.2    Fisher, R.M.3    Carneheim, C.4    Csikasz, R.I.5    Bertrand-Michel, J.6
  • 31
    • 84862532981 scopus 로고    scopus 로고
    • Very long-chain-fatty acids enhance adipogenesis through coregulation of Elovl3 and PPARgamma in 3T3-L1 cells
    • Kobayashi T, Fujimori K. Very long-chain-fatty acids enhance adipogenesis through coregulation of Elovl3 and PPARgamma in 3T3-L1 cells. Am J Physiol Endocrinol Metab 2012;302:E1461-E1471.
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , pp. E1461-E1471
    • Kobayashi, T.1    Fujimori, K.2
  • 32
    • 84954539755 scopus 로고    scopus 로고
    • Vitamin D regulates fatty acid composition in subcutaneous adipose tissue through Elovl3
    • Ji L, Gupta M, Feldman BJ. Vitamin D regulates fatty acid composition in subcutaneous adipose tissue through Elovl3. Endocrinology 2016;157:91-97.
    • (2016) Endocrinology , vol.157 , pp. 91-97
    • Ji, L.1    Gupta, M.2    Feldman, B.J.3
  • 34
    • 25144456888 scopus 로고    scopus 로고
    • Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation
    • Jakobsson A, Jorgensen JA, Jacobsson A. Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation. Am J Physiol Endocrinol Metab 2005;289:E517-E526.
    • (2005) Am J Physiol Endocrinol Metab , vol.289 , pp. E517-E526
    • Jakobsson, A.1    Jorgensen, J.A.2    Jacobsson, A.3
  • 37
    • 0035098277 scopus 로고    scopus 로고
    • The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction
    • Cavallini G, Donati A, Gori Z, Pollera M, Bergamini E. The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction. Exp Gerontol 2001;36:497-506.
    • (2001) Exp Gerontol , vol.36 , pp. 497-506
    • Cavallini, G.1    Donati, A.2    Gori, Z.3    Pollera, M.4    Bergamini, E.5
  • 38
    • 51349095898 scopus 로고    scopus 로고
    • Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
    • Zhang C, Cuervo AM. Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 2008;14:959-965.
    • (2008) Nat Med , vol.14 , pp. 959-965
    • Zhang, C.1    Cuervo, A.M.2
  • 41
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006;439:484-489.
    • (2006) Nature , vol.439 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3    Christoffolete, M.A.4    Kim, B.W.5    Sato, H.6
  • 42
    • 84906928425 scopus 로고    scopus 로고
    • FGF21 as a stress hormone: the roles of FGF21 in stress adaptation and the treatment of metabolic diseases
    • Kim KH, Lee MS. FGF21 as a stress hormone: the roles of FGF21 in stress adaptation and the treatment of metabolic diseases. Diabetes Metab J 2014;38:245-251.
    • (2014) Diabetes Metab J , vol.38 , pp. 245-251
    • Kim, K.H.1    Lee, M.S.2
  • 43
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    • Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007;5:415-425.
    • (2007) Cell Metab , vol.5 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3    Ding, X.4    Gautron, L.5    Parameswara, V.6
  • 44
    • 84969204029 scopus 로고    scopus 로고
    • The nuclear receptor Rev-erbalpha regulates adipose tissue-specific FGF21 signaling
    • Jager J, Wang F, Fang B, Lim HW, Peed LC, Steger DJ, et al. The nuclear receptor Rev-erbalpha regulates adipose tissue-specific FGF21 signaling. J Biol Chem 2016;291:10867-10875.
    • (2016) J Biol Chem , vol.291 , pp. 10867-10875
    • Jager, J.1    Wang, F.2    Fang, B.3    Lim, H.W.4    Peed, L.C.5    Steger, D.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.