Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells

Cell Stem Cell

Volumn 21, Issue 1, 2017, Pages 65-77.e5

  Jadhav, Unmesh ^a,b   Saxena, Madhurima ^a,b   O'Neill, Nicholas K ^a   Saadatpour, Assieh ^a,c   Yuan, Guo Cheng ^a,c,d   Herbert, Zachary ^a   Murata, Kazutaka ^a,b   Shivdasani, Ramesh A ^a,b,d,e  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

accessible chromatin; cell plasticity; chromatin modulation; dedifferentiation; facultative stem cells; intestinal stem cells; reserve stem cells

Indexed keywords

BMI1 PROTEIN; CD69 ANTIGEN; EPITHELIAL CELL ADHESION MOLECULE; GHRELIN; MESSENGER RNA; PROGRAMMED DEATH 1 LIGAND 1; RNA; ULEX EUROPAEUS AGGLUTININ; G PROTEIN COUPLED RECEPTOR; LGR5 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL DEDIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; COMPARATIVE STUDY; CRYPT CELL; ENHANCER REGION; ENTEROENDOCRINE CELL; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GAMMA IRRADIATION; GENE EXPRESSION; GOBLET CELL; IMMUNOFLUORESCENCE; LGR5+ STEM CELL LINE; MOUSE; NONHUMAN; PANETH CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SECRETORY CELL; ANIMAL; CYTOLOGY; DUODENUM; METABOLISM; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; CELL DEDIFFERENTIATION; DUODENUM; ENTEROENDOCRINE CELLS; MICE; MICE, TRANSGENIC; RECEPTORS, G-PROTEIN-COUPLED; STEM CELLS;

EID: 85021119272     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2017.05.001     Document Type: Article

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