메뉴 건너뛰기




Volumn 195, Issue 12, 2017, Pages 1567-1575

Early lung disease in infants and preschool children with cystic fibrosis: What have we learned and what should we do about it?

Author keywords

Cystic fibrosis; Early intervention; Early lung disease; Newborn screening

Indexed keywords

CHILD; CLINICAL PRACTICE; CYSTIC FIBROSIS; DISEASE COURSE; DISEASE SEVERITY; HUMAN; INFANT; LUNG DISEASE; LUNG FUNCTION; PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; REVIEW; THERAPY EFFECT; COMPLICATION; LUNG; PATHOPHYSIOLOGY;

EID: 85021161375     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201606-1107CI     Document Type: Review
Times cited : (100)

References (88)
  • 3
    • 0017198208 scopus 로고
    • The lung in cystic fibrosis: A quantitative study including prevalence of pathologic findings among different age groups
    • Bedrossian CW, Greenberg SD, Singer DB, Hansen JJ, Rosenberg HS. The lung in cystic fibrosis: a quantitative study including prevalence of pathologic findings among different age groups. Hum Pathol 1976;7:195-204.
    • (1976) Hum Pathol , vol.7 , pp. 195-204
    • Bedrossian, C.W.1    Greenberg, S.D.2    Singer, D.B.3    Hansen, J.J.4    Rosenberg, H.S.5
  • 4
    • 0020082418 scopus 로고
    • Quantitative evaluation of the development of tracheal submucosal glands in infants with cystic fibrosis and control infants
    • Sturgess J, Imrie J. Quantitative evaluation of the development of tracheal submucosal glands in infants with cystic fibrosis and control infants. Am J Pathol 1982;106:303-311.
    • (1982) Am J Pathol , vol.106 , pp. 303-311
    • Sturgess, J.1    Imrie, J.2
  • 18
    • 84951064471 scopus 로고    scopus 로고
    • Cystic fibrosis in young children: A review of disease manifestation, progression, and response to early treatment
    • Van Devanter DR, Kahle JS, O'Sullivan AK, Sikirica S, Hodgkins PS. Cystic fibrosis in young children: a review of disease manifestation, progression, and response to early treatment. J Cyst Fibros 2016;15:147-157.
    • (2016) J Cyst Fibros , vol.15 , pp. 147-157
    • Van Devanter, D.R.1    Kahle, J.S.2    O'Sullivan, A.K.3    Sikirica, S.4    Hodgkins, P.S.5
  • 19
    • 84942416048 scopus 로고    scopus 로고
    • Evolution of cystic fibrosis lung function in the early years
    • Bush A, Sly PD. Evolution of cystic fibrosis lung function in the early years. Curr Opin Pulm Med 2015;21:602-608.
    • (2015) Curr Opin Pulm Med , vol.21 , pp. 602-608
    • Bush, A.1    Sly, P.D.2
  • 20
    • 0029010510 scopus 로고
    • Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis
    • Armstrong DS, Grimwood K, Carzino R, Carlin JB, Olinsky A, Phelan PD. Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis. BMJ 1995;310:1571-1572.
    • (1995) BMJ , vol.310 , pp. 1571-1572
    • Armstrong, D.S.1    Grimwood, K.2    Carzino, R.3    Carlin, J.B.4    Olinsky, A.5    Phelan, P.D.6
  • 21
    • 84894892301 scopus 로고    scopus 로고
    • Airway inflammation is present by 4 months in CF infants diagnosed on newborn screening
    • Thursfield RM, Bush A, Alton EW, Davies JC. Airway inflammation is present by 4 months in CF infants diagnosed on newborn screening. Pediatr Pulmonol 2012;47:352.
    • (2012) Pediatr Pulmonol , vol.47 , pp. 352
    • Thursfield, R.M.1    Bush, A.2    Alton, E.W.3    Davies, J.C.4
  • 22
    • 79955005042 scopus 로고    scopus 로고
    • Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis
    • Ranganathan SC, Parsons F, Gangell C, Brennan S, Stick SM, Sly PD; Australian Respiratory Early Surveillance Team for Cystic Fibrosis. Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis. Thorax 2011;66:408-413.
