메뉴 건너뛰기




Volumn 7, Issue 1, 2017, Pages

NAD+ loss, a new player in AhR biology: Prevention of thymus atrophy and hepatosteatosis by NAD+ repletion

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; DIOXIN; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; SIRTUIN;

EID: 85019612811     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-02332-9     Document Type: Article
Times cited : (35)

References (47)
  • 1
    • 0028006520 scopus 로고
    • The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds
    • Okey, A. B., Riddick, D. S. & Harper, P. A. The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Toxicol. Lett. 70, 1-22 (1994).
    • (1994) Toxicol. Lett. , vol.70 , pp. 1-22
    • Okey, A.B.1    Riddick, D.S.2    Harper, P.A.3
  • 2
    • 0038381492 scopus 로고    scopus 로고
    • Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor
    • Bunger, M. K. et al. Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem 278, 17767-17774 (2003).
    • (2003) J Biol Chem , vol.278 , pp. 17767-17774
    • Bunger, M.K.1
  • 3
    • 0020010617 scopus 로고
    • 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
    • Poland, A. & Knutson, J. C. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22, 517-554 (1982).
    • (1982) Annu. Rev. Pharmacol. Toxicol. , vol.22 , pp. 517-554
    • Poland, A.1    Knutson, J.C.2
  • 4
    • 34447530842 scopus 로고    scopus 로고
    • An aryl hydrocarbon receptor odyssey to the shores of toxicology: The Deichmann Lecture, International Congress of Toxicology-XI
    • Okey, A. B. An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI. Toxicol. Sci. 98, 5-38 (2007).
    • (2007) Toxicol. Sci. , vol.98 , pp. 5-38
    • Okey, A.B.1
  • 5
    • 59149097949 scopus 로고    scopus 로고
    • Regulation of constitutive and inducible AHR signaling: Complex interactions involving the AHR repressor
    • Hahn, M. E., Allan, L. L. & Sherr, D. H. Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor. Biochem. Pharmacol. 77, 485-497 (2009).
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 485-497
    • Hahn, M.E.1    Allan, L.L.2    Sherr, D.H.3
  • 6
    • 33751440795 scopus 로고    scopus 로고
    • Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice
    • Boverhof, D. R. et al. Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice. Toxicol. Sci 94, 398-416 (2006).
    • (2006) Toxicol. Sci , vol.94 , pp. 398-416
    • Boverhof, D.R.1
  • 7
    • 78649901987 scopus 로고    scopus 로고
    • Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect
    • Diani-Moore, S. et al. Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect. J. Biol. Chem. 285, 38801-38810 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 38801-38810
    • Diani-Moore, S.1
  • 8
    • 84869121812 scopus 로고    scopus 로고
    • Exploring the therapeutic space around NAD+
    • Houtkooper, R. H. & Auwerx, J. Exploring the therapeutic space around NAD+. J. Cell Biol. 199, 205-209 (2012).
    • (2012) J. Cell Biol. , vol.199 , pp. 205-209
    • Houtkooper, R.H.1    Auwerx, J.2
  • 9
    • 0035976732 scopus 로고    scopus 로고
    • TCDD-inducible poly(ADP-ribose) polymerase: A novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Ma, Q., Baldwin, K. T., Renzelli, A. J., McDaniel, A. & Dong, L. TCDD-inducible poly(ADP-ribose) polymerase: a novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. Biophys. Res. Commun. 289, 499-506 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.289 , pp. 499-506
    • Ma, Q.1    Baldwin, K.T.2    Renzelli, A.J.3    McDaniel, A.4    Dong, L.5
  • 10
    • 71049126064 scopus 로고    scopus 로고
    • Dioxin-dependent and dioxin-independent gene batteries: Comparison of liver and kidney in AHR-null mice
    • Boutros, P. C., Bielefeld, K. A., Pohjanvirta, R. & Harper, P. A. Dioxin-dependent and dioxin-independent gene batteries: comparison of liver and kidney in AHR-null mice. Toxicol. Sci 112, 245-256 (2009).
