Novel antibiotics targeting respiratory ATP synthesis in gram-positive pathogenic bacteria

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 8, 2012, Pages 4131-4139

  Balemans, Wendy ^a   Vranckx, Luc ^a   Lounis, Nacer ^a   Pop, Ovidiu ^b,e   Guillemont, Jérôme ^c   Vergauwen, Karen ^a   Mol, Selena ^b,e   Gilissen, Ron ^d   Motte, Magali ^c   Lançois, David ^c   De Bolle, Miguel ^a   Bonroy, Kristien ^a   Lill, Holger ^b,e   Andries, Koen ^a   Bald, Dirk ^b,e   Koul, Anil ^a  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c JOHNSON AND JOHNSON   (United States)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^e AMSTERDAM INSTITUTE FOR MOLECULES   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BEDAQUILINE; DICYCLOHEXYLCARBODIIMIDE; LEVOFLOXACIN; LINEZOLID; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; QUINOLINE DERIVATIVE;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; BIOFILM; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; GENE MUTATION; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ATP SYNTHETASE COMPLEXES; BIOFILMS; CELL LINE, TUMOR; DRUG RESISTANCE, BACTERIAL; GRAM-POSITIVE BACTERIA; HELA CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; MITOCHONDRIA; MYCOBACTERIUM TUBERCULOSIS; QUINOLINES; SEQUENCE ALIGNMENT; STAPHYLOCOCCUS AUREUS;

EID: 84864381330     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00273-12     Document Type: Article

References (41)

