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Volumn 37, Issue 2, 2016, Pages 1651-1662

HIF-2α regulates CDCP1 to promote PKCδ-mediated migration in hepatocellular carcinoma

Author keywords

CDCP1; Hepatocellular carcinoma; HIF 2 ; Metastasis; PKC

Indexed keywords

CUB DOMAIN CONTAINING PROTEIN 1; GLYCOPROTEIN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; PROTEIN KINASE C DELTA; PROTEIN TYROSINE KINASE; TYROSINE; UNCLASSIFIED DRUG; ACETYLCYSTEINE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CDCP1 PROTEIN, HUMAN; CELL ADHESION MOLECULE; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; LEUKOCYTE ANTIGEN; TUMOR PROTEIN;

EID: 84940201568     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-3527-7     Document Type: Article
Times cited : (28)

References (38)
  • 1
    • 68049105076 scopus 로고    scopus 로고
    • Role of hypoxia in the hallmarks of human cancer
    • COI: 1:CAS:528:DC%2BD1MXptlOnuro%3D, PID: 19479945
    • Ruan K, Song G, Ouyang G. Role of hypoxia in the hallmarks of human cancer. J Cell Biochem. 2009;107(6):1053–62. doi:10.1002/jcb.22214.
    • (2009) J Cell Biochem , vol.107 , Issue.6 , pp. 1053-1062
    • Ruan, K.1    Song, G.2    Ouyang, G.3
  • 2
    • 69949146316 scopus 로고    scopus 로고
    • Hypoxia and pluripotency in embryonic and embryonal carcinoma stem cell biology
    • COI: 1:CAS:528:DC%2BD1MXht1Squ7zK
    • Silvan U, Diez-Torre A, Arluzea J, Andrade R, Silio M, Arechaga J. Hypoxia and pluripotency in embryonic and embryonal carcinoma stem cell biology. Differ; Res Biol Divers. 2009;78(2–3):159–68. doi:10.1016/j.diff.2009.06.002.
    • (2009) Differ; Res Biol Divers , vol.78 , Issue.2-3 , pp. 159-168
    • Silvan, U.1    Diez-Torre, A.2    Arluzea, J.3    Andrade, R.4    Silio, M.5    Arechaga, J.6
  • 3
    • 77952723369 scopus 로고    scopus 로고
    • Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids
    • COI: 1:CAS:528:DC%2BC3cXnslyqtbk%3D, PID: 20513003
    • Menrad H, Werno C, Schmid T, Copanaki E, Deller T, Dehne N, et al. Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids. Hepatology. 2010;51(6):2183–92. doi:10.1002/hep.23597.
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 2183-2192
    • Menrad, H.1    Werno, C.2    Schmid, T.3    Copanaki, E.4    Deller, T.5    Dehne, N.6
  • 5
    • 0036493984 scopus 로고    scopus 로고
    • Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer
    • COI: 1:CAS:528:DC%2BD38Xit1KhtLk%3D, PID: 11888900
    • Leek RD, Talks KL, Pezzella F, Turley H, Campo L, Brown NS, et al. Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer. Cancer Res. 2002;62(5):1326–9.
    • (2002) Cancer Res , vol.62 , Issue.5 , pp. 1326-1329
    • Leek, R.D.1    Talks, K.L.2    Pezzella, F.3    Turley, H.4    Campo, L.5    Brown, N.S.6
  • 6
    • 33750630119 scopus 로고    scopus 로고
    • Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
    • COI: 1:CAS:528:DC%2BD28Xht1Glu7nE, PID: 17097563
    • Holmquist-Mengelbier L, Fredlund E, Lofstedt T, Noguera R, Navarro S, Nilsson H, et al. Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell. 2006;10(5):413–23. doi:10.1016/j.ccr.2006.08.026.
    • (2006) Cancer Cell , vol.10 , Issue.5 , pp. 413-423
    • Holmquist-Mengelbier, L.1    Fredlund, E.2    Lofstedt, T.3    Noguera, R.4    Navarro, S.5    Nilsson, H.6
  • 7
    • 33646248422 scopus 로고    scopus 로고
    • Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells
    • COI: 1:CAS:528:DC%2BD28XksVKksLs%3D, PID: 16611993
    • Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol. 2006;26(9):3514–26. doi:10.1128/MCB.26.9.3514-3526.2006.
