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Volumn 70, Issue 5, 2017, Pages 520-526

The antibiotic resistance crisis, with a focus on the United States

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

EID: 85019621483     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2017.30     Document Type: Review
Times cited : (351)

References (91)
  • 1
    • 33646818699 scopus 로고    scopus 로고
    • Antibiotic resistance in bacteria and its future for novel antibiotic development
    • Yoneyama, H. & Katsumata, R. Antibiotic resistance in bacteria and its future for novel antibiotic development. Biosci. Biotechnol. Biochem. 70, 1060-1075 (2006).
    • (2006) Biosci. Biotechnol. Biochem. , vol.70 , pp. 1060-1075
    • Yoneyama, H.1    Katsumata, R.2
  • 2
    • 79251604303 scopus 로고    scopus 로고
    • Quinolones: From antibiotics to autoinducers
    • Heeb,S.et al. Quinolones: from antibiotics to autoinducers. FEMS Microbiol. Rev. 35, 247-274 (2011).
    • (2011) FEMS Microbiol. Rev. , vol.35 , pp. 247-274
    • Heeb, S.1
  • 3
    • 33845719937 scopus 로고    scopus 로고
    • Antibacterial discovery and development - The failure of success?
    • Fernandes, P. Antibacterial discovery and development-the failure of success? Nat. Biotechnol. 24, 1497-1503 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1497-1503
    • Fernandes, P.1
  • 4
    • 0034646538 scopus 로고    scopus 로고
    • Pathways of discovery: Infectious history
    • Lederberg, J. Pathways of discovery: infectious history. Science 288, 287-293 (2000).
    • (2000) Science , vol.288 , pp. 287-293
    • Lederberg, J.1
  • 5
    • 21044444480 scopus 로고    scopus 로고
    • Isolation of novel bacteria and actinomycetes using soil-extract agar medium
    • Hamaki, T. et al. Isolation of novel bacteria and actinomycetes using soil-extract agar medium. J. Biosci. Bioeng. 99, 485-492 (2005).
    • (2005) J. Biosci. Bioeng. , vol.99 , pp. 485-492
    • Hamaki, T.1
  • 6
    • 0038561132 scopus 로고    scopus 로고
    • Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
    • Ikeda, H. et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat. Biotechnol. 21, 526-531 (2003).
    • (2003) Nat. Biotechnol. , vol.21 , pp. 526-531
    • Ikeda, H.1
  • 7
    • 85019640248 scopus 로고    scopus 로고
    • Fusidic acid
    • (accessed 23 January 2017)
    • Christiansen, K. J. Fusidic acid. Antimicrobe. Available at http://www.antimicrobe.org/ d29.asp (accessed 23 January 2017).
    • Antimicrobe
    • Christiansen, K.J.1
  • 8
    • 55249104697 scopus 로고    scopus 로고
    • Low hanging fruit in infectious disease drug development
    • Kraus, C. N. Low hanging fruit in infectious disease drug development. Curr. Opin. Microbiol. 11, 434-438 (2008).
    • (2008) Curr. Opin. Microbiol. , vol.11 , pp. 434-438
    • Kraus, C.N.1
  • 9
    • 78649588915 scopus 로고    scopus 로고
    • Defensin mimetics: Nature knows best
    • Scott, R. W. Defensin mimetics: nature knows best. Am. Biotechnol. Lab. 27, 16-19 (2009).
    • (2009) Am. Biotechnol. Lab. , vol.27 , pp. 16-19
    • Scott, R.W.1
  • 10
    • 33644535147 scopus 로고    scopus 로고
    • Natural products - The future scaffolds for novel antibiotics?
    • Butler, M. S. & Buss, A. D. Natural products-the future scaffolds for novel antibiotics? Biochem. Pharmacol. 71, 919-929 (2006).
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 919-929
    • Butler, M.S.1    Buss, A.D.2
  • 12
    • 67650388245 scopus 로고    scopus 로고
    • Squashing superbugs - The race for new antibiotics
    • Walsh, C. T. & Fischbach, M. A. Squashing superbugs - the race for new antibiotics. Sci. Am. 301, 44-51 (2009).
    • (2009) Sci. Am. , vol.301 , pp. 44-51
    • Walsh, C.T.1    Fischbach, M.A.2
  • 14
    • 84907190279 scopus 로고    scopus 로고
    • Antibiotic effectiveness: Balancing conservation against innovation
    • Laxminarayan, R. Antibiotic effectiveness: balancing conservation against innovation. Science 345, 1299-1301 (2014).
