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Volumn , Issue , 2013, Pages 429-445

LC-MS Bioanalysis of Ester Prodrugs and Other Esterase Labile Molecules

Author keywords

Dried blood spots; Enzyme inhibitors; Ester prodrugs; Esterase labile molecules; Incurred sample reanalysis; PH control; Stability assessment

Indexed keywords

BLOOD; ENZYME INHIBITION; MOLECULES; PLASMA STABILITY; SYSTEM STABILITY;

EID: 85019327183     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118671276.ch34     Document Type: Chapter
Times cited : (6)

References (44)
  • 1
    • 0000312120 scopus 로고
    • Serum esterases
    • Aldrige WN. Serum esterases. Biochem J 1952;53:110-117.
    • (1952) Biochem J , vol.53 , pp. 110-117
    • Aldrige, W.N.1
  • 2
    • 78650658989 scopus 로고    scopus 로고
    • Impact of plasma and whole-blood anticoagulant counter ion choice on drug stability and matrix effects during bioanalysis
    • Bergeron M, Bergeron A, Furtado M, Garofolo F. Impact of plasma and whole-blood anticoagulant counter ion choice on drug stability and matrix effects during bioanalysis. Bioanalysis 2009;1(3):537-548.
    • (2009) Bioanalysis , vol.1 , Issue.3 , pp. 537-548
    • Bergeron, M.1    Bergeron, A.2    Furtado, M.3    Garofolo, F.4
  • 3
    • 0000996349 scopus 로고
    • A new type of esterase in hogkidney extract
    • Bergmann F, Segal R, Rimon S. A new type of esterase in hogkidney extract. Biochem J 1957;67(3):481-486.
    • (1957) Biochem J , vol.67 , Issue.3 , pp. 481-486
    • Bergmann, F.1    Segal, R.2    Rimon, S.3
  • 4
    • 78650668645 scopus 로고    scopus 로고
    • Factors affecting the stability of drugs and drug metabolites in biological matrices
    • Briscoe CJ, Hage DS. Factors affecting the stability of drugs and drug metabolites in biological matrices. Bioanalysis 2009;1(1):205-220.
    • (2009) Bioanalysis , vol.1 , Issue.1 , pp. 205-220
    • Briscoe, C.J.1    Hage, D.S.2
  • 5
    • 43949089130 scopus 로고    scopus 로고
    • A method for quantifying the unstable and highly polar drug nafamostat mesilate in human plasma with optimized solid-phase extraction and ESI-MS detection: more accurate evaluation for pharmacokinetic study
    • Cao YG, Zhang M, Yu D, Shao JP, Chen YC, Liu XQ. A method for quantifying the unstable and highly polar drug nafamostat mesilate in human plasma with optimized solid-phase extraction and ESI-MS detection: more accurate evaluation for pharmacokinetic study. Anal Bioanal Chem 2008;391(3):1063-1071.
    • (2008) Anal Bioanal Chem , vol.391 , Issue.3 , pp. 1063-1071
    • Cao, Y.G.1    Zhang, M.2    Yu, D.3    Shao, J.P.4    Chen, Y.C.5    Liu, X.Q.6
  • 6
    • 70349512947 scopus 로고    scopus 로고
    • Studies on the influence of esterase inhibitor to the pharmacokinetic profiles of oseltamivir and oseltamivir carboxylate in rats using an improved LC/MS/MS method
    • Chang Q, Chow MS, Zuo Z. Studies on the influence of esterase inhibitor to the pharmacokinetic profiles of oseltamivir and oseltamivir carboxylate in rats using an improved LC/MS/MS method. Biomed Chromatogr 2009;23(8):852-857.
    • (2009) Biomed Chromatogr , vol.23 , Issue.8 , pp. 852-857
    • Chang, Q.1    Chow, M.S.2    Zuo, Z.3
  • 7
    • 26444483440 scopus 로고    scopus 로고
    • Stabilizing drug molecules in biological samples
    • Chen J, Hsieh Y. Stabilizing drug molecules in biological samples. Ther Drug Monit 2005;27(5):617-624.