    • (2006) Mol Cell Biol , vol.26 , Issue.9 , pp. 3514-3526
    • Hu, C.J.1    Iyer, S.2    Sataur, A.3    Covello, K.L.4    Chodosh, L.A.5    Simon, M.C.6
  • 8
    • 0035860147 scopus 로고    scopus 로고
    • Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
    • COI: 1:CAS:528:DC%2BD3MXpt1Kisbs%3D, PID: 11556841
    • Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Talks K, Pezzella F, et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer. 2001;85(6):881–90. doi:10.1054/bjoc.2001.2018.
    • (2001) Br J Cancer , vol.85 , Issue.6 , pp. 881-890
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Turley, H.4    Talks, K.5    Pezzella, F.6
  • 9
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    • COI: 1:CAS:528:DC%2BD2MXlslCjt7Y%3D, PID: 15964822
    • Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol. 2005;25(13):5675–86. doi:10.1128/MCB.25.13.5675-5686.2005.
    • (2005) Mol Cell Biol , vol.25 , Issue.13 , pp. 5675-5686
    • Raval, R.R.1    Lau, K.W.2    Tran, M.G.3    Sowter, H.M.4    Mandriota, S.J.5    Li, J.L.6
  • 10
    • 84860520642 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2alpha activation promotes colorectal cancer progression by dysregulating iron homeostasis
    • COI: 1:CAS:528:DC%2BC38Xmt1ymt74%3D, PID: 22419665
    • Xue X, Taylor M, Anderson E, Hao C, Qu A, Greenson JK, et al. Hypoxia-inducible factor-2alpha activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res. 2012;72(9):2285–93. doi:10.1158/0008-5472.CAN-11-3836.
    • (2012) Cancer Res , vol.72 , Issue.9 , pp. 2285-2293
    • Xue, X.1    Taylor, M.2    Anderson, E.3    Hao, C.4    Qu, A.5    Greenson, J.K.6
  • 11
    • 84874484590 scopus 로고    scopus 로고
    • Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway
    • COI: 1:CAS:528:DC%2BC3sXjsFelurY%3D, PID: 23212661
    • Sun HX, Xu Y, Yang XR, Wang WM, Bai H, Shi RY, et al. Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. Hepatology. 2013;57(3):1088–97. doi:10.1002/hep.26188.
    • (2013) Hepatology , vol.57 , Issue.3 , pp. 1088-1097
    • Sun, H.X.1    Xu, Y.2    Yang, X.R.3    Wang, W.M.4    Bai, H.5    Shi, R.Y.6
  • 12
    • 34447537888 scopus 로고    scopus 로고
    • Prognostic significance of HIF-2alpha/EPAS1 expression in hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD2sXos1Cmsrw%3D, PID: 17589895
    • Bangoura G, Liu ZS, Qian Q, Jiang CQ, Yang GF, Jing S. Prognostic significance of HIF-2alpha/EPAS1 expression in hepatocellular carcinoma. World J Gastroenterol: WJG. 2007;13(23):3176–82.
    • (2007) World J Gastroenterol : WJG , vol.13 , Issue.23 , pp. 3176-3182
    • Bangoura, G.1    Liu, Z.S.2    Qian, Q.3    Jiang, C.Q.4    Yang, G.F.5    Jing, S.6
  • 13
    • 1542314896 scopus 로고    scopus 로고
    • Expression of HIF-2alpha/EPAS1 in hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD2cXislaltbk%3D, PID: 14966910
    • Bangoura G, Yang LY, Huang GW, Wang W. Expression of HIF-2alpha/EPAS1 in hepatocellular carcinoma. World J Gastroenterol: WJG. 2004;10(4):525–30.
    • (2004) World J Gastroenterol : WJG , vol.10 , Issue.4 , pp. 525-530
    • Bangoura, G.1    Yang, L.Y.2    Huang, G.W.3    Wang, W.4
  • 14
    • 84922391659 scopus 로고    scopus 로고
    • HIFs enhance the migratory and neoplastic capacities of hepatocellular carcinoma cells by promoting EMT
    • COI: 1:CAS:528:DC%2BC2cXotFymur8%3D
    • Liu Y, Yan X, Xu Y, Luo F, Ye J, Yan H, et al. HIFs enhance the migratory and neoplastic capacities of hepatocellular carcinoma cells by promoting EMT. Tumour Biol: J Int Soc Oncodev Biol Med. 2014;35(8):8103–14. doi:10.1007/s13277-014-2056-0.
    • (2014) Tumour Biol : J Int Soc Oncodev Biol Med , vol.35 , Issue.8 , pp. 8103-8114
    • Liu, Y.1    Yan, X.2    Xu, Y.3    Luo, F.4    Ye, J.5    Yan, H.6
  • 15
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • COI: 1:CAS:528:DC%2BD1cXksFGnsQ%3D%3D, PID: 18083107
    • Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007;131(6):1190–203. doi:10.1016/j.cell.2007.11.025.
    • (2007) Cell , vol.131 , Issue.6 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3    Possemato, A.4    Yu, J.5    Haack, H.6
  • 16
    • 0035913186 scopus 로고    scopus 로고
    • Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer
    • COI: 1:CAS:528:DC%2BD3MXlvFOisLg%3D, PID: 11466621
    • Scherl-Mostageer M, Sommergruber W, Abseher R, Hauptmann R, Ambros P, Schweifer N. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene. 2001;20(32):4402–8.
    • (2001) Oncogene , vol.20 , Issue.32 , pp. 4402-4408
    • Scherl-Mostageer, M.1    Sommergruber, W.2    Abseher, R.3    Hauptmann, R.4    Ambros, P.5    Schweifer, N.6
  • 17
    • 54949158631 scopus 로고    scopus 로고
    • Microarray-based identification of CUB-domain containing protein 1 as a potential prognostic marker in conventional renal cell carcinoma
    • COI: 1:CAS:528:DC%2BD1cXht1yru7rI, PID: 18483744
    • Awakura Y, Nakamura E, Takahashi T, Kotani H, Mikami Y, Kadowaki T, et al. Microarray-based identification of CUB-domain containing protein 1 as a potential prognostic marker in conventional renal cell carcinoma. J Cancer Res Clin Oncol. 2008;134(12):1363–9. doi:10.1007/s00432-008-0412-4.
    • (2008) J Cancer Res Clin Oncol , vol.134 , Issue.12 , pp. 1363-1369
    • Awakura, Y.1    Nakamura, E.2    Takahashi, T.3    Kotani, H.4    Mikami, Y.5    Kadowaki, T.6
  • 18
    • 79952165882 scopus 로고    scopus 로고
    • VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration
    • COI: 1:CAS:528:DC%2BC3MXhslyjsbw%3D, PID: 21233420
    • Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, et al. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci U S A. 2011;108(5):1931–6. doi:10.1073/pnas.1011777108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.5 , pp. 1931-1936
    • Razorenova, O.V.1    Finger, E.C.2    Colavitti, R.3    Chernikova, S.B.4    Boiko, A.D.5    Chan, C.K.6
  • 19
    • 80054073804 scopus 로고    scopus 로고
    • Effect of the tyrosine kinase inhibitor lapatinib on CUB-domain containing protein (CDCP1)-mediated breast cancer cell survival and migration
    • COI: 1:CAS:528:DC%2BC3MXhtlaks7fI, PID: 21945930
    • Seidel J, Kunc K, Possinger K, Jehn C, Luftner D. Effect of the tyrosine kinase inhibitor lapatinib on CUB-domain containing protein (CDCP1)-mediated breast cancer cell survival and migration. Biochem Biophys Res Commun. 2011;414(1):226–32. doi:10.1016/j.bbrc.2011.09.062.
    • (2011) Biochem Biophys Res Commun , vol.414 , Issue.1 , pp. 226-232
    • Seidel, J.1    Kunc, K.2    Possinger, K.3    Jehn, C.4    Luftner, D.5
  • 20
    • 33847757539 scopus 로고    scopus 로고
    • Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells
    • COI: 1:CAS:528:DC%2BD2sXjtFGrtr8%3D, PID: 17335815
    • Perry SE, Robinson P, Melcher A, Quirke P, Buhring HJ, Cook GP, et al. Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. FEBS Lett. 2007;581(6):1137–42. doi:10.1016/j.febslet.2007.02.025.
    • (2007) FEBS Lett , vol.581 , Issue.6 , pp. 1137-1142
    • Perry, S.E.1    Robinson, P.2    Melcher, A.3    Quirke, P.4    Buhring, H.J.5    Cook, G.P.6
  • 21
    • 77953797255 scopus 로고    scopus 로고
    • CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation
    • COI: 1:CAS:528:DC%2BC3cXntlKltbk%3D, PID: 20501830
    • Miyazawa Y, Uekita T, Hiraoka N, Fujii S, Kosuge T, Kanai Y, et al. CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation. Cancer Res. 2010;70(12):5136–46. doi:10.1158/0008-5472.CAN-10-0220.
    • (2010) Cancer Res , vol.70 , Issue.12 , pp. 5136-5146
    • Miyazawa, Y.1    Uekita, T.2    Hiraoka, N.3    Fujii, S.4    Kosuge, T.5    Kanai, Y.6
  • 22
    • 79952147398 scopus 로고    scopus 로고
    • CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis
    • COI: 1:CAS:528:DC%2BC3MXhs1SmsbY%3D, PID: 21220330
    • Liu H, Ong SE, Badu-Nkansah K, Schindler J, White FM, Hynes RO. CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proc Natl Acad Sci U S A. 2011;108(4):1379–84. doi:10.1073/pnas.1017228108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.4 , pp. 1379-1384
    • Liu, H.1    Ong, S.E.2    Badu-Nkansah, K.3    Schindler, J.4    White, F.M.5    Hynes, R.O.6
  • 23
    • 35649025769 scopus 로고    scopus 로고
    • CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma
    • COI: 1:CAS:528:DC%2BD2sXht1GltrfE, PID: 17785447
    • Uekita T, Jia L, Narisawa-Saito M, Yokota J, Kiyono T, Sakai R. CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. Mol Cell Biol. 2007;27(21):7649–60. doi:10.1128/MCB.01246-07.
    • (2007) Mol Cell Biol , vol.27 , Issue.21 , pp. 7649-7660
    • Uekita, T.1    Jia, L.2    Narisawa-Saito, M.3    Yokota, J.4    Kiyono, T.5    Sakai, R.6
  • 24
    • 62849106338 scopus 로고    scopus 로고
    • Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung
    • COI: 1:CAS:528:DC%2BD1MXjt1WrtLs%3D, PID: 19077003
    • Ikeda J, Oda T, Inoue M, Uekita T, Sakai R, Okumura M, et al. Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung. Cancer Sci. 2009;100(3):429–33. doi:10.1111/j.1349-7006.2008.01066.x.
    • (2009) Cancer Sci , vol.100 , Issue.3 , pp. 429-433
    • Ikeda, J.1    Oda, T.2    Inoue, M.3    Uekita, T.4    Sakai, R.5    Okumura, M.6
  • 25
    • 84874491920 scopus 로고    scopus 로고
    • Identification of CDCP1 as a hypoxia-inducible factor 2alpha (HIF-2alpha) target gene that is associated with survival in clear cell renal cell carcinoma patients
    • COI: 1:CAS:528:DC%2BC3sXkvVKms78%3D, PID: 23378636
    • Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, et al. Identification of CDCP1 as a hypoxia-inducible factor 2alpha (HIF-2alpha) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc Natl Acad Sci U S A. 2013;110(9):3483–8. doi:10.1073/pnas.1222435110.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.9 , pp. 3483-3488
    • Emerling, B.M.1    Benes, C.H.2    Poulogiannis, G.3    Bell, E.L.4    Courtney, K.5    Liu, H.6
  • 26
    • 17444403210 scopus 로고    scopus 로고
    • The C2 domain of PKCdelta is a phosphotyrosine binding domain
    • COI: 1:CAS:528:DC%2BD2MXjvV2jtbs%3D, PID: 15851033
    • Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP. The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell. 2005;121(2):271–80. doi:10.1016/j.cell.2005.02.019.
