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Volumn 35, Issue , 2017, Pages 30-39

The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO N (3 CHLORO 4 FLUOROPHENYL) N' HYDROXY 1,2,5 OXADIAZOLE 3 CARBOXIMIDAMIDE; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; ARGINASE; ARGINASE INHIBITOR; ARGININE; CB 1158; DEXAMETHASONE; DOCETAXEL; EPACADOSTAT; GDC 0919; HYDROLASE INHIBITOR; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; INDOXIMOD; IPILIMUMAB; LENALIDOMIDE; N(G) HYDROXYARGININE; NIVOLUMAB; PACLITAXEL; PEMBROLIZUMAB; PF 06840003; PNEUMOCOCCUS VACCINE; S (2 BORONOETHYL)CYSTEINE HYDROCHLORIDE; SILDENAFIL; TADALAFIL; TAMOXIFEN; TERGENPUMATUCEL L; TRYPTOPHAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; [3 (AMINOCARBONYL)FUROXAN 4YL]METHYLSALICYLIC ACID; TRANSFORMING GROWTH FACTOR BETA;

EID: 85019951577     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2017.05.002     Document Type: Review
Times cited : (116)

References (64)
  • 1
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • Brahmer, J., et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N. Engl. J. Med. 373 (2015), 123–135.
    • (2015) N. Engl. J. Med. , vol.373 , pp. 123-135
    • Brahmer, J.1
  • 2
    • 77953775808 scopus 로고    scopus 로고
    • Control of immune response by amino acid metabolism
    • Grohmann, U., Bronte, V., Control of immune response by amino acid metabolism. Immunol. Rev. 236 (2010), 243–264.
    • (2010) Immunol. Rev. , vol.236 , pp. 243-264
    • Grohmann, U.1    Bronte, V.2
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden, M.G., Cantley, L.C., Thompson, C.B., Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324 (2009), 1029–1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 5
    • 84992478733 scopus 로고    scopus 로고
    • L-arginine modulates T. cell metabolism and enhances survival and anti-tumor activity
    • p. 829–842.e13 This is the first work demonstrating that L-arginine plays a crucial control of metabolic fitness, survival capacity, and anti-tumor activity of central memory T cells.
    • Geiger, R., et al. L-arginine modulates T. cell metabolism and enhances survival and anti-tumor activity. Cell, 167, 2016 p. 829–842.e13 This is the first work demonstrating that L-arginine plays a crucial control of metabolic fitness, survival capacity, and anti-tumor activity of central memory T cells.
    • (2016) Cell , vol.167
    • Geiger, R.1
  • 6
    • 0041845173 scopus 로고    scopus 로고
    • L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes
    • Rodriguez, P.C., et al. L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes. J. Immunol. 171 (2003), 1232–1239.
    • (2003) J. Immunol. , vol.171 , pp. 1232-1239
    • Rodriguez, P.C.1
  • 7
    • 33846933459 scopus 로고    scopus 로고
    • L-arginine availability regulates T-lymphocyte cell-cycle progression
    • Rodriguez, P.C., Quiceno, D.G., Ochoa, A.C., L-arginine availability regulates T-lymphocyte cell-cycle progression. Blood 109 (2007), 1568–1573.
    • (2007) Blood , vol.109 , pp. 1568-1573
    • Rodriguez, P.C.1    Quiceno, D.G.2    Ochoa, A.C.3
  • 9
    • 0036402941 scopus 로고    scopus 로고
    • Regulation of enzymes of the urea cycle and arginine metabolism
    • Morris, S.M. Jr., Regulation of enzymes of the urea cycle and arginine metabolism. Annu. Rev. Nutr. 22 (2002), 87–105.
    • (2002) Annu. Rev. Nutr. , vol.22 , pp. 87-105
    • Morris, S.M.1
  • 10
    • 0036020220 scopus 로고    scopus 로고
    • Expression of the liver form of arginase in erythrocytes
    • Kim, P.S., et al. Expression of the liver form of arginase in erythrocytes. Mol. Genet. Metab. 76 (2002), 100–110.
    • (2002) Mol. Genet. Metab. , vol.76 , pp. 100-110
    • Kim, P.S.1
  • 11
    • 33947608432 scopus 로고    scopus 로고
    • Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils
    • Jacobsen, L.C., et al. Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils. Blood 109 (2007), 3084–3087.