    • (2014) Science , vol.345 , pp. 1299-1301
    • Laxminarayan, R.1
  • 15
    • 85014074805 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention (CDC), (accessed 24 January 2017)
    • Centers for Disease Control and Prevention (CDC) Biggest threats. Available at https://www.cdc.gov/drugresistance/biggest-threats.html (accessed 24 January 2017).
    • Biggest Threats
  • 16
    • 84939574142 scopus 로고    scopus 로고
    • Investigational new treatments for Clostridium difficile infection
    • Ivarsson, M. E., Leroux, J. C. & Castagner, B. Investigational new treatments for Clostridium difficile infection. Drug Discov. Today 20, 602-608 (2015).
    • (2015) Drug Discov. Today , vol.20 , pp. 602-608
    • Ivarsson, M.E.1    Leroux, J.C.2    Castagner, B.3
  • 17
    • 33644544089 scopus 로고    scopus 로고
    • Empirical antibacterial drug discovery-foundation in natural products
    • Singh, S. B. & Barrett, J. F. Empirical antibacterial drug discovery-foundation in natural products. Biochem. Pharmacol. 71, 1006-1015 (2006).
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1006-1015
    • Singh, S.B.1    Barrett, J.F.2
  • 18
    • 34447097735 scopus 로고    scopus 로고
    • Resistance redux
    • Davies, J. Resistance redux. EMBO Rep. 8, 616-621 (2007).
    • (2007) EMBO Rep. , vol.8 , pp. 616-621
    • Davies, J.1
  • 19
    • 84881119572 scopus 로고    scopus 로고
    • Antibiotic resistance: The last resort
    • McKenna, M. Antibiotic resistance: the last resort. Nature 499, 394-396 (2013).
    • (2013) Nature , vol.499 , pp. 394-396
    • McKenna, M.1
  • 21
    • 85019598926 scopus 로고    scopus 로고
    • Clpping persistence
    • Cain, C. ClpPing Persistence. SciBX 6 (2013).
    • (2013) SciBX , vol.6
    • Cain, C.1
  • 22
    • 85019603797 scopus 로고    scopus 로고
    • Overcoming resistance
    • The Scientist staff
    • The Scientist staff. Overcoming resistance. Scientist 28, (2014).
    • (2014) Scientist , pp. 28
  • 23
    • 85040342159 scopus 로고    scopus 로고
    • House clears chemicals bill
    • Erickson, B. House clears chemicals bill. Chem. Eng. News 93, 6 (2015).
    • (2015) Chem. Eng. News , vol.93 , pp. 6
    • Erickson, B.1
  • 24
    • 79956107885 scopus 로고    scopus 로고
    • Combinations of antibiotics and non-antibiotic drugs enhance antimicrobial efficacy
    • Ejim, L. et al. Combinations of antibiotics and non-antibiotic drugs enhance antimicrobial efficacy. Nat. Chem. Biol. 7, 348-350 (2011).
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 348-350
    • Ejim, L.1
  • 25
    • 84885658935 scopus 로고    scopus 로고
    • Vaccines: An age-old problem
    • DeWeerdt, S. Vaccines: an age-old problem. Nature 502, 58-59 (2013).
    • (2013) Nature , vol.502 , pp. 58-59
    • DeWeerdt, S.1
  • 26
    • 84877267006 scopus 로고    scopus 로고
    • Advances in the development of new tuberculosis drugs and treatment regimens
    • Zumla, A., Nahid, P. & Cole, S. T. Advances in the development of new tuberculosis drugs and treatment regimens. Nat. Rev. Drug Discov. 12, 388-404 (2013).
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 388-404
    • Zumla, A.1    Nahid, P.2    Cole, S.T.3
  • 27
    • 84885630506 scopus 로고    scopus 로고
    • Drug development: A combined effort
    • Maxmen, A. Drug development: a combined effort. Nature 502, 54-56 (2013).
    • (2013) Nature , vol.502 , pp. 54-56
    • Maxmen, A.1
  • 28
    • 84885005029 scopus 로고    scopus 로고
    • Applying insights from biofilm biology to drug development-can a new approach be developed?
    • Bjarnsholt, T. et al. Applying insights from biofilm biology to drug development-can a new approach be developed? Nat. Rev. Drug Discov. 12, 781-808 (2013).
