-
1
-
-
0344305525
-
Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies
-
Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry. 2003;60:1187-1192.
-
(2003)
Arch Gen Psychiatry
, vol.60
, pp. 1187-1192
-
-
Sullivan, P.F.1
Kendler, K.S.2
Neale, M.C.3
-
2
-
-
84904804929
-
Biological insights from 108 schizophreniaassociated genetic loci
-
Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophreniaassociated genetic loci. Nature. 2014;511:421-427.
-
(2014)
Nature
, vol.511
, pp. 421-427
-
-
-
6
-
-
84868331824
-
The immune theory of psychiatric diseases: A key role for activated microglia and circulating monocytes
-
Beumer W, Gibney SM, Drexhage RC, et al. The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes. J Leukoc Biol. 2012;92:959-975.
-
(2012)
J Leukoc Biol
, vol.92
, pp. 959-975
-
-
Beumer, W.1
Gibney, S.M.2
Drexhage, R.C.3
-
7
-
-
0034671891
-
Functional requirement for class I MHC in CNS development and plasticity
-
Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ. Functional requirement for class I MHC in CNS development and plasticity. Science. 2000;290:2155-2159.
-
(2000)
Science
, vol.290
, pp. 2155-2159
-
-
Huh, G.S.1
Boulanger, L.M.2
Du, H.3
Riquelme, P.A.4
Brotz, T.M.5
Shatz, C.J.6
-
8
-
-
33646199097
-
Synaptic scaling mediated by glial TNF-alpha
-
Stellwagen D, Malenka RC. Synaptic scaling mediated by glial TNF-alpha. Nature. 2006;440:1054-1059.
-
(2006)
Nature
, vol.440
, pp. 1054-1059
-
-
Stellwagen, D.1
Malenka, R.C.2
-
9
-
-
84861427387
-
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
-
Schafer DP, Lehrman EK, Kautzman AG, et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron. 2012;74:691-705.
-
(2012)
Neuron
, vol.74
, pp. 691-705
-
-
Schafer, D.P.1
Lehrman, E.K.2
Kautzman, A.G.3
-
10
-
-
84888348687
-
TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement
-
Bialas AR, Stevens B. TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci. 2013;16:1773-1782.
-
(2013)
Nat Neurosci
, vol.16
, pp. 1773-1782
-
-
Bialas, A.R.1
Stevens, B.2
-
11
-
-
84888103008
-
Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathw a y
-
Gallagher D, Norman AA, Woodard CL, et al. Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathw a y. Cell Stem Cell. 2013;13:564-576.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 564-576
-
-
Gallagher, D.1
Norman, A.A.2
Woodard, C.L.3
-
12
-
-
35148872226
-
Maternal immune activation alters fetal brain development through interleukin-6
-
Smith SE, Li J, Garbett K, Mirnics K, Patterson PH. Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci. 2007;27:10695-10702.
-
(2007)
J Neurosci
, vol.27
, pp. 10695-10702
-
-
Smith, S.E.1
Li, J.2
Garbett, K.3
Mirnics, K.4
Patterson, P.H.5
-
13
-
-
77951620737
-
Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey
-
Short SJ, Lubach GR, Karasin AI, et al. Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey. Biol Psychiatry. 2010;67:965-973.
-
(2010)
Biol Psychiatry
, vol.67
, pp. 965-973
-
-
Short, S.J.1
Lubach, G.R.2
Karasin, A.I.3
-
14
-
-
84863782741
-
Childhood infection and adult schizophrenia: A meta-analysis of population-based studies
-
Khandaker GM, Zimbron J, Dalman C, Lewis G, Jones PB. Childhood infection and adult schizophrenia: a meta-analysis of population-based studies. Schizophr Res. 2012;139:161-168.
-
(2012)
Schizophr Res
, vol.139
, pp. 161-168
-
-
Khandaker, G.M.1
Zimbron, J.2
Dalman, C.3
Lewis, G.4
Jones, P.B.5
-
15
-
-
84904132951
-
Meta-analysis of the association between N-methyl-D-aspartate receptor antibodies and schizophrenia, schizoaffective disorder, bipolar disorder, and major depressive disorder
-
Pearlman DM, Najjar S. Meta-analysis of the association between N-methyl-D-aspartate receptor antibodies and schizophrenia, schizoaffective disorder, bipolar disorder, and major depressive disorder. Schizophr Res. 2014;157:249-258.
-
(2014)
Schizophr Res
, vol.157
, pp. 249-258
-
-
Pearlman, D.M.1
Najjar, S.2
-
16
-
-
84890788392
-
A nationwide study on the risk of autoimmune diseases in individuals with a personal or a family history of schizophrenia and related psychosis
-
Benros ME, Pedersen MG, Rasmussen H, Eaton WW, Nordentoft M, Mortensen PB. A nationwide study on the risk of autoimmune diseases in individuals with a personal or a family history of schizophrenia and related psychosis. Am J Psychiatry. 2014;171:218-226.
-
(2014)
Am J Psychiatry
, vol.171
, pp. 218-226
-
-
Benros, M.E.1
Pedersen, M.G.2
Rasmussen, H.3
Eaton, W.W.4
Nordentoft, M.5
Mortensen, P.B.6
-
17
-
-
80052853015
-
Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects
-
Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry. 2011;70:663-671.
-
(2011)
Biol Psychiatry
, vol.70
, pp. 663-671
-
-
Miller, B.J.1
Buckley, P.2
Seabolt, W.3
Mellor, A.4
Kirkpatrick, B.5
-
18
-
-
84873055619
-
Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia
-
Fillman SG, Cloonan N, Catts VS, et al. Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia. Mol Psychiatry. 2013;18:206-214.
-
(2013)
Mol Psychiatry
, vol.18
, pp. 206-214
-
-
Fillman, S.G.1
Cloonan, N.2
Catts, V.S.3
-
19
-
-
84931060145
-
Are anti-inflammatory therapies viable treatments for psychiatric disorders?: Where the rubber meets the road
-
Miller AH, Raison CL. Are anti-inflammatory therapies viable treatments for psychiatric disorders?: where the rubber meets the road. JAMA Psychiatry. 2015;72:527-528.
-
(2015)
JAMA Psychiatry
, vol.72
, pp. 527-528
-
-
Miller, A.H.1
Raison, C.L.2
-
20
-
-
84892647238
-
Efficacy of anti-inflammatory agents to improve symptoms in patients with schizophrenia: An update
-
Sommer IE, van Westrhenen R, Begemann MJ, de Witte LD, Leucht S, Kahn RS. Efficacy of anti-inflammatory agents to improve symptoms in patients with schizophrenia: an update. Schizophr Bull. 2014;40:181-191.
-
(2014)
Schizophr Bull
, vol.40
, pp. 181-191
-
-
Sommer, I.E.1
Van Westrhenen, R.2
Begemann, M.J.3
De Witte, L.D.4
Leucht, S.5
Kahn, R.S.6
-
22
-
-
84892572641
-
Immune system disturbances in schizophrenia
-
Horváth S, Mirnics K. Immune system disturbances in schizophrenia. Biol Psychiatry. 2014;75:316-323.
-
(2014)
Biol Psychiatry
, vol.75
, pp. 316-323
-
-
Horváth, S.1
Mirnics, K.2
-
23
-
-
0032790648
-
Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: Effects of confounding factors and diagnosis
-
Haack M, Hinze-Selch D, Fenzel T, et al. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J Psychiatr Res. 1999;33:407-418.
-
(1999)
J Psychiatr Res
, vol.33
, pp. 407-418
-
-
Haack, M.1
Hinze-Selch, D.2
Fenzel, T.3
-
24
-
-
68449090594
-
Common variants conferring risk of schizophrenia
-
Stefansson H, Ophoff RA, Steinberg S, et al. Common variants conferring risk of schizophrenia. Nature. 2009;460:744-747.
-
(2009)
Nature
, vol.460
, pp. 744-747
-
-
Stefansson, H.1
Ophoff, R.A.2
Steinberg, S.3
-
25
-
-
84873525772
-
Variation in the major histocompatibility complex [MHC] gene family in schizophrenia: Associations and functional implications
-
Debnath M, Cannon DM, Venkatasubramanian G. Variation in the major histocompatibility complex [MHC] gene family in schizophrenia: associations and functional implications. Prog Neuropsychopharmacol Biol Psychiatry. 2013;42:49-62.
-
(2013)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.42
, pp. 49-62
-
-
Debnath, M.1
Cannon, D.M.2
Venkatasubramanian, G.3
-
26
-
-
77956192274
-
Common variants conferring risk of schizophrenia: A pathway analysis of GWAS data
-
Jia P, Wang L, Meltzer H Y, Zhao Z. Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. Schizophr Res. 2010;122:38-42.
-
(2010)
Schizophr Res
, vol.122
, pp. 38-42
-
-
Jia, P.1
Wang, L.2
Meltzer, H.Y.3
Zhao, Z.4
-
27
-
-
84923077204
-
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
-
Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci 2015;18:199-209.
-
(2015)
Nat Neurosci
, vol.18
, pp. 199-209
-
-
-
28
-
-
78649489009
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
-
Franke A, McGovern DP, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010;42:1118-1125.
