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Volumn 2, Issue , 2016, Pages

L1000CDS2: LINCS L1000 characteristic direction signatures search engine

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EID: 85020403526     PISSN: None     EISSN: 20567189     Source Type: Journal    
DOI: 10.1038/npjsba.2016.15     Document Type: Article
Times cited : (236)

References (34)
  • 1
    • 1442335997 scopus 로고    scopus 로고
    • Gene expression–based high-throughput screening (GE-HTS) and application to leukemia differentiation
    • Stegmaier, K. et al. Gene expression–based high-throughput screening (GE-HTS) and application to leukemia differentiation. Nat. Genet. 36, 257–263 (2004).
    • (2004) Nat. Genet , vol.36 , pp. 257-263
    • Stegmaier, K.1
  • 2
    • 33749335282 scopus 로고    scopus 로고
    • The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
    • Lamb, J. et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929–1935 (2006).
    • (2006) Science , vol.313 , pp. 1929-1935
    • Lamb, J.1
  • 3
    • 47249146126 scopus 로고    scopus 로고
    • Drug target identification using side-effect similarity
    • Campillos, M., Kuhn, M., Gavin, A.-C., Jensen, L. J. & Bork, P. Drug target identification using side-effect similarity. Science 321, 263–266 (2008).
    • (2008) Science , vol.321 , pp. 263-266
    • Campillos, M.1    Kuhn, M.2    Gavin, A.-C.3    Jensen, L.J.4    Bork, P.5
  • 4
    • 84899086512 scopus 로고    scopus 로고
    • The characteristic direction: A geometrical approach to identify differentially expressed genes
    • Clark, N. R. et al. The characteristic direction: a geometrical approach to identify differentially expressed genes. BMC Bioinformatics 15, 79 (2014).
    • (2014) BMC Bioinformatics , vol.15 , pp. 79
    • Clark, N.R.1
  • 6
    • 84867520667 scopus 로고    scopus 로고
    • Analysing RNA-Seq data with the DESeq package
    • Anders, S. Analysing RNA-Seq data with the DESeq package. Mol. Biol. 43, 1–17 (2010).
    • (2010) Mol. Biol , vol.43 , pp. 1-17
    • Anders, S.1
  • 7
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher, V. G., Tibshirani, R. & Chu, G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl Acad. Sci. USA 98, 5116–5121 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 8
    • 0037392942 scopus 로고    scopus 로고
    • The specificities of protein kinase inhibitors: An update
    • McLauchlan, H., Elliott, M. & Cohen, P. The specificities of protein kinase inhibitors: an update. Biochem. J. 371, 199–204 (2003).
    • (2003) Biochem. J , vol.371 , pp. 199-204
    • McLauchlan, H.1    Elliott, M.2    Cohen, P.3
  • 9
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: Kyoto encyclopedia of genes and genomes
    • Kanehisa, M. & Goto, S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27–30 (2000).
    • (2000) Nucleic Acids Res , vol.28 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 10
    • 0034069495 scopus 로고    scopus 로고
    • Gene Ontology: Tool for the unification of biology
    • Ashburner, M. et al. Gene Ontology: tool for the unification of biology. Nature Genet. 25, 25–29 (2000).
    • (2000) Nature Genet , vol.25 , pp. 25-29
    • Ashburner, M.1
  • 11
    • 77957243164 scopus 로고    scopus 로고
    • ChEA: Transcription factor regulation inferred from integrating genome-wide ChIP-X experiments
    • Lachmann, A. et al. ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments. Bioinformatics 26, 2438–2444 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 2438-2444
    • Lachmann, A.1
  • 12
    • 7444260846 scopus 로고    scopus 로고
    • The ENCODE (ENCyclopedia of DNA elements) project
    • Consortium, E. P. The ENCODE (ENCyclopedia of DNA elements) project. Science 306, 636–640 (2004).
    • (2004) Science , vol.306 , pp. 636-640
  • 13
    • 61449203001 scopus 로고    scopus 로고
    • KEA: Kinase enrichment analysis
    • Lachmann, A. & Ma’ayan, A. KEA: kinase enrichment analysis. Bioinformatics 25, 684–686 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 684-686
    • Lachmann, A.1    Ma’Ayan, A.2
  • 14
    • 84855171722 scopus 로고    scopus 로고
    • MRNA profiling linked to multiple upstream regulatory layers
    • Chen, E. Y. et al. mRNA profiling linked to multiple upstream regulatory layers. Bioinformatics 28, 105–111 (2012).
    • (2012) Bioinformatics , vol.28 , pp. 105-111
    • Chen, E.Y.1
  • 15
    • 84948800043 scopus 로고    scopus 로고
    • Drug target prioritization by perturbed gene expression and network information
    • Isik, Z., Baldow, C., Cannistraci, C. V. & Schroeder, M. Drug target prioritization by perturbed gene expression and network information. Sci. Rep. 5, 17417 (2015).
    • (2015) Sci. Rep , vol.5 , pp. 17417
    • Isik, Z.1    Baldow, C.2    Cannistraci, C.V.3    Schroeder, M.4
  • 16
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    • Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603–607 (2012).
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1
  • 17
    • 80054744851 scopus 로고    scopus 로고
    • Therapeutics of ebola hemorrhagic fever: Whole-genome transcriptional analysis of successful disease mitigation
    • Yen, J. Y. et al. Therapeutics of ebola hemorrhagic fever: whole-genome transcriptional analysis of successful disease mitigation. J. Infect. Dis. 204, S1043–S1052 (2011).