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 781-808
    • Bjarnsholt, T.1
  • 29
    • 84874755540 scopus 로고    scopus 로고
    • Advances in discovery of new antibacterials for combating metabolically resting bacteria
    • Bald, D. & Koul, A. Advances in discovery of new antibacterials for combating metabolically resting bacteria. Drug Discov. Today 18, 250-255 (2013).
    • (2013) Drug Discov. Today , vol.18 , pp. 250-255
    • Bald, D.1    Koul, A.2
  • 30
    • 84864381330 scopus 로고    scopus 로고
    • Novel antibiotics targeting respiratory ATP synthesis in Grampositive pathogenic bacteria
    • Balemans, W. et al. Novel antibiotics targeting respiratory ATP synthesis in Grampositive pathogenic bacteria. Antimicrob. Agents Chemother. 56, 4131-4139 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 4131-4139
    • Balemans, W.1
  • 31
    • 0035173818 scopus 로고    scopus 로고
    • GlpD and PlsB participate in persister cell formation in Escherichia coli
    • Spoering, A. L. & Lewis, K. GlpD and PlsB participate in persister cell formation in Escherichia coli. J. Bacteriol. 183, 6746-6751 (2001).
    • (2001) J. Bacteriol. , vol.183 , pp. 6746-6751
    • Spoering, A.L.1    Lewis, K.2
  • 32
    • 50349141358 scopus 로고
    • Treatment of staphylococcal infections with penicillin by intermittent sterilization
    • Bigger, J. W. Treatment of staphylococcal infections with penicillin by intermittent sterilization. Lancet 244, 497-500 (1944).
    • (1944) Lancet , vol.244 , pp. 497-500
    • Bigger, J.W.1
  • 33
    • 84888019629 scopus 로고    scopus 로고
    • Activated ClpP kills persisters and eradicates a chronic biofilm infection
    • Conlon, B. P. et al. Activated ClpP kills persisters and eradicates a chronic biofilm infection. Nature 503, 365-370 (2013).
    • (2013) Nature , vol.503 , pp. 365-370
    • Conlon, B.P.1
  • 35
    • 27144460621 scopus 로고    scopus 로고
    • Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
    • Broetz-Oesterhelt, H. et al. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nat. Med. 11, 1082-1087 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 1082-1087
    • Broetz-Oesterhelt, H.1
  • 36
    • 84982155987 scopus 로고    scopus 로고
    • AUN high-level meeting on antimicrobials-who do we need?
    • Laxminarayan, R. et al. UN high-level meeting on antimicrobials-who do we need? Lancet 388, 218-220 (2016).
    • (2016) Lancet , vol.388 , pp. 218-220
    • Laxminarayan, R.1
  • 37
    • 0035131616 scopus 로고    scopus 로고
    • Quo vadis, biotech? (Part 2)
    • Drews, J. Quo vadis, biotech? (Part 2). Drug Discov. Today 6, 21-26 (2001).
    • (2001) Drug Discov. Today , vol.6 , pp. 21-26
    • Drews, J.1
  • 39
    • 35348824837 scopus 로고    scopus 로고
    • Natural products as a screening resource
    • Harvey, A. L. Natural products as a screening resource. Curr. Opin. Chem. Biol. 11, 480-484 (2007).
    • (2007) Curr. Opin. Chem. Biol. , vol.11 , pp. 480-484
    • Harvey, A.L.1
  • 40
    • 25144520617 scopus 로고    scopus 로고
    • Can biotech deliver new antibiotics?
    • Barrett, J. F. Can biotech deliver new antibiotics? Curr. Opin. Microbiol. 8, 498-503 (2005).
    • (2005) Curr. Opin. Microbiol. , vol.8 , pp. 498-503
    • Barrett, J.F.1
  • 42
    • 0000128581 scopus 로고    scopus 로고
    • Fighting the clock
    • Watkins, K. J. Fighting the clock. Chem. Eng. News 80, 27-33 (2002).
    • (2002) Chem. Eng. News , vol.80 , pp. 27-33
    • Watkins, K.J.1
  • 43
    • 0036221208 scopus 로고    scopus 로고
    • Personalized medicine or block-busterology?
    • Burrill, G. S. Personalized medicine or block-busterology? BioPharm 15, 46-50 (2002).
