A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk

Diabetes

Volumn 66, Issue 7, 2017, Pages 2019-2032

  Manning, Alisa ^a,b,c   Highland, Heather M ^d,e   Gasser, Jessica ^a   Sim, Xueling ^f,g   Tukiainen, Taru ^a,b,c   Fontanillas, Pierre ^a,h   Grarup, Niels ⁱ   Rivas, Manuel A ^j   Mahajan, Anubha ^j   Locke, Adam E ^f   Cingolani, Pablo ^k   Pers, Tune H ^a,i,l,m   Viñuela, Ana ^n,o,p   Brown, Andrew A ^q,r   Wu, Ying ^s   Flannick, Jason ^a,b   Fuchsberger, Christian ^f   Gamazon, Eric R ^t,u   Gaulton, Kyle J ^j,v   Im, Hae Kyung ^t   Teslovich, Tanya M ^f   Blackwell, Thomas W ^f   Bork Jensen, Jette ⁱ   Burtt, Noël P ^a   Chen, Yuhui ^j   Green, Todd ^a   Hartl, Christopher ^a   Kang, Hyun Min ^f   Kumar, Ashish ^j,w   Ladenvall, Claes ^x   Ma, Clement ^f   Moutsianas, Loukas ^j   Pearson, Richard D ^j   Perry, John R B ^j,y,z   Rayner, N William ^j,q,aa   Robertson, Neil R ^j,aa   Scott, Laura J ^f   van de Bunt, Martijn ^j,aa   Eriksson, Johan G ^{ab,ac,ad,ae,af}   Jula, Antti ^af   Koskinen, Seppo ^af   Lehtimäki, Terho ^ag   Palotie, Aarno ^a,b,ab   Raitakari, Olli T ^ah,ai   Jacobs, Suzanne B R ^a   Wessel, Jennifer ^aj,ak   Chu, Audrey Y ^al   Scott, Robert A ^z   Goodarzi, Mark O ^am   Blancher, Christine ^j   Buck, Gemma ^j   Buck, David ^j   Chines, Peter S ^an   Gabriel, Stacey ^a   Gjesing, Anette P ⁱ   Groves, Christopher J ^aa   Hollensted, Mette ⁱ   Huyghe, Jeroen R ^f   Jackson, Anne U ^f   Jun, Goo ^f   Justesen, Johanne Marie ⁱ   Mangino, Massimo ⁿ   Murphy, Jacquelyn ^a   Neville, Matt ^aa   Onofrio, Robert ^a   Small, Kerrin S ⁿ   Stringham, Heather M ^f   Trakalo, Joseph ^j   Banks, Eric ^a   Carey, Jason ^a   Carneiro, Mauricio O ^a   Depristo, Mark ^a   Farjoun, Yossi ^a   Fennell, Timothy ^a   Goldstein, Jacqueline I ^a,b   Grant, George ^a   de Angelis, Martin Hrabé ^ao,ap,aq   Maguire, Jared ^a   Neale, Benjamin M ^a,b   Poplin, Ryan ^a   Purcell, Shaun ^a,b,ar   Schwarzmayr, Thomas ^ao   Shakir, Khalid ^a   Smith, Joshua D ^as   Strom, Tim M ^ao,aq   Wieland, Thomas ^ao   Lindstrom, Jaana ^af   Brandslund, Ivan ^at,au   Christensen, Cramer ^au   Surdulescu, Gabriela L ⁿ   Lakka, Timo A ^av,aw   Doney, Alex S F ^ax   Nilsson, Peter ^x   Wareham, Nicholas J ^z   Langenberg, Claudia ^z   Varga, Tibor V ^x   Franks, Paul W ^x,ay,az   Rolandsson, Olov ^az   Rosengren, Anders H ^x   Farook, Vidya S ^ba   Thameem, Farook ^bb   Puppala, Sobha ^ba   Kumar, Satish ^ba   Lehman, Donna M ^bb   Jenkinson, Christopher P ^bb,bc   Curran, Joanne E ^ba   Hale, Daniel Esten ^bb   Fowler, Sharon P ^bb   Arya, Rector ^bb   Defronzo, Ralph A ^bb   Abboud, Hanna E ^bb   Syvänen, Ann Christine ^bd   Hicks, Pamela J ^be   Palmer, Nicholette D ^be   Ng, Maggie C Y ^be   Bowden, Donald W ^be   Freedman, Barry I ^be   Esko, Tõnu ^a,c,l,bf   Mägi, Reedik ^bf   Milani, Lili ^bf   Mihailov, Evelin ^bf   Metspalu, Andres ^bf   Narisu, Narisu ^an   Kinnunen, Leena ^af   Bonnycastle, Lori L ^an   Swift, Amy ^an   Pasko, Dorota ^y   Wood, Andrew R ^y   Fadista, João ^x   Pollin, Toni I ^bg   Barzilai, Nir ^bh   Atzmon, Gil ^bh,bi   