Decreased expression of acetyl-CoA synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma

Cancer Science

Volumn 108, Issue 7, 2017, Pages 1338-1346

  Sun, Lin ^a   Kong, Yinlong ^a   Cao, Manqing ^b,c   Zhou, Hongyuan ^a   Li, Huikai ^a   Cui, Yunlong ^a   Fang, Feng ^a   Zhang, Wei ^a   Li, Jiafeng ^a   Zhu, Xiaolin ^a   Li, Qiang ^a   Song, Tianqiang ^a   Zhang, Ti ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Acetylation; ACSS2; hepatocellular carcinoma; HIF 2 ; metastasis

Indexed keywords

ACETYL COENZYME A; ACETYL COENZYME A SYNTHASE 2; BETA ACTIN; CYCLIN D1; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 2ALPHA; NERVE CELL ADHESION MOLECULE; PHOSPHOGLYCERATE KINASE; PHOSPHOGLYCERATE KINASE 1; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; UVOMORULIN; VASCULOTROPIN; VIMENTIN; ACETATE COENZYME A LIGASE; ACSS2 PROTEIN, HUMAN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1;

ADULT; ADVANCED CANCER; ARTICLE; CANCER GRADING; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL HYPOXIA; CELL INVASION; CELL MIGRATION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DNA METHYLATION; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE SILENCING; HEPATIC PORTAL VEIN; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MICROANGIOPATHY; MIDDLE AGED; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN EXPRESSION; SURVIVAL RATE; TUMOR INVASION; TUMOR VOLUME; ACETYLATION; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LIVER TUMOR; METABOLISM; MORTALITY; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACETATE-COA LIGASE; ACETYLATION; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; DISEASE-FREE SURVIVAL; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 85019850616     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.13252     Document Type: Article

References (38)

1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015; 65: 87–108.
2. Zhong JH, Ke Y, Gong WF et al. Hepatic resection associated with good survival for selected patients with intermediate and advanced-stage hepatocellular carcinoma. Ann Surg 2014; 260: 329–40.
3. Kokudo T, Hasegawa K, Matsuyama Y et al. Survival benefit of liver resection for hepatocellular carcinoma associated with portal vein invasion. J Hepatol 2016; 65: 938–43.
4. Singal AG, Marrero JA. Recent advances in the treatment of hepatocellular carcinoma. Curr Opin Gastroenterol 2010; 26: 189–95.
5. Nath B, Szabo G. Hypoxia and hypoxia inducible factors: diverse roles in liver diseases. Hepatology 2012; 55: 622–33.
6. Ruan K, Song G, Ouyang G. Role of hypoxia in the hallmarks of human cancer. J Cell Biochem 2009; 107: 1053–62.
7. Jiang J, Tang YL, Liang XH. EMT: a new vision of hypoxia promoting cancer progression. Cancer Biol Ther 2011; 11: 714–23.
8. Keith B, Johnson RS, Simon MC. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 2011; 12: 9–22.
9. Koukourakis MI, Giatromanolaki A, Skarlatos J et al. Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Can Res 2001; 61: 1830–2.
10. Lofstedt T, Fredlund E, Holmquist-Mengelbier L et al. Hypoxia inducible factor-2alpha in cancer. Cell Cycle 2007; 6: 919–26.
11. Dioum EM, Chen R, Alexander MS et al. Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 2009; 324: 1289–93.
12. Cao M, Gao J, Zhou H et al. HIF-2alpha regulates CDCP1 to promote PKCdelta-mediated migration in hepatocellular carcinoma. Tumour Biol 2016; 37: 1651–62.
13. Schug ZT, Peck B, Jones DT et al. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell 2015; 27: 57–71.
14. Comerford SA, Huang Z, Du X et al. Acetate dependence of tumors. Cell 2014; 159: 1591–602.
15. Chen R, Xu M, Nagati JS et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE 2015; 10: e0116515.
16. Xu M, Nagati JS, Xie J et al. An acetate switch regulates stress erythropoiesis. Nat Med 2014; 20: 1018–26.
17. Bjornson E, Mukhopadhyay B, Asplund A et al. Stratification of hepatocellular carcinoma patients based on acetate utilization. Cell Rep 2015; 13: 2014–26.
18. Lakhter AJ, Hamilton J, Konger RL, Brustovetsky N, Broxmeyer HE, Naidu SR. Glucose-independent acetate metabolism promotes melanoma cell survival and tumor growth. J Biol Chem 2016; 291: 21869–79.
19. Yoshii Y, Furukawa T, Yoshii H et al. Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism. Cancer Sci 2009; 100: 821–7.
20. Li Y, Tang Y, Ye L et al. Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray. J Cancer Res Clin Oncol 2003; 129: 43–51.
21. Li Y, Tang ZY, Ye SL et al. Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97. World J Gastroenterol 2001; 7: 630–6.
22. Tian J, Tang Z, Ye S. Establishment of a human hepatocellular carcinoma (HCC) cell line with high metastatic potential (MHCC97) and its biological characteristics. Zhonghua Zhong liu za zhi [Chinese Journal of Oncology] 1998; 20: 405–7.
23. Tian J, Tang ZY, Ye SL et al. New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis. Br J Cancer 1999; 81: 814–21.
24. Guo K, Kang NX, Li Y et al. Regulation of HSP27 on NF-kappaB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis. BMC Cancer 2009; 9: 100.
25. Ye XZ, Zhu DH, Shen DW. Ultrastructures of LO2 normal adult hepatocytes over successive in vitrocultures. Acta Biol Exp Sin 1980; 13: 3612–41.
26. Befani C, Mylonis I, Gkotinakou IM et al. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol 2013; 45: 2359–68.
27. Diepenbruck M, Christofori G. Epithelial-mesenchymal transition (EMT) and metastasis: yes, no, maybe? Curr Opin Cell Biol 2016; 43: 7–13.
28. Gupta GP, Massague J. Cancer metastasis: building a framework. Cell 2006; 127: 679–95.
29. Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell 2012; 150: 12–27.
30. Ferreira WA, Pinheiro Ddo R, Costa Junior CA et al. An update on the epigenetics of glioblastomas. Epigenomics 2016; 8: 1289–305.
31. Lyssiotis CA, Cantley LC. Acetate fuels the cancer engine. Cell 2014; 159: 1492–4.
32. Mashimo T, Pichumani K, Vemireddy V et al. Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell 2014; 159: 1603–14.
33. Gao X, Lin SH, Ren F et al. Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun 2016; 7: 11960.
34. Hur H, Kim YB, Ham IH, Lee D. Loss of ACSS2 expression predicts poor prognosis in patients with gastric cancer. J Surg Oncol 2015; 112: 585–91.
35. Bae JM, Kim JH, Oh HJ et al. Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma. Mod Pathol 2016; 30: 267–277.
36. Chen Y, Shi Y, Dai G. [Role of HIF-induced EMT in invasion andmetastasis of tumor]. Zhong nan da xue xue bao Yi xue ban = Journal of Central South University Medical Sciences 2016; 41: 872–8.
37. Guo Q, Qin W. DKK3 blocked translocation of beta-catenin/EMT induced by hypoxia and improved gemcitabine therapeutic effect in pancreatic cancer Bxpc-3 cell. J Cell Mol Med 2015; 19: 2832–41.
38. Zhou C, Liu J, Tang Y et al. Coexpression of hypoxia-inducible factor-2alpha, TWIST2, and SIP1 may correlate with invasion and metastasis of salivary adenoid cystic carcinoma. J Oral Pathol Med 2012; 41: 424–31.