    • (2009) Toxicol. Sci , vol.112 , pp. 245-256
    • Boutros, P.C.1    Bielefeld, K.A.2    Pohjanvirta, R.3    Harper, P.A.4
  • 11
    • 30044452058 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries
    • Tijet, N. et al. Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries. Mol. Pharmacol. 69, 140-153 (2006).
    • (2006) Mol. Pharmacol. , vol.69 , pp. 140-153
    • Tijet, N.1
  • 12
    • 0142179992 scopus 로고    scopus 로고
    • Cell proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor
    • Laiosa, M. D. et al. Cell proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor. J. Immunol. 171, 4582-4591 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 4582-4591
    • Laiosa, M.D.1
  • 13
    • 20544460373 scopus 로고    scopus 로고
    • Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDDmediated hepatotoxicity
    • Boverhof, D. R. et al. Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDDmediated hepatotoxicity. Toxicol. Sci. 85, 1048-1063 (2005).
    • (2005) Toxicol. Sci. , vol.85 , pp. 1048-1063
    • Boverhof, D.R.1
  • 14
    • 84865355122 scopus 로고    scopus 로고
    • Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice
    • Angrish, M. M., Mets, B. D., Jones, A. D. & Zacharewski, T. R. Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice. Toxicol. Sci 128, 377-386 (2012).
    • (2012) Toxicol. Sci , vol.128 , pp. 377-386
    • Angrish, M.M.1    Mets, B.D.2    Jones, A.D.3    Zacharewski, T.R.4
  • 15
    • 77955488532 scopus 로고    scopus 로고
    • A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis
    • Lee, J. H. et al. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology 139, 653-663 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 653-663
    • Lee, J.H.1
  • 16
    • 84873694897 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADPribosyltransferase and repressor of aryl hydrocarbon receptor transactivation
    • MacPherson, L. et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADPribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res 41, 1604-1621 (2013).
    • (2013) Nucleic Acids Res , vol.41 , pp. 1604-1621
    • MacPherson, L.1
  • 17
    • 10944270187 scopus 로고    scopus 로고
    • The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
    • Revollo, J. R., Grimm, A. A. & Imai, S. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J. Biol. Chem. 279, 50754-50763 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 50754-50763
    • Revollo, J.R.1    Grimm, A.A.2    Imai, S.3
  • 18
    • 2342550554 scopus 로고    scopus 로고
    • Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
    • Bieganowski, P. & Brenner, C. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell 117, 495-502 (2004).
    • (2004) Cell , vol.117 , pp. 495-502
    • Bieganowski, P.1    Brenner, C.2
  • 19
    • 84862022077 scopus 로고    scopus 로고
    • The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat dietinduced obesity
    • Canto, C. et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat dietinduced obesity. Cell Metab. 15, 838-847 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 838-847
    • Canto, C.1
  • 20
    • 79953752384 scopus 로고    scopus 로고
    • PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
    • Bai, P. et al. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 13, 461-468 (2011).
    • (2011) Cell Metab. , vol.13 , pp. 461-468
    • Bai, P.1
  • 21
    • 84868519888 scopus 로고    scopus 로고
    • Histone H2AX phosphorylation: A marker for DNA damage
    • Sharma, A., Singh, K. & Almasan, A. Histone H2AX phosphorylation: a marker for DNA damage. Methods Mol. Biol 920, 613-626 (2012).
    • (2012) Methods Mol. Biol , vol.920 , pp. 613-626
    • Sharma, A.1    Singh, K.2    Almasan, A.3
  • 22
    • 0035289536 scopus 로고    scopus 로고
    • Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke
    • Abdelkarim, G. E. et al. Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int. J. Mol. Med. 7, 255-260 (2001).