Glaser, Benjamin ^bj   Thorand, Barbara ^ao,ap   Strauch, Konstantin ^ao,bk   Peters, Annette ^ao,ap,bl   Roden, Michael ^bm,bn   Müller Nurasyid, Martina ^ao,bk,bl,bo   Liang, Liming ^ay   Kriebel, Jennifer ^ao,ap   Illig, Thomas ^ao,bp   Grallert, Harald ^ao,ap   Gieger, Christian ^ao   Meisinger, Christa ^ao   Lannfelt, Lars ^bq   Musani, Solomon K ^br   Griswold, Michael ^br   Taylor, Herman A ^bs   Wilson, Gregory ^bt   Correa, Adolfo ^bs   Oksa, Heikki ^bu   Scott, William R ^bv   Afzal, Uzma ^bv   Tan, Sian Tsung ^bw,bx   Loh, Marie ^bv,by,bz   Chambers, John C ^bv,bx,ca   Sehmi, Jobanpreet ^bw,bx   Kooner, Jaspal Singh ^bw   Lehne, Benjamin ^bv   Cho, Yoon Shin ^cb   Lee, Jong Young ^cc   Han, Bok Ghee ^cd   Käräjämäki, Annemari ^ae,ce   Qi, Qibin ^ay,bh   Qi, Lu ^c,ay   Huang, Jinyan ^ay   Hu, Frank B ^ay   E Mel Ander, Ol L ^x   Orho Melander, Marju ^x   Below, Jennifer E ^cf   Aguilar, David ^cg   Wong, Tien Yin ^ch,ci   U, Jianjun Li ^g,cj   Khor, Chiea Chuen ^g,ch,ci,cj   Chia, Kee Seng ^g   Lim, Wei Yen ^g   Cheng, Ching Yu ^g,ch,ci,ck   Chan, Edmund ^cl   Shyong Tai, E ^g,ck,cl   Aung, Tin ^ch,ci   Linneberg, Allan ^cm,cn,co   Isomaa, Bo ^ad,cp   Meitinger, Thomas ^ao,aq,bl   Tuomi, Tiinamaija ^ac,ad   Hakaste, Liisa ^ad   Na Kravi C, Jasmi ^x   Jørgensen, Marit E ^cq   Lauritzen, Torsten ^cr   Deloukas, Panos ^q   Stirrups, Kathleen E ^cs,ct   I Ne R Owen, Kat Har ^aa,cu   Farmer, Andrew J ^aa   Frayling, Timothy M ^y   O’rahilly, Stephen P ^z   Walker, Mark ^cv   Levy, Jonathan C ^aa   Hodgkiss, Dylan ⁿ   Hattersley, Andrew T ^y   Kuulasmaa, Teemu ^av   Stan?cáková, Alena ^av   Barroso, Inês ^q,z   Bharadwaj, Dwaipayan ^cw   Chan, Juliana ^cx   Chandak, Giriraj R ^cy   Daly, Mark J ^b   Donnelly, Peter J ^j,cz   Ebrahim, Shah B ^da   Elliott, Paul ^bv   Fingerlin, Tasha ^db   Froguel, Philippe ^dc   Hu, Cheng ^dd   Jia, Weiping ^dd   Ma, Ronald C W ^cx   McVean, Gilean ^j   Park, Taesung ^de   Prabhakaran, Dorairaj ^da   Sandhu, Manjinder ^q,df   Scott, James ^bw   Sladek, Rob ^k,dg,dh   Tandon, Nikhil ^di   Teo, Yik Ying ^g   Zeggini, Eleftheria ^q   Watanabe, Richard M ^dj   Koistinen, Heikki A ^ac,af,dk   Antero Kesaniemi, Y ^dl   Uusitupa, Matti ^av   Spector, Timothy D ⁿ   Salomaa, Veikko ^af   Rauramaa, Rainer ^av   Palmer, Colin N A ^dm   Prokopenko, Inga ^j,aa,bv   Morris, Andrew D ^dm   Bergman, Richard N ^am   Collins, Francis S ^an   Lind, Lars ^bd   Ingelsson, Erik ^bd,dn   Tuomilehto, Jaakko ^af,do,dp,dq   Karpe, Fredrik ^aa,cu   Groop, Leif ^x   Jørgensen, Torben ^cm,dr   Hansen, Torben ^i,ds   Pedersen, Oluf ⁱ   Kuusisto, Johanna ^av,aw   Abecasis, Gonçalo ^f   Bell, Graeme I ^dt   Blangero, John ^ba   Cox, Nancy J ^t   Duggirala, Ravindranath ^ba   Seielstad, Mark ^du,dv   Wilson, James G ^bs   Dupuis, Josee ^dw,dx   Ripatti, Samuli ^q,ab   Hanis, Craig L ^cf   Florez, Jose C ^a,b,c   Mohlke, Karen L ^s   Meigs, James B ^a,b,c   Laakso, Markku ^av,aw   Morris, Andrew P ^j,bf,dy   Boehnke, Michael ^f   Altshuler, David ^a,b,c,dz   McCarthy, Mark I ^j,aa,cu   Gloyn, Anna L ^j,aa,cu   Lindgren, Cecilia M ^a,j   more..

