메뉴 건너뛰기




Volumn 10, Issue 4, 2004, Pages 10-17

Antibacterial drug discovery in the 21st century

Author keywords

Anti infective; Antibacterial agents; Antibiotics; Drug discovery; Research; Resistance

Indexed keywords

7 [[(2 AMINO 5 CHLORO 4 THIAZOLYL)(HYDROXYIMINO)ACETYL]AMINO] 3 [[3 [[(2 AMINOETHYL)THIO]METHYL] 4 PYRIDINYL]THIO] 8 OXO 5 THIA 1 AZABICYCLO[4.2.0]OCT 2 ENE 2 CARBOXYLIC ACID; AMIKACIN; AMOXICILLIN; AMPICILLIN; ANALGESIC AGENT; ANESTHETIC AGENT; ANTHRAX VACCINE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; AZITHROMYCIN; AZTREONAM; BIOLOGICAL MARKER; CARDIOVASCULAR AGENT; CEFACLOR; CEFALEXIN; CEFALORIDINE; CEFALOTIN; CEFEPIME; CEFOPERAZONE; CEFOTAXIME; CEFRADINE; CEFTAZIDIME; CEFTOBIPROLE MEDOCARIL; CEFTRIAXONE; CENTRAL NERVOUS SYSTEM AGENTS; CIPROFLOXACIN; CLAVULANIC ACID; CLOXACILLIN; CYTOCHROME P450; DALBAVANCIN; DALFOPRISTIN PLUS QUINUPRISTIN; DAPTOMYCIN; DICLOXACILLIN; DORIPENEM; DOXYCYCLINE; ERTAPENEM; GARENOXACIN; GASTROINTESTINAL AGENT; GATIFLOXACIN; GEMIFLOXACIN; GENTAMICIN; HEMATOLOGIC AGENT; ICLAPRIM; IMIPENEM; IMMUNOGLOBULIN; IVERMECTIN; LEVOFLOXACIN; LINEZOLID; MEROPENEM; METICILLIN; MICONAZOLE; MINOCYCLINE; MONOAMINE OXIDASE INHIBITOR; MOXIFLOXACIN; NALIDIXIC ACID; NEW DRUG; NONSTEROID ANTIINFLAMMATORY AGENT; NORFLOXACIN; OFLOXACIN; ORITAVANCIN; OXACILLIN; PENICILLIN DERIVATIVE; PENICILLIN G; POLYMYXIN DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RAMOPLANIN; SPARFLOXACIN; STREPTOMYCIN; SULBACTAM; TAZOBACTAM; TELITHROMYCIN; TETRACYCLINE; TIGECYCLINE; TOBRAMYCIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

EID: 16644389654     PISSN: 14709465     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1465-0691.2004.1005.x     Document Type: Article
Times cited : (84)