    • (2001) Int. J. Mol. Med. , vol.7 , pp. 255-260
    • Abdelkarim, G.E.1
  • 23
    • 33750445309 scopus 로고    scopus 로고
    • NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity
    • Yang, T. & Sauve, A. A. NAD Metabolism and Sirtuins: Metabolic Regulation of Protein Deacetylation in Stress and Toxicity. AAPS J. 8, E632-643 (2006).
    • (2006) AAPS J. , vol.8 , pp. E632-643
    • Yang, T.1    Sauve, A.A.2
  • 24
    • 84930687902 scopus 로고    scopus 로고
    • Nuclear ADP-ribosylation and its role in chromatin plasticity, cell differentiation, and epigenetics
    • Hottiger, M. O. Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics. Annu. Rev. Biochem. 84, 227-263 (2015).
    • (2015) Annu. Rev. Biochem. , vol.84 , pp. 227-263
    • Hottiger, M.O.1
  • 25
    • 31044445366 scopus 로고    scopus 로고
    • Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    • Mostoslavsky, R. et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329 (2006).
    • (2006) Cell , vol.124 , pp. 315-329
    • Mostoslavsky, R.1
  • 26
    • 77956315551 scopus 로고    scopus 로고
    • Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis
    • Kim, H. S. et al. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 12, 224-236 (2010).
    • (2010) Cell Metab. , vol.12 , pp. 224-236
    • Kim, H.S.1
  • 27
    • 69249221533 scopus 로고    scopus 로고
    • Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6
    • Michishita, E. et al. Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Cell Cycle 8, 2664-2666 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 2664-2666
    • Michishita, E.1
  • 29
    • 41349090663 scopus 로고    scopus 로고
    • SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
    • Michishita, E. et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452, 492-496 (2008).
    • (2008) Nature , vol.452 , pp. 492-496
    • Michishita, E.1
  • 30
    • 85006641138 scopus 로고    scopus 로고
    • PARP inhibition protects against alcoholic and nonalcoholic steatohepatitis
    • Mukhopadhyay, P. PARP inhibition protects against alcoholic and nonalcoholic steatohepatitis. Journal of hepatology (2016).
    • (2016) Journal of Hepatology
    • Mukhopadhyay, P.1
  • 31
    • 84950327004 scopus 로고    scopus 로고
    • Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice
    • Gariani, K. et al. Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology 63, 1190-1204 (2016).
    • (2016) Hepatology , vol.63 , pp. 1190-1204
    • Gariani, K.1
  • 32
    • 84995578451 scopus 로고    scopus 로고
    • Steatohepatitis: PARP inhibition protective against alcoholic steatohepatitis and NASH
    • Ray, K. Steatohepatitis: PARP inhibition protective against alcoholic steatohepatitis and NASH. Nature reviews. Gastroenterology & hepatology 14, 3 (2017).
    • (2017) Nature Reviews. Gastroenterology & Hepatology , vol.14 , pp. 3
    • Ray, K.1
  • 33
    • 84937555760 scopus 로고    scopus 로고
    • Biology of poly(ADP-ribose) polymerases: The factotums of cell maintenance
    • Bai, P. Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance. Mol Cell 58, 947-958 (2015).
    • (2015) Mol Cell , vol.58 , pp. 947-958
    • Bai, P.1
  • 34
    • 79952032653 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats
    • Yang, S. J. et al. Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. PLoS One 6, e17057 (2011).
    • (2011) PLoS One , vol.6 , pp. e17057
    • Yang, S.J.1
  • 35
    • 58149090925 scopus 로고    scopus 로고
    • SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
    • Kawahara, T. L. et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 136, 62-74 (2009).
    • (2009) Cell , vol.136 , pp. 62-74
    • Kawahara, T.L.1
  • 36
    • 84878971275 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3
    • He, J. et al. Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3. Mol Cell Biol 33, 2047-2055 (2013).
