Regulation of HSP27 on NF-κB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis

BMC Cancer

Volumn 9, Issue , 2009, Pages

  Guo, Kun ^a,b   Kang, Nan Xiao ^b   Li, Yan ^a,b   Sun, Lu ^b   Gan, Lin ^a   Cui, Feng Jie ^a,b   Gao, Mei Dong ^a   Liu, Kun Yin ^a,b  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; HEAT SHOCK PROTEIN 27; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SMALL INTERFERING RNA; HSPB1 PROTEIN, HUMAN; I KAPPA B; I KAPPA B BETA; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; DNA MICROARRAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; METASTASIS POTENTIAL; NICK END LABELING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; CANCER INVASION; CELL MOTION; GENETIC TRANSFECTION; GENETICS; IMMUNOPRECIPITATION; LIVER TUMOR; METABOLISM; METASTASIS; PATHOLOGY; PHOSPHORYLATION; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HSP27 HEAT-SHOCK PROTEINS; HUMANS; I-KAPPA B PROTEINS; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; LIVER NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 65649115127     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-9-100     Document Type: Article

References (31)

1. Boedefeld WM Bland KI Heslin MJ Recent insights into angiogenesis, apoptosis, invasion, and metastasis in colorectal carcinoma Ann Surg Oncol 2003, 10(8):839-851. 14527901
2. Townson JL Naumov GN Chambers AF The role of apoptosis in tumor progression and metastasis Curr Mol Med 2003, 3(7):631-642. 14601637
3. Harlozinska A Progress in molecular mechanisms of tumor metastasis and angiogenesis Anticancer Res 2005, 25(5):3327-3333. 16101146
4. Luo JL Kamata H Karin M IKK/NF-kappaB signaling: Balancing life and death - a new approach to cancer therapy J Clin Invest 2005, 115(10):2625-2632. 1236696 16200195
5. Greten FR Eckmann L Greten TF Park JM Li ZW Egan LJ Kagnoff MF Karin M IKKbeta links inflammation and tumorigenesis in a mouse model of colitis- associated cancer Cell 2004, 118(3):285-296. 15294155
6. Pikarsky E Porat RM Stein I Abramovitch R Amit S Kasem S Gutkovich-Pyest E Urieli-Shoval S Galun E Ben-Neriah Y NF-kappaB functions as a tumour promoter in inflammation-associated cancer Nature 2004, 431(7007):461-466. 15329734
7. Mosser DD Morimoto RI Molecular chaperones and the stress of oncogenesis Oncogene 2004, 23(16):2907-2918. 15077153
8. Parcellier A Schmitt E Gurbuxani S Seigneurin-Berny D Pance A Chantôme A Plenchette S Khochbin S Solary E Garrido C HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation Mol Cell Biol 2003, 23(16):5790-5802. 166315 12897149
9. Concannon CG Gorman AM Samali A On the role of Hsp27 in regulating apoptosis Apoptosis 2003, 8(1):61-70. 12510153
10. Guo K Liu YK Zhou HJ Dai Z Zhang JB Sun RX Chen J Sun QL Lu WJ Kang XN Chen P Involvement of protein kinase C beta-extracellular signal-regulating kinase 1/2/p38 mitogen-activated protein kinase-heat shock protein 27 activation in hepatocellular carcinoma cell motility and invasion Cancer Sci 2008, 99(3):486-496. 18167130
11. Li Y Tang ZY Ye SL Liu YK Chen J Xue Q Chen J Gao DM Bao WH Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97 World J Gastroenterol 2001, 7(5):630-636. 11819844
12. Song HY Liu YK Feng JT Cui JF Dai Z Zhang LJ Feng JX Shen HL Tang ZY Proteomic analysis on metastasis- associated proteins of human hepatocellular carcinoma tissues J Cancer Res Clin Oncol 2006, 132(2):92-98. 16261346
13. Moudy AM Handran SD Goldberg MP Ruffin N Karl I Kranz-Eble P DeVivo DC Rothman SM Abnormal calcium homeostasis and mitochondrial polarization in a human encephalomyopathy Proc Natl Acad Sci USA 1995, 92(3):729-733. 42693 7846043
14. Smiley ST Reers M Mottola-Hartshorn C Lin M Chen A Smith TW Steele GD Jr Chen LB Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1 Proc Natl Acad Sci USA 1991, 88(9):3671-3675. 51514 2023917
15. O'Neill PA Shaaban AM West CR Dodson A Jarvis C Moore P Davies MP Sibson DR Foster CS Increased risk of malignant progression in benign proliferating breast lesions defined by expression of heat shock protein 27 Br J Cancer 2004, 90(1):182-188. 14710227
16. Soti C Nagy E Giricz Z Vigh L Csermely P Ferdinandy P Heat shock proteins as emerging therapeutic targets Br J Pharmacol 2005, 146(6):769-780. 1751210 16170327
17. Ciocca DR Calderwood SK Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications Cell Stress Chaperones 2005, 10(2):86-103. 1176476 16038406
18. Feng JT Liu YK Song HY Dai Z Qin LX Almofti MR Fang CY Lu HJ Yang PY Tang ZY Heat-shock protein 27: A potential biomarker for hepatocellular carcinoma identified by serum proteome analysis Proteomics 2005, 5(17):4581-4588. 16240287
19. Blachere NE Srivastava PK Heat shock protein-based cancer vaccines and related thoughts on immunogenicity of human tumors Semin Cancer Biol 1995, 6(6):349-355. 8938273
20. Concannon CG Orrenius S Samali A Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c Gene Expr 2001, 9(4-5):195-201. 11444529
21. Arrigo AP The cellular "networking" of mammalian Hsp27 and its functions in the control of protein folding, redox state and apoptosis Adv Exp Med Biol 2007, 594:14-26. 17205671
22. Bryantsev AL Kurchashova SY Golyshev SA Polyakov VY Wunderink HF Kanon B Budagova KR Kabakov AE Kampinga HH Regulation of stress-induced intracellular sorting and chaperone function of Hsp27 (HspB1) in mammalian cells Biochem J 2007, 407(3):407-417. 2275061 17650072
23. Kato K Hasegawa K Goto S Inaguma Y Dissociation as a result of phosphorylation of an aggregated form of the small stress protein, hsp27 J Biol Chem 1994, 269(15):11274-11278. 8157658
24. Lambert H Charette SJ Bernier AF Guimond A Landry J HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus J Biol Chem 1999, 274(14):9378-9385. 10092617
25. Dolcet X Llobet D Pallares J Matias-Guiu X NF-kB in development and progression of human cancer Virchows Arch 2005, 446(5):475-482. 15856292
26. Karin M The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation J Biol Chem 1999, 274(39):27339-27342. 10488062
27. Monks NR Biswas DK Pardee AB Blocking anti-apoptosis as a strategy for cancer chemotherapy: NF-kappaB as a target J Cell Biochem 2004, 92(4):646-650. 15211562
28. Tai DI Tsai SL Chang YH Huang SN Chen TC Chang KS Liaw YF Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma Cancer 2000, 89(11):2274-2281. 11147598
29. Broemer M Krappmann D Scheidereit C Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation Oncogene 2004, 23(31):5378-5386. 15077173
30. Bhattacharyya S Dudeja PK Tobacman JK Carrageenan-induced NFkappaB activation depends on distinct pathways mediated by reactive oxygen species and Hsp27 or by Bcl10 Biochim Biophys Acta 2008, 1780(7-8):973-982. 18452717
31. Pittet JF Lee H Pespeni M O'Mahony A Roux J Welch WJ Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90 J Immunol 2005, 174(1):384-394. 15611262