Variation in the major histocompatibility complex [MHC] gene family in schizophrenia: Associations and functional implications

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 42, Issue , 2013, Pages 49-62

  Debnath, Monojit ^a   Cannon, Dara M ^b   Venkatasubramanian, Ganesan ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Infection; Inflammation; MHC; Neurodevelopment; Schizophrenia; Synaptic plasticity

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MICRORNA;

AUTOIMMUNE DISEASE; BRAIN FUNCTION; COGNITIVE DEFECT; ENDOPHENOTYPE; EPIGENETICS; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HISTOCOMPATIBILITY GENE; HLA MATCHING; HUMAN; IMMUNOGENETICS; INFLAMMATORY DISEASE; MAJOR HISTOCOMPATIBILITY COMPLEX GENE; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVOUS SYSTEM INFLAMMATION; NEUROBIOLOGY; NONHUMAN; PHARMACOGENETICS; PREGNANCY COMPLICATION; REVIEW; RISK FACTOR; SCHIZOPHRENIA;

ANIMALS; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; SCHIZOPHRENIA;

EID: 84873525772     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.07.009     Document Type: Review

References (260)

1. Agartz I., Brown A.A., Rimol L.M., Hartberg C.B., Dale A.M., Melle I., et al. Common sequence variants in the major histocompatibility complex region associate with cerebral ventricular size in schizophrenia. Biol Psychiatry 2011, 70:696-698.
2. Akaho R., Matsushita I., Narita K., Okazaki Y., Okabe Y., Matsushita M., et al. Support for an association between HLA-DR1 and schizophrenia in the Japanese population. Am J Med Genet 2000, 96:725-727.
3. Amar A., Segman R.H., Shtrussberg S., Sherman L., Safirman C., Lerer B., et al. An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201. Int J Neuropsychopharmacol 1998, 1:41-44.
4. Andersson G., Svensson A.C., Setterblad N., Rask L. Retro elements in the human MHC class II region. Trends Genet 1998, 14:109-114.
5. Antonova E., Kumari V., Morris R., Halari R., Anilkumar A., Mehrotra R., et al. The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study. Biol Psychiatry 2005, 58:457-467.
6. Arias I., Sorlozano A., Villegas E., de Dios Luna J., McKenney K., Cervilla J., et al. Infectious agents associated with schizophrenia: a meta-analysis. Schizophr Res 2012, 136:128-136.
7. Arinami T., Otsuka Y., Hamaguchi H., Itokawa M., Aoki J., Shibuya H., et al. Evidence supporting an association between the DRB1 gene and schizophrenia in Japanese. Schizophr Res 1998, 32:81-86.
8. Arolt V., Lencer R., Nolte A., Muller-Myhsok B., Purmann S., Schurmann M., et al. Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am J Med Genet 1996, 67:564-579.
9. Arolt V., Lencer R., Purmann S., Schurmann M., Muller-Myhsok B., Krecker K., et al. Testing for linkage of eye tracking dysfunction and schizophrenia to markers on chromosomes 6, 8, 9, 20 and 22 in families multiply affected with schizophrenia. Am J Med Genet 1999, 88:603-606.
10. Asaka A., Okazaki Y., Namura I., Juji T. Study of HLA antigens among Japanese schizophrenics. Br J Psychiatry 1981, 138:498-500.
11. Athanasiou M.C., Dettling M., Cascorbi I., Mosyagin I., Salisbury B.A., Pierz K.A., et al. Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis. J Clin Psychiatry 2011, 72:458-463.
12. Baranzini S.E., Elfstrom C., Chang S.Y., Butunoi C., Murray R., Higuchi R., et al. Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression. J Immunol 2000, 165:6576-6582.
13. Barco A., Patterson S., Alarcon J.M., Gromova P., Mata-Roig M., Morozov A., et al. Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture. Neuron 2005, 48:123-137.
14. Benros M.E., Nielsen P.R., Nordentoft M., Eaton W.W., Dalton S.O., Mortensen P.B. Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study. Am J Psychiatry 2011, 168:1303-1310.
15. Bilbo S.D., Schwarz J.M. Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci 2009, 3:14.
16. Billiards S.S., Haynes R.L., Folkerth R.D., Trachtenberg F.L., Liu L.G., Volpe J.J., et al. Development of microglia in the cerebral white matter of the human fetus and infant. J Comp Neurol 2006, 497:199-208.
17. Blackwell J.M., Jamieson S.E., Burgner D. HLA and infectious diseases. Clin Microbiol Rev 2009, 22:370-385.
18. Blackwood D.H., Muir W.J., Stephenson A., Wentzel J., Adhiah A., Walker M.J., et al. Reduced expression of HLA-B35 in schizophrenia. Psychiatr Genet 1996, 6:51-59.
19. Bogacki P.A., Borkowska A., Wojtanowska-Bogacka M., Rybakowski J.K. Relationship between class I and II HLA antigens in schizophrenia and eye movement disturbances: a preliminary study. Neuropsychobiology 2005, 51:204-210.
20. Boulanger L.M. Immune proteins in brain development and synaptic plasticity. Neuron 2009, 64:93-109.
21. Boulanger L.M., Shatz C.J. Immune signaling in neural development, synaptic plasticity and disease. Nat Rev Neurosci 2004, 5:521-531.
22. Brown A.S., Patterson P.H. Maternal infection and schizophrenia: implications for prevention. Schizophr Bull 2011, 37:284-290.
23. Brown A.S., Schaefer C.A., Quesenberry C.P., Liu L., Babulas V.P., Susser E.S. Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry 2005, 162:767-773.
24. Buckley P.F., Miller B.J., Lehrer D.S., Castle D.J. Psychiatric comorbidities and schizophrenia. Schizophr Bull 2009, 35:383-402.
25. Caillat-Zucman S. Molecular mechanisms of HLA association with autoimmune diseases. Tissue Antigens 2009, 73:1-8.
26. Callicott J.H., Bertolino A., Mattay V.S., Langheim F.J.P., Duyn J., Coppola R., et al. Physiological dysfunction of the dosrolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex 2000, 10:1078-1092.
27. Carroll L.S., Owen M.J. Genetic overlap between autism, schizophrenia and bipolar disorder. Genome Med 2009, 1:102.
28. Carter C.J. Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii. Schizophr Bull 2009, 35:1163-1182.
29. Carter C.J. Schizophrenia: a pathogenetic autoimmune disease caused by viruses and pathogens and dependent on genes. J Pathog 2011, [Article ID 128318, 37 pages].