    • (2005) Cell , vol.121 , Issue.2 , pp. 271-280
    • Benes, C.H.1    Wu, N.2    Elia, A.E.3    Dharia, T.4    Cantley, L.C.5    Soltoff, S.P.6
  • 27
    • 44849141807 scopus 로고    scopus 로고
    • CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma
    • COI: 1:CAS:528:DC%2BD1cXnslKjsbk%3D, PID: 18467693
    • Uekita T, Tanaka M, Takigahira M, Miyazawa Y, Nakanishi Y, Kanai Y, et al. CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma. Am J Pathol. 2008;172(6):1729–39. doi:10.2353/ajpath.2008.070981.
    • (2008) Am J Pathol , vol.172 , Issue.6 , pp. 1729-1739
    • Uekita, T.1    Tanaka, M.2    Takigahira, M.3    Miyazawa, Y.4    Nakanishi, Y.5    Kanai, Y.6
  • 28
    • 0034782172 scopus 로고    scopus 로고
    • Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97
    • COI: 1:STN:280:DC%2BD383mtlylsg%3D%3D, PID: 11819844
    • Li Y, Tang ZY, Ye SL, Liu YK, Chen J, Xue Q, et al. Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97. World J Gastroenterol: WJG. 2001;7(5):630–6.
    • (2001) World J Gastroenterol : WJG , vol.7 , Issue.5 , pp. 630-636
    • Li, Y.1    Tang, Z.Y.2    Ye, S.L.3    Liu, Y.K.4    Chen, J.5    Xue, Q.6
  • 29
    • 84858986330 scopus 로고    scopus 로고
    • The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration
    • COI: 1:CAS:528:DC%2BC38XktlKrtL8%3D, PID: 22315226
    • Dong Y, He Y, de Boer L, Stack MS, Lumley JW, Clements JA, et al. The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration. J Biol Chem. 2012;287(13):9792–803. doi:10.1074/jbc.M111.335448.
    • (2012) J Biol Chem , vol.287 , Issue.13 , pp. 9792-9803
    • Dong, Y.1    He, Y.2    de Boer, L.3    Stack, M.S.4    Lumley, J.W.5    Clements, J.A.6
  • 30
    • 84883506031 scopus 로고    scopus 로고
    • Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells
    • COI: 1:CAS:528:DC%2BC3sXhs1WiurzL, PID: 23958427
    • Befani C, Mylonis I, Gkotinakou IM, Georgoulias P, Hu CJ, Simos G, et al. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol. 2013;45(11):2359–68. doi:10.1016/j.biocel.2013.07.025.
    • (2013) Int J Biochem Cell Biol , vol.45 , Issue.11 , pp. 2359-2368
    • Befani, C.1    Mylonis, I.2    Gkotinakou, I.M.3    Georgoulias, P.4    Hu, C.J.5    Simos, G.6
  • 31
    • 77956210264 scopus 로고    scopus 로고
    • Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta
    • COI: 1:CAS:528:DC%2BC3cXhtVahtbvJ, PID: 20551327
    • He Y, Wortmann A, Burke LJ, Reid JC, Adams MN, Abdul-Jabbar I, et al. Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta. J Biol Chem. 2010;285(34):26162–73. doi:10.1074/jbc.M109.096453.
    • (2010) J Biol Chem , vol.285 , Issue.34 , pp. 26162-26173
    • He, Y.1    Wortmann, A.2    Burke, L.J.3    Reid, J.C.4    Adams, M.N.5    Abdul-Jabbar, I.6
  • 32
    • 45849101294 scopus 로고    scopus 로고
    • Migration of renal carcinoma cells is dependent on protein kinase Cdelta via beta1 integrin and focal adhesion kinase
    • COI: 1:CAS:528:DC%2BD1cXmtlSntLY%3D, PID: 18425341
    • Brenner W, Greber I, Gudejko-Thiel J, Beitz S, Schneider E, Walenta S, et al. Migration of renal carcinoma cells is dependent on protein kinase Cdelta via beta1 integrin and focal adhesion kinase. Int J Oncol. 2008;32(5):1125–31.
