Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia

Nature Medicine

Volumn 7, Issue 3, 2001, Pages 338-343

  Han, Byung Hee ^a   DeMattos, Ronald B ^a   Dugan, Laura L ^a   Kim Han, Jeong Sook ^a   Brendza, Robert P ^a   Fryer, John D ^a   Kierson, Malca ^a   Cirrito, John ^a   Quick, Kevin ^a   Harmony, Judith A K ^b   Aronow, Bruce J ^c   Holtzman, David M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CLUSTERIN; GLUCOSE; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN CELL; BRAIN INJURY; BRAIN ISCHEMIA; CELL DEATH; CELLULAR DISTRIBUTION; CEREBRAL PALSY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; HYPOXIA; IN VIVO STUDY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SEIZURE;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; BRAIN; CASPASE 3; CASPASES; CELL DEATH; CLUSTERIN; FLUORESCENT ANTIBODY TECHNIQUE; GLYCOPROTEINS; HYPOXIA-ISCHEMIA, BRAIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, IMMUNOELECTRON; MOLECULAR CHAPERONES;

ANIMALIA;

EID: 0035102694     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/85487     Document Type: Article

References (38)

1. Experimental biology of cerebral hypoxia-ischemia: Relation to perinatal brain damage
2. The influence of immaturity on hypoxic-ischemic brain damage in the rat
3. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
4. Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia
5. Bcl-XL is an anti-apoptotic regulator for postnatal CNS neurons
6. No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo
7. Analysis of Sertoli cell-secreted proteins by 2-dimensional gel electrophoresis
8. Purification and characterization of a cell aggregating factor (clusterin), the major glycoprotein in ram rete testis fluid
9. Sulfated glycoprotein 2: New relationships of this multi-functional protein to neurodegeneration
10. Clusterin is a secreted mammalian chaperone
11. Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat
12. Clusterin accumulates in dying neurons following status epilepticus
13. Induction of clusterin in the immature brain following a hypoxic-ischemic injury
14. BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia
15. Clusterin (SGP-2): A multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain
16. Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis
17. Apoptosis has a prolonged role in the neurodegeneration after hypoxia ischemia in the newborn rat
18. Combined oxygen and glucose deprivation in cortical cell culture: Calcium-dependent and calcium-independent mechanisms of neuronal injury
19. Nascent astrocyte particles differ from lipoproteins in CSF
20. Sulfated glycoprotein-2 (SGP-2) mRNA is expressed in rat striatal astrocytes following ibotenic acid lesions
21. An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy
22. The cerebrospinal-fluid form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex
23. Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
24. Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin
25. Immunological localization of glycoprotein 330, low density lipoprotein receptor related protein and 39 kDa receptor associated protein in embryonic mouse tissues
26. Prevention of cell death induced by tumor necrosis factor α in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin)
27. Effects of clusterin overexpression on TNFα- and TGFβ-mediated death of L929 cells
28. Clusterin protects against oxidative stress in vitro through aggregative and nonaggregative properties
29. Cytotoxic sensitivity to tumor necrosis factor-α in PC3 and LNCaP prostatic cancer cells is regulated by extracellular levels of SGP-2 (clusterin)
30. MK-801 protects the neonatal brain from hypoxic-ischemic damage
31. Clusterin (apol) protects against in vitro amyloid-β(1-40) neurotoxicity
32. Clusterin biogenesis is altered during apoptosis in the regressing rat ventral prostate
33. Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death
34. Targeted disruption of the mouse transforming growth factor-β 1 gene results in multifocal inflammatory disease
35. Muscarinic receptor subtypes in the lateral geniculate nucleus: A light and electron microscopic analysis
36. A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins
37. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate