Metabolic anticipation in Mycobacterium tuberculosis

Nature Microbiology

Volumn 2, Issue , 2017, Pages

  Eoh, Hyungjin ^a,c   Wang, Zhe ^a   Layre, Emilie ^b,d   Rath, Poonam ^a   Morris, Roxanne ^a   Branch Moody, D ^b   Rhee, Kyu Y ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; AMPICILLIN; CORD FACTOR; GLUCOSE; GLYCOLIPID; INTERLEUKIN 12P40; PENTOSE PHOSPHATE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOENOLPYRUVATE; STREPTOMYCIN; TREHALOSE; TREHALOSE MONOMYCOLATE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; MYCOLIC ACID; PEPTIDOGLYCAN;

ANIMAL CELL; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL MEMBRANE; BACTERIAL METABOLISM; BACTERIAL VIABILITY; BONE MARROW DERIVED MACROPHAGE; CARBOHYDRATE SYNTHESIS; CATABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; CYTOKINE RELEASE; GLYCOLYSIS; HYPOXIA; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; ADAPTATION; CELL CYCLE; CELL WALL; METABOLISM; PHYSIOLOGY;

ADAPTATION, PHYSIOLOGICAL; CELL CYCLE; CELL WALL; HYPOXIA; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; PEPTIDOGLYCAN;

EID: 85019654620     PISSN: None     EISSN: 20585276     Source Type: Journal    
DOI: 10.1038/nmicrobiol.2017.84     Document Type: Article

References (30)

1. Russell, D. G., Barry, C. E. III & Flynn, J. L. Tuberculosis: what we don't know can, and does, hurt us. Science 328, 852-856 (2010).
2. Blaser, M. J., & Kirschner, D. The equilibria that allow bacterial persistence in human hosts. Nature 449, 843-849 (2007).
3. Rustad, T. R., Sherrid, A. M., Minch, K. J., & Sherman, D. R. Hypoxia: a window into Mycobacterium tuberculosis latency. Cell Microbiol. 11, 1151-1159 (2009).
4. Lakshminarayana, S. B., et al. Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents. J. Antimicrob. Chemother. 70, 857-867 (2015).
5. Warner, D. F., & Mizrahi, V. Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy. Clin. Microbiol. Rev. 19, 558-570 (2006).
6. Watanabe, S., et al. Fumarate reductase activity maintains an energized membrane in anaerobic mycobacterium tuberculosis. PLoS Pathog. 7, e1002287 (2011).
7. Eoh, H., & Rhee, K. Y. Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 110, 6554-6559 (2013).
8. Ortega, C., et al. Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch. PLoS Biol. 12, e1001746 (2014).
9. Ortega, C., et al. Systematic survey of serine hydrolase activity in Mycobacterium tuberculosis defines changes associated with persistence. Cell Chem. Biol. 23, 290-298 (2016).
10. Schubert, O. T., et al. Absolute proteome composition and dynamics during dormancy and resuscitation of Mycobacterium tuberculosis. Cell Host Microbe. 18, 96-108 (2015).
11. Kalscheuer, R., & Koliwer-Brandl, H. Genetics of mycobacterial trehalose metabolism. Microbiol. Spectr. http://dx.doi.org/10.1128/microbiolspec.MGM2-0002-2013 (2014).
12. Ishikawa, E., et al. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-Type lectin Mincle. J. Exp. Med. 206, 2879-2888 (2009).
13. Galagan, J. E., et al. The Mycobacterium tuberculosis regulatory network and hypoxia. Nature 499, 178-183 (2013).
14. Kalscheuer, R., et al. Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway. Nat. Chem. Biol. 6, 376-384 (2010).
15. Miah, F., et al. Flux through trehalose synthase flows from trehalose to the alpha anomer of maltose in mycobacteria. Chem. Biol. 20, 487-493 (2013).
16. Stincone, A., et al. The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol. Rev. Camb. Philos. Soc. 90, 927-963 (2015)
17. Walsh, C. T., Benson, T. E., Kim, D. H., & Lees, W. J. The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesis. Chem. Biol. 3, 83-91 (1996).
18. De Smet, K. A., et al. Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosis. Microbiology 145, 3177-3184 (1999).
19. Venturelli, O. S., Zuleta, I., Murray, R. M., & El-Samad, H. Population diversification in a yeast metabolic program promotes anticipation of environmental shifts. PLoS Biol. 13, e1002042 (2015).
20. Mitchell, A., et al. Adaptive prediction of environmental changes by microorganisms. Nature 460, 220-224 (2009).
21. Tagkopoulos, I., Liu, Y. C., & Tavazoie, S. Predictive behavior within microbial genetic networks. Science 320, 1313-1317 (2008).
22. Warner, D. F. Mycobacterium tuberculosis metabolism. Cold Spring Harb. Perspect. Med. 5, pii.a021121 (2015).
23. Rao, S. P., Alonso, S., Rand, L., Dick, T., & Pethe, K. The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 105, 11945-11950 (2008).
24. Boutte, C. C., et al. A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis. eLife 5, e14590 (2016).
25. Backus, K. M., et al. The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-Active site regions. J. Biol. Chem. 289, 25041-25053 (2014).
26. van Heerden, J. H., et al. Lost in transition: start-up of glycolysis yields subpopulations of nongrowing cells. Science 343, 1245114 (2014).
27. Lenaerts, A., Barry, C. E. III & Dartois, V. Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses. Immunol. Rev. 264, 288-307 (2015).
28. De Carvalho, L. P., et al. Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chem. Biol. 17, 1122-1131 (2010).
29. Layre, E., et al. A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis. Chem. Biol. 18, 1537-1549 (2011).
30. Ehrt, S., et al. Reprogramming of the macrophage transcriptome in response to interferon-? and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J. Exp. Med. 194, 1123-1140 (2001).