The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 25041-25053

  Backus, Keriann M ^a,c,f   Dolan, Michael A ^b   Barry, Conor S ^c   Joe, Maju ^d   McPhie, Peter ^e   Boshoff, Helena I M ^a   Lowary, Todd L ^d   Davis, Benjamin G ^c   Barry, Clifton E ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF ALBERTA   (Canada)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CATALYST ACTIVITY; ENZYMES; MOLECULAR DYNAMICS; REACTION KINETICS;

ARABINOGALACTAN; CATALYZE TRANSESTERIFICATION; HEXASACCHARIDES; MOLECULAR DYNAMICS SIMULATIONS; MYCOBACTERIUM TUBERCULOSIS; N-TERMINAL HELIX; NATURAL SUBSTRATES; SUBSTRATE SELECTIVITY;

SUBSTRATES;

6 AZIDO TREHALOSE; 6 AZIDO TREHALOSE 6' MONOMYCOLATE; ACYLTRANSFERASE; ARABINOGALACTAN; MYCOBACTERIUM ANTIGEN; MYCOBACTERIUM TUBERCULOSIS ANTIGEN 85A; MYCOBACTERIUM TUBERCULOSIS ANTIGEN 85B; MYCOBACTERIUM TUBERCULOSIS ANTIGEN 85C; TREHALOSE; UNCLASSIFIED DRUG; ANTIGEN 85A, MYCOBACTERIUM TUBERCULOSIS; ANTIGEN 85B, MYCOBACTERIUM TUBERCULOSIS; ANTIGEN 85C, MYCOBACTERIUM TUBERCULOSIS; ARABAN; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CORD FACTOR; GALACTAN; POLYSACCHARIDE; PROTEIN BINDING; TREHALOSE MONOMYCOLATE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIBODY COMBINING SITE; ARTICLE; BINDING SITE; CARBOHYDRATE SYNTHESIS; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; HYDROGEN BOND; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; BIOCATALYSIS; CARBOHYDRATE ANALYSIS; CELL WALL; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR GENETICS; MUTATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY;

ACYLTRANSFERASES; AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BINDING SITES; BIOCATALYSIS; CARBOHYDRATE SEQUENCE; CATALYTIC DOMAIN; CELL WALL; CORD FACTORS; GALACTANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; MYCOBACTERIUM TUBERCULOSIS; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 84906979512     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.581579     Document Type: Article

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