30. Cazzullo C.L., Smeraldi E., Penati G. The leucocyte antigenic system HL-A as possible genetic marker of schizophrenia. Br J Psychiatry 1974, 125:612-615.
31. Chao Y.L., Shen Y.C., Liao D.L., Chen J.Y., Wang Y.C., Lai I.C., et al. Association study of HLA-A gene and schizophrenia in Han Chinese from Taiwan. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:1834-1837.
32. Charron D. HLA, immunogenetics, pharmacogenetics and personalized medicine. Vox Sang 2011, 100:163-166.
33. Chaudhry IB, Hallak J, Husain N, Minhas FA, Stirling J, Richardson P, et al. Minocycline benefits symptoms in early schizophrenia; a randomised double-blind placebo-controlled clinical trial in patients on standard treatment. J Psychopharmacol in press.
34. Chen S.J., Chao Y.L., Chen C.Y., Chang C.M., Wu E.C.H., Wu C.S., et al. Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study. Br J Psychiatry 2012, 200:374-380.
35. Chien Y.L., Wu Y.Y., Chen C.H., Gau S.S.F., Huang Y.S., Chien W.H., et al. Association of HLA-DRB1 alleles and neuropsychological function in autism. Psychiatr Genet 2012, 22:46-49.
36. Childs E.J., Sobel E.M., Palmer C.G.S., Sinsheimer J.S. Detection of intergenerational genetic effects with application to HLA-B matching as a risk factor for schizophrenia. Hum Hered 2011, 72:161-172.
37. Chowdari K.V., Xu K., Zhang F., Ma C., Li T., Xie B.Y., et al. Immune related genetic polymorphisms and schizophrenia among the Chinese. Hum Immunol 2001, 62:714-724.
38. Chowdhury N.I., Remington G., Kennedy J.L. Genetics of antipsychotic-induced side effects and agranulocytosis. Curr Psychiatry Rep 2011, 13:156-165.
39. Corriveau R.A., Huh G.S., Shatz C.J. Regulation of Class I MHC gene expression in the developing and mature CNS by neural activity. Neuron 1998, 21:505-520.
40. Craddock R.M., Lockstone H.E., Rider D.A., Wayland M.T., Harris L.J., et al. Altered T-cell function in schizophrenia: a cellular model to investigate molecular disease mechanisms. PLoS One 2007, 2:e692.
41. Crespi B.J., Thiselton D.L. Comparative immunogenetics of autism and schizophrenia. Genes Brain Behav 2011, 10:689-701.
42. Czerski P.M., Rybakowski F., Kapelski P., Rybakowski J.K., Dmitrzak-Weglarz M., Leszczynska-Rodziewicz A., et al. Association of tumor necrosis factor-308 G/A promoter polymorphism with schizophrenia and bipolar affective disorder in a Polish population. Neuropsychobiology 2008, 57:88-94.
43. Dalman C., Allebeck P., Cullberg J., Grunewald C., Koster M. Obstetric complications and the risk of schizophrenia: a longitudinal study of a national birth cohort. Arch Gen Psychiatry 1999, 56:234-240.
44. de Jong S., van Eijk K.R., Zeegers D.W., Strengman E., Janson E., Veldink J.H., et al. Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes. Eur J Hum Genet 2012, [Epub ahead of print].
45. Debnath M., Chaudhuri T.K. The role of HLA-G in cytokine homeostasis during early pregnancy complicated with maternal infections: a novel etiopathological approach to the neurodevelopmental understanding of schizophrenia. Med Hypotheses 2006, 66:286-293.
46. Debnath M., Das S.K., Bera N.K., Nayak C.R., Chaudhuri T.K. Genetic associations between delusional disorder and paranoid schizophrenia: a novel etiologic approach. Can J Psychiatry 2006, 51:342-349.
47. Debnath M., Doyle K.M., Langan C., McDonald C., Leonard B., Cannon D.M. Recent advances in psychoneuroimmunology: inflammation in psychiatric disorders. Transl Neurosci 2011, 2:121-137.
48. Degreef G., Ashtari M., Bogerts B., Bilder R.M., Jody D.N., Alvir J.M., et al. Volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients. Arch Gen Psychiatry 1992, 49:531-537.
49. Dettling M., Schaub R.T., Mueller-Oerlinghausen B., Roots I., Cascorbi I. Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry. Pharmacogenetics 2001, 11:135-141.
50. Dettling M., Cascorbi I., Opgen-Rhein C., Schaub R. Clozapine-induced agranulocytosis in schizophrenic Caucasians: confirming clues for associations with human leukocyte class I and II antigens. Pharmacogenomics J 2007, 7:325-332.
51. Dickerson F.B., Boronow J.J., Stallings, Origoni A.E., Ruslanova I., Yolken R.H. Association of serum antibodies to herpes simplex virus 1 with cognitive deficits in individuals with schizophrenia. Arch Gen Psychiatry 2003, 60:466-472.
52. Dolinoy D.C., Weidman J.R., Jirtle R.L. Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod Toxicol 2007, 23:297-307.
53. Doorduin J., de Vries E.F.J., Willemsen A.T.M., de Groot J.C., Dierckx R.A., Klein H.C. Neuroinflammation in schizophrenia-related psychosis: a PET study. J Nucl Med 2009, 50:1801-1807.
54. Doxiadis G.M., de Groot N., Bontrop R.E. Impact of endogenous intronic retroviruses on MHC class II diversity and stability. J Virol 2008, 82:6667-6677.
55. Eaton W.W., Byrne M., Ewald H., Mors O., Chen C.Y., Agerbo E., et al. Association of schizophrenia and autoimmune diseases: linkage of Danish national registers. Am J Psychiatry 2006, 163:521-528.
56. Eaton W.W., Pedersen M.G., Nielson P.R., Mortensen P.B. Autoimmune diseases, bipolar disorder, and non-affective psychosis. Bipolar Disord 2010, 12:638-646.
57. Eberhard G., Franzén G., Löw B. Schizophrenia susceptibility and HL-A antigen. Neuropsychobiology 1975, 1:211-217.
58. Escande-Beillard N., Washburn L., Zekzer D., Wu Z.P., Eitan S., Ivkovic S., et al. Neurons preferentially respond to self MHC class I allele products regardless of peptide presented. J Immunol 2010, 184:816-823.
59. Fellerhoff B., Wank R. Transporter associated with antigen processing and the chaperone tapasin: are non-classical HLA genes keys to the pathogenesis of schizophrenia?. Med Hypotheses 2009, 72:535-538.