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e The University of North Carolina at Chapel Hill   (United States)

^f UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^h 23andMe ^*  (United States)

ⁱ University of Copenhagen   (Denmark)

^j UNIVERSITY OF OXFORD   (United Kingdom)

^k MCGILL UNIVERSITY   (Canada)

^l BOSTON CHILDREN S HOSPITAL   (United States)

^m STATENS SERUM INSTITUT   (Denmark)

ⁿ KING'S COLLEGE LONDON   (United Kingdom)

^o UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^p UNIVERSITY OF GENEVA   (Switzerland)

^q WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^r OSLO UNIVERSITY HOSPITAL   (Norway)

^s UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^t UNIVERSITY OF CHICAGO   (United States)

^u UNIVERSITY OF AMSTERDAM   (Netherlands)

^v UNIVERSITY OF CALIFORNIA   (United States)

^w UNIVERSITY OF BASEL   (Switzerland)

^x LUND UNIVERSITY   (Sweden)

^y UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^z UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^aa UNIVERSITY OF OXFORD   (United Kingdom)

^ab UNIVERSITY OF HELSINKI   (Finland)

^ac HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^ad FOLKHÄLSAN RESEARCH CENTER   (Finland)

^ae VAASA CENTRAL HOSPITAL   (Finland)

^af NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^ag FIMLAB LABORATORIES   (Finland)

^ah TURKU UNIVERSITY HOSPITAL   (Finland)

^ai UNIVERSITY OF TURKU   (Finland)

^aj INDIANA UNIVERSITY   (United States)

^ak INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^al BRIGHAM AND WOMEN S HOSPITAL   (United States)

^am CEDARS SINAI MEDICAL CENTER   (United States)

^an NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^ao INSTITUTE OF EPIDEMIOLOGY   (Germany)

^ap GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^aq TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^ar MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^as UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^at UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^au LILLEBAELT HOSPITAL   (Denmark)

^av UNIVERSITY OF EASTERN FINLAND   (Finland)

^aw KUOPIO UNIVERSITY HOSPITAL   (Finland)

^ax NINEWELLS HOSPITAL   (United Kingdom)

^ay HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^az UMEÅ UNIVERSITY   (Sweden)

^ba SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^bb UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^bc SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^bd UPPSALA UNIVERSITY   (Sweden)

^be WAKE FOREST SCHOOL OF MEDICINE   (United States)

^bf UNIVERSITY OF TARTU   (Estonia)