    • (2007) Blood , vol.109 , pp. 3084-3087
    • Jacobsen, L.C.1
  • 12
    • 79955809907 scopus 로고    scopus 로고
    • Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation
    • Rotondo, R., et al. Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation. J. Leukoc. Biol. 89 (2011), 721–727.
    • (2011) J. Leukoc. Biol. , vol.89 , pp. 721-727
    • Rotondo, R.1
  • 13
    • 84962062339 scopus 로고    scopus 로고
    • Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation
    • Monticelli, L.A., et al. Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat. Immunol. 17 (2016), 656–665.
    • (2016) Nat. Immunol. , vol.17 , pp. 656-665
    • Monticelli, L.A.1
  • 14
    • 84919427210 scopus 로고    scopus 로고
    • Evolutionary roots of arginase expression and regulation
    • Dzik, J.M., Evolutionary roots of arginase expression and regulation. Front. Immunol., 5, 2014, 544.
    • (2014) Front. Immunol. , vol.5 , pp. 544
    • Dzik, J.M.1
  • 15
    • 84919718171 scopus 로고    scopus 로고
    • Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma
    • Hackett, C.S., et al. Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell Rep. 9 (2014), 1034–1046.
    • (2014) Cell Rep. , vol.9 , pp. 1034-1046
    • Hackett, C.S.1
  • 16
    • 84889595600 scopus 로고    scopus 로고
    • Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection
    • Elahi, S., et al. Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection. Nature 504 (2013), 158–162.
    • (2013) Nature , vol.504 , pp. 158-162
    • Elahi, S.1
  • 17
    • 0037307359 scopus 로고    scopus 로고
    • Arginase in patients with breast cancer
    • Porembska, Z., et al. Arginase in patients with breast cancer. Clin. Chim. Acta 328 (2003), 105–111.
    • (2003) Clin. Chim. Acta , vol.328 , pp. 105-111
    • Porembska, Z.1
  • 18
    • 0028107424 scopus 로고
    • Serum arginase level in patients with gastric cancer
    • Wu, C.W., et al. Serum arginase level in patients with gastric cancer. J. Clin. Gastroenterol. 18 (1994), 84–85.
    • (1994) J. Clin. Gastroenterol. , vol.18 , pp. 84-85
    • Wu, C.W.1
  • 19
    • 20944434107 scopus 로고    scopus 로고
    • Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers
    • Bronte, V., et al. Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J. Exp. Med. 201 (2005), 1257–1268.
    • (2005) J. Exp. Med. , vol.201 , pp. 1257-1268
    • Bronte, V.1
  • 20
    • 84942884570 scopus 로고    scopus 로고
    • Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity
    • Mussai, F., et al. Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity. Cancer Res. 75 (2015), 3043–3053.
    • (2015) Cancer Res. , vol.75 , pp. 3043-3053
    • Mussai, F.1
  • 21
    • 84886416794 scopus 로고    scopus 로고
    • Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
    • Mussai, F., et al. Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment. Blood 122 (2013), 749–758.
    • (2013) Blood , vol.122 , pp. 749-758
    • Mussai, F.1
  • 22
    • 84873735398 scopus 로고    scopus 로고
    • Arginase II. expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer
    • Ino, Y., et al. Arginase II. expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer. PLoS One, 8, 2013, e55146.
    • (2013) PLoS One , vol.8 , pp. e55146
    • Ino, Y.1
  • 23
    • 84941622047 scopus 로고    scopus 로고
    • Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages
    • Ugel, S., et al. Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages. J. Clin. Invest. 125 (2015), 3365–3376.
    • (2015) J. Clin. Invest. , vol.125 , pp. 3365-3376
    • Ugel, S.1
  • 24
    • 23444456772 scopus 로고    scopus 로고
    • Regulation of immune responses by L-arginine metabolism
    • Bronte, V., Zanovello, P., Regulation of immune responses by L-arginine metabolism. Nat. Rev. Immunol. 5 (2005), 641–654.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 641-654
    • Bronte, V.1    Zanovello, P.2
  • 25
    • 84941695057 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected
    • Marvel, D., Gabrilovich, D.I., Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J. Clin. Invest. 125 (2015), 3356–3364.
    • (2015) J. Clin. Invest. , vol.125 , pp. 3356-3364
    • Marvel, D.1    Gabrilovich, D.I.2
  • 26
    • 77950829023 scopus 로고    scopus 로고
    • Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
    • Nagaraj, S., et al. Mechanism of T cell tolerance induced by myeloid-derived suppressor cells. J. Immunol. 184 (2010), 3106–3116.