    • (2011) Thorax , vol.66 , pp. 408-413
    • Ranganathan, S.C.1    Parsons, F.2    Gangell, C.3    Brennan, S.4    Stick, S.M.5    Sly, P.D.6
  • 28
    • 84937631483 scopus 로고    scopus 로고
    • Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy
    • Cantin AM, Hartl D, Konstan MW, Chmiel JF. Inflammation in cystic fibrosis lung disease: pathogenesis and therapy. J Cyst Fibros 2015;14:419-430.
    • (2015) J Cyst Fibros , vol.14 , pp. 419-430
    • Cantin, A.M.1    Hartl, D.2    Konstan, M.W.3    Chmiel, J.F.4
  • 29
    • 0036320272 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis
    • Emerson J, Rosenfeld M, McNamara S, Ramsey B, Gibson RL. Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis. Pediatr Pulmonol 2002;34:91-100.
    • (2002) Pediatr Pulmonol , vol.34 , pp. 91-100
    • Emerson, J.1    Rosenfeld, M.2    McNamara, S.3    Ramsey, B.4    Gibson, R.L.5
  • 31
    • 84902477603 scopus 로고    scopus 로고
    • Differential geographical risk of initial Pseudomonas aeruginosa acquisition in young US children with cystic fibrosis
    • Psoter KJ, Rosenfeld M, De Roos AJ, Mayer JD, Wakefield J. Differential geographical risk of initial Pseudomonas aeruginosa acquisition in young US children with cystic fibrosis. Am J Epidemiol 2014;179:1503-1513.
    • (2014) Am J Epidemiol , vol.179 , pp. 1503-1513
    • Psoter, K.J.1    Rosenfeld, M.2    De Roos, A.J.3    Mayer, J.D.4    Wakefield, J.5
  • 33
    • 84943744505 scopus 로고    scopus 로고
    • Association of meteorological and geographical factors and risk of initial Pseudomonas aeruginosa acquisition in young children with cystic fibrosis
    • Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Bryan M, Rosenfeld M. Association of meteorological and geographical factors and risk of initial Pseudomonas aeruginosa acquisition in young children with cystic fibrosis. Epidemiol Infect 2016;155:1075-1083.
    • (2016) Epidemiol Infect , vol.155 , pp. 1075-1083
    • Psoter, K.J.1    De Roos, A.J.2    Wakefield, J.3    Mayer, J.D.4    Bryan, M.5    Rosenfeld, M.6
  • 35
    • 84937516045 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years
    • ACFBAL Study Investigators
    • Kidd TJ, Ramsay KA, Vidmar S, Carlin JB, Bell SC, Wainwright CE, Grimwood K, ACFBAL Study Investigators. Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years. J Cyst Fibros 2015;14:361-369.
    • (2015) J Cyst Fibros , vol.14 , pp. 361-369
    • Kidd, T.J.1    Ramsay, K.A.2    Vidmar, S.3    Carlin, J.B.4    Bell, S.C.5    Wainwright, C.E.6    Grimwood, K.7
  • 36
    • 0030995361 scopus 로고    scopus 로고
    • Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis
    • Frederiksen B, Koch C, Høiby N. Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis. Pediatr Pulmonol 1997;23:330-335.
    • (1997) Pediatr Pulmonol , vol.23 , pp. 330-335
    • Frederiksen, B.1    Koch, C.2    Høiby, N.3
  • 38
    • 78149361309 scopus 로고    scopus 로고
    • Value of serology in predicting Pseudomonas aeruginosa infection in young children with cystic fibrosis
    • members of AREST CF and ACFBAL Trial
    • Douglas TA, Brennan S, Berry L, Winfield K, Wainwright CE, Grimwood K, Stick SM, Sly PD; members of AREST CF and ACFBAL Trial. Value of serology in predicting Pseudomonas aeruginosa infection in young children with cystic fibrosis. Thorax 2010;65:985-990.