References (40)
  • 1
    • 0040784412 scopus 로고    scopus 로고
    • The discovery of penicillin: So many get it wrong
    • Diggins FW. The discovery of penicillin: so many get it wrong. Biologist 2000; 47: 115-9.
    • (2000) Biologist , vol.47 , pp. 115-159
    • Diggins, F.W.1
  • 2
    • 0015687707 scopus 로고
    • Selman Abraham Waksman, PhD, 22 July 1888-16 August 1973. Streptomycin reported
    • Schatz A, Bugie E, Waksman SA. Selman Abraham Waksman, PhD, 22 July 1888-16 August 1973. Streptomycin reported. Ann Intern Med 1973, 79: 678.
    • (1973) Ann. Intern. Med. , vol.79 , pp. 678
    • Schatz, A.1    Bugie, E.2    Waksman, S.A.3
  • 3
    • 0000123301 scopus 로고
    • An enzyme from bacteria able to destroy penicillin
    • Abraham EP, Chain E. An enzyme from bacteria able to destroy penicillin. Nature 1940; 146: 837.
    • (1940) Nature , vol.146 , pp. 837
    • Abraham, E.P.1    Chain, E.2
  • 4
    • 0030633357 scopus 로고    scopus 로고
    • Origins, acquisition and dissemination of antibiotic resistance determinants
    • discussion 27-35
    • Davies JE. Origins, acquisition and dissemination of antibiotic resistance determinants. Ciba Foundation Symp 1997; 207: 15-27; discussion 27-35.
    • (1997) Ciba Foundation Symp. , vol.207 , pp. 15-27
    • Davies, J.E.1
  • 5
    • 0017748906 scopus 로고
    • Evidence for two distinct types of penicillinase-producing Neisseria gonorrhoeae
    • Perine PL, Schalla W, Siegel MS, et al. Evidence for two distinct types of penicillinase-producing Neisseria gonorrhoeae. Lancet 1977; 2: 993-7.
    • (1977) Lancet , vol.2 , pp. 993-997
    • Perine, P.L.1    Schalla, W.2    Siegel, M.S.3
  • 6
    • 0035477673 scopus 로고    scopus 로고
    • The emergence and evolution of methicillin-resistant Staphylococcus aureus
    • Hiramatsu K, Cui L, Kuroda M, Ito T. The emergence and evolution of methicillin-resistant Staphylococcus aureus. Trends Microbiol 2001; 9: 486-93.
    • (2001) Trends Microbiol. , vol.9 , pp. 486-493
    • Hiramatsu, K.1    Cui, L.2    Kuroda, M.3    Ito, T.4
  • 7
    • 0000766118 scopus 로고
    • Quinolone resistance in clinical practice: Occurrence and importance
    • 2nd Edn. (eds Hooper, DC, Wolfson, JS American Society for Microbiology)
    • 3. Peterson LR. Quinolone resistance in clinical practice: occurrence and importance. In: Quinolone Antimicrobial Agents, 2nd Edn. (eds Hooper, DC, Wolfson, JS American Society for Microbiology): 119-37.
    • (1993) Quinolone Antimicrobial Agents , pp. 119-137
    • Peterson, L.R.1
  • 8
    • 0014693167 scopus 로고
    • Gentamicin-resistant Staphylococcus aureus
    • Lacey RW, Mitchell AA. Gentamicin-resistant Staphylococcus aureus. Lancet 1969; 2: 1425-6.
    • (1969) Lancet , vol.2 , pp. 1425-1426
    • Lacey, R.W.1    Mitchell, A.A.2
  • 9
    • 0020325452 scopus 로고
    • Trapping of nonhydrolyzable cephalosporins by cephalosporinases in Enterobacter cloacae and Pseudomonas aeruginosa as a possible resistance mechanism
    • Then RL, Angehrn P. Trapping of nonhydrolyzable cephalosporins by cephalosporinases in Enterobacter cloacae and Pseudomonas aeruginosa as a possible resistance mechanism. Antimicrob Agents Chemother 1982; 21: 711-7.
    • (1982) Antimicrob. Agents Chemother. , vol.21 , pp. 711-717
    • Then, R.L.1    Angehrn, P.2
  • 10
    • 0021024916 scopus 로고
    • Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens
    • Knothe H, Shah P, Krcmery V, Antal M, Mitsuhashi S. Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Infection 1983; 11: 315-7.
    • (1983) Infection , vol.11 , pp. 315-317
    • Knothe, H.1    Shah, P.2    Krcmery, V.3    Antal, M.4    Mitsuhashi, S.5
  • 11
    • 0034011731 scopus 로고    scopus 로고
    • Linezolid
    • discussion 828
    • Clemett D, Markham A, Linezolid. Drugs 2000; 59: 815-27; discussion 828.
    • (2000) Drugs , vol.59 , pp. 815-827
    • Clemett, D.1    Markham, A.2
  • 12
    • 0842263829 scopus 로고    scopus 로고
    • Oxazolidinones activity, mode of action, and mechanism of resistance
    • Bozdogan B, Appelbaum PC. Oxazolidinones activity, mode of action, and mechanism of resistance. Int J Antimicrob Agents 2004; 23: 113-9.
    • (2004) Int. J. Antimicrob. Agents , vol.23 , pp. 113-139
    • Bozdogan, B.1    Appelbaum, P.C.2
  • 13
    • 0030628585 scopus 로고    scopus 로고
    • The evoution of β-lactamases
    • (eds Chadwick, DJ, Goode, J.). John Wiley & Sons Ciba Foundation Symposium, Vol