    • (2010) J. Immunol. , vol.184 , pp. 3106-3116
    • Nagaraj, S.1
  • 27
    • 80054694464 scopus 로고    scopus 로고
    • Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    • Molon, B., et al. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J. Exp. Med. 208 (2011), 1949–1962.
    • (2011) J. Exp. Med. , vol.208 , pp. 1949-1962
    • Molon, B.1
  • 28
    • 84895528474 scopus 로고    scopus 로고
    • The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment
    • De Sanctis, F., et al. The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment. Front. Immunol., 5, 2014, 69.
    • (2014) Front. Immunol. , vol.5 , pp. 69
    • De Sanctis, F.1
  • 29
    • 84995615046 scopus 로고    scopus 로고
    • T cell cancer therapy requires CD40-CD40L activation of tumor necrosis factor and inducible nitric-oxide-synthase-producing dendritic cells
    • This work highlights, for the first time, ARG1 has a hierarchical negative role when compared to NOS2 in creating a tumor-derived immunosuppressive environment.
    • Marigo, I., et al. T cell cancer therapy requires CD40-CD40L activation of tumor necrosis factor and inducible nitric-oxide-synthase-producing dendritic cells. Cancer Cell 30 (2016), 377–390 This work highlights, for the first time, ARG1 has a hierarchical negative role when compared to NOS2 in creating a tumor-derived immunosuppressive environment.
    • (2016) Cancer Cell , vol.30 , pp. 377-390
    • Marigo, I.1
  • 30
    • 84896523643 scopus 로고    scopus 로고
    • Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production
    • Pico de Coana, Y., et al. Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production. Cancer Immunol. Res. 1 (2013), 158–162.
    • (2013) Cancer Immunol. Res. , vol.1 , pp. 158-162
    • Pico de Coana, Y.1
  • 31
    • 0038215374 scopus 로고    scopus 로고
    • Tolerance, DCs and tryptophan: much ado about IDO
    • Grohmann, U., Fallarino, F., Puccetti, P., Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol. 24 (2003), 242–248.
    • (2003) Trends Immunol. , vol.24 , pp. 242-248
    • Grohmann, U.1    Fallarino, F.2    Puccetti, P.3
  • 32
    • 34748835898 scopus 로고    scopus 로고
    • IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation
    • Puccetti, P., Grohmann, U., IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation. Nat. Rev. Immunol. 7 (2007), 817–823.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 817-823
    • Puccetti, P.1    Grohmann, U.2
  • 33
    • 84926652188 scopus 로고    scopus 로고
    • Tryptophan-degrading enzymes in tumoral immune resistance
    • van Baren, N., Van den Eynde, B.J., Tryptophan-degrading enzymes in tumoral immune resistance. Front. Immunol., 6, 2015, 34.
    • (2015) Front. Immunol. , vol.6 , pp. 34
    • van Baren, N.1    Van den Eynde, B.J.2
  • 34
    • 84995561810 scopus 로고    scopus 로고
    • NAD+ salvage pathway in cancer metabolism and therapy
    • Kennedy, B.E., et al. NAD+ salvage pathway in cancer metabolism and therapy. Pharmacol. Res. 114 (2016), 274–283.
    • (2016) Pharmacol. Res. , vol.114 , pp. 274-283
    • Kennedy, B.E.1
  • 35
    • 85013038512 scopus 로고    scopus 로고
    • IDO2: a pathogenic mediator of inflammatory autoimmunity
    • Merlo, L.M., Mandik-Nayak, L., IDO2: a pathogenic mediator of inflammatory autoimmunity. Clin. Med. Insights Pathol. 9 (2016), 21–28.
    • (2016) Clin. Med. Insights Pathol. , vol.9 , pp. 21-28
    • Merlo, L.M.1    Mandik-Nayak, L.2
  • 36
    • 33646893538 scopus 로고    scopus 로고
    • The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells
    • Fallarino, F., et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J. Immunol. 176 (2006), 6752–6761.
    • (2006) J. Immunol. , vol.176 , pp. 6752-6761
    • Fallarino, F.1
  • 37
    • 84868220730 scopus 로고    scopus 로고
    • Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion
    • Platten, M., Wick, W., Van den Eynde, B.J., Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res. 72 (2012), 5435–5440.
    • (2012) Cancer Res. , vol.72 , pp. 5435-5440
    • Platten, M.1    Wick, W.2    Van den Eynde, B.J.3
  • 38
    • 84904216760 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor control of a disease tolerance defence pathway
    • Bessede, A., et al. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature 511 (2014), 184–190.