1. Andries K, et al. 2005. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307:223-227. (Pubitemid 40116230)
2. Augustin J, Gotz F. 1990. Transformation of Staphylococcus epidermidis and other staphylococcal species with plasmid DNA by electroporation. FEMS Microbiol. Lett. 54:203-207.
3. Bald D, Koul A. 2010. Respiratory ATP synthesis: the new generation of mycobacterial drug targets? FEMS Microbiol. Lett. 308:1-7.
4. Bald D, Noji H, Stumpp MT, Yoshida M, Hisabori T. 2000. ATPase activity of a highly stable alpha(3)beta(3)gamma subcomplex of thermophilic F(1) can be regulated by the introduced regulatory region of gamma subunit of chloroplast F(1). J. Biol. Chem. 275:12757-12762. (Pubitemid 30241429)
5. Boucher HW, et al. 2009. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America Clin. Infect. Dis. 48:1-12.
6. Braine T. 2011. Race against time to develop new antibiotics. Bull. World Health Organ. 89:88-89.
7. Ceri H, et al. 1999. The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J. Clin. Microbiol. 37:1771-1776. (Pubitemid 29235221)
8. CLSI. 2011. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard M07-A8, 8th edition, vol. 29, no. 2. CLSI, Wayne, PA.
9. Cotter PD, Gahan CG, Hill C. 2000. Analysis of the role of the Listeria monocytogenes F0F1-AtPase operon in the acid tolerance response. Int. J. Food Microbiol. 60:137-146.
10. Cox RA, Cook GM. 2007. Growth regulation in the mycobacterial cell. Curr. Mol. Med. 7:231-245. (Pubitemid 46767784)
11. Ferrandiz MJ, de la Campa AG. 2002. The membrane-associated F(0)F(1) ATPase is essential for the viability of Streptococcus pneumoniae. FEMS Microbiol. Lett. 212:133-138. (Pubitemid 34655599)
12. Fischbach MA, Walsh CT. 2009. Antibiotics for emerging pathogens. Science 325:1089-1093.
13. Foster JW, Hall HK. 1991. Inducible pH homeostasis and the acid tolerance response of Salmonella typhimurium. J. Bacteriol. 173:5129-5135.
14. Garcia JJ, Ogilvie I, Robinson BH, Capaldi RA. 2000. Structure, functioning, and assembly of the ATP synthase in cells from patients with the T8993G mitochondrial DNA mutation. Comparison with the enzyme in Rho(0) cells completely lacking mtdna. J. Biol. Chem. 275:11075-11081. (Pubitemid 30212749)
15. Haagsma AC, et al. 2009. Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue. Antimicrob. Agents Chemother. 53:1290-1292.
16. Haagsma AC, Driessen NN, Hahn MM, Lill H, Bald D. 2010. ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction. FEMS Microbiol. Lett. 313:68-74.
17. Haagsma AC, et al. 2011. Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase. PLoS One 6:e23575. doi:10.1371/journal.pone.0023575.
18. Hauschild T, Luthje P, Schwarz S. 2005. Staphylococcal tetracycline-MLSB resistance plasmid pSTE2 is the product of an RSA-mediated in vivo recombination. J. Antimicrob. Chemother. 56:399-402. (Pubitemid 41158532)
19. Hurdle JG, O'Neill AJ, Chopra I, Lee RE. 2011. Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nat. Rev. Microbiol. 9:62-75.
20. Junge W, Sielaff H, Engelbrecht S. 2009. Torque generation and elastic power transmission in the rotary F(O)F(1)-ATPase. Nature 459:364-370.
21. Klionsky DJ, Brusilow WS, Simoni RD. 1984. In vivo evidence for the role of the epsilon subunit as an inhibitor of the proton-translocating ATPase of Escherichia coli. J. Bacteriol. 160:1055-1060. (Pubitemid 15219479)
22. Ko HSY, et al. 2011. Screening of essential genes in Staphylococcus aureus N315 using comparative genomics and allelic replacement mutagenesis. J. Microbiol. Biotechnol. 16:623-632.
23. Koul A, Arnoult E, Lounis N, Guillemont J, Andries K. 2011. The challenge of new drug discovery for tuberculosis. Nature 469:483-490.
24. Koul A, et al. 2007. Diarylquinolines target subunit c of mycobacterial ATP synthase. Nat. Chem. Biol. 3:323-324. (Pubitemid 46789271)
25. Koul A, et al. 2008. Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis. J. Biol. Chem. 283:25273-25280.
26. Lewis K. 2007. Persister cells, dormancy and infectious disease. Nat. Rev. Microbiol. 5:48-56. (Pubitemid 44942303)
27. Lu P, et al. 2011. Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels. Antimicrob. Agents Chemother. 55:5354-5357.
28. O'Neill AJ, McLaws F, Kahlmeter G, Henriksen AS, Chopra I. 2007. Genetic basis of resistance to fusidic acid in staphylococci. Antimicrob. Agents Chemother. 51:1737-1740. (Pubitemid 46744153)
29. Rao SP, Alonso S, Rand L, Dick T, Pethe K. 2008. The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A. 105:11945-11950.
30. Resch A, Rosenstein R, Nerz C, Gotz F. 2005. Differential gene expression profiling of Staphylococcus aureus cultivated under biofilm and planktonic conditions. Appl. Environ. Microbiol. 71:2663-2676. (Pubitemid 40647013)
31. Rhee KY, et al. 2011. Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol. 19:307-314.
32. Santana M, et al. 1994. Bacillus subtilis F0F1 ATPase: DNA sequence of the atp operon and characterization of atp mutants. J. Bacteriol. 176:6802-6811. (Pubitemid 24349416)
33. Sassetti CM, Rubin EJ. 2007. The open book of infectious diseases. Nat. Med. 13:279-280. (Pubitemid 46376667)
34. Spellberg B, et al. 2011. Combating antimicrobial resistance: policy recommendations to save lives. Clin. Infect. Dis. 52(Suppl 5):S397-S428.
35. Stewart PS, Franklin MJ. 2008. Physiological heterogeneity in biofilms. Nat. Rev. Microbiol. 6:199-210. (Pubitemid 351256315)
36. Suzuki T, Ueno H, Mitome N, Suzuki J, Yoshida M. 2002. F(0) of ATP synthase is a rotary proton channel. Obligatory coupling of proton translocation with rotation of c-subunit ring. J. Biol. Chem. 277:13281-13285. (Pubitemid 34952699)
37. Talbot GH, et al. 2006. Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America. Clin. Infect. Dis. 42:657-668. (Pubitemid 43271379)
38. Tran SL, Cook GM. 2005. The F1Fo-ATP synthase of Mycobacterium smegmatis is essential for growth. J. Bacteriol. 187:5023-5028. (Pubitemid 40962223)
39. Wagner S, et al. 2008. Tuning Escherichia coli for membrane protein overexpression. Proc. Natl. Acad. Sci. U. S. A. 105:14371-14376.
40. Weinstein EA, et al. 2005. Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs. Proc. Natl. Acad. Sci. U. S. A. 102:4548-4553. (Pubitemid 40397149)
41. Xie DL, et al. 1993. The atp2 operon of the green bacterium Chlorobium limicola. Biochim. Biophys. Acta 1172:267-273.