    • (2005) Ther Drug Monit , vol.27 , Issue.5 , pp. 617-624
    • Chen, J.1    Hsieh, Y.2
  • 8
    • 78650655207 scopus 로고    scopus 로고
    • DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors
    • D'Arienzo CJ, Ji QC, Discenza L, et al. DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors. Bioanalysis 2010;2(8):1415-1422.
    • (2010) Bioanalysis , vol.2 , Issue.8 , pp. 1415-1422
    • D'Arienzo, C.J.1    Ji, Q.C.2    Discenza, L.3
  • 9
    • 0035043976 scopus 로고    scopus 로고
    • Effect of anticoagulants and storage temperatures on stability of plasma and serum hormones
    • Evans MJ, Livesey JH, Ellis MJ, Yandle TG. Effect of anticoagulants and storage temperatures on stability of plasma and serum hormones. Clin Biochem 2001;34(2):107-112.
    • (2001) Clin Biochem , vol.34 , Issue.2 , pp. 107-112
    • Evans, M.J.1    Livesey, J.H.2    Ellis, M.J.3    Yandle, T.G.4
  • 10
    • 79959404112 scopus 로고    scopus 로고
    • Blood stability testing: European bioanalysis forum view on current challenges for regulated bioanalysis
    • Freisleben A, Brudny-Klöppel M, Mulder H, de Vries R, de Zwart M, Timmerman P. Blood stability testing: European bioanalysis forum view on current challenges for regulated bioanalysis. Bioanalysis 2011;3(12):1333-1336.
    • (2011) Bioanalysis , vol.3 , Issue.12 , pp. 1333-1336
    • Freisleben, A.1    Brudny-Klöppel, M.2    Mulder, H.3    De Vries, R.4    De Zwart, M.5    Timmerman, P.6
  • 11
    • 78650643244 scopus 로고    scopus 로고
    • Effective screening approach to select esterase inhibitors used for stabilizing ester-containing prodrugs analyzed by LC-MS/MS
    • Fung EN, Zheng N, Arnold ME, Zeng J. Effective screening approach to select esterase inhibitors used for stabilizing ester-containing prodrugs analyzed by LC-MS/MS. Bioanalysis 2010;2(4):733-743.
    • (2010) Bioanalysis , vol.2 , Issue.4 , pp. 733-743
    • Fung, E.N.1    Zheng, N.2    Arnold, M.E.3    Zeng, J.4
  • 12
    • 79952025597 scopus 로고    scopus 로고
    • Determination of oseltamivir (Tamiflu-R) and oseltamivir carboxylate in dried blood spots using offline or online extraction
    • Heinig K, Wirz T, Bucheli F, Gajate-Perez A. Determination of oseltamivir (Tamiflu-R) and oseltamivir carboxylate in dried blood spots using offline or online extraction. Bioanalysis 2011;3(4):421-437.
    • (2011) Bioanalysis , vol.3 , Issue.4 , pp. 421-437
    • Heinig, K.1    Wirz, T.2    Bucheli, F.3    Gajate-Perez, A.4
  • 13
    • 77951247279 scopus 로고    scopus 로고
    • Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine
    • Ishizuka T, Fujimori I, Kato M, et al. Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine. J Biol Chem 2010;285(16):11892-11902.
    • (2010) J Biol Chem , vol.285 , Issue.16 , pp. 11892-11902
    • Ishizuka, T.1    Fujimori, I.2    Kato, M.3
  • 14
    • 80555131102 scopus 로고    scopus 로고
    • Method development and validation of the simultaneous determination of a novel topoisomerase 1 inhibitor, the prodrug, and the active metabolite in human plasma using column-switching LC-MS/MS, and its application in a clinical trial
    • Kamei T, Uchimura T, Nishimiya K, Kawanishi T. Method development and validation of the simultaneous determination of a novel topoisomerase 1 inhibitor, the prodrug, and the active metabolite in human plasma using column-switching LC-MS/MS, and its application in a clinical trial. J Chromatogr B Analyt Technol Biomed Life Sci 2011;879(30):3415-3422.