60. Fellerhoff B., Laumbacher B., Wank R. High risk of schizophrenia and other mental disorders associated with chlamydial infections: hypothesis to combine drug treatment and adoptive immunotherapy. Med Hypotheses 2005, 65:243-252.
61. Fellerhoff B., Laumbacher B., Mueller N., Gu S., Wank R. Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10. Mol Psychiatry 2007, 12:264-272.
62. Fernando M.M.A., Stevens C.R., Walsh E.C., De Jager P.L., Goyette P., et al. Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet 2008, 4:e1000024.
63. Fernando M.M.A., Freudenberg J., Lee A., Morris D.L., Boteva L., Rhodes B., et al. Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interesting loci at MSH5, HLA-DPB1 and HLA-G. Ann Rheum Dis 2012, 71:777-784.
64. Figueiredo T.C., de Oliveira J.R. Reconsidering the association between the major histocompatibility complex and bipolar disorder. J Mol Neurosci 2012, 47:26-30.
65. Foster J.A., Quan N., Stern E.L., Kristensson K., Herkenham M. Induced neuronal expression of class I major histocompatibility complex mRNA in acute and chronic inflammation models. J Neuroimmunol 2002, 131:83-91.
66. Fourgeaud L., Boulanger L.M. Role of immune molecules in the establishment and plasticity of glutamatergic synapses. Eur J Neurosci 2010, 32:207-217.
67. Fourgeaud L., Devenport C.M., Tyler C.M., Cheng T.T., Spencer M.B., Boulanger L.M. MHC class I modulates NMDA receptor function and AMPA receptor trafficking. Proc Natl Acad Sci U S A 2010, 107:22278-22283.
68. Fujita Y., Ishima T., Kunitachi S., Hagiwara H., Zhang L., Iyo M., et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:336-339.
69. Garay P.A., McAllister A.K. Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders. Front Synaptic Neurosci 2010, 2:1-16.
70. Gattaz W.F., Seitz M., Beckmann H. A possible association between HLA B-27 and vulnerability to schizophrenia. Pers Individ Differ 1985, 6:283-285.
71. Gejman P.V., Sanders A.R., Duan J. The role of genetics in the etiology of schizophrenia. Psychiatr Clin North Am 2010, 33:35-66.
72. Gibson S., Hwai Z., Straub R.E., Walsh D., Kendler K.S., Gill M. HLA and schizophrenia: refutation of reported associations with A9 (A23/A24), DR4, and DQ beta1*0602. Am J Med Genet 1999, 88:416-421.
73. Glatt S.J., Everall I.P., Kreman W.S., Corbeil J., Sasik R., Khanlou N., et al. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Proc Natl Acad Sci U S A 2005, 102:15533-15538.
74. Glynn M.W., Elmer B.M., Garay P.A., Liu X.B., Needleman L.A., El-Sabeawy F., et al. MHCI negatively regulates synapse density during the establishment of cortical connections. Nat Neurosci 2011, 14:442-451.
75. Goddard C.A., Butts D.A., Shatz C.A. Regulation of CNS synapses by neuronal MHC class I. Proc Natl Acad Sci U S A 2007, 104:6828-6833.
76. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003, 160:636-664.
77. Gough S.C.L., Simmonds M.J. The HLA region and autoimmune disease: associations and mechanisms of action. Curr Genomics 2007, 8:453-465.
78. Greenwood T.A., Light G.A., Swerdlow N.R., Radant A.D., Braff D.L. Association analysis of 94 candidate genes and schizophrenia-related endophenotypes. PLoS One 2012, 7:e29630.
79. Grosskopf A., Müller N., Malo A., Wank R. Potential role for the narcolepsy and multiple sclerosis associated HLA allele in schizophrenia subtypes. Schizophr Res 1998, 30:187-189.
80. Haavik J., Halmoy A., Hegvik T.A., Johansson S. Maternal genotypes as predictors of offspring mental health: the next frontier of genomic medicine?. Future Neurol 2011, 6:731-743.
81. Hagberg H., Gressens P., Mallard C. Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults. Ann Neurol 2012, 71:444-457.
82. Haider M.Z., Zahid M.A. Human leukocyte antigen-DQB1 alleles are not associated with schizophrenia in Kuwaiti Arabs. Psychiatry Clin Neurosci 2004, 58:236-239.
83. Haider M.Z., Zahid M.A., Dalal H.N., Razik M.A. Human leukocyte antigen (HLA) DRB1 alleles in Kuwaiti Arabs with schizophrenia. Am J Med Genet 2000, 96:870-872.
84. Haig D. Genetic conflicts in human pregnancy. Q Rev Biol 1993, 68:495-532.
85. Hall M.H., Smoller J.W. A new role for endophenotypes in the GWAS era: functional characterization of risk variants. Harv Rev Psychiatry 2010, 18:67-74.
86. Hammer C., Ehrenreich H. Variants in the MHC genomic region and neurotropic infection status in schizophrenia: potential insights into etiology, pathogenesis and/or severity of schizophrenic subphenotypes. Neurol Psychiatry Brain Res 2012, 18:58-59.
87. Hanisch U.K. Microglia as a source and target of cytokines. Glia 2002, 40:140-155.
88. Harrison P.J. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology 2004, 174:151-162.
89. Hashimoto K. Microglial activation in schizophrenia and minocycline treatment. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:1758-1759. [author reply 1760].
90. Hashimoto K. Abnormality of cerebral perfusion in the posterior cingulated gyrus of a refractory patient with schizophrenia and minocycline treatment. Prog Neuropsychopharmacol Biol Psychiatry 2010, 34:1132. [author reply 1133-1134].
91. Hawi Z., Gibson S., Straub R.E., Walsh D., Kendler K.S., Gill M. Schizophrenia and HLA: no association with PCR-SSOP typed classical loci in a large Irish familial sample. Am J Med Genet 1999, 88:422-429.
92. Henikoff S., Matzke M.A. Exploring and explaining epigenetic effects. Trends Genet 1997, 13:293-295.
93. Hiby S.E., Walker J.J., O'Shaughnessy K.M., Redman C.W.G., Carrington, Trowsdale J., et al. Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 2004, 200:957-965.
94. Hoftberger R., Aboul-Enein F., Brueck W., Lucchinetti C., Rodriguez M., Schmidbauer M., et al. Expression of major histocompatibility complex class I molecules on the different cell types in multiple sclerosis lesions. Brain Pathol 2004, 14:43-50.