    • (2010) Thorax , vol.65 , pp. 985-990
    • Douglas, T.A.1    Brennan, S.2    Berry, L.3    Winfield, K.4    Wainwright, C.E.5    Grimwood, K.6    Stick, S.M.7    Sly, P.D.8
  • 39
    • 79960151730 scopus 로고    scopus 로고
    • Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: A randomized trial
    • ACFBAL Study Investigators
    • Wainwright CE, Vidmar S, Armstrong DS, Byrnes CA, Carlin JB, Cheney J, Cooper PJ, Grimwood K, Moodie M, Robertson CF, et al.; ACFBAL Study Investigators. Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial. JAMA 2011;306:163-171.
    • (2011) JAMA , vol.306 , pp. 163-171
    • Wainwright, C.E.1    Vidmar, S.2    Armstrong, D.S.3    Byrnes, C.A.4    Carlin, J.B.5    Cheney, J.6    Cooper, P.J.7    Grimwood, K.8    Moodie, M.9    Robertson, C.F.10
  • 43
    • 84966691911 scopus 로고    scopus 로고
    • The nasal microbiota in infants with cystic fibrosis in the first year of life: A prospective cohort study
    • Mika M, Korten I, Qi W, Regamey N, Frey U, Casaulta C, Latzin P, Hilty M; SCILD study group. The nasal microbiota in infants with cystic fibrosis in the first year of life: a prospective cohort study. Lancet Respir Med 2016;4:627-635.
    • (2016) Lancet Respir Med , vol.4 , pp. 627-635
    • Mika, M.1    Korten, I.2    Qi, W.3    Regamey, N.4    Frey, U.5    Casaulta, C.6    Latzin, P.7    Hilty, M.8
  • 45
    • 1542377466 scopus 로고    scopus 로고
    • Early morphologic changes in the lungs of asymptomatic infants and young children with cystic fibrosis
    • Brody AS. Early morphologic changes in the lungs of asymptomatic infants and young children with cystic fibrosis. J Pediatr 2004;144:145-146.
    • (2004) J Pediatr , vol.144 , pp. 145-146
    • Brody, A.S.1
  • 48
    • 67649476123 scopus 로고    scopus 로고
    • Bronchiectasis in an asymptomatic infant with cystic fibrosis diagnosed following newborn screening
    • Mott LS, Gangell CL, Murray CP, Stick SM, Sly PD, Arest CF. Bronchiectasis in an asymptomatic infant with cystic fibrosis diagnosed following newborn screening. J Cyst Fibros 2009;8:285-857.
    • (2009) J Cyst Fibros , vol.8 , pp. 285-857
    • Mott, L.S.1    Gangell, C.L.2    Murray, C.P.3    Stick, S.M.4    Sly, P.D.5    Arest, C.F.6
  • 49
    • 39049084491 scopus 로고    scopus 로고
    • Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis
    • Gustafsson PM, De Jong PA, Tiddens HA, Lindblad A. Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis. Thorax 2008;63:129-134.
    • (2008) Thorax , vol.63 , pp. 129-134
    • Gustafsson, P.M.1    De Jong, P.A.2    Tiddens, H.A.3    Lindblad, A.4
  • 50
    • 79956360940 scopus 로고    scopus 로고
    • Lung Clearance Index and HRCT are complementary markers of lung abnormalities in young children with CF
    • Owens CM, Aurora P, Stanojevic S, Bush A, Wade A, Oliver C, Calder A, Price J, Carr SB, Shankar A, et al.; London Cystic Fibrosis Collaboration. Lung Clearance Index and HRCT are complementary markers of lung abnormalities in young children with CF. Thorax 2011;66:481-488.
    • (2011) Thorax , vol.66 , pp. 481-488
    • Owens, C.M.1    Aurora, P.2    Stanojevic, S.3    Bush, A.4    Wade, A.5    Oliver, C.6    Calder, A.7    Price, J.8    Carr, S.B.9    Shankar, A.10
  • 51
    • 0034868951 scopus 로고    scopus 로고
    • Lung function testing in infants with cystic fibrosis: Lessons from the past and future directions
    • Gappa M, Ranganathan SC, Stocks J. Lung function testing in infants with cystic fibrosis: lessons from the past and future directions. Pediatr Pulmonol 2001;32:228-245.