    • (2011) J Chromatogr B Analyt Technol Biomed Life Sci , vol.879 , Issue.30 , pp. 3415-3422
    • Kamei, T.1    Uchimura, T.2    Nishimiya, K.3    Kawanishi, T.4
  • 15
    • 77957021259 scopus 로고    scopus 로고
    • Determination of a peroxisome proliferator-activated receptor γ agonist, 1-(transmethylimino-N-oxy)-6-(2-morpholinoethoxy-3-phenyl-1Hindene-2-carboxylic acid ethyl ester (KR-62980) in rat plasma by liquid chromatography-tandem mass spectrometry
    • Kim MS, Song JS, Roh H, et al. Determination of a peroxisome proliferator-activated receptor γ agonist, 1-(transmethylimino-N-oxy)-6-(2-morpholinoethoxy-3-phenyl-1Hindene-2-carboxylic acid ethyl ester (KR-62980) in rat plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 2011;54(1):121-126.
    • (2011) J Pharm Biomed Anal , vol.54 , Issue.1 , pp. 121-126
    • Kim, M.S.1    Song, J.S.2    Roh, H.3
  • 16
    • 70449526714 scopus 로고    scopus 로고
    • Improving the ex vivo stability of drug ester compounds in rat and dog serum: inhibition of the specific esterases and implications on their identity
    • Koitka M, Höchel J, Gieschen H, Borchert HH. Improving the ex vivo stability of drug ester compounds in rat and dog serum: inhibition of the specific esterases and implications on their identity. J Pharm Biomed Anal 2010;51(3):664-678.
    • (2010) J Pharm Biomed Anal , vol.51 , Issue.3 , pp. 664-678
    • Koitka, M.1    Höchel, J.2    Gieschen, H.3    Borchert, H.H.4
  • 17
    • 84858624941 scopus 로고    scopus 로고
    • Quantitative determination of oseltamivir and oseltamivir carboxylate in human fluoride EDTA plasma including the ex vivo stability using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
    • Kromdijk W, Rosing H, van den Broek MP, Beijnen JH, Huitema AD. Quantitative determination of oseltamivir and oseltamivir carboxylate in human fluoride EDTA plasma including the ex vivo stability using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2012;891-892:57-63.
    • (2012) J Chromatogr B Analyt Technol Biomed Life Sci , vol.891-892 , pp. 57-63
    • Kromdijk, W.1    Rosing, H.2    Van Den Broek, M.P.3    Beijnen, J.H.4    Huitema, A.D.5
  • 18
    • 0033917858 scopus 로고    scopus 로고
    • Phenacetin deacetylase activity in human liver microsomes: distribution, kinetics, and chemical inhibition and stimulation
    • Kudo S, Umehara K, Hosokawa M, Miyamoto G, Chiba K, Satouh T. Phenacetin deacetylase activity in human liver microsomes: distribution, kinetics, and chemical inhibition and stimulation. J Pharmacol Exp Ther 2000;294(1):80-87.
    • (2000) J Pharmacol Exp Ther , vol.294 , Issue.1 , pp. 80-87
    • Kudo, S.1    Umehara, K.2    Hosokawa, M.3    Miyamoto, G.4    Chiba, K.5    Satouh, T.6
  • 19
    • 75149186915 scopus 로고    scopus 로고
    • Dried blood spot sampling in combination with LCMS/MS for quantitative analysis of small molecules
    • Li W, Tse FL. Dried blood spot sampling in combination with LCMS/MS for quantitative analysis of small molecules. Biomed Chromatogr 2010;24(1):49-65.
    • (2010) Biomed Chromatogr , vol.24 , Issue.1 , pp. 49-65
    • Li, W.1    Tse, F.L.2
  • 20
    • 78650633249 scopus 로고    scopus 로고
    • Strategies in quantitative LC-MS/MS analysis of unstable small molecules in biological matrices
    • Li W, Zhang J, Tse FL. Strategies in quantitative LC-MS/MS analysis of unstable small molecules in biological matrices. Biomed Chromatogr 2011;25(1-2):258-277.