    • (2014) Nature , vol.511 , pp. 184-190
    • Bessede, A.1
  • 39
    • 84926632405 scopus 로고    scopus 로고
    • The coevolution of IDO1 and AhR in the emergence of regulatory T-cells in mammals
    • Grohmann, U., Puccetti, P., The coevolution of IDO1 and AhR in the emergence of regulatory T-cells in mammals. Front. Immunol., 6, 2015, 58.
    • (2015) Front. Immunol. , vol.6 , pp. 58
    • Grohmann, U.1    Puccetti, P.2
  • 40
    • 84870476787 scopus 로고    scopus 로고
    • Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase
    • Orabona, C., Pallotta, M.T., Grohmann, U., Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase. Mol. Med. 18 (2012), 834–842.
    • (2012) Mol. Med. , vol.18 , pp. 834-842
    • Orabona, C.1    Pallotta, M.T.2    Grohmann, U.3
  • 41
    • 58549107152 scopus 로고    scopus 로고
    • SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis
    • This work demonstrated the occurrence of regulatory proteloysis occurring to IDO1 in DCs exposed to inflammatory signals.
    • Orabona, C., et al. SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis. Proc. Natl. Acad. Sci. U. S. A. 105 (2008), 20828–20833 This work demonstrated the occurrence of regulatory proteloysis occurring to IDO1 in DCs exposed to inflammatory signals.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 20828-20833
    • Orabona, C.1
  • 42
    • 79952201446 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond
    • Orabona, C., Grohmann, U., Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond. Methods Mol. Biol. 677 (2011), 269–280.
    • (2011) Methods Mol. Biol. , vol.677 , pp. 269-280
    • Orabona, C.1    Grohmann, U.2
  • 43
    • 84990184780 scopus 로고    scopus 로고
    • Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1
    • Albini, E., et al. Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1. J. Cell Mol. Med. 21 (2017), 165–176.
    • (2017) J. Cell Mol. Med. , vol.21 , pp. 165-176
    • Albini, E.1
  • 44
    • 54049130424 scopus 로고    scopus 로고
    • Cutting edge: autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells
    • Belladonna, M.L., et al. Cutting edge: autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells. J. Immunol. 181 (2008), 5194–5198.
    • (2008) J. Immunol. , vol.181 , pp. 5194-5198
    • Belladonna, M.L.1
  • 45
    • 0028979170 scopus 로고
    • Transforming growth factor-beta stimulates arginase activity in macrophages: implications for the regulation of macrophage cytotoxicity
    • Boutard, V., et al. Transforming growth factor-beta stimulates arginase activity in macrophages: implications for the regulation of macrophage cytotoxicity. J. Immunol. 155 (1995), 2077–2084.
    • (1995) J. Immunol. , vol.155 , pp. 2077-2084
    • Boutard, V.1
  • 46
    • 85012926948 scopus 로고    scopus 로고
    • A relay pathway between arginine and tryptophan metabolism confers immunosuppressive properties on dendritic cells
    • This work highlights, for the first time, an immunosuppressive, entwined pathway between TGF-β, Arg1, and iDO1.
    • Mondanelli, G., et al. A relay pathway between arginine and tryptophan metabolism confers immunosuppressive properties on dendritic cells. Immunity 46 (2017), 233–244 This work highlights, for the first time, an immunosuppressive, entwined pathway between TGF-β, Arg1, and iDO1.
    • (2017) Immunity , vol.46 , pp. 233-244
    • Mondanelli, G.1
  • 47
    • 80052020183 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
    • Pallotta, M.T., et al. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat. Immunol. 12 (2011), 870–878.
    • (2011) Nat. Immunol. , vol.12 , pp. 870-878
    • Pallotta, M.T.1
  • 48
    • 0027202387 scopus 로고
    • Polyamines are essential for cell transformation by pp60v-src: delineation of molecular events relevant for the transformed phenotype
    • Holtta, E., Auvinen, M., Andersson, L.C., Polyamines are essential for cell transformation by pp60v-src: delineation of molecular events relevant for the transformed phenotype. J. Cell Biol. 122 (1993), 903–914.
    • (1993) J. Cell Biol. , vol.122 , pp. 903-914
    • Holtta, E.1    Auvinen, M.2    Andersson, L.C.3
  • 49
    • 81255138408 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives
    • Godin-Ethier, J., et al. Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin. Cancer Res. 17 (2011), 6985–6991.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6985-6991
    • Godin-Ethier, J.1
  • 50
    • 77957881272 scopus 로고    scopus 로고
    • Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer
    • Gannon, P.O., et al. Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer. PLoS One, 5, 2010, e12107.