    • Bush K. The evoution of β-lactamases. In: Antibiotic Resistance: Origins, Evolution, Selection and Spread. (eds Chadwick, DJ, Goode, J.). John Wiley & Sons 1997,152-66. Ciba Foundation Symposium, Vol. 207.
    • (1997) Antibiotic Resistance: Origins, Evolution, Selection and Spread , vol.207 , pp. 152-166
    • Bush, K.1
  • 14
    • 0031029659 scopus 로고    scopus 로고
    • Evolution and dissemination of β-lactamases accelerated by generations of β-laclam antibiotics
    • Medeiros AA. Evolution and dissemination of β-lactamases accelerated by generations of β-laclam antibiotics. Clinic Infect Dis 1997; 24: S19-45.
    • (1997) Clinic. Infect. Dis. , vol.24
    • Medeiros, A.A.1
  • 15
    • 0032826448 scopus 로고    scopus 로고
    • Polymyxin B sulfate and colistin: Old antibiotics for emerging multiresistant Gram-negative bacteria
    • Evans ME, Feola DJ, Rapp RP. Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant Gram-negative bacteria. Ann Pharmacother 1999; 33: 960-7.
    • (1999) Ann. Pharmacother. , vol.33 , pp. 960-967
    • Evans, M.E.1    Feola, D.J.2    Rapp, R.P.3
  • 16
    • 1242314277 scopus 로고    scopus 로고
    • Community-acquired methicillin-resistant Staphylococcus aureus isolated in Switzerland contains the Panton-Valentine leukocidin or exfoliative toxin genes
    • Liassine N, Auckenthaler R, Descombes MC, Bes M, Vandenesch F, Etienne J. Community-acquired methicillin-resistant Staphylococcus aureus isolated in Switzerland contains the Panton-Valentine leukocidin or exfoliative toxin genes. J Clin Microbiol 2004; 42: 825-8.
    • (2004) J. Clin. Microbiol. , vol.42 , pp. 825-828
    • Liassine, N.1    Auckenthaler, R.2    Descombes, M.C.3    Bes, M.4    Vandenesch, F.5    Etienne, J.6
  • 17
    • 16644364407 scopus 로고    scopus 로고
    • The need for new antibiotics
    • Livermore DM. The need for new antibiotics. Clin Microbiol Infect 2004; 10(Suppl. 4): 1-9.
    • (2004) Clin. Microbiol. Infect. , vol.10 , Issue.SUPPL. 4 , pp. 1-9
    • Livermore, D.M.1
  • 18
    • 0018790675 scopus 로고
    • Legionnaires' disease more on staining and isolation of Legionella pneumophila
    • Porschen RK. Legionnaires' disease more on staining and isolation of Legionella pneumophila. N Engl J Med 1979; 300: 369-70.
    • (1979) N. Engl. J. Med. , vol.300 , pp. 369-370
    • Porschen, R.K.1
  • 20
    • 0023686268 scopus 로고
    • The Campylobacter pylori story
    • Marshall Bj. The Campylobacter pylori story. Scand J Gastroenterol 1988; 146(Suppl): 58-66.
    • (1988) Scand. J. Gastroenterol. , vol.146 , Issue.SUPPL. , pp. 58-66
    • Marshall, B.J.1
  • 21
    • 0033616862 scopus 로고    scopus 로고
    • Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serologicat evidence for Chlamydia pneumoniae infection: The AZithromycin in Coronary Artery Disease: Elimination if Myocardial Infection with Chlamydia (ACADEMIC) study
    • [See comment]
    • Anderson JL, Muhlestein JB, Carlquist J et al. Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serologicat evidence for Chlamydia pneumoniae infection: The AZithromycin in Coronary Artery Disease: Elimination if Myocardial Infection with Chlamydia (ACADEMIC) study. [See comment]. Circulation 1999; 99: 1540-7.
    • (1999) Circulation , vol.99 , pp. 1540-1547
    • Anderson, J.L.1    Muhlestein, J.B.2    Carlquist, J.3
  • 22
    • 0141853937 scopus 로고    scopus 로고
    • Atherogenic effects of Chlamydia pneunioniae: Refuting the innocent bystander hypothesis
    • Selzman CH, Netea MG, Zimmerman N4A, et al. Atherogenic effects of Chlamydia pneunioniae: refuting the innocent bystander hypothesis. J Thoracic Cardiovas Surg 2003, 126: 688-93.
    • (2003) J. Thoracic. Cardiovas. Surg. , vol.126 , pp. 688-693
    • Selzman, C.H.1    Netea, M.G.2    Zimmerman, N.A.3
  • 23
    • 0038813828 scopus 로고    scopus 로고
    • Detection of Chlamydia pneumoniae in cholesteatoma tissue: Any pathogenetic role?
    • Ronchetti F, Ronchetti R, Guglielmi F, et al. Detection of Chlamydia pneumoniae in cholesteatoma tissue: any pathogenetic role? Otol Neurotol 2003; 24: 353-7.
    • (2003) Otol. Neurotol. , vol.24 , pp. 353-357
    • Ronchetti, F.1    Ronchetti, R.2    Guglielmi, F.3
  • 24
  • 25
    • 0035909398 scopus 로고    scopus 로고
    • Genetic sleuths rush to identify anthrax strains in mail attacks
    • Dalton R. Genetic sleuths rush to identify anthrax strains in mail attacks. Nature 2001; 413: 657-8.
    • (2001) Nature , vol.413 , pp. 657-658
    • Dalton, R.1