    • (2011) Biomed Chromatogr , vol.25 , Issue.1-2 , pp. 258-277
    • Li, W.1    Zhang, J.2    Tse, F.L.3
  • 21
    • 27944503828 scopus 로고    scopus 로고
    • Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diasteromeric opioid peptides in biological media from various animal species including human
    • Liederer BM, Borchardt RT. Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diasteromeric opioid peptides in biological media from various animal species including human. J Pharm Sci 2005;94(10):2198-2206.
    • (2005) J Pharm Sci , vol.94 , Issue.10 , pp. 2198-2206
    • Liederer, B.M.1    Borchardt, R.T.2
  • 22
    • 33745031316 scopus 로고    scopus 로고
    • Enzymes involved in the bioconversion of ester-based prodrugs
    • Liederer BM, Borchardt RT. Enzymes involved in the bioconversion of ester-based prodrugs. J Pharm Sci 2006;95(6):1177-1195.
    • (2006) J Pharm Sci , vol.95 , Issue.6 , pp. 1177-1195
    • Liederer, B.M.1    Borchardt, R.T.2
  • 23
    • 33748685657 scopus 로고    scopus 로고
    • Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases
    • Lindegardh N, Davies GR, Tran TH, et al. Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases. Antimicrob Agents Chemother 2006;50(9):3197-3199.
    • (2006) Antimicrob Agents Chemother , vol.50 , Issue.9 , pp. 3197-3199
    • Lindegardh, N.1    Davies, G.R.2    Tran, T.H.3
  • 24
    • 79952016469 scopus 로고    scopus 로고
    • Identifying trends and developing solutions for incurred sample reanalysis failure investigations in a bioanalytical CRO
    • Meng M, Reuschel S, Bennett P. Identifying trends and developing solutions for incurred sample reanalysis failure investigations in a bioanalytical CRO. Bioanalysis 2011;3(4):449-465.
    • (2011) Bioanalysis , vol.3 , Issue.4 , pp. 449-465
    • Meng, M.1    Reuschel, S.2    Bennett, P.3
  • 25
    • 0029024175 scopus 로고
    • Species differences in hydrolysis of isocarbacyclin methyl ester (TEI-9090) by blood esterases
    • Minagawa T, Kohno Y, Suwa T, Tsuji A. Species differences in hydrolysis of isocarbacyclin methyl ester (TEI-9090) by blood esterases. Biochem Pharmacol 1995;49(10):1361-1365.
    • (1995) Biochem Pharmacol , vol.49 , Issue.10 , pp. 1361-1365
    • Minagawa, T.1    Kohno, Y.2    Suwa, T.3    Tsuji, A.4
  • 26
    • 13244279430 scopus 로고    scopus 로고
    • The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane
    • Olivera-Bravo S, Ivorra I, Morales A. The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane. Br J Pharmacol 2005;144(1):88-97.
    • (2005) Br J Pharmacol , vol.144 , Issue.1 , pp. 88-97
    • Olivera-Bravo, S.1    Ivorra, I.2    Morales, A.3
  • 27
    • 67649111006 scopus 로고    scopus 로고
    • Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues
    • Peterson LW, McKenna CE. Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues. Expert Opin Drug Deliv 2009;6(4):405-420.
    • (2009) Expert Opin Drug Deliv , vol.6 , Issue.4 , pp. 405-420
    • Peterson, L.W.1    McKenna, C.E.2
  • 29
  • 30
    • 80052814011 scopus 로고    scopus 로고
    • LC-MS/MS determination of betamethasone and its phosphate and acetate esters in human plasma after sample stabilization
    • Salem II, Alkhatib M, Najib N. LC-MS/MS determination of betamethasone and its phosphate and acetate esters in human plasma after sample stabilization. J Pharm Biomed Anal 2011;56(5):983-991.