    • (2002) BioPharm , vol.15 , pp. 46-50
    • Burrill, G.S.1
  • 44
    • 16644389654 scopus 로고    scopus 로고
    • Antibacterial drug discovery in the 21st century
    • Bush, K. Antibacterial drug discovery in the 21st century. Clin. Microbiol. Infect. 10 (suppl 4), 10-17 (2004).
    • (2004) Clin. Microbiol. Infect. , vol.10 , pp. 10-17
    • Bush, K.1
  • 45
    • 70350464668 scopus 로고    scopus 로고
    • New directions in drug discovery
    • 36, 56, 66, 80
    • Fox, S., Farr-Jones, S. & Yund, M. A. New directions in drug discovery. Gen. Eng. News 19, 10, 36, 56, 66, 80 (1999).
    • (1999) Gen. Eng. News , vol.19 , pp. 10
    • Fox, S.1    Farr-Jones, S.2    Yund, M.A.3
  • 46
    • 0038593636 scopus 로고    scopus 로고
    • Screening's age of insecurity
    • Ausman, D. J. Screening's age of insecurity. Modern Drug Discov. 4, 32-34 (2001).
    • (2001) Modern Drug Discov. , vol.4 , pp. 32-34
    • Ausman, D.J.1
  • 47
    • 0035204617 scopus 로고    scopus 로고
    • Realism in drug discovery-could Cassandra be right?
    • Horrobin, D. F. Realism in drug discovery-could Cassandra be right? Nat. Biotechnol. 19, 1099-1100 (2001).
    • (2001) Nat. Biotechnol. , vol.19 , pp. 1099-1100
    • Horrobin, D.F.1
  • 48
    • 0036489886 scopus 로고    scopus 로고
    • Mother nature's combinatorial libraries: Their influence on the synthesis of drugs
    • Kingston, D. G. & Newman, D. J. Mother nature's combinatorial libraries: their influence on the synthesis of drugs. Curr. Opin. Drug Discov. Dev. 5, 304-316 (2002).
    • (2002) Curr. Opin. Drug Discov. Dev. , vol.5 , pp. 304-316
    • Kingston, D.G.1    Newman, D.J.2
  • 49
    • 84890222706 scopus 로고    scopus 로고
    • Nature provides the answer
    • Waldmann, H. & Breinbauer, R. Nature provides the answer. Screening 6, 46-48 (2002).
    • (2002) Screening , vol.6 , pp. 46-48
    • Waldmann, H.1    Breinbauer, R.2
  • 50
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
    • Newman, D. J. Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J. Med. Chem. 51, 2589-2599 (2008).
    • (2008) J. Med. Chem. , vol.51 , pp. 2589-2599
    • Newman, D.J.1
  • 51
    • 4444221536 scopus 로고    scopus 로고
    • Antibiotic discovery: State of the state
    • Shlaes, D. M., Projan, S. J. & Edwards, J. E. Jr Antibiotic discovery: state of the state. ASM News 70, 275-281 (2004).
    • (2004) ASM News , vol.70 , pp. 275-281
    • Shlaes, D.M.1    Projan, S.J.2    Edwards, J.E.3
  • 52
    • 36949030717 scopus 로고    scopus 로고
    • Novel approaches to developing new antibiotics for bacterial infections
    • Coates, A. R. & Hu, Y. Novel approaches to developing new antibiotics for bacterial infections. Br. J. Pharmacol. 152, 1147-1154 (2007).
    • (2007) Br. J. Pharmacol. , vol.152 , pp. 1147-1154
    • Coates, A.R.1    Hu, Y.2
  • 53
    • 54849405130 scopus 로고    scopus 로고
    • Renaissance in antibacterial discovery from actinomycetes
    • Baltz, R. H. Renaissance in antibacterial discovery from actinomycetes. Curr. Opin. Pharmacol. 8, 557-563 (2008).
    • (2008) Curr. Opin. Pharmacol. , vol.8 , pp. 557-563
    • Baltz, R.H.1
  • 54
    • 85019643366 scopus 로고    scopus 로고
    • SciBx Special Issue on Antibiotic Resistance
    • Cain, C. in: Antibiotic Resistance, SciBx Special Issue on Antibiotic Resistance. 2-4 (2013).
    • (2013) Antibiotic Resistance , pp. 2-4
    • Cain, C.1
  • 55
    • 3943076153 scopus 로고    scopus 로고
    • Why it is important to continue antibacterial drug discovery
    • Bush, K. Why it is important to continue antibacterial drug discovery. ASM News 70, 282-287 (2004).