    • (2001) Pediatr Pulmonol , vol.32 , pp. 228-245
    • Gappa, M.1    Ranganathan, S.C.2    Stocks, J.3
  • 52
    • 0014531389 scopus 로고
    • Ventilatory function in infants with cystic fibrosis: Physiological assessment of halation therapy
    • Phelan PD, Gracey M, Williams HE, Anderson CM. Ventilatory function in infants with cystic fibrosis: physiological assessment of halation therapy. Arch Dis Child 1969;44:393-400.
    • (1969) Arch Dis Child , vol.44 , pp. 393-400
    • Phelan, P.D.1    Gracey, M.2    Williams, H.E.3    Anderson, C.M.4
  • 53
    • 80051850244 scopus 로고    scopus 로고
    • Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening
    • AREST CF Investigators
    • Hall GL, Logie KM, Parsons F, Schulzke SM, Nolan G, Murray C, Ranganathan S, Robinson P, Sly PD, Stick SM, et al.; AREST CF Investigators. Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening. PLoS One 2011;6:e23932.
    • (2011) PLoS One , vol.6 , pp. e23932
    • Hall, G.L.1    Logie, K.M.2    Parsons, F.3    Schulzke, S.M.4    Nolan, G.5    Murray, C.6    Ranganathan, S.7    Robinson, P.8    Sly, P.D.9    Stick, S.M.10
  • 54
    • 85021069579 scopus 로고    scopus 로고
    • Endexpiratory lung volume is not associated with gas trapping on CT in early cystic fibrosis lung disease [abstract]
    • Rosenow TM, Mok C, Ramsay KA, Murray C, Hall GL, Stick SM. Endexpiratory lung volume is not associated with gas trapping on CT in early cystic fibrosis lung disease [abstract]. Am J Respir Crit Care Med 2016;193:A5591.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. A5591
    • Rosenow, T.M.1    Mok, C.2    Ramsay, K.A.3    Murray, C.4    Hall, G.L.5    Stick, S.M.6
  • 61
    • 84899046260 scopus 로고    scopus 로고
    • Cystic fibrosis: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases
    • Pittman JE, Cutting G, Davis SD, Ferkol T, Boucher R. Cystic fibrosis: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc 2014;11:S161-S168.
    • (2014) Ann Am Thorac Soc , vol.11 , pp. S161-S168
    • Pittman, J.E.1    Cutting, G.2    Davis, S.D.3    Ferkol, T.4    Boucher, R.5
  • 62
    • 80051566309 scopus 로고    scopus 로고
    • Exciting new clinical trials in cystic fibrosis: Infants need not apply
    • Stick SM, Sly PD. Exciting new clinical trials in cystic fibrosis: infants need not apply. Am J Respir Crit Care Med 2011;183:1577-1578.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1577-1578
    • Stick, S.M.1    Sly, P.D.2
  • 63
    • 84950129551 scopus 로고    scopus 로고
    • Parental experience of information and education processes following diagnosis of their infant with cystic fibrosis via newborn screening
    • AREST-CF
    • Jessup M, Douglas T, Priddis L, Branch-Smith C, Shields L, Arest CF; AREST-CF. Parental experience of information and education processes following diagnosis of their infant with cystic fibrosis via newborn screening. J Pediatr Nurs 2016;31:e233-e241.
    • (2016) J Pediatr Nurs , vol.31 , pp. e233-e241
    • Jessup, M.1    Douglas, T.2    Priddis, L.3    Branch-Smith, C.4    Shields, L.5    Arest, C.F.6
  • 64
    • 84905732526 scopus 로고    scopus 로고
    • What do parents experience and how do they cope with the AREST-CF early surveillance program for infants and children with cystic fibrosis?
    • ARESTCF
    • Branch-Smith C, Pooley J, Shields L, Stick S, Douglas T; ARESTCF. What do parents experience and how do they cope with the AREST-CF early surveillance program for infants and children with cystic fibrosis? J Cyst Fibros 2013;12:S3.
    • (2013) J Cyst Fibros , vol.12 , pp. S3
    • Branch-Smith, C.1    Pooley, J.2    Shields, L.3    Stick, S.4    Douglas, T.5
  • 65
    • 77951887288 scopus 로고    scopus 로고
    • Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: A randomized controlled trial
    • Saiman L, Anstead M, Mayer-Hamblett N, Lands LC, Kloster M, Hocevar-Trnka J, Goss CH, Rose LM, Burns JL, Marshall BC, et al.; AZ0004 Azithromycin Study Group. Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA 2010;303:1707-1715.
