Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation

Molecular Cell

Volumn 66, Issue 5, 2017, Pages 635-647.e7

  Oyler Yaniv, Jennifer ^a,b,c   Oyler Yaniv, Alon ^a,d   Shakiba, Mojdeh ^b   Min, Nina K ^a   Chen, Ying Han ^e   Cheng, Sheue yann ^a   Krichevsky, Oleg ^d   Altan Bonnet, Nihal ^e   Altan Bonnet, Grégoire ^a,b,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Weill Cornell Medical Center   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

cytokine signaling; IFN ; phosphatidylserine; quantitative biology; transcriptional regulation; tumor inflammation; tumor microenvironment

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 23; JANUS KINASE; PHOSPHATIDYLSERINE; STAT PROTEIN; AUTACOID; GAMMA INTERFERON RECEPTOR; INTERFERON RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, MOUSE; STAT1 PROTEIN; STAT1 PROTEIN, MOUSE;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CANCER IMMUNOTHERAPY; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; EXPOSURE; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOCOMPETENT CELL; INFLAMMATION; MELANOMA CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PHENOTYPE; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION; TH1 CELL; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BIOLOGICAL MODEL; BIOLOGY; C57BL MOUSE; CELL COMMUNICATION; COCULTURE; COMPUTER SIMULATION; EXPERIMENTAL MELANOMA; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC DATABASE; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROCEDURES; RAW 264.7 CELL LINE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYROID TUMOR; TIME FACTOR; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL LINE;

ANIMALS; CELL COMMUNICATION; CELL LINE, TUMOR; COCULTURE TECHNIQUES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DATABASES, GENETIC; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-23; JANUS KINASES; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PHOSPHATIDYLSERINES; PHOSPHORYLATION; PTEN PHOSPHOHYDROLASE; RAW 264.7 CELLS; RECEPTORS, INTERFERON; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; THYROID NEOPLASMS; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 85020105536     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.05.011     Document Type: Article

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