    • (2011) J Pharm Biomed Anal , vol.56 , Issue.5 , pp. 983-991
    • Salem, I.I.1    Alkhatib, M.2    Najib, N.3
  • 31
    • 0035086676 scopus 로고    scopus 로고
    • In vitro stability of cocaine in whole blood and plasma including ecgonine as a target analyte
    • Skopp G, Klingmann A, Pötsch L, Mattern R. In vitro stability of cocaine in whole blood and plasma including ecgonine as a target analyte. Ther Drug Monit 2001;23(2):174-181.
    • (2001) Ther Drug Monit , vol.23 , Issue.2 , pp. 174-181
    • Skopp, G.1    Klingmann, A.2    Pötsch, L.3    Mattern, R.4
  • 32
    • 0021800252 scopus 로고
    • Prodrugs: Do they have advantages in clinical practice?
    • Stella VJ, Charman WN, Naringrekar VH. Prodrugs: Do they have advantages in clinical practice? Drugs 1985;29(5):455-473.
    • (1985) Drugs , vol.29 , Issue.5 , pp. 455-473
    • Stella, V.J.1    Charman, W.N.2    Naringrekar, V.H.3
  • 33
    • 84861227429 scopus 로고    scopus 로고
    • Simultaneous determination of caffeic acid phenethyl ester and its metabolite caffeic acid in dog plasma using liquid chromatography tandem mass spectrometry
    • Tang C, Sojinu OS. Simultaneous determination of caffeic acid phenethyl ester and its metabolite caffeic acid in dog plasma using liquid chromatography tandem mass spectrometry. Talanta 2012;94:232-239.
    • (2012) Talanta , vol.94 , pp. 232-239
    • Tang, C.1    Sojinu, O.S.2
  • 34
    • 21144442350 scopus 로고    scopus 로고
    • Stability of spironolactone in rat plasma: strict temperature control of blood and plasma samples is required in rat pharmacokinetic studies
    • Tokumura T, Muraoka A, Masutomi T, Machida Y. Stability of spironolactone in rat plasma: strict temperature control of blood and plasma samples is required in rat pharmacokinetic studies. Biol Pharm Bull 2005;28(6):1126-1128.
    • (2005) Biol Pharm Bull , vol.28 , Issue.6 , pp. 1126-1128
    • Tokumura, T.1    Muraoka, A.2    Masutomi, T.3    Machida, Y.4
  • 36
    • 34147173942 scopus 로고    scopus 로고
    • Stability of caffeic acid phenethyl ester and its fluorinated derivative in rat plasma
    • Wang X, Bowman PD, Kerwin SM, Stavchansky S. Stability of caffeic acid phenethyl ester and its fluorinated derivative in rat plasma. Biomed Chromatogr 2007;21(4):343-350.
    • (2007) Biomed Chromatogr , vol.21 , Issue.4 , pp. 343-350
    • Wang, X.1    Bowman, P.D.2    Kerwin, S.M.3    Stavchansky, S.4
  • 37
    • 0029114725 scopus 로고
    • The in vitro degradation of cisatracurium, the R, cis-R_-isomer of atracurium, in human and rat plasma
    • Welch RM, Brown A, Ravitch J, Dahl R. The in vitro degradation of cisatracurium, the R, cis-R_-isomer of atracurium, in human and rat plasma. Clin Pharmacol Ther 1995;58(2):132-142.
    • (1995) Clin Pharmacol Ther , vol.58 , Issue.2 , pp. 132-142
    • Welch, R.M.1    Brown, A.2    Ravitch, J.3    Dahl, R.4
  • 38
    • 0034682944 scopus 로고    scopus 로고
    • Development of a highperformance liquid chromatographic-mass spectrometric assay for the specific and sensitive quantification of Ro 64-0802, an anti-influenza drug, and its pro-drug, oseltamivir, in human and animal plasma and urine
    • Wiltshire H, Wiltshire B, Citron A, et al. Development of a highperformance liquid chromatographic-mass spectrometric assay for the specific and sensitive quantification of Ro 64-0802, an anti-influenza drug, and its pro-drug, oseltamivir, in human and animal plasma and urine. J Chromatogr B Biomed Sci Appl 2000;745(2):373-388.