    • (2010) JAMA , vol.303 , pp. 1707-1715
    • Saiman, L.1    Anstead, M.2    Mayer-Hamblett, N.3    Lands, L.C.4    Kloster, M.5    Hocevar-Trnka, J.6    Goss, C.H.7    Rose, L.M.8    Burns, J.L.9    Marshall, B.C.10
  • 67
    • 84866143187 scopus 로고    scopus 로고
    • Prevalence of cystic fibrosis pathogens in the oropharynx of healthy children and implications for cystic fibrosis care
    • Rosenfeld M, Bernardo-Ocampo C, Emerson J, Genatossio A, Burns J, Gibson R. Prevalence of cystic fibrosis pathogens in the oropharynx of healthy children and implications for cystic fibrosis care. J Cyst Fibros 2012;11:456-457.
    • (2012) J Cyst Fibros , vol.11 , pp. 456-457
    • Rosenfeld, M.1    Bernardo-Ocampo, C.2    Emerson, J.3    Genatossio, A.4    Burns, J.5    Gibson, R.6
  • 68
    • 33947155711 scopus 로고    scopus 로고
    • Infant care patterns at epidemiologic study of cystic fibrosis sites that achieve superior childhood lung function
    • Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis
    • Padman R, McColley SA, Miller DP, Konstan MW, Morgan WJ, Schechter MS, Ren CL, Wagener JS; Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis. Infant care patterns at epidemiologic study of cystic fibrosis sites that achieve superior childhood lung function. Pediatrics 2007;119:e531-e537.
    • (2007) Pediatrics , vol.119 , pp. e531-e537
    • Padman, R.1    McColley, S.A.2    Miller, D.P.3    Konstan, M.W.4    Morgan, W.J.5    Schechter, M.S.6    Ren, C.L.7    Wagener, J.S.8
  • 70
    • 0035666058 scopus 로고    scopus 로고
    • A two-year randomized, placebocontrolled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities
    • Quan JM, Tiddens HA, Sy JP, McKenzie SG, Montgomery MD, Robinson PJ, Wohl ME, Konstan MW; Pulmozyme Early Intervention Trial Study Group. A two-year randomized, placebocontrolled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities. J Pediatr 2001;139:813-820.
    • (2001) J Pediatr , vol.139 , pp. 813-820
    • Quan, J.M.1    Tiddens, H.A.2    Sy, J.P.3    McKenzie, S.G.4    Montgomery, M.D.5    Robinson, P.J.6    Wohl, M.E.7    Konstan, M.W.8
  • 73
    • 0035021689 scopus 로고    scopus 로고
    • Use of computerized tomography and chest x-rays in evaluating efficacy of aerosolized recombinant human DNase in cystic fibrosis patients younger than age 5 years: A preliminary study
    • Nasr SZ, Kuhns LR, Brown RW, Hurwitz ME, Sanders GM, Strouse PJ. Use of computerized tomography and chest x-rays in evaluating efficacy of aerosolized recombinant human DNase in cystic fibrosis patients younger than age 5 years: a preliminary study. Pediatr Pulmonol 2001;31:377-382.
    • (2001) Pediatr Pulmonol , vol.31 , pp. 377-382
    • Nasr, S.Z.1    Kuhns, L.R.2    Brown, R.W.3    Hurwitz, M.E.4    Sanders, G.M.5    Strouse, P.J.6
  • 74
    • 61549124077 scopus 로고    scopus 로고
    • Recovery of birth weight z score within 2 years of diagnosis is positively associated with pulmonary status at 6 years of age in children with cystic fibrosis
    • Wisconsin Cystic Fibrosis Neonatal Screening G
    • Lai HJ, Shoff SM, Farrell PM, Wisconsin Cystic Fibrosis Neonatal Screening G; Wisconsin Cystic Fibrosis Neonatal Screening Group. Recovery of birth weight z score within 2 years of diagnosis is positively associated with pulmonary status at 6 years of age in children with cystic fibrosis. Pediatrics 2009;123:714-722.