    • (2013) Mol Cell Biol , vol.33 , pp. 2047-2055
    • He, J.1
  • 37
    • 38149118871 scopus 로고    scopus 로고
    • The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues
    • Hakme, A., Huber, A., Dolle, P. & Schreiber, V. The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues. Dev. Dyn. 237, 209-215 (2008).
    • (2008) Dev. Dyn. , vol.237 , pp. 209-215
    • Hakme, A.1    Huber, A.2    Dolle, P.3    Schreiber, V.4
  • 39
    • 0032865455 scopus 로고    scopus 로고
    • Detection of immunotoxicity of benzo[a]pyrene in a subacute toxicity study after oral exposure in rats
    • De Jong, W. H., Kroese, E. D., Vos, J. G. & Van Loveren, H. Detection of immunotoxicity of benzo[a]pyrene in a subacute toxicity study after oral exposure in rats. Toxicol. Sci 50, 214-220 (1999).
    • (1999) Toxicol. Sci , vol.50 , pp. 214-220
    • De Jong, W.H.1    Kroese, E.D.2    Vos, J.G.3    Van Loveren, H.4
  • 40
    • 0024342824 scopus 로고
    • Evaluation of the immunotoxicity of low level PCB exposure in the rat
    • Smialowicz, R. J. et al. Evaluation of the immunotoxicity of low level PCB exposure in the rat. Toxicology 56, 197-211 (1989).
    • (1989) Toxicology , vol.56 , pp. 197-211
    • Smialowicz, R.J.1
  • 41
    • 0036132764 scopus 로고    scopus 로고
    • Evaluation of the potential effects of ingredients added to cigarettes.Part 4: Subchronic inhalation toxicity
    • Vanscheeuwijck, P. M. et al. Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity. Food Chem. Toxicol 40, 113-131 (2002).
    • (2002) Food Chem. Toxicol , vol.40 , pp. 113-131
    • Vanscheeuwijck, P.M.1
  • 42
    • 38149094985 scopus 로고    scopus 로고
    • Arsenite-induced thymus atrophy is mediated by cell cycle arrest: A characteristic downregulation of E2F-related genes revealed by a microarray approach
    • Nohara, K. et al. Arsenite-induced thymus atrophy is mediated by cell cycle arrest: a characteristic downregulation of E2F-related genes revealed by a microarray approach. Toxicol. Sci 101, 226-238 (2008).
    • (2008) Toxicol. Sci , vol.101 , pp. 226-238
    • Nohara, K.1
  • 43
    • 79953752384 scopus 로고    scopus 로고
    • PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
    • Bai, P. et al. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab 13, 461-468 (2011).
    • (2011) Cell Metab , vol.13 , pp. 461-468
    • Bai, P.1
  • 44
    • 20344371900 scopus 로고    scopus 로고
    • Insights into thymic aging and regeneration
    • Taub, D. D. & Longo, D. L. Insights into thymic aging and regeneration. Immunol. Rev. 205, 72-93 (2005).
    • (2005) Immunol. Rev. , vol.205 , pp. 72-93
    • Taub, D.D.1    Longo, D.L.2
  • 45
    • 84864401965 scopus 로고    scopus 로고
    • Age-associated changes in oxidative stress and NAD(+) metabolism in human tissue
    • Massudi, H. et al. Age-Associated Changes In Oxidative Stress and NAD(+) Metabolism In Human Tissue. PLoS One 7, e42357.
    • PLoS One , vol.7 , pp. e42357
    • Massudi, H.1
  • 46
    • 0028071185 scopus 로고
    • Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver
    • Rifkind, A. B., Kanetoshi, A., Orlinick, J., Capdevila, J. H. & Lee, C. Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver. J Biol Chem 269, 3387-3396 (1994).
    • (1994) J Biol Chem , vol.269 , pp. 3387-3396
    • Rifkind, A.B.1    Kanetoshi, A.2    Orlinick, J.3    Capdevila, J.H.4    Lee, C.5
  • 47
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
    • Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 25, 402-408 (2001).
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.