    • (2000) J Chromatogr B Biomed Sci Appl , vol.745 , Issue.2 , pp. 373-388
    • Wiltshire, H.1    Wiltshire, B.2    Citron, A.3
  • 39
    • 33744969383 scopus 로고    scopus 로고
    • Involvement of human blood arylesterase and liver microsomal carboxylesterase in nafamostat hydrolysis
    • Yamaori S, Fujiyama N, Kushihara M, et al. Involvement of human blood arylesterase and liver microsomal carboxylesterase in nafamostat hydrolysis. Drug Metab Pharmacokinet 2006;21(2):147-155.
    • (2006) Drug Metab Pharmacokinet , vol.21 , Issue.2 , pp. 147-155
    • Yamaori, S.1    Fujiyama, N.2    Kushihara, M.3
  • 40
    • 0036827812 scopus 로고    scopus 로고
    • In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-DAla-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs
    • Yang JZ, Chen W, Borchardt RT. In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-DAla-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs. J Pharmacol Exp Ther 2002;303(2):840-848.
    • (2002) J Pharmacol Exp Ther , vol.303 , Issue.2 , pp. 840-848
    • Yang, J.Z.1    Chen, W.2    Borchardt, R.T.3
  • 41
    • 0032904639 scopus 로고    scopus 로고
    • Characterization of esterases involved in the steroselective hydrolysis of estertype prodrugs of propranolol in rat liver and plasma
    • Yoshigae Y, Imai T, Taketani M, Otagiri M. Characterization of esterases involved in the steroselective hydrolysis of estertype prodrugs of propranolol in rat liver and plasma. Chirality 1999;11:10-13.
    • (1999) Chirality , vol.11 , pp. 10-13
    • Yoshigae, Y.1    Imai, T.2    Taketani, M.3    Otagiri, M.4
  • 42
    • 34249652463 scopus 로고    scopus 로고
    • Simultaneous determination of a selective adenosine 2A agonist, BMS-068645, and its acid metabolite in human plasma by liquid chromatography-tandem mass spectrometry-evaluation of the esterase inhibitor, diisopropyl fluorophosphate, in the stabilization of a labile estercontaining drug
    • Zeng J, Onthank D, Crane P, et al. Simultaneous determination of a selective adenosine 2A agonist, BMS-068645, and its acid metabolite in human plasma by liquid chromatography-tandem mass spectrometry-evaluation of the esterase inhibitor, diisopropyl fluorophosphate, in the stabilization of a labile estercontaining drug. J Chromatogr B Analyt Technol Biomed Life Sci 2007;852(1-2):77-84.
    • (2007) J Chromatogr B Analyt Technol Biomed Life Sci , vol.852 , Issue.1-2 , pp. 77-84
    • Zeng, J.1    Onthank, D.2    Crane, P.3
  • 43
    • 0037085033 scopus 로고    scopus 로고
    • Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity
    • Zhang JG, Fariss MW. Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity. Biochem Pharmacol 2002;63:751-754.
    • (2002) Biochem Pharmacol , vol.63 , pp. 751-754
    • Zhang, J.G.1    Fariss, M.W.2
  • 44
    • 79959900247 scopus 로고    scopus 로고
    • Development and validation of a sample stabilization strategy and a UPLCMS/MS method for the simultaneous quantitation of acetylcholine (ACh), histamine (HA), and its metabolites in rat cerebrospinal fluid (CSF)
    • Zhang Y, Tingley FD 3rd, Tseng E, et al. Development and validation of a sample stabilization strategy and a UPLCMS/MS method for the simultaneous quantitation of acetylcholine (ACh), histamine (HA), and its metabolites in rat cerebrospinal fluid (CSF). J Chromatogr B Analyt Technol Biomed Life Sci 2011;879(22):2023-2033.
    • (2011) J Chromatogr B Analyt Technol Biomed Life Sci , vol.879 , Issue.22 , pp. 2023-2033
    • Zhang, Y.1    Tingley, F.D.2    Tseng, E.3


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