Very long-chain-fatty acids enhance adipogenesis through coregulation of Elovl3 and PPARγ in 3T3-L1 cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 302, Issue 12, 2012, Pages

  Kobayashi, Takeshi ^a   Fujimori, Ko ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Adipocytes; Elongation of very long chain fatty acids 3; Peroxisome proliferator activated receptor

Indexed keywords

ELONGATION OF VERY LONG CHAIN FATTY ACID 13; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; SMALL INTERFERING RNA; TRIACYLGLYCEROL; TROGLITAZONE; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPOGENESIS; LIPOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION;

3T3-L1 CELLS; ACETYLTRANSFERASES; ADIPOCYTES; ADIPOGENESIS; ANIMALS; BLOTTING, WESTERN; CHROMATIN IMMUNOPRECIPITATION; FATTY ACIDS; GENETIC VECTORS; GLYCEROL; HELA CELLS; HUMANS; LIPOLYSIS; LUCIFERASES; MICE; PPAR GAMMA; RNA; RNA INTERFERENCE; TRIGLYCERIDES;

EID: 84862532981     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00623.2011     Document Type: Article

References (45)

1. Anzulovich A, Mir A, Brewer M, Ferreyra G, Vinson C, Baler R. Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional status. J Lipid Res 47: 2690-2700, 2006.
2. Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, Klingenhoff A, Frisch M, Bayerlein M, Werner T. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21: 2933-2942, 2005.
3. Christodoulides C, Vidal-Puig A. PPARs and adipocyte function. Mol Cell Endocrinol 318: 61-68, 2010.
4. Cook HW. Fatty Acid Desaturation and Chain Elongation in Eucaryotes. Amsterdam: Elsevier Science, 2002.
5. Denic V, Weissman JS. A molecular caliper mechanism for determining very long-chain fatty acid length. Cell 130: 663-677, 2007.
6. Farmer SR. Transcriptional control of adipocyte formation. Cell Metab 4: 263-273, 2006.
7. Fujimori K, Kadoyama K, Urade Y. Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of Notch-HES signaling and enhancement of AP-2 beta function in brain-derived TE671 cells. J Biol Chem 280: 18452-18461, 2005.
8. Fujimori K, Ueno T, Nagata N, Kashiwagi K, Aritake K, Amano F, Urade Y. Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase. J Biol Chem 285: 8880- 8886, 2010.
9. Guillou H, Zadravec D, Martin PG, Jacobsson A. The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. Prog Lipid Res 49: 186-199, 2010.
10. Hammarstedt A, Andersson CX, Rotter Sopasakis V, Smith U. The effect of PPARgamma ligands on the adipose tissue in insulin resistance. Prostaglandins Leukot Essent Fatty Acids 73: 65-75, 2005.
11. Jakobsson A, Jorgensen JA, Jacobsson A. Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation. Am J Physiol Endocrinol Metab 289: E517-E526, 2005.
12. Jakobsson A, Westerberg R, Jacobsson A. Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog Lipid Res 45: 237-249, 2006.
13. Jorgensen JA, Zadravec D, Jacobsson A. Norepinephrine and rosigli-tazone synergistically induce Elovl3 expression in brown adipocytes. Am J Physiol Endocrinol Metab 293: E1159-E1168, 2007.
14. Jump DB. Mammalian fatty acid elongases. Methods Mol Biol 579: 375-389, 2009.
15. Kim JB, Wright HM, Wright M, Spiegelman BM. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci USA 95: 4333-4337, 1998.
16. Kitazawa H, Miyamoto Y, Shimamura K, Nagumo A, Tokita S. Development of a high-density assay for long-chain fatty acyl-CoA elongases. Lipids 44: 765-773, 2009.
17. Lawrence JW, Kroll DJ, Eacho PI. Ligand-dependent interaction of hepatic fatty acid-binding protein with the nucleus. J Lipid Res 41: 1390-1401, 2000.
18. Lefterova MI, Lazar MA. New developments in adipogenesis. Trends Endocrinol Metab 20: 107-114, 2009.
19. Leonard AE, Pereira SL, Sprecher H, Huang YS. Elongation of long-chain fatty acids. Prog Lipid Res 43: 36-54, 2004.
20. Levert KL, Waldrop GL, Stephens JM. A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis. J Biol Chem 277: 16347-16350, 2002.