95. Horacek J., Flegr J., Tintera J., Verebova K., Spaniel F., Novak T., et al. Latent toxoplasmosis reduces gray matter density in schizophrenia but not in controls: voxel-based-morphometry (VBM) study. World J Biol Psychiatry 2011, 00:1-9.
96. Huh C.S., Boulanger L.M., Riquelme P.A., Brotz T.M., Shatz C.J. Functional requirement for class I MHC in CNS development and plasticity. Science 2000, 290:2155-2159.
97. Hylenius S., Andersen A.M.N., Melbye M., Hviid T.V.F. Association between HLA-G genotype and risk of preeclampsia: a case-control study using family triads. Mol Hum Reprod 2004, 10:237-246.
98. Ikeda M., Aleksic B., Kinoshita Y., Okochi T., Kawashima K., Kushima I., et al. Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry 2011, 65:472-478.
99. Ikeda M, Aleksic B, Yamada K, Iwayama-Shigeno Y, Matsuo K, Numata S, et al. Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population. Molecular Psychiatry in press.
100. Ivanyi D., Zemek P., Ivanyi P. HLA antigens in schizophrenia. Tissue Antigens 1976, 8:217-220.
101. Ivanyi D., Zemek P., Ivanyi P. HLA antigens as possible markers of heterogeneity in schizophrenia. Int J Immunogenet 1978, 5:165-172.
102. Javitt D.C. Glutamate and schizophrenia: phencyclidine, N-methyl-d-aspartate receptors, and dopamine-glutamate interactions. Int Rev Neurobiol 2007, 78:69-108.
103. Jhamnani K, Shivakumar V, Kalmady S, Rao NP, Venkatasubramanian G. Successful use of add-on minocycline for treatment of persistent negative symptoms in schizophrenia. J Neuropsychiatry Clin Neurosci in press.
104. Jia P., Wang L., Fanous A.H., Chen X., Kendler K.S., Zhao Z. A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. J Med Genet 2012, 49:96-103.
105. Johnson W.G., Buyske S., Mars A.E., Sreenath M., Stenroos E.S., Williams T.A., et al. HLA-DR4 as a risk allele for autism acting in mothers of probands possibly during pregnancy. Arch Pediatr Adolesc Med 2009, 163:542-546.
106. Jones A.L., Mowry B.J., Pender M.P., Greer J.M. Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?. Immunol Cell Biol 2005, 83:9-17.
107. Juckel G., Manitz M.P., Brune M., Friebe A., Heneka M.T., Wolf R.J. Microglial activation in a neuroinflammational animal model of schizophrenia - a pilot study. Schizophr Res 2011, 131:96-100.
108. Jun T.Y., Pae C.U., Chae J.H., Pyo C.W., Han H. Human leukocyte antigen alleles in patients with bipolar disorder in the Korean population. Psychiatry Clin Neurosci 2002, 56:453-457.
109. Kadasah S., Arfin M., Tariq M. HLA-DRB1 association with schizophrenia in Saudi Arabian patients. Int J Psychiatry Clin Pract 2011, 15:112-117.
110. Kaminsky Z., Tochigi M., Jia P., Pal M., Mill J., Kwan A., et al. A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. Mol Psychiatry 2012, 17:728-740.
111. Kano S.C., Nwulia E., Niwa M., Chen Y., Sawa A., Cascella N. Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia. Neurosci Res 2011, 71:289-293.
112. Kantrowitz J.T., Javitt D.C. N-methyal-d-aspartate (NMDA) receptor dysfunction or dysregulations: the final common pathway on the road to schizophrenia?. Brain Res Bull 2010, 83:108-121.
113. Kawasaki H., Iwamuro S. Potential roles of histones in host defense as antimicrobial agents. Infect Disord Drug Targets 2008, 8:195-205.
114. Kim J.J., Shirts B.H., Dayal M., Bacanu S.A., Wood J., Xie W., et al. Are exposure to cytomegalovirus and genetic variation on chromosome 6p joint risk factors for schizophrenia?. Ann Med 2007, 39:145-153.
115. Kitazawa M., Ohnuma T., Takebayashi Y., Shibata N., Baba H., Ohi K., et al. No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2012, 159B:456-464.
116. Kneeland R.E., Fatemi S.H. Viral infection, inflammation and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2013, 42:35-48. (this issue).
117. Kocerha J., Faghihi M.A., Lopez-Toledano M.A., Huang J., Ramsey A.J., Caron M.G., et al. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc Natl Acad Sci U S A 2009, 106:3507-3512.
118. Korner J., Propping P., Fritze J. HLA-DR2-frequencies in affective disorder. Br J Psychiatry 1990, 156:907-908.
119. Krause D., Wagner J., Matz J., Weidinger E., Obermeier M., Riedel M., et al. Monocytic HLA DR antigens in schizophrenic patients. Neurosci Res 2012, 72:87-93.
120. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996, 19:312-318.
121. Lafon M., Prehaud C., Megret F., Lafage M., Mouillot M., Roa M., et al. Modulation of HLA-G expression in human neural cells after neurotropic viral infections. J Virol 2005, 79:15226-15237.
122. Lahdelma L., Ahokas A., Andersson L.C., Huttunen M., Sarna S., Koskimies S. Association between HLA-A1 allele and schizophrenia gene(s) in patients refractory to conventional neuroleptics but responsive to clozapine medication. Tissue Antigens 1998, 51:200-203.
123. Lahdelma L., Ahokas A., Andersson L.C., Suvisaari J., Hovatta I., Huttunen M.O., et al. Human leukocyte antigen-A1 predicts a good therapeutic response to clozapine with a low risk of agranulocytosis in patients with schizophrenia. J Clin Psychopharmacol 2001, 21:4-7.
124. Laumbacher B., Muller N., Bondy B., Schlesinger B., Gu S., Fellerhoff B., et al. Significant frequency deviation of the class I polymorphism HLA-A10 in schizophrenic patients. J Med Genet 2003, 40:217-219.
125. Leboyer M., Tamouza R., Charron D., Faucard R., Perron H. Human endogenous retrovirus type W (HERV-W) in schizophrenia: a new avenue of research at the gene-environment interface. World J Biol Psychiatry 2011, [Epub ahead of print].
126. Lee L.C., Zachary A.A., Leffell M.S., Newschaffer C.J., Matteson K.J., Tyler J.D., et al. HLA-DR4 in families with autism. Pediatr Neurol 2006, 35:303-307.