    • (2009) Pediatrics , vol.123 , pp. 714-722
    • Lai, H.J.1    Shoff, S.M.2    Farrell, P.M.3
  • 75
    • 85052907527 scopus 로고    scopus 로고
    • Vitamin D deficiency is associated with increased risk of lower respiratory infection with S. Aureus among infants & preschool children with CF [abstract]
    • Douglas T, Park J, Ranganathan S, Hart E, Carzino R, Skoric B, Garratt L, Ebdon A, Sly PD, Stick S. Vitamin D deficiency is associated with increased risk of lower respiratory infection with S. aureus among infants & preschool children with CF [abstract]. Pediatr Pulmonol 2012;47:A264.
    • (2012) Pediatr Pulmonol , vol.47 , pp. A264
    • Douglas, T.1    Park, J.2    Ranganathan, S.3    Hart, E.4    Carzino, R.5    Skoric, B.6    Garratt, L.7    Ebdon, A.8    Sly, P.D.9    Stick, S.10
  • 76
    • 33847711906 scopus 로고    scopus 로고
    • Cystic fibrosis mortality and survival in the UK: 1947-2003
    • Dodge JA, Lewis PA, Stanton M, Wilsher J. Cystic fibrosis mortality and survival in the UK: 1947-2003. Eur Respir J 2007;29:522-526.
    • (2007) Eur Respir J , vol.29 , pp. 522-526
    • Dodge, J.A.1    Lewis, P.A.2    Stanton, M.3    Wilsher, J.4
  • 78
    • 84875451063 scopus 로고    scopus 로고
    • Understanding the costs of care for cystic fibrosis: An analysis by age and health state
    • van Gool K, Norman R, Delatycki MB, Hall J, Massie J. Understanding the costs of care for cystic fibrosis: an analysis by age and health state. Value Health 2013;16:345-355.
    • (2013) Value Health , vol.16 , pp. 345-355
    • Van Gool, K.1    Norman, R.2    Delatycki, M.B.3    Hall, J.4    Massie, J.5
  • 79
    • 85021078832 scopus 로고    scopus 로고
    • accessed 2016 Jun. 1
    • Queensland Children's Medical Research Institute. Prevention of bronchiectasis in infants with CF; 2016 [accessed 2016 Jun. 1]. Available from: https://clinicaltrials.gov/ct2/show/NCT01270074
    • (2016) Prevention of Bronchiectasis in Infants with CF
  • 80
    • 85021082648 scopus 로고    scopus 로고
    • accessed 2016 Jun. 1
    • CF Therapeutics Development Network Coordinating Center. Inhaled study of inhaled saline in cystic fibrosis; 2016 [accessed 2016 Jun. 1]. Available from: https://clinicaltrials.gov/ct2/show/NCT00709280
    • (2016) Inhaled Study of Inhaled Saline in Cystic Fibrosis
  • 86
    • 84877054679 scopus 로고    scopus 로고
    • Magnetic resonance imaging of cystic fibrosis lung disease
    • Wielpütz MO, Eichinger M, Puderbach M. Magnetic resonance imaging of cystic fibrosis lung disease. J Thorac Imaging 2013;28:151-159.
    • (2013) J Thorac Imaging , vol.28 , pp. 151-159
    • Wielpütz, M.O.1    Eichinger, M.2    Puderbach, M.3
  • 88
    • 84941087623 scopus 로고    scopus 로고
    • Respiratory tract exacerbations revisited: Ventilation, inflammation, perfusion, and structure (VIPS) monitoring to redefine treatment
    • Tiddens HA, Stick SM, Wild JM, Ciet P, Parker GJ, Koch A, Vogel-Claussen J. Respiratory tract exacerbations revisited: ventilation, inflammation, perfusion, and structure (VIPS) monitoring to redefine treatment. Pediatr Pulmonol 2015;50:S57-S65.
    • (2015) Pediatr Pulmonol , vol.50 , pp. S57-S65
    • Tiddens, H.A.1    Stick, S.M.2    Wild, J.M.3    Ciet, P.4    Parker, G.J.5    Koch, A.6    Vogel-Claussen, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.