-
(2010)
Nat Genet
, vol.42
, pp. 1118-1125
-
-
Franke, A.1
McGovern, D.P.2
Barrett, J.C.3
-
29
-
-
80051684615
-
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
-
Sawcer S, Hellenthal G, Pirinen M et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011;476:214-219.
-
(2011)
Nature
, vol.476
, pp. 214-219
-
-
Sawcer, S.1
Hellenthal, G.2
Pirinen, M.3
-
30
-
-
78049347495
-
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
-
Strange A, Capon F, Spencer CC et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 2010;42:985-990.
-
(2010)
Nat Genet
, vol.42
, pp. 985-990
-
-
Strange, A.1
Capon, F.2
Spencer, C.C.3
-
31
-
-
77952888454
-
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
-
Stahl EA, Raychaudhuri S, Remmers EF, et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet. 2010;42:508-514.
-
(2010)
Nat Genet
, vol.42
, pp. 508-514
-
-
Stahl, E.A.1
Raychaudhuri, S.2
Remmers, E.F.3
-
32
-
-
79952195585
-
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
-
Anderson CA, Boucher G, Lees CW, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet. 2011;43:246-252.
-
(2011)
Nat Genet
, vol.43
, pp. 246-252
-
-
Anderson, C.A.1
Boucher, G.2
Lees, C.W.3
-
33
-
-
84928612813
-
∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
-
∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat Genet. 2015;47:172-179.
-
(2015)
Nat Genet
, vol.47
, pp. 172-179
-
-
Goyette, P.1
Boucher, G.2
Mallon, D.3
-
34
-
-
84870512735
-
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
-
Tsoi LC, Spain SL, Knight J, et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 2012;44:1341-1348.
-
(2012)
Nat Genet
, vol.44
, pp. 1341-1348
-
-
Tsoi, L.C.1
Spain, S.L.2
Knight, J.3
-
35
-
-
78049450213
-
Accurately assessing the risk of schizophrenia conferred by rare copynumber variation affecting genes with brain function
-
Raychaudhuri S, Korn JM, McCarroll SA, et al. Accurately assessing the risk of schizophrenia conferred by rare copynumber variation affecting genes with brain function. PLoS Genet. 2010;6:e1001097.
-
(2010)
PLoS Genet
, vol.6
, pp. e1001097
-
-
Raychaudhuri, S.1
Korn, J.M.2
McCarroll, S.A.3
-
36
-
-
84969307847
-
Partitioning heritability by functional category using GWAS summary statistics
-
Finucane H. Partitioning heritability by functional category using GWAS summary statistics. bioRxiv. 2015; doi:10.1101/014241.
-
(2015)
BioRxiv
-
-
Finucane, H.1
-
37
-
-
77956331627
-
Integrating common and rare genetic variation in diverse human populations
-
Altshuler DM, Gibbs RA, Peltonen L et al. Integrating common and rare genetic variation in diverse human populations. Nature 2010;467:52-58.
-
(2010)
Nature
, vol.467
, pp. 52-58
-
-
Altshuler, D.M.1
Gibbs, R.A.2
Peltonen, L.3
-
38
-
-
78549251736
-
Analysing biological pathways in genome-wide association studies
-
Wang K, Li M, Hakonarson H. Analysing biological pathways in genome-wide association studies. Nat Rev Genet. 2010;11:843-854.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 843-854
-
-
Wang, K.1
Li, M.2
Hakonarson, H.3
-
39
-
-
85046267540
-
Parsing genetic associations in the MHC in schizophrenia
-
Copenhagen, Denmark, 15 October
-
Mukherjee S, Ripke S, Andreassen O et al. Parsing genetic associations in the MHC in schizophrenia. Presented at 22nd World Congress of Psychiatric Genetics, Copenhagen, Denmark, 15 October 2014.
-
(2014)
22nd World Congress of Psychiatric Genetics
-
-
Mukherjee, S.1
Ripke, S.2
Andreassen, O.3
-
40
-
-
84958074030
-
Schizophrenia risk from complex variation of complement component 4
-
Sekar A, Bialas AR, de Rivera H, et al. Schizophrenia risk from complex variation of complement component 4. Nature 2016;530:177-183.
-
(2016)
Nature
, vol.530
, pp. 177-183
-
-
Sekar, A.1
Bialas, A.R.2
De Rivera, H.3
-
41
-
-
84893919352
-
De novo mutations in schizophrenia implicate synaptic networks
-
Fromer M, Pocklington AJ, Kavanagh DH, et al. De novo mutations in schizophrenia implicate synaptic networks. Nature. 2014;506:179-184.
-
(2014)
Nature
, vol.506
, pp. 179-184
-
-
Fromer, M.1
Pocklington, A.J.2
Kavanagh, D.H.3
-
42
-
-
84923328885
-
Recurrent de novo mutations implicate novel genes underlying simplex autism risk
-
O'Roak BJ, Stessman HA, Boyle EA, et al. Recurrent de novo mutations implicate novel genes underlying simplex autism risk. Nat Commun. 2014;5:5595.