127. Levkovitz Y., Mendlovich S., Riwkes S., Braw Y., Levkovitch-Verbin H., Gal G., et al. A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. J Clin Psychiatry 2010, 71:138-149.
128. Lewis D.A., Levitt P. Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 2002, 25:409-432.
129. Lewis C.M., Levinson D.F., Wise L.H., DeLisi L.E., Straub R.E., Hovatta I., et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am J Hum Genet 2003, 73:34-48.
130. Li T., Underhill J., Liu X.H., Sham P.C., Donaldson P., Murray R.M., et al. Transmission disequilibrium analysis of HLA class II DRB1, DQA1, DQB1 and DPB1 polymorphisms in schizophrenia using family trios from a Han Chinese population. Schizophr Res 2001, 49:73-78.
131. Li T., Li Z., Chen P., Zhao Q., Wang T., Huang K., et al. Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese. Biol Psychiatry 2010, 68:671-673.
132. Lidman O., Olsson T., Piehl F. Expression of non-classical MHC class I (RT1-U) in certain neuronal populations of the central nervous system. Eur J Neurosci 1999, 11:4468-4472.
133. Lieberman J.A., Yunis J., Egea E., Canoso R.T., Kane J.M., Yunis E.J. HLA-B38, DR4, DQw3 and clozapine-induced agranulocytosis in Jewish patients with schizophrenia. Arch Gen Psychiatry 1990, 47:945-948.
134. Lincoln M.R., Ramagopalan S.V., Chao M.J., Herera B.M., DeLuca G.C., Orton S.M., et al. Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. Proc Natl Acad Sci U S A 2009, 106:7542-7547.
135. Linda H., Hammarberg H., Piehl F., Khademi M., Olsson T. Expression of MHC class I heavy chain and beta2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neurons. J Neuroimmunol 1999, 101:76-86.
136. Lozano J.M., Gonzalez R., Kindelan J.M., Rouas-Freiss N., Caballos R., Dausset J., et al. Monocytes and T lymphocytes in HIV-1-positive patients express HLA-G molecule. AIDS 2002, 16:347-351.
137. Lubin F.D., Roth T.L., Sweatt J.D. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J Neurosci 2008, 28:10576-10586.
138. Luchins D., Torrey E.F., Weinberger D.R., Zalcman S., DeLisi L., Johnson A., et al. HLA antigens in schizophrenia: differences between patients with and without evidence of brain atrophy. Br J Psychiatry 1980, 136:243-248.
139. Luder C.G., Lang C., Giraldo-Velasquez M., Algner M., Gerdes J., Gross U. Toxoplasma gondii inhibits MHC class II expression in neural antigen-presenting cells by down-regulating the class II transactivator CIITA. J Neuroimmunol 2003, 134:12-24.
140. Ma D.K., Marchetto M.C., Guo J.U., Ming G.L., Gage F.H., Song H. Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci 2010, 13:1338-1344.
141. Mack D.G., Johnson J.J., Roberts F., et al. HLA-class II genes modify outcome of Toxoplasma gondii infection. Int J Parasitol 1999, 29:1351-1358.
142. Marchini M., Scorza R., Antonioli R., Scarone S., Grassi B., Epifani M., et al. HLA-A2 and B35 are strong predictors of responsiveness to clozapine: preliminary data in Italian schizophrenia patients. Schizophr Res 2001, 48:363-365.
143. Matsumoto S., Sasaki T., Imamura A., Matsuo K., Kayashima T., Hashida A., et al. HLA class I distribution in Japanese patients with schizophrenia. Am J Med Genet 2002, 114:42-45.
144. McDonald P., O'Reilly R., Singh S.M. Methylation analysis of the NOTCH4 -25 C/T polymorphism in schizophrenia. Psychiatr Genet 2011, 21:5-13.
145. McGuffin P., Gottesman I.I. Risk factors for schizophrenia. N Engl J Med 1999, 341:370-371.
146. Mexal S., Frank M., Berger R., Adams C.E., Ross R.G., Freedman R., et al. Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokers. Brain Res Mol Brain Res 2005, 139:317-332.
147. Meyer U. Developmental neuroinflammation and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2011, [Epub ahead of print].
148. Mill J., Tang T., Kaminsky Z., Khare T., Yazdanpanah S., Bouchard L., et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet 2008, 82:696-711.
149. Miller B.J., Buckley P., Seabott W., Mellor A., Kirkpatrick B. Meta-analysis of cytokine alterations in schizophrenia: clinical studies and antipsychotic effects. Biol Psychiatry 2011, 70:663-671.
150. Mittal V.A., Ellman L.M., Cannon T.D. Gene-environment interaction and covariation in schizophrenia: the role of obstetric complications. Schizophr Bull 2008, 34:1083-1094.
151. Monji A., Kato T., Kanba S. Cytokines and schizophrenia: microglia hypothesis of schizophrenia. Psychiatry Clin Neurosci 2009, 63:257-265.
152. Monji A., Kato T.A., Mizoguchi Y., Horikawa H., Seki Y., Kasai M., et al. Neuroinflammation in schizophrenia especially focussed on the role of microglia. Prog Neuropsychopharmacol Biol Psychiatry 2013, 42:115-121. (this issue).
153. Mortensen P.B., Pedersen C.B., Westergaard T., Wohlfahrt J., Ewald H., Mors O., et al. Effects of family history and place and season of birth on the risk of schizophrenia. N Engl J Med 1999, 340:603-608.
154. Muller N., Schwarz M. Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission. Neurotox Res 2006, 10:131-148.
155. Muller N., Schwarz M. The role of immune system in schizophrenia. Curr Immunol Rev 2010, 6:213-220.
156. Muller N, Wagner JK, Krause D, Weidinger E, Wildeneuer A, Obermeier M, et al. Impaired monocyte activation in schizophrenia. Psychiatry Research in press.
157. Nakatani N., Hattori E., Ohnishi T., Dean B., Iwayama Y., Matsumoto I., et al. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. Hum Mol Genet 2006, 12:1949-1962.
158. Narita K., Sasaki T., Akaho R., Okazaki Y., Kusumi I., Kato T., et al. Human leukocyte antigen and season of birth in Japanese patients with schizophrenia. Am J Psychiatry 2000, 157:1173-1175.
159. Nejentsev S., Howson J.M., Walker N.M., Szeszko J., Field S.F., Stevens H.E., et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007, 450:887-892.
160. Neumann H., Schmidt H., Cavalie A., Jenne D., Wekerle H. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. J Exp Med 1997, 185:305-316.