    • (2004) ASM News , vol.70 , pp. 282-287
    • Bush, K.1
  • 57
    • 34247511117 scopus 로고    scopus 로고
    • Engineering the glycosylation of natural products in actinomycetes
    • Salas, J. A. & Mendez, C. Engineering the glycosylation of natural products in actinomycetes. Trends Microbiol. 15, 219-232 (2007).
    • (2007) Trends Microbiol. , vol.15 , pp. 219-232
    • Salas, J.A.1    Mendez, C.2
  • 58
    • 43749107330 scopus 로고    scopus 로고
    • Genetically engineered biosynthesis of macrolide derivatives including 4-amino-4,6-dideoxy-L-glucose from Streptomyces venezuelaeYJ003-OTBP3
    • Pageni, B. B. et al. Genetically engineered biosynthesis of macrolide derivatives including 4-amino-4,6-dideoxy-L-glucose from Streptomyces venezuelaeYJ003-OTBP3. J. Microbiol. Biotechnol. 18, 88-94 (2007).
    • (2007) J. Microbiol. Biotechnol. , vol.18 , pp. 88-94
    • Pageni, B.B.1
  • 59
    • 49749126041 scopus 로고    scopus 로고
    • Sweet antibiotics - The role of glycosidic residues in antibiotic and antitumor activity and their randomization
    • Kren, V. & Rezanta, T. Sweet antibiotics-the role of glycosidic residues in antibiotic and antitumor activity and their randomization. FEMS Microbiol. Rev. 32, 858-889 (2008).
    • (2008) FEMS Microbiol. Rev. , vol.32 , pp. 858-889
    • Kren, V.1    Rezanta, T.2
  • 60
    • 33644557421 scopus 로고    scopus 로고
    • When will the genomics investment pay off for antibacterial discovery?
    • Mills, S. D. When will the genomics investment pay off for antibacterial discovery? Biochem. Pharmacol. 71, 1096-1102 (2006).
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1096-1102
    • Mills, S.D.1
  • 61
    • 34249907531 scopus 로고    scopus 로고
    • Strategies to unravel the function of orphan biosynthesis pathways: Recent examples and future prospects
    • Gross, H. Strategies to unravel the function of orphan biosynthesis pathways: recent examples and future prospects. Appl. Microbiol. Biotechnol. 75, 267-277 (2007).
    • (2007) Appl. Microbiol. Biotechnol. , vol.75 , pp. 267-277
    • Gross, H.1
  • 62
    • 34447302758 scopus 로고    scopus 로고
    • Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinospora tropica
    • Udwary, D. W. et al. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinospora tropica. Proc. Natl Acad. Sci. USA 104, 10376-10381 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 10376-10381
    • Udwary, D.W.1
  • 63
    • 42549165756 scopus 로고    scopus 로고
    • Bacterial hosts for natural product production
    • Zhang, H., Wang, Y. & Pfeifer, B. A. Bacterial hosts for natural product production. Mol. Pharm. 5, 212-225 (2008).
    • (2008) Mol. Pharm. , vol.5 , pp. 212-225
    • Zhang, H.1    Wang, Y.2    Pfeifer, B.A.3
  • 64
    • 45149124021 scopus 로고    scopus 로고
    • Molecular genetic mining of the Aspergillus secondary metabolome: Discovery of the emericellamide biosynthetic pathway
    • Chiang, Y. M. et al. Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. Chem. Biol. 15, 527-532 (2008).
    • (2008) Chem. Biol. , vol.15 , pp. 527-532
    • Chiang, Y.M.1
  • 65
    • 65549083361 scopus 로고    scopus 로고
    • Strategies for the discovery of new natural products by genome mining
    • Zerkly, M. & Challis, G. L. Strategies for the discovery of new natural products by genome mining. ChemBioChem 10, 625-633 (2009).
    • (2009) ChemBioChem , vol.10 , pp. 625-633
    • Zerkly, M.1    Challis, G.L.2
  • 66
    • 27544477567 scopus 로고    scopus 로고
    • Discovery of a new peptide natural product from Streptomyces coelicolor genome mining
    • Lautru, S., Deeth, R. J., Bailey, L. M. & Challi, G. L. Discovery of a new peptide natural product from Streptomyces coelicolor genome mining. Nat. Chem. Biol. 1, 265-269 (2005).
