Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5

ChemMedChem

Volumn 12, Issue 13, 2017, Pages 1033-1044

  Wang, Hezhen ^a   Huwaimel, Bader ^a   Verma, Kshitij ^a   Miller, James ^b   Germain, Todd M ^c   Kinarivala, Nihar ^a   Pappas, Dimitri ^c   Brookes, Paul S ^b   Trippier, Paul C ^a,c  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c TEXAS TECH UNIVERSITY   (United States)

Author keywords

anticancer agents; atpenin A5; mitochondria; mitochondrial complex II; succinate dehydrogenase

Indexed keywords

(2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)(FURAN 2 YL)METHANONE; (RAC) 2,3 DIMETHOXY 5 (1 METHOXYHEXYL)PYRIDIN 4 OL; (RAC) 3 (1 HYDROXYHEXYL) 5,6 DIMETHOXYPYRIDINE 2,4 DIOL; (RAC) 5 (1 HYDROXYHEXYL) 2,3 DIMETHOXYPYRIDIN 4 OL; (RAC) 5 (1 HYDROXYHEXYL) 2,3 DIMETHOXYPYRIDIN 4 YL DIISOPROPYLCARBAMATE; 1 (2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL) 5 HYDROXYPENTAN 1 ONE; 1 (2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)DECAN 1 ONE; 1 (2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)HEPTAN 1 ONE; 1 (2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)HEXAN 1 ONE; 1 (2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)NONAN 1 ONE; 1 (2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)OCTAN 1 ONE; 1 (2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)PENTAN 1 ONE; 1 (2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)TRIDECAN 1 ONE; 1 (2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)UNDECAN 1 ONE; 1 (4 HYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)HEXAN 1 ONE; 1 (5,6 DIMETHOXY 2,4 BIS(METHOXYMETHOXY)PYRIDIN 3 YL)HEXAN 1 OL; 2,3 DIMETHOXYPYRIDIN 4 YL DIISOPROPYLCARBAMATE; 5 (BENZYLOXY) 1 (2,4 DIHYDROXY 5,6 DIMETHOXYPYRIDIN 3 YL)PENTAN 1 ONE; 5 BROMO 2,3 DIMETHOXYPYRIDIN 4 YL DIISOPROPYLCARBAMATE; ANTINEOPLASTIC AGENT; ATPENIN A5; DIAZOXIDE; ENZALUTAMIDE; HYDROGEN; NATURAL PRODUCT; OXIDOREDUCTASE INHIBITOR; UNCLASSIFIED DRUG; ETOPOSIDE; PHENYLTHIOHYDANTOIN; PYRIDONE DERIVATIVE; SUCCINATE DEHYDROGENASE;

ANIMAL TISSUE; ANTAGONIST POTENCY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; COLUMN CHROMATOGRAPHY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG OXIDATION; DRUG PURIFICATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; EMBRYO; HEART MITOCHONDRION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; LIPOPHILICITY; MALE; MITOCHONDRIAL ENERGY TRANSFER; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; HEK293 CELL LINE; MOUSE; PIG; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CATALYTIC DOMAIN; CELL LINE, TUMOR; ELECTRON TRANSPORT; ETOPOSIDE; HEK293 CELLS; HUMANS; MICE; MODELS, MOLECULAR; PHENYLTHIOHYDANTOIN; PYRIDONES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINATE DEHYDROGENASE; SWINE;

EID: 85021171930     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201700196     Document Type: Article

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