-
(2014)
Nat Commun
, vol.5
, pp. 5595
-
-
O'Roak, B.J.1
Stessman, H.A.2
Boyle, E.A.3
-
43
-
-
59749085381
-
Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation
-
Hamdan FF, Gauthier J, Spiegelman D, et al. Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation. N Engl J Med. 2009;360:599-605.
-
(2009)
N Engl J Med
, vol.360
, pp. 599-605
-
-
Hamdan, F.F.1
Gauthier, J.2
Spiegelman, D.3
-
44
-
-
33747595466
-
Stratified false discovery control for large-scale hypothesis testing with application to genome-wide association studies
-
Sun L, Craiu RV, Paterson AD, Bull SB. Stratified false discovery control for large-scale hypothesis testing with application to genome-wide association studies. Genet Epidemiol. 2006;30:519-530.
-
(2006)
Genet Epidemiol
, vol.30
, pp. 519-530
-
-
Sun, L.1
Craiu, R.V.2
Paterson, A.D.3
Bull, S.B.4
-
45
-
-
84883465830
-
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
-
Cross-Disorder Group of the Psychiatric Genomics Consortium. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013;45:984-994.
-
(2013)
Nat Genet
, vol.45
, pp. 984-994
-
-
-
46
-
-
84866518216
-
An anatomically comprehensive atlas of the adult human brain transcriptome
-
Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489:391-399.
-
(2012)
Nature
, vol.489
, pp. 391-399
-
-
Hawrylycz, M.J.1
Lein, E.S.2
Guillozet-Bongaarts, A.L.3
-
47
-
-
46149097136
-
Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy
-
Magen D, Georgopoulos C, Bross P, et al. Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy. Am J Hum Genet. 2008;83:30-42.
-
(2008)
Am J Hum Genet
, vol.83
, pp. 30-42
-
-
Magen, D.1
Georgopoulos, C.2
Bross, P.3
-
48
-
-
0035126793
-
A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories
-
Jones MW, Errington ML, French PJ, et al. A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci. 2001;4:289-296.
-
(2001)
Nat Neurosci
, vol.4
, pp. 289-296
-
-
Jones, M.W.1
Errington, M.L.2
French, P.J.3
-
49
-
-
0037013246
-
A transmembrane tight junction protein selectively expressed on endothelial cells and platelets
-
Nasdala I, Wolburg-Buchholz K, Wolburg H, et al. A transmembrane tight junction protein selectively expressed on endothelial cells and platelets. J Biol Chem. 2002;277:16294-16303.
-
(2002)
J Biol Chem
, vol.277
, pp. 16294-16303
-
-
Nasdala, I.1
Wolburg-Buchholz, K.2
Wolburg, H.3
-
50
-
-
77954966128
-
NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy
-
Gómez-Sintes R, Lucas JJ. NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J Clin Invest. 2010;120:2432-2445.
-
(2010)
J Clin Invest
, vol.120
, pp. 2432-2445
-
-
Gómez-Sintes, R.1
Lucas, J.J.2
-
51
-
-
0035102694
-
Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia
-
Han BH, DeMattos RB, Dugan LL, et al. Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Nat Med. 2001;7:338-343.
-
(2001)
Nat Med
, vol.7
, pp. 338-343
-
-
Han, B.H.1
DeMattos, R.B.2
Dugan, L.L.3
-
52
-
-
84896829795
-
A genotype-first approach to defining the subtypes of a complex disease
-
Stessman HA, Bernier R, Eichler EE. A genotype-first approach to defining the subtypes of a complex disease. Cell. 2014;156:872-877.
-
(2014)
Cell
, vol.156
, pp. 872-877
-
-
Stessman, H.A.1
Bernier, R.2
Eichler, E.E.3
-
53
-
-
84885020424
-
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
-
Ripke S, O'Dushlaine C, Chambert K, et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet. 2013;45:1150-1159.
-
(2013)
Nat Genet
, vol.45
, pp. 1150-1159
-
-
Ripke, S.1
O'Dushlaine, C.2
Chambert, K.3
-
54
-
-
84908001014
-
Elevated maternal C-reactive protein and increased risk of schizophrenia in a national birth cohort
-
Canetta S, Sourander A, Surcel HM, et al. Elevated maternal C-reactive protein and increased risk of schizophrenia in a national birth cohort. Am J Psychiatry. 2014;171:960-968.
-
(2014)
Am J Psychiatry
, vol.171
, pp. 960-968
-
-
Canetta, S.1
Sourander, A.2
Surcel, H.M.3
|