161. Nimgaonkar V.L., Rudert W.A., Zhang X.R., Tsoi W.F., Trucco M., Saha N. Further evidence for an association between schizophrenia and the HLA DQB1 gene locus. Schizophr Res 1995, 18:43-49.
162. Nimgaonkar V.L., Rudert W.A., Zhang X., Trucco M., Ganguli R. Negative association of schizophrenia with HLA DQB1*0602: evidence from a second African-American cohort. Schizophr Res 1997, 23:81-86.
163. Nunes S.O., Borelli S.D., Matsuo T., Watanabe M.A., Itano E.N. The association of the HLA in patients with schizophrenia, schizoaffective disorder, and in their biological relatives. Schizophr Res 2005, 76:195-198.
164. O'Keefe G.M., Nguyen V.T., Benveniste E.N. Regulation and function of class II major histocompatibility complex CD40, and B7 expression in macrophages and microglia: implications in neurological diseases. J Neurovirol 2002, 8:496-512.
165. Ober C. HLA and pregnancy: the paradox of the fetal allograft. Am J Hum Genet 1998, 62:1-5.
166. Ober C., Hyslop T., Elias S., Weitkamp L.R., Hauck W.W. Human leukocyte antigen matching and fetal loss: results of a 10year prospective study. Hum Reprod 1998, 13:33-38.
167. Ohi K., Hashimoto R., Yasuda Y., Nemoto K., Ohnishi T., Fukumoto M., et al. Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia. PLoS One 2012, 7:e29780.
168. Oliveira A.L., Thams S., Lidman O., Piehl F., Hökfelt T., Kärre K., et al. A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy. Proc Natl Acad Sci U S A 2004, 101:17843-17848.
169. Onno M., Pangault C., Le Friec G., Guilloux V., Andre P., Fauchet R. Modulation of HLA-G antigens expression by human cytomegalovirus: specific induction in activated macrophages harboring human cytomegalovirus infection. J Immunol 2000, 164:6426-6434.
170. Opgen-Rhein C., Dettling M. Clozapine-induced agranulocytosis and its genetic determinants. Pharmacogenomics 2008, 9:1101-1111.
171. Owen M.J., Craddock N., O'Donovan M.C. Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia. Arch Gen Psychiatry 2010, 67:667-673.
172. Ozcan M.E., Taskin R., Banoglu R., Babacan M., Tuncer E. HLA antigens in schizophrenia and mood disorders. Biol Psychiatry 1996, 39:891-895.
173. Palmer C.G. Evidence for maternal-fetal genotype incompatibility as a risk factor for schizophrenia. J Biomed Biotechnol 2010, 2010:576318.
174. Palmer C.G.S., Hsieh H.J., Reed E.F., et al. HLA-B maternal-fetal genotype matching increases risk of schizophrenia. Am J Hum Genet 2006, 79:710-715.
175. Papiol S., Malzahn D., Kastner A., Sperling S., Begemann M., Stefansson H., et al. Dissociation of accumulated genetic risk and disease severity in patients with schizophrenia. Transl Psychiatry 2011, 1:e45.
176. + T lymphocytes. J Neuroimmunol 2006, 171:145-155.
177. Patterson P.H. Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav Brain Res 2009, 204:313-321.
178. Perron H., Mekaoui L., Bernard C., Veas F., Stefas I., Leboyer M. Endogenous retrovirus type W GAG and envelope protein antigenemia in serum of schizophrenic patients. Biol Psychiatry 2008, 64:1019-1023.
179. Pidsley R., Dempster E.L., Mill J. Brain weight in males is correlated with DNA methylation at IGF2. Mol Psychiatry 2010, 15:880-881.
180. Potvin S., Stip E., Sepehry A.A., Gendron A., Bah R., Kouassi E. Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 2008, 63:801-808.
181. Prasad K.M., Bamne M.N., Shirts B.H., Goradia D., Mannali V., Pancholi K.M., et al. Grey matter changes associated with host genetic variation and exposure to herpes simplex virus 1 (HSV1) in first episode schizophrenia. Schizophr Res 2010, 118:232-239.
182. Prasad K.M., Eack S.M., Goradia D., Pancholi K.M., Keshavan M.S., Yolken R.H., et al. Progressive gray matter loss and changes in cognitive functioning associated with exposure to herpes simplex virus 1 in schizophrenia: a longitudinal study. Am J Psychiatry 2011, 168:822-830.
183. Ptak C., Petronis A. Epigenetic approaches to psychiatric disorders. Dialogues Clin Neurosci 2010, 12:25-35.
184. Purcell S.M., Wray N.R., Stone J.L., Visscher P.M., O'Donovan M.C., Sullivan P.F., et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460:748-752.
185. Raha-Chowdhury R., Andrews S.R., Gruen J.R. CAT 53: a protein phosphatise 1 nuclear targeting subunit encoded in the MHC class I region expressed in the regions of the brain involved in memory, learning, and Alzheimer's disease. Brain Res Mol Brain Res 2005, 138:70-83.
186. Rakyan V.K., Hildmann T., Novik K.L., Lewin J., Tost J., Cox A.V., et al. DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project. PLoS Biol 2004, 2:e405.
187. Redwine J.M., Buchmeier M.J., Evans C.F. In vivo expression of major histocompatibility complex molecules on oligodendrocytes and neurons during viral infection. Am J Pathol 2001, 159:1219-1224.
188. Rioux J.D., Goyette P., Vyse T.J., Hammarström L., Fernando M.M., Green T., et al. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A 2009, 106:18680-18685.
189. Ripke S., Sanders A.R., Kendler K.S., Levinson D.F., Sklar P., Holmans P.A., et al. Genome wide association study identifies five new schizophrenia loci. Nat Genet 2011, 43:969-976.
190. Roig B., Virgos C., Franco N., Martorell L., Valero J., Costas J., et al. The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia. Mol Psychiatry 2007, 9:833-841.
191. Rosler M., Bellaire W., Gressnich N., Giannitsis D., Jarovici A. HLA antigens in schizophrenia, major depressive disorder and schizoaffective disorder. Med Microbiol Immunol 1983, 172:57-65.
192. Rutten B.P.F., Mill J. Epigenetic mediation of environmental influences in major psychiatric disorders. Schizophr Bull 2009, 35:1045-1056.
193. Saetre P., Emilsson L., Axelsson E., Kreuger J., Lindholm E., Jazin E. Inflammation-related genes up-regulated in schizophrenia brains. BMC Psychiatry 2007, 7:46.