    • (2008) Int J Oncol , vol.32 , Issue.5 , pp. 1125-1131
    • Brenner, W.1    Greber, I.2    Gudejko-Thiel, J.3    Beitz, S.4    Schneider, E.5    Walenta, S.6
  • 33
    • 0037468568 scopus 로고    scopus 로고
    • Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen
    • COI: 1:CAS:528:DC%2BD3sXitlyqt7o%3D, PID: 12660814
    • Hooper JD, Zijlstra A, Aimes RT, Liang H, Claassen GF, Tarin D, et al. Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene. 2003;22(12):1783–94. doi:10.1038/sj.onc.1206220.
    • (2003) Oncogene , vol.22 , Issue.12 , pp. 1783-1794
    • Hooper, J.D.1    Zijlstra, A.2    Aimes, R.T.3    Liang, H.4    Claassen, G.F.5    Tarin, D.6
  • 34
    • 84655161946 scopus 로고    scopus 로고
    • HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression
    • COI: 1:CAS:528:DC%2BC3MXhs1aisbzM
    • Keith B, Johnson RS, Simon MC. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer. 2012;12(1):9–22. doi:10.1038/nrc3183.
    • (2012) Nat Rev Cancer , vol.12 , Issue.1 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 35
    • 78651231169 scopus 로고    scopus 로고
    • Correlations of hypoxia-inducible factor-1alpha/hypoxia-inducible factor-2alpha expression with angiogenesis factors expression and prognosis in non-small cell lung cancer
    • PID: 21362301
    • Wu XH, Qian C, Yuan K. Correlations of hypoxia-inducible factor-1alpha/hypoxia-inducible factor-2alpha expression with angiogenesis factors expression and prognosis in non-small cell lung cancer. Chin Med J. 2011;124(1):11–8.
    • (2011) Chin Med J , vol.124 , Issue.1 , pp. 11-18
    • Wu, X.H.1    Qian, C.2    Yuan, K.3
  • 36
    • 56449095636 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer
    • COI: 1:CAS:528:DC%2BD1cXhtlOmt73E, PID: 19010893
    • Helczynska K, Larsson AM, Holmquist Mengelbier L, Bridges E, Fredlund E, Borgquist S, et al. Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer. Cancer Res. 2008;68(22):9212–20. doi:10.1158/0008-5472.CAN-08-1135.
    • (2008) Cancer Res , vol.68 , Issue.22 , pp. 9212-9220
    • Helczynska, K.1    Larsson, A.M.2    Holmquist Mengelbier, L.3    Bridges, E.4    Fredlund, E.5    Borgquist, S.6
  • 37
    • 73149112785 scopus 로고    scopus 로고
    • HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization
    • COI: 1:CAS:528:DC%2BD1MXhsFSnu7%2FL
    • Noguera R, Fredlund E, Piqueras M, Pietras A, Beckman S, Navarro S, et al. HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization. Clin Cancer Res: Off J Am Assoc Cancer Res. 2009;15(23):7130–6. doi:10.1158/1078-0432.CCR-09-0223.
    • (2009) Clin Cancer Res : Off J Am Assoc Cancer Res , vol.15 , Issue.23 , pp. 7130-7136
    • Noguera, R.1    Fredlund, E.2    Piqueras, M.3    Pietras, A.4    Beckman, S.5    Navarro, S.6
  • 38
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • COI: 1:CAS:528:DC%2BD2sXksFWjsr0%3D, PID: 17418410
    • Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell. 2007;11(4):335–47. doi:10.1016/j.ccr.2007.02.006.
    • (2007) Cancer Cell , vol.11 , Issue.4 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.J.3    Diehl, J.A.4    Simon, M.C.5


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