  • 26
    • 0035216045 scopus 로고    scopus 로고
    • In vitro resistance of Bacillus anthracis Sterne to doxycycline, macrolicles and quinolones
    • Brook I, Elliott TB, Pryor HI, et al. In vitro resistance of Bacillus anthracis Sterne to doxycycline, macrolicles and quinolones. Int J Antimicrob Agents 2001; 18: 559-62.
    • (2001) Int. J. Antimicrob. Agents , vol.18 , pp. 559-562
    • Brook, I.1    Elliott, T.B.2    Pryor, H.I.3
  • 27
    • 1542327666 scopus 로고    scopus 로고
    • Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infc-Jion
    • Shen Y, Zhukovskaya NL, Zimmer MI, et al. Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infc-Jion. Proc Natl Acad Sci USA 2004; 101: 3242-7.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3242-3247
    • Shen, Y.1    Zhukovskaya, N.L.2    Zimmer, M.I.3
  • 29
    • 0035170062 scopus 로고    scopus 로고
    • Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG
    • Kang J, Wang L, Chen XL, Triggle DJ, Rampe D. Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG. Melec Pharmacol 2001; 59: 122-6.
    • (2001) Melec. Pharmacol. , vol.59 , pp. 122-126
    • Kang, J.1    Wang, L.2    Chen, X.L.3    Triggle, D.J.4    Rampe, D.5
  • 30
    • 0038778550 scopus 로고    scopus 로고
    • Safety and tolerability of linezolid
    • French G. Safety and tolerability of linezolid. J Antimicrob Chemother 2003, 51: ii45-53.
    • (2003) J. Antimicrob. Chemother. , vol.51
    • French, G.1
  • 31
    • 0036343455 scopus 로고    scopus 로고
    • The ketolides: A critical review
    • Zhanel GG, Walters M, Noreddin A, et al. The ketolides: a critical review. Drugs 2002; 62: 1771-804.
    • (2002) Drugs , vol.62 , pp. 1771-1804
    • Zhanel, G.G.1    Walters, M.2    Noreddin, A.3
  • 32
    • 0035338343 scopus 로고    scopus 로고
    • Risks in new drug development: Approval success rates for investigational drugs
    • Dimasi JA. Risks in new drug development: approval success rates for investigational drugs. Clin Pharmacol Therapeutics 2001; 69: 297-307.
    • (2001) Clin. Pharmacol. Therapeutics , vol.69 , pp. 297-307
    • Dimasi, J.A.1
  • 34
    • 0028895424 scopus 로고
    • Research and development costs for new drugs by therapeutic category. A study of the US pharmaceutical industry
    • DiMasi JA, Hansen RW, Grabowski HG, Lasagna L. Research and development costs for new drugs by therapeutic category. A study of the US pharmaceutical industry. Pharmacoeconomics 1995; 7: 152-69.
    • (1995) Pharmacoeconomics , vol.7 , pp. 152-169
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3    Lasagna, L.4
  • 35
    • 0141758355 scopus 로고    scopus 로고
    • Infectious diseases in the 21st century: Increasing threats, fewer new treatments and a premium on prevention
    • Projan SJ. Infectious diseases in the 21st century: increasing threats, fewer new treatments and a premium on prevention. Curr Opin Pharmacol 2003; 3: 457-8.
    • (2003) Curr. Opin. Pharmacol. , vol.3 , pp. 457-458
    • Projan, S.J.1
  • 36
    • 21744448422 scopus 로고    scopus 로고
    • IMS Health World Review
    • IMS Health World Review 2003.
    • (2003)
  • 37
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi JA, Hansen RW, Grabowski HG. The price of innovation: new estimates of drug development costs. J Health Econom 2003; 22: 151-85.
    • (2003) J. Health Econom. , vol.22 , pp. 151-185
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 38
    • 3943076153 scopus 로고    scopus 로고
    • Why it is important to continue antibacterial drug discovery
    • Bush K. Why it is important to continue antibacterial drug discovery. ASM News 2004; 70: 282-7.
    • (2004) ASM News , vol.70 , pp. 282-287
    • Bush, K.1
  • 39
    • 15544384259 scopus 로고    scopus 로고
    • Update: Antibacterial drug discovery: Is it all downhill from here?
    • Projan S, Shlaes D, Update: antibacterial drug discovery: is it all downhill from here? Clin Microbiol Infect 2004; 10(Suppl. 4): 18-22.
    • (2004) Clin. Microbiol. Infect. , vol.10 , Issue.SUPPL. 4 , pp. 18-22
    • Projan, S.1    Shlaes, D.2
  • 40
    • 16644367566 scopus 로고    scopus 로고
    • Antimicrobial drug development the past, the present, and the future
    • Powers JH. Antimicrobial drug development the past, the present, and the future. Clin Microbiol Infect 2004; 10(Suppl. 4): 23-30.
    • (2004) Clin. Microbiol. Infect. , vol.10 , Issue.SUPPL. 4 , pp. 23-30
    • Powers, J.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.