Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: A retrospective review of 77 cases and analysis of efficacy-predicting criteria

European Journal of Pediatrics

Volumn 157, Issue 8, 1998, Pages 628-633

  Touati, G ^a,b   Poggi Travert, F ^b   Ogier De Baulny, H ^a   Rahier, J ^c   Brunelle, F ^b   Nihoul Fekete, C ^b   Czernichow, P ^a   Saudubray, J M ^b  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Diazoxide; Hyperinsulinism; Hypoglycaemia; Management; Sulphonylureas

Indexed keywords

DIAZOXIDE; SULFONYLUREA;

ARTICLE; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; HYPOGLYCEMIA; INFANT; INSULIN RELEASE; MAJOR CLINICAL STUDY; NEWBORN; PRIORITY JOURNAL; TREATMENT OUTCOME;

DIAZOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIA; INFANT; INFANT, NEWBORN; MALE; PROGNOSIS; RECURRENCE; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 0031856155     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004310050900     Document Type: Article

References (28)

1. Abu-Osba YK, Manasra KB, Matthew PM (1989) Complications of diazoxide treatment in persistent neonatal hyperinsulinism. Arch Dis Child 64:1496-1500
2. Baker L, Stanley CA (1977) Hyperinsulinism in infancy: a pathophysiologic approach to diagnosis and treatment. In: Chiumello G, Laron Z eds. Recent progress in pediatric endocrinology. Academic press, London, pp 89-100
3. Bougneres PF, Landier F, Garnier P, Job JC, Chaussain JL (1985) Treatment of insulin excess by continuous subcutaneous infusion of somatostatin and glucagon in an infant. J Pediatr 106:792-794
4. Daneman D, Ehrlich RM (1993) The enigma of persistent hyperinsulinemic hypoglycemia in infancy. J Pediatr 123:573-575
5. De Lonlay P, Fournet JC, Rahier J, Gross-Morand MS, Poggi-Travert F, Foussier V, Bonnefont JP, Brusset MC, Brunelle F, Robert JJ, Nihoul-Fekete C, Saudubray JM, Junien C (1997) Somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy. J Clin Invest 100:802-807
6. Dubois J, Brunelle F, Touati G, Sebag G, Nuttin C, Thach T, Nihoul-Fekete C, Rahier J, Saudubray JM (1995) Hyperinsulinism in children: diagnostic value of pancreatic venous sampling correlated with clinical, pathological and surgical outcome in 25 cases. Pediatr Radiol 25:512-516
7. Fernandes J, Berger R (1993) Hypoglycemia: principles of diagnosis and treatment in children. In Gregory JW, Aynsley-Green A (eds). Hypoglycemia. Baillières Clin Endocrinol Metab 7:591-609
8. Finegold DN, Stanley CA, Baker L (1980) Glycemic response to glucagon during fasting hypoglycemia: an aid in the diagnosis of hyperinsulinism. J Pediatr 96:257-259
9. Flatt PR, Shibier O, Szeckowka J, Berggren PO (1994) New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic B-cell. Diabete Métab 20:157-162
10. Glaser B, Hirsch HJ, Landau H (1993) Persistent hyperinsulinaemic hypoglycaemia of infancy: long-term octreotide treatment without pancreatectomy. J Pediatr 123:644-650
11. Goossens A, Gepts W, Saudubray JM, Bonnefont JP, Nihoul-Fekete C, Heitz PU, Kloppel G (1989) Diffuse and focal nesidioblastosis. A clinicopathological study of 24 patients with persistent neonatal hyperinsulinemic hypoglycemia. Am J Surg Pathol 13:766-775
12. Grant DB, Dunger DB, Burns EC (1986) Long-term treatment with diazoxide in childhood hyperinsulinism. Acta Endocrinol (Suppl) 279:340-345
13. Haymond MW, Pagliara AS, Bier DM (1989) Endocrine and metabolic aspects of fuel homeostasis in the fœtus and neonate. In: De Groot, et al (eds) Endocrinology vol. 3. WB Saunders, Pa. pp:2215-2241
14. Horev Z, Ipp M, Levey P, Daneman D (1991) Familial hyperinsulinism: successful conservative management. J Pediatr 119:717-720
15. Lindley KJ, Dunne MJ, Kane C, Shepherd RM, Squires PE, James RFL, Johnson PRV, Eckhardt S, Wakeling E, Dattani M, Milla PJ, Aynsley-Green A (1996) Ionic control of β cell function in nesidioblastosis. A possible therapeutic role for calcium channel blockade. Arch Dis Child 74:373-378
16. Poggi-Travert F, Rahier J, Brunelle F, Fekete C, Saudubray JM (1994) Hyperinsulinismes de l'enfant: a propos d'une série de 56 cas (1984-1994). In: Journées parisiennes de pédiatrie. Flammarion Sciences Paris, pp 29-42
17. Rahier J, Falt K, Munterfering H, Becker K, Gepts W, Falkmer S (1984) The basic structural lesion of persistent neonatal hypoglycemia with hyperinsulinism: deficiency of pancreatic D cells or hyperactivity of B cells ? Diabetologia 26:282-289
18. Rotenstein D, Serbin S, Welsh T (1992) Palliative treatment of hyperinsulinism with cyproheptadine and diazoxide. Pediatrics. 9:212-215
19. Sempoux S, Guiot Y, Lefevre A, Nihoul-Fekete C, Jaubert F, Saudubray JM, Rahier J (1998) Neonatal hyperinsulinemic hypoglycemia: heterogeneity of the syndrome and keys for differential diagnosis. J Clin Endocrinol Metab (in press) 43:1455-1461
20. Spitz L, Bhargava RK, Grant DB, Leonard JV (1992) Surgical treatment of hyperinsulinaemic hypoglycemia in infancy and childhood. Arch Dis Child 67:201-205
21. Spitz L, Buick RG, Grant DB (1986) Surgical treatment of nesidioblastosis. Pediatr Surg 1:26-29
22. Stanley CA (1997) Hyperinsulinism in infants and children. Pediatr Endocrinol 44:363-374
23. Stanley CA, Baker L (1976) Hyperinsulinism in infants and children. Adv Pediatr 23:315-355
24. Tauber MT, Harris AG, Rochiccioli P (1994) Clinical use of the long acting somatostatin analogue octreotide in pediatrics. Eur J Pediatr 153:304-310
25. Thomas CG, Cuenca RE, Azizkhan RG, Underwood LE, Carney CN (1988) Changing concept of islet cell dysplasia in neonatal and infantile hyperinsulinism. World J Surg 12:598-609
26. Thomas PM, Cote GJ, Wohlik N, Haddad B, Matthews PM, Rabl W, Aguilar-Bryan L, Gagel RF, Bryan J (1995) Mutations in the sulphonylurea receptor gene in familial hyperinsulinemichypoglycemia of infancy. Science 268:426-429
27. Touati G (1991) Les hyperinsulinismes chez l'enfant. Etude de 56 cas. Apport des prélèvements veineux étagés d'insuline par cathétérisme trans-hépatique au diagnostic de localisation. Thèse pour le Doctorat d'Etat., Université Paris 7, France
28. Worden FP, Freidenberg G, Prescovitz OH (1994) The diagnosis and management of neonatal hyperinsulinism. Endocrinologist 4:196-204