    • (2005) Nat. Chem. Biol. , vol.1 , pp. 265-269
    • Lautru, S.1    Deeth, R.J.2    Bailey, L.M.3    Challi, G.L.4
  • 67
    • 33749474044 scopus 로고    scopus 로고
    • Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression and mechanistic study of the germacradienol/geosmin synthase
    • Cane, D. E. et al. Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression and mechanistic study of the germacradienol/geosmin synthase. J. Antibiot. 59, 471-479 (2006).
    • (2006) J. Antibiot. , vol.59 , pp. 471-479
    • Cane, D.E.1
  • 68
    • 33646512641 scopus 로고    scopus 로고
    • Genome mining in Streptomyces coelicolor: Molecular cloning and characterization of a new sesquiterpene synthase from S. Coelicolor
    • Lin, X., Hopson, R. & Cane, D. E. Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase from S. coelicolor. J. Am. Chem. Soc. 128, 6022-6023 (2006).
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 6022-6023
    • Lin, X.1    Hopson, R.2    Cane, D.E.3
  • 69
    • 33845212858 scopus 로고    scopus 로고
    • Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining
    • Song, L. et al. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J. Am. Chem. Soc. 128, 14754-14755 (2006).
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 14754-14755
    • Song, L.1
  • 70
    • 33646837704 scopus 로고    scopus 로고
    • Identification of genes for mycothiol biosynthesis in Streptomyces coelicolor A3
    • Park, J. H., Cha, C. J. & Roe, J. H. Identification of genes for mycothiol biosynthesis in Streptomyces coelicolor A3. J. Microbiol. 44, 121-125 (2006).
    • (2006) J. Microbiol. , vol.44 , pp. 121-125
    • Park, J.H.1    Cha, C.J.2    Roe, J.H.3
  • 71
    • 33645105253 scopus 로고    scopus 로고
    • Antibiotic-producing ability by representatives of a newly discovered lineage of actinomycetes
    • Busti, E. et al. Antibiotic-producing ability by representatives of a newly discovered lineage of actinomycetes. Microbiology 152, 675-683 (2006).
    • (2006) Microbiology , vol.152 , pp. 675-683
    • Busti, E.1
  • 72
    • 10344228215 scopus 로고    scopus 로고
    • Status of the microbial census
    • Schloss, P. D. & Handelsman, J. Status of the microbial census. Mol. Biol. Rev. 68, 686-691 (2004).
    • (2004) Mol. Biol. Rev. , vol.68 , pp. 686-691
    • Schloss, P.D.1    Handelsman, J.2
  • 73
    • 0028946084 scopus 로고
    • Phylogenetic identification and in situ detection of individual microbial cells without cultivation
    • Amann, R. I., Ludwig, W. & Schleifer, K. H. Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol. Rev. 59, 143-169 (1995).
    • (1995) Microbiol. Rev. , vol.59 , pp. 143-169
    • Amann, R.I.1    Ludwig, W.2    Schleifer, K.H.3
  • 74
    • 33846977029 scopus 로고    scopus 로고
    • Global diversity and distribution of macrofungi
    • Mueller, G. M. et al. Global diversity and distribution of macrofungi. Biodivers. Conserv. 16, 37-48 (2007).
    • (2007) Biodivers. Conserv. , vol.16 , pp. 37-48
    • Mueller, G.M.1
  • 75
    • 0011530831 scopus 로고    scopus 로고
    • Mushrooms: The extent of the unexplored potential
    • Hawksworth, J. Mushrooms: the extent of the unexplored potential. J. Med. Mushrooms 3, 333-337 (2001).
    • (2001) J. Med. Mushrooms , vol.3 , pp. 333-337
    • Hawksworth, J.1
  • 78
    • 19144366814 scopus 로고    scopus 로고
    • Metagenomics and industrial applications
    • Lorenz, P. & Eck, J. Metagenomics and industrial applications. Nat. Rev. Microbiol. 3, 510-516 (2005).
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 510-516
    • Lorenz, P.1    Eck, J.2
  • 79
    • 41749090471 scopus 로고    scopus 로고
    • Drugs from hidden bugs: Their discovery via untapped resources
    • Lefevre, F. et al. Drugs from hidden bugs: their discovery via untapped resources. Res. Microbiol. 159, 153-161 (2008).