    • (2010) PLoS One , vol.5 , pp. e12107
    • Gannon, P.O.1
  • 51
    • 0037223170 scopus 로고    scopus 로고
    • IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice
    • Bronte, V., et al. IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice. J. Immunol. 170 (2003), 270–278.
    • (2003) J. Immunol. , vol.170 , pp. 270-278
    • Bronte, V.1
  • 52
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • Uyttenhove, C., et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat. Med. 9 (2003), 1269–1274.
    • (2003) Nat. Med. , vol.9 , pp. 1269-1274
    • Uyttenhove, C.1
  • 53
    • 4143130091 scopus 로고    scopus 로고
    • Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
    • Rodriguez, P.C., et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 64 (2004), 5839–5849.
    • (2004) Cancer Res. , vol.64 , pp. 5839-5849
    • Rodriguez, P.C.1
  • 54
    • 85002822361 scopus 로고    scopus 로고
    • Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response
    • Lorvik, K.B., et al. Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response. Cancer Res. 76 (2016), 6864–6876.
    • (2016) Cancer Res. , vol.76 , pp. 6864-6876
    • Lorvik, K.B.1
  • 55
    • 20144375187 scopus 로고    scopus 로고
    • Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination
    • De Santo, C., et al. Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination. Proc. Natl. Acad. Sci. U. S. A. 102 (2005), 4185–4190.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 4185-4190
    • De Santo, C.1
  • 56
    • 33751531874 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
    • Serafini, P., et al. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J. Exp. Med. 203 (2006), 2691–2702.
    • (2006) J. Exp. Med. , vol.203 , pp. 2691-2702
    • Serafini, P.1
  • 57
    • 85041478960 scopus 로고    scopus 로고
    • Immuno-oncology agent CB-1158 is a potent and selective arginase inhibitor and causes an immune-mediated anti-tumor response
    • Works, M., et al. Immuno-oncology agent CB-1158 is a potent and selective arginase inhibitor and causes an immune-mediated anti-tumor response. Cancer Res., 76, 2016.
    • (2016) Cancer Res. , vol.76
    • Works, M.1
  • 58
    • 41349088840 scopus 로고    scopus 로고
    • Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells
    • Lob, S., et al. Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells. Blood 111 (2008), 2152–2154.
    • (2008) Blood , vol.111 , pp. 2152-2154
    • Lob, S.1
  • 59
    • 33846689594 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses
    • Hou, D.Y., et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res. 67 (2007), 792–801.
    • (2007) Cancer Res. , vol.67 , pp. 792-801
    • Hou, D.Y.1
  • 60
    • 84978175044 scopus 로고    scopus 로고
    • The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells
    • Jochems, C., et al. The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells. Oncotarget 7 (2016), 37762–37772.
    • (2016) Oncotarget , vol.7 , pp. 37762-37772
    • Jochems, C.1
  • 61
    • 77951718214 scopus 로고    scopus 로고
    • Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
    • Liu, X., et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood 115 (2010), 3520–3530.
    • (2010) Blood , vol.115 , pp. 3520-3530
    • Liu, X.1
  • 62
    • 85011563659 scopus 로고    scopus 로고
    • Updated results from a phase 1/2 study of epacadostat (INCB024360) in combination with ipilimumab in patients with metastatic melanoma
    • Gibney, G., et al. Updated results from a phase 1/2 study of epacadostat (INCB024360) in combination with ipilimumab in patients with metastatic melanoma. Eur. J. Cancer 51 (2015), S106–S107.
    • (2015) Eur. J. Cancer , vol.51 , pp. S106-S107
    • Gibney, G.1
  • 63
    • 0036852170 scopus 로고    scopus 로고
    • CTLA-4-Ig regulates tryptophan catabolism in vivo
    • Grohmann, U., et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat. Immunol. 3 (2002), 1097–1101.
    • (2002) Nat. Immunol. , vol.3 , pp. 1097-1101
    • Grohmann, U.1
  • 64
    • 85019881540 scopus 로고    scopus 로고
    • Abstract 4863: PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors
    • Tumang, J., et al. Abstract 4863: PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors. Cancer Res., 76, 2016, 4863.
    • (2016) Cancer Res. , vol.76 , pp. 4863
    • Tumang, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.