^bg UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^bh ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^bi UNIVERSITY OF HAIFA   (Israel)

^bj HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^bk UNIVERSITY OF MUNICH   (Germany)

^bl DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^bm HEINRICH HEINE UNIVERSITY   (Germany)

^bn LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^bo LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^bp HANNOVER MEDICAL SCHOOL   (Germany)

^bq UPPSALA UNIVERSITY   (Sweden)

^br UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^bs UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^bt JACKSON STATE UNIVERSITY   (United States)

^bu PIRKANMAA HOSPITAL DISTRICT   (Finland)

^bv IMPERIAL COLLEGE LONDON   (United Kingdom)

^bw NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^bx EALING HOSPITAL NHS TRUST   (United Kingdom)

^by UNIVERSITY OF OULU   (Finland)

^bz AGENCY FOR SCIENCE   (Singapore)

^ca IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^cb Hallym University   (South Korea)

^cc Ministry of Health and Welfare   (South Korea)

^cd Korea National Institute of Health   (South Korea)

^ce Vaasa Health Care Center   (Finland)

^cf UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^cg BAYLOR COLLEGE OF MEDICINE   (United States)

^ch SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^ci NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^cj GENOME INSTITUTE OF SINGAPORE   (Singapore)

^ck DUKE NUS MEDICAL SCHOOL   (Singapore)

^cl Dept Medicine Endocrinol Diabet   (Singapore)

^cm GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^cn International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^co UNIVERSITY OF COPENHAGEN   (Denmark)

^cp CSIR Institute of Genomics & Integrative Biology ^*  (Finland)

^cq STENO DIABETES CENTER   (Denmark)

^cr AARHUS UNIVERSITY   (Denmark)

^cs QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^ct UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^cu OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^cv NEWCASTLE UNIVERSITY   (United Kingdom)

^cw CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^cx CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^cy CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^cz UNIVERSITY OF OXFORD   (United Kingdom)

^da CENTRE FOR CHRONIC DISEASE CONTROL   (India)

^db Department of Civil and Environmental Engineering at Colorado State University and the Department of Environmental and Occupational Health at the Colorado School of Public Health   (United States)

^dc INSTITUT DE BIOLOGIE DE LILLE   (France)

^dd SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^de Seoul National University   (South Korea)

^df UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^dg MCGILL UNIVERSITY   (Canada)

^dh MCGILL UNIVERSITY   (Canada)

^di ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^dj UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^dk MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^dl UNIVERSITY OF OULU   (Finland)

^dm UNIVERSITY OF DUNDEE   (United Kingdom)

^dn STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^do DANUBE UNIVERSITY KREMS   (Austria)

^dp KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^dq DASMAN DIABETES INSTITUTE   (Kuwait)

^dr AALBORG UNIVERSITY   (Denmark)

^ds UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^dt UNIVERSITY OF CHICAGO   (United States)

^du UNIVERSITY OF CALIFORNIA   (United States)

^dv BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^dw BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^dx NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^dy UNIVERSITY OF LIVERPOOL   (United Kingdom)

^dz MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AKT1 PROTEIN; AKT3 PROTEIN; GLUCOSE; INSULIN; MESSENGER RNA; PROTEIN KINASE B BETA; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; AKT2 PROTEIN, HUMAN; PROTEIN KINASE B;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DIET RESTRICTION; FINLAND; FINN (CITIZEN); GENE EXPRESSION; GENE FREQUENCY; GENE INACTIVATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GLUCOSE HOMEOSTASIS; GLYCEMIC CONTROL; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MONOGENIC DISORDER; MUTATIONAL ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PENETRANCE; PHENOTYPE; PLECKSTRIN HOMOLOGY DOMAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; WHOLE EXOME SEQUENCING; AFRICAN AMERICAN; ALLELE; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; CAUCASIAN; GENETIC PREDISPOSITION; GENETICS; HISPANIC; INSULIN RESISTANCE; METABOLISM; ODDS RATIO;

AFRICAN AMERICANS; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FASTING; FINLAND; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HISPANIC AMERICANS; HUMANS; INSULIN; INSULIN RESISTANCE; ODDS RATIO; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 85021073183     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db16-1329     Document Type: Article

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