    • (2008) Res. Microbiol. , vol.159 , pp. 153-161
    • Lefevre, F.1
  • 80
    • 71349088748 scopus 로고    scopus 로고
    • Achievements and new knowledge unraveled by metagenomic approaches
    • Simon, C. & Daniel, R. Achievements and new knowledge unraveled by metagenomic approaches. Appl. Microbiol. Biotechnol. 85, 265-276 (2009).
    • (2009) Appl. Microbiol. Biotechnol. , vol.85 , pp. 265-276
    • Simon, C.1    Daniel, R.2
  • 81
    • 84886803095 scopus 로고    scopus 로고
    • Antibiotics in the clinical pipeline in 2013
    • Butler, M. S., Blaskovich, M. A. & Cooper, M. A. Antibiotics in the clinical pipeline in 2013. J. Antibiot. 66, 571-591 (2013).
    • (2013) J. Antibiot. , vol.66 , pp. 571-591
    • Butler, M.S.1    Blaskovich, M.A.2    Cooper, M.A.3
  • 82
    • 80053937055 scopus 로고    scopus 로고
    • The antibiotic R&D pipeline: An update
    • Jabes, D. The antibiotic R&D pipeline: an update. Curr. Opin. Microbiol. 14, 564-566 (2011).
    • (2011) Curr. Opin. Microbiol. , vol.14 , pp. 564-566
    • Jabes, D.1
  • 83
    • 78049467253 scopus 로고    scopus 로고
    • Importance of new companies for drug discovery: Origins of a decade of new drugs
    • Kneller, R. Importance of new companies for drug discovery: origins of a decade of new drugs. Nat. Rev. Drug Discov. 9, 867-882 (2010).
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 867-882
    • Kneller, R.1
  • 84
    • 85019590923 scopus 로고    scopus 로고
    • U.S. Department of Health & Human Services, Public Health Emergency (accessed 25 January 2017)
    • U.S. Department of Health & Human Services, Public Health Emergency. Jarrett, E BARDA Broad Spectrum Antimicrobials (BSA) Program. Available at https://www.phe. gov/ASPRBlog/Lists/Posts/Post.aspx?ID=97 (accessed 25 January 2017).
    • Jarrett, E BARDA Broad Spectrum Antimicrobials (BSA) Program
  • 85
    • 84862912729 scopus 로고    scopus 로고
    • The NIH's role in accelerating translational sciences
    • Reed, J. C. et al. The NIH's role in accelerating translational sciences. Nat. Biotechnol. 10, 16-19 (2012).
    • (2012) Nat. Biotechnol. , vol.10 , pp. 16-19
    • Reed, J.C.1
  • 86
    • 84861658306 scopus 로고    scopus 로고
    • NIH initiative aims to partner academics with pharmaceutical companies to revive failed drug candidates
    • Jarvis, L. M. NIH initiative aims to partner academics with pharmaceutical companies to revive failed drug candidates. Chem. Eng. News 90, 41-43 (2012).
    • (2012) Chem. Eng. News , vol.90 , pp. 41-43
    • Jarvis, L.M.1
  • 87
    • 84873513511 scopus 로고    scopus 로고
    • Incentives aim to boost antibiotic development
    • Roberts, J. P. Incentives aim to boost antibiotic development. Nat. Biotechnol. 30, 735-736 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 735-736
    • Roberts, J.P.1
  • 88
    • 84877318780 scopus 로고    scopus 로고
    • Antimicrobial peptides stage a comeback
    • Fox, J. L. Antimicrobial peptides stage a comeback. Nat. Biotechnol. 31, 379-382 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 379-382
    • Fox, J.L.1
  • 89
    • 84872488958 scopus 로고    scopus 로고
    • Bacteriocins - A viable alternative to antibiotics?
    • Cotter, P. D., Ross, P. & Hill, C. Bacteriocins-a viable alternative to antibiotics? Nat. Rev. Microbiol. 11, 95-103 (2013).
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 95-103
    • Cotter, P.D.1    Ross, P.2    Hill, C.3
  • 90
    • 84877249773 scopus 로고    scopus 로고
    • Medicines from microbiota
    • Olle, B. Medicines from microbiota. Nat. Biotechnol. 31, 309-315 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 309-315
    • Olle, B.1
  • 91
    • 84908016514 scopus 로고    scopus 로고
    • Anti-infective monoclonals step in where antimicrobials fail
    • Fox, J. L. Anti-infective monoclonals step in where antimicrobials fail. Nat. Biotechnol. 31, 952-954 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 952-954
    • Fox, J.L.1


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