194. Sankar A., MacKenzie R.N., Foster J.A. Loss of class I MHC function alters behavior and stress reactivity. J Neuroimmunol 2012, 244:8-15.
195. Sasaki T., Matsushita M., Nanko S., Fukuda R., Kennedy J.L., Tokunaga K. Schizophrenia and the HLA-DRB1 gene in the Japanese population. Am J Psychiatry 1999, 156:771-773.
196. Schmitt A., Leonardi-Essmann F., Durrenberger P.F., Parlapani E., Schneider-Axmann T., Spanagel R., et al. Regulation of immune-modulatory genes in left superior temporal cortex of schizophrenia patients: a genome-wide microarray study. World J Biol Psychiatry 2011, 12:201-215.
197. Schwab S.G., Hallmayer J., Freimann J., Lerer B., Albus M., Borrmann-Hassenbach M., et al. Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia. Am J Med Genet 2002, 114:315-320.
198. Sequeira P.A., Martin M.V., Vawter M.P. The first decade and beyond of transcriptional profiling in schizophrenia. Neurobiol Dis 2012, 45:23-36.
199. Shatz C.J. MHC class I: an unexpected role in neuronal plasticity. Neuron 2009, 64:40-45.
200. Shayevitz C., Cohen O.S., Faraone S.V., Glatt S.J. A re-review of the association between the NOTCH4 locus and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2012, 159B:477-483.
201. Shenton M.E., Dickey C.C., Frumin M., McCarley R.W. A review of MRI findings in schizophrenia. Schizophr Res 2001, 49:1-52.
202. Shi J., Levinson D.F., Duan J., Sanders A.R., Zheng Y., Peer I., et al. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 2009, 460:753-757.
203. Shiina T., Inoko H., Kulski J.K. An update of the HLA genomic region, locus information and disease associations: 2004. Tissue Antigens 2004, 64:631-649.
204. Shiina T., Hosomichi K., Inoko H., Kulski J.K. The HLA genomic loci map: expression, interaction, diversity and disease. J Hum Genet 2009, 54:15-39.
205. Shirts B.H., Kim J.J., Reich S., Dickerson F.B., Yolken R.H., Devlin B., et al. Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk. Schizophr Res 2007, 94:342-353.
206. Singh B., Bera N., De S., Nayak C.R., Chaudhuri T.K. Study of HLA Class I gene in Indian schizophrenic patients of Siliguri, West Bengal. Psychiatr Res 2011, 189:215-219.
207. Smeraldi E., Bellodi L., Scorza-Smeraldi R., Fabio G., Sacchetti E. HLA-SD antigens and schizophrenia: statistical and genetical considerations. Tissue Antigens 1976, 8:191-196.
208. Smeraldi E., Negri F., Melica A.M., Scorza-Smeraldi R., Fabio G., Bonara P., et al. HLA typing and affective disorders: a study in the Italian population. Neuropsychobiology 1978, 4:344-352.
209. Soderlund J., Schroder J., Nordin C., Samuelsson M., Walter-Jallow L., Karlsson H., et al. Activation in brain interleukin-1beta in schizophrenia. Mol Psychiatry 2009, 14:1069-1071.
210. Steel C.D., Hahto S.M., Ciavarra R.P. Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system. Virology 2009, 387:117-126.
211. Stefansson H., Ophoff R.A., Steinberg S., Andreassen O.A., Cichon S., Rujescu D., et al. Common variants conferring risk of schizophrenia. Nature 2009, 460:744-747.
212. Steinberg S., de Jong S., Andreassen O.A., Werge T., Borglum A.D., Mors O., et al. Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Hum Mol Genet 2011, 20:4076-4081.
213. Steiner J., Mawrin C., Ziegeler A., Bielau H., Ullrich O., Bernstein H.G., et al. Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization. Acta Neuropathol 2006, 112:305-316.
214. Sterner K.N., Weckle A., Chugani H.T., Tarca A.L., Sherwood C.C., Hof P.R., et al. Dynamic gene expression in the human cerebral cortex distinguishes children from adults. PLoS One 2012, 7:e37714.
215. Strous R.D., Shoenfeld Y. Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited. J Autoimmun 2006, 27:71-80.
216. Stubbs E.G., Ritvo E.R., Mason-Brothers A. Autism and shared parental HLA antigens. J Am Acad Child Psychiatry 1985, 24:182-185.
217. Sullivan P.F., Kendler K.S., Neale M.C. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003, 60:1187-1192.
218. Sutherland J.E., Costa M. Epigenetics and the environment. Ann N Y Acad Sci 2003, 983:151-160.
219. Suzuki Y., Wong S.Y., Grumet F.C., Fessel J., Montoya J.G., Zolopa A.R., et al. Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients. J Infect Dis 1996, 173:265-268.
220. Tarabeux J., Kebir O., Gauthier J., Hamdan F.F., Xiong L., Piton A., et al. Rare mutations in N-methyl-d-aspartate glutamate receptors in autism spectrum disorders and schizophrenia. Transl Psychiatry 2011, 1:e55.
221. Thorsby E., Lie B.A. HLA associated genetic predisposition to autoimmune diseases: genes involved and possible mechanisms. Transpl Immunol 2005, 14:175-182.
222. Tochigi M., Ohashi J., Umekage T., Kohda K., Hibino H., Otowa T., et al. Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia. Neurosci Lett 2002, 329:201-214.
223. Torres A.R., Maciulis A., Stubbs E.G., Cutler A., Odell D. The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder. Hum Immunol 2002, 63:311-316.
224. Torres A.R., Westover J.B., Rosenspire A.J. HLA immune function genes in Autism. Autism Res Treat 2012, 2012. Article ID 959073, 13 pages.
225. Toulopoulou T., Picchioni M., Rijsdijk F., Hall M.H., Ettinger U., Sham P., et al. Substantial genetic overlap between neurocognition and schizophrenia: genetic modeling in twin samples. Arch Gen Psychiatry 2007, 64:1348-1355.
226. Traherne J.A. Human MHC architechture and evolution: implications for disease association studies. Int J Immunogenet 2008, 35:179-192.
227. Trowsdale J. The MHC disease and selection. Immunol Lett 2011, 137:1-8.
228. Uçok A., Akar U., Polat A., Yazici O. Human leukocyte antigen alleles in patients with bipolar disorder in Turkey. Eur Psychiatry 2005, 20:83.
229. Valevski A., Klein T., Gazit E., Meged S., Stein D., Elizur A., et al. HLA-B38 and clozapine induced agranulocytosis in Israeli Jewish schizophrenic patients. Eur J Immunogenet 1998, 25:11-13.
230. van Berckel B.N., Bossong M.G., Boellaard R., Kloet R., Schuitemaker A., Caspers E., et al. Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C] PK11195 positron emission tomography study. Biol Psychiatry 2008, 64:820-822.
231. Van Den Elsen P.J., van Eggermond M.C., Wierda R.J. Epigenetic control in immune function. Adv Exp Med Biol 2011, 711:36-49.
232. van Haren N.E., Bakker S.C., Kahn R.S. Genes and structural brain imaging in schizophrenia. Curr Opin Psychiatry 2008, 21:161-167.
233. van Haren N.E., Rijsdijk F., Schnack H.G., Picchioni M.M., Toulopoulou T., Weisbrod M., et al. The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium. Biol Psychiatry 2012, 71:915-921.
234. van Os J., Kapur S. Schizophrenia. Lancet 2009, 374:635-645.
235. van Os J., Rutten B.P., Poulton R. Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr Bull 2008, 34:1066-1082.
236. van Os J., Kenis G., Rutten B.P. The environment and schizophrenia. Nature 2010, 468:203-212.
237. Venkatasubramanian G., Jayakumar P.N., Gangadhar B.N., Keshavan M.S. Automated MRI parcellation study of regional volume and thickness of prefrontal cortex (PFC) in antipsychotic-naive schizophrenia. Acta Psychiatr Scand 2008, 117:420-431.
238. Venkatasubramanian G., Jayakumar P.N., Gangadhar B.N., Keshavan M.S. Neuroanatomical correlates of neurological soft signs in antipsychotic-naive schizophrenia. Psychiatr Res 2008, 164:215-222.
239. Ventura T., Lobo A., Marco J.C. HLA antigens in bipolar affective patients. Actas Luso Esp Neurol Psiquiatr Cienc Afines 1990, 18:339-343.
240. Walton E., Turner J., Gollub R.L., Manoach D.S., Yendiki A., Ho B.C., et al. Cumulative genetic risk and prefrontal activity in patients with schizophrenia. Schizophr Bull 2012, [Epub ahead of print].
241. Warren R.P., Odell J.D., Warren W.L., Burger R.A., Maciulis A., Daniels W.W., et al. Strong association of the third hypervariable region of HLA-DR beta 1 with autism. J Neuroimmunol 1996, 67:97-102.
242. Wassink T.H., Nopoulos P., Pietila J., Crowe R.R., Andreasen N.C. NOTCH4 and the frontal lobe in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2003, 118B:1-7.
243. Weis S., Llenos I.C., Sabunciyan S., Dulay J.R., Isler L., Yolken R., et al. Reduced expression of human endogenous retrovirus (HERV)-W GAG protein in the cingulate gyrus and hippocampus in schizophrenia, bipolar disorder, and depression. J Neural Transm 2007, 114:645-655.
244. Wierzba-Bobrowicz T., Lewandowska E., Kosno-Kruszewska E., Lechowicz W., Pasennik E., Schmidt-Sidor B. Degeneration of microglial cells in frontal and temporal lobes of chronic schizophrenics. Folia Neuropathol 2004, 42:157-165.
245. Wierzba-Bobrowicz T., Lewandowska E., Lechowicz W., Stepien T., Pasennik E. Quantitative analysis of activated microglia, ramified and damage of processes in the frontal and temporal lobes of chronic schizophrenics. Folia Neuropathol 2005, 43:81-89.
246. Williams H.J., Craddock N., Russo G., Hamshere M., Moskvina V., Dwyer S., et al. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross traditional diagnostic boundaries. Hum Mol Genet 2011, 20:387-391.
247. Wong G.H., Bartlett P.F., Clark-Lewis I., Battye F., Schrader J.W. Inducible expression of H-2 and Ia antigens on brain cells. Nature 1984, 310:688-691.
248. Wright K.L., Ting J.P. Epigenetic regulation of MHC-II and CIITA genes. Trends Immunol 2006, 27:405.
249. Wright P., Donaldson P.T., Curtis V.A., Underhill J.A., Doherty D.G., Murray R.M. Immunogenetic markers in schizophrenia: HLA A9 revisited. Schizophr Res 1995, 15:1-50.
250. Wright P., Donaldson P.T., Underhill J.A., Choudhuri K., Doherty D.G., Murray R.M. Genetic association of the HLA-DRB1 gene locus on chromosome 6p21.3 with schizophrenia. Am J Psychiatry 1996, 153:1530-1533.
251. Wright P., Nimgaonkar V.L., Donaldson P.T., Murray R.M. Schizophrenia and HLA: a review. Schizophr Res 2001, 47:1-12.
252. Wu Z.P., Washburn L., Bilousova T.V., Boudzinskaia M., Escande-Beillard N., Querubin J., et al. Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair. J Neuroimmunol 2011, 232:8-16.
253. Yirmiya R., Goshen I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun 2011, 25:181-213.
254. Yolken R., Torrey E. Are some cases of psychosis caused by microbial agents? A review of the evidence. Mol Psychiatry 2008, 13:470-479.
255. Yolken R.H., Torey E.F., Liberman J.A., Yang S., Dickerson F.B. Serological evidence of exposure to herpes simplex virus type 1 is associated with cognitive deficits in the CATIE schizophrenia sample. Schizophr Res 2011, 128:61-65.
256. Yue H.W., Wang H.F., Sun L.D., Tang F.L., Liu Z.H., Zhang H.X., et al. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet 2011, 43:1228-1231.
257. Yunis J.J., Corzo D., Salazar M., Lieberman J.A., Howard A., Yunis E.J. HLA associations in clozapine-induced agranulocytosis. Blood 1995, 86:1177-1183.
258. Zakharyan R., Khoyetsyan A., Arakelyan A., Boyajyan A., Gevorgyan A., Stahelova A., et al. Association of C1QB gene polymorphism with schizophrenia in Armenian population. BMC Med Genet 2011, 12:126.
259. Zamani M.G., DeHert M., Spaepen M., Hermans M., Marynen P., Cassiman J.J., et al. Study of the possible association of HLA class II CD4 and CD3 polymorphisms with schizophrenia. Am J Med Genet B Neuropsychiatr Genet 1994, 54:372-377.
260. Zohar O., Reiter Y., Bennink J.R., Lev A., Cavallaro S., Paratore S., et al. Cutting edge: MHC class I-Ly49 interaction regulates neuronal function. J Immunol 2008, 180:6447-6451.