    • (2011) J. Infect. Dis , vol.204 , pp. S1043-S1052
    • Yen, J.Y.1
  • 18
    • 80055084611 scopus 로고    scopus 로고
    • Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression
    • Wahl-Jensen, V. et al. Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression. PLoS Negl. Trop. Dis. 5, e1359 (2011).
    • (2011) Plos Negl. Trop. Dis , vol.5
    • Wahl-Jensen, V.1
  • 19
    • 84911371938 scopus 로고    scopus 로고
    • Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
    • Rasmussen, A. L. et al. Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance. Science 346, 987–991 (2014).
    • (2014) Science , vol.346 , pp. 987-991
    • Rasmussen, A.L.1
  • 20
    • 68349133176 scopus 로고    scopus 로고
    • Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection
    • Panchal, R. G. et al. Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection. Cell Host Microbe 6, 162–173 (2009).
    • (2009) Cell Host Microbe , vol.6 , pp. 162-173
    • Panchal, R.G.1
  • 21
    • 39749089452 scopus 로고    scopus 로고
    • The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever
    • Rubins, K. et al. The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever. Genome Biol. 8, R174 (2007).
    • (2007) Genome Biol , vol.8 , pp. R174
    • Rubins, K.1
  • 22
    • 84876100615 scopus 로고    scopus 로고
    • Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool
    • Chen, E. Y. et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics 14, 128 (2013).
    • (2013) BMC Bioinformatics , vol.14 , pp. 128
    • Chen, E.Y.1
  • 23
    • 84903376081 scopus 로고    scopus 로고
    • Inhibition of CDK2 promotes inducible regulatory T-cell differentiation through TGFβ-Smad3 signaling pathway
    • Gu, H., Ding, L., Xiong S.-d., Gao X.-m. & Zheng, B. Inhibition of CDK2 promotes inducible regulatory T-cell differentiation through TGFβ-Smad3 signaling pathway. Cell Immunol. 290, 138–144 (2014).
    • (2014) Cell Immunol , vol.290 , pp. 138-144
    • Gu, H.1    Ding, L.2    Xiong, S.-D.3    Gao, X.-M.4    Zheng, B.5
  • 24
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong, Z., Wen, Z. & Darnell, J. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264, 95–98 (1994).
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.3
  • 26
    • 79952153637 scopus 로고    scopus 로고
    • Inhibition of GSK-3β activity with lithium in vitro attenuates sepsis-induced changes in muscle protein turnover
    • Bertsch, S., Lang, C. H. & Vary, T. C. Inhibition of GSK-3β activity with lithium in vitro attenuates sepsis-induced changes in muscle protein turnover. Shock (Augusta, GA) 35, 266 (2011).
    • (2011) Shock (Augusta, GA) , vol.35 , pp. 266
    • Bertsch, S.1    Lang, C.H.2    Vary, T.C.3
  • 27
    • 84901949581 scopus 로고    scopus 로고
    • A renewed focus on the interplay between viruses and mitochondrial metabolism
    • Claus, C. & Liebert, U. G. A renewed focus on the interplay between viruses and mitochondrial metabolism. Arch. Virol. 159, 1267–1277 (2014).
    • (2014) Arch. Virol , vol.159 , pp. 1267-1277
    • Claus, C.1    Liebert, U.G.2
  • 28
    • 85053136862 scopus 로고
    • The effect of interferon on experimental Ebola virus infection in rhesus monkeys
    • Bowen, E. et al. The effect of interferon on experimental Ebola virus infection in rhesus monkeys. Interferon 5, 5 (1978).
    • (1978) Interferon , vol.5 , pp. 5
    • Bowen, E.1
  • 29
    • 0347360271 scopus 로고    scopus 로고
    • 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β
    • Kunick, C., Lauenroth, K., Leost, M., Meijer, L. & Lemcke, T. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β. Bioorg. Med. Chem. Lett. 14, 413–416 (2004).
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 413-416
    • Kunick, C.1    Lauenroth, K.2    Leost, M.3    Meijer, L.4    Lemcke, T.5
  • 30
    • 4344571581 scopus 로고    scopus 로고
    • Rank products: A simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments
    • Breitling, R., Armengaud, P., Amtmann, A. & Herzyk, P. Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett. 573, 83–92 (2004).
    • (2004) FEBS Lett , vol.573 , pp. 83-92
    • Breitling, R.1    Armengaud, P.2    Amtmann, A.3    Herzyk, P.4
  • 31
    • 84891767304 scopus 로고    scopus 로고
    • DrugBank 4.0: Shedding new light on drug metabolism
    • Law, V. et al. DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res. 42, D1091–D1097 (2014).
    • (2014) Nucleic Acids Res , vol.42 , pp. D1091-D1097
    • Law, V.1
  • 32
    • 84931052054 scopus 로고    scopus 로고
    • Dynamics of the discovery process of protein-protein interactions from low content studies
    • Wang, Z., Clark, N. R. & Ma’ayan, A. Dynamics of the discovery process of protein-protein interactions from low content studies. BMC Syst. Biol. 9, 26 (2015).
    • (2015) BMC Syst. Biol , vol.9 , pp. 26
    • Wang, Z.1    Clark, N.R.2    Ma’Ayan, A.3
  • 33
    • 84891767304 scopus 로고    scopus 로고
    • DrugBank 4.0: Shedding new light on drug metabolism
    • Law, V. et al. DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res. 42, D1091–D1097 (2014).
    • (2014) Nucleic Acids Res , vol.42 , pp. D1091-D1097
    • Law, V.1


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