21. Madsen L, Petersen RK, Kristiansen K. Regulation of adipocyte differentiation and function by polyunsaturated fatty acids. Biochim Biophys Acta 1740: 266-286, 2005.
22. Mandrup S, Sorensen RV, Helledie T, Nohr J, Baldursson T, Gram C, Knudsen J, Kristiansen K. Inhibition of 3T3-L1 adipocyte differentiation by expression of acyl-CoA-binding protein antisense RNA. J Biol Chem 273: 23897-23903, 1998.
23. Massiera F, Saint-Marc P, Seydoux J, Murata T, Kobayashi T, Narumiya S, Guesnet P, Amri EZ, Negrel R, Ailhaud G. Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res 44: 271-279, 2003.
24. McArthur MJ, Atshaves BP, Frolov A, Foxworth WD, Kier AB, Schroeder F. Cellular uptake and intracellular trafficking of long chain fatty acids. J Lipid Res 40: 1371-1383, 1999.
25. McNeel RL, Smith EO, Mersmann HJ. Isomers of conjugated linoleic acid modulate human preadipocyte differentiation. In Vitro Cell Dev Biol Anim 39: 375-382, 2003.
26. Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Proc Natl Acad Sci USA 107: 18439-18444, 2010.
27. Pi-Sunyer X. The medical risks of obesity. Postgrad Med 121: 21-33, 2009.
28. Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 93: S64-S73, 2008.
29. Rosen E, Eguchi J, Xu Z. Transcriptional targets in adipocyte biology. Expert Opin Ther Targets 2009.
30. Schmid B, Rippmann JF, Tadayyon M, Hamilton BS. Inhibition of fatty acid synthase prevents preadipocyte differentiation. Biochem Biophys Res Commun 328: 1073-1082, 2005.
31. Sharma AM, Staels B. Review. Peroxisome proliferator-activated receptor gamma and adipose tissue-understanding obesity-related changes in regulation of lipid and glucose metabolism. J Clin Endocrinol Metab 92: 386-395, 2007.
32. Sheng Z, Otani H, Brown MS, Goldstein JL. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc Natl Acad Sci USA 92: 935-938, 1995.
33. Siersbaek R, Nielsen R, Mandrup S. PPARgamma in adipocyte differentiation and metabolism-novel insights from genome-wide studies. FEBS Lett 584: 3242-3249, 2010.
34. Stahl A, Gimeno RE, Tartaglia LA, Lodish HF. Fatty acid transport proteins: a current view of a growing family. Trends Endocrinol Metab 12: 266-273, 2001.
35. Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 77: 289-312, 2008.
36. Tvrdik P, Asadi A, Kozak LP, Nedergaard J, Cannon B, Jacobsson A. Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue. J Bol Chem 272: 31738-31746, 1997.
37. Tvrdik P, Westerberg R, Silve S, Asadi A, Jakobsson A, Cannon B, Loison G, Jacobsson A. Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. J Cell Biol 149: 707-718, 2000.
38. Villa PM, Laivuori H, Kajantie E, Kaaja R. Free fatty acid profiles in preeclampsia. Prostaglandins Leukot Essent Fatty Acids 81: 17-21, 2009.
39. Wang H, Qiang L, Farmer SR. Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes. Mol Cell Biol 28: 188-200, 2008.
40. Wang Y, Botolin D, Christian B, Busik J, Xu J, Jump DB. Tissue-specific, nutritional, and developmental regulation of rat fatty acid elon-gases. J Lipid Res 46: 706-715, 2005.
41. Westerberg R, Mansson JE, Golozoubova V, Shabalina IG, Backlund EC, Tvrdik P, Retterstol K, Capecchi MR, Jacobsson A. ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue. J Biol Chem 281: 4958-4968, 2006.
42. Westerberg R, Tvrdik P, Unden AB, Mansson JE, Norlen L, Jakob-sson A, Holleran WH, Elias PM, Asadi A, Flodby P, Toftgard R, Capecchi MR, Jacobsson A. Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem 279: 5621-5629, 2004.
43. White UA, Stephens JM. Transcriptional factors that promote formation of white adipose tissue. Mol Cell Endocrinol 318: 10-14, 2010.
44. Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol Cell 3: 397-403, 1999.
45. Zadravec D, Brolinson A, Fisher RM, Carneheim C, Csikasz RI, Bertrand-Michel J, Boren J, Guillou H, Rudling M, Jacobsson A. Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity. FASEB